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Arachidonic acid metabolism CYP450 pathway is deregulated in hepatocellular carcinoma and associated with microvascular invasion
In this study, we investigated the expression of key genes involved in the arachidonic acid metabolism pathway in HCC using a combination of bioinformatics, proteomics and immunohistochemistry analyses. Through a comprehensive analysis of publicly available datasets, clinical HCC tissues, and tissue microarrays, we compared the expression of hepatic arachidonic acid metabolic genes. We observed significant downregulation of cytochrome P450 (CYP450) pathway genes at both the messenger RNA and protein levels in HCC tissues compared to normal liver tissues. Furthermore, we observed a strong correlation between the deregulatio...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Kai Wang Ji-Hua Shi Jie Gao Yaohui Sun Zhihui Wang Xiaoyi Shi Wenzhi Guo Yang Jin Shuijun Zhang Source Type: research
Performance responses of lactating Rahmani ewes fed diet supplemented with < em > Enterococcus faecium < /em > NRC-3 or < em > Lactobacillus rhamnosus < /em >
Anim Biotechnol. 2023 Sep 1:1-9. doi: 10.1080/10495398.2023.2252013. Online ahead of print.ABSTRACTProduction of new types of probiotics for animal nutrition mainly depends on the appropriate bacterial strain and efficient substrate. Therefore, this study aimed to evaluate the impact of two probiotic strains containing 1.2 × 108 (CFU/g), produced on permeate media on performance responses of Rahmani ewes. Thirty early lactating ewes (about 2-3 years old and weighting on average 43.2 ± 0.3 kg) were randomly divided into three groups of 10 animals each using a completely randomized design. The 1st group was fed the basal d...
Source: Animal Biotechnology - September 1, 2023 Category: Biotechnology Authors: H H Azzaz A A Awad H A Murad Noha A Hassaan Source Type: research
Mechanistic insights into sulfur source-driven physiological responses and metabolic reorganization in the fuel-biodesulfurizing < em > Rhodococcus qingshengii < /em > IGTS8
Appl Environ Microbiol. 2023 Sep 1:e0082623. doi: 10.1128/aem.00826-23. Online ahead of print.ABSTRACTComparative proteomics and untargeted metabolomics were combined to study the physiological and metabolic adaptations of Rhodococcus qingshengii IGTS8 under biodesulfurization conditions. After growth in a chemically defined medium with either dibenzothiophene (DBT) or MgSO4 as the sulfur source, many differentially produced proteins and metabolites associated with several metabolic and physiological processes were detected including the metabolism of carbohydrates, amino acids, lipids, nucleotides, vitamins, protein synth...
Source: Applied and Environmental Microbiology - September 1, 2023 Category: Microbiology Authors: Julie Zumsteg Aur élie Hirschler Christine Carapito Lo ïc Maurer Claire Villette Dimitri Heintz Christiane Dahl Ashraf El Nayal Vartul Sangal Huda Mahmoud Alain Van Dorsselaer Wael Ismail Source Type: research
Biological function, regulatory mechanism, and clinical application of mannose in cancer
Biochim Biophys Acta Rev Cancer. 2023 Aug 30:188970. doi: 10.1016/j.bbcan.2023.188970. Online ahead of print.ABSTRACTStudies examining the regulatory roles and clinical applications of monosaccharides other than glucose in cancer have been neglected. Mannose, a common type of monosaccharide found in human body fluids and tissues, primarily functions in protein glycosylation rather than carbohydrate metabolism. Recent research has demonstrated direct anticancer effects of mannose in vitro and in vivo. Simply supplementing cell culture medium or drinking water with mannose achieved these effects. Moreover, mannose enhances t...
Source: Biochimica et Biophysica Acta - September 1, 2023 Category: Biochemistry Authors: Haoyi Jin Xi Liu Hong-Xu Liu Source Type: research
Mechanistic insights into sulfur source-driven physiological responses and metabolic reorganization in the fuel-biodesulfurizing < em > Rhodococcus qingshengii < /em > IGTS8
Appl Environ Microbiol. 2023 Sep 1:e0082623. doi: 10.1128/aem.00826-23. Online ahead of print.ABSTRACTComparative proteomics and untargeted metabolomics were combined to study the physiological and metabolic adaptations of Rhodococcus qingshengii IGTS8 under biodesulfurization conditions. After growth in a chemically defined medium with either dibenzothiophene (DBT) or MgSO4 as the sulfur source, many differentially produced proteins and metabolites associated with several metabolic and physiological processes were detected including the metabolism of carbohydrates, amino acids, lipids, nucleotides, vitamins, protein synth...
Source: Applied and Environmental Microbiology - September 1, 2023 Category: Microbiology Authors: Julie Zumsteg Aur élie Hirschler Christine Carapito Lo ïc Maurer Claire Villette Dimitri Heintz Christiane Dahl Ashraf El Nayal Vartul Sangal Huda Mahmoud Alain Van Dorsselaer Wael Ismail Source Type: research
Performance responses of lactating Rahmani ewes fed diet supplemented with < em > Enterococcus faecium < /em > NRC-3 or < em > Lactobacillus rhamnosus < /em >
Anim Biotechnol. 2023 Sep 1:1-9. doi: 10.1080/10495398.2023.2252013. Online ahead of print.ABSTRACTProduction of new types of probiotics for animal nutrition mainly depends on the appropriate bacterial strain and efficient substrate. Therefore, this study aimed to evaluate the impact of two probiotic strains containing 1.2 × 108 (CFU/g), produced on permeate media on performance responses of Rahmani ewes. Thirty early lactating ewes (about 2-3 years old and weighting on average 43.2 ± 0.3 kg) were randomly divided into three groups of 10 animals each using a completely randomized design. The 1st group was fed the basal d...
Source: Animal Biotechnology - September 1, 2023 Category: Biotechnology Authors: H H Azzaz A A Awad H A Murad Noha A Hassaan Source Type: research
Mechanistic insights into sulfur source-driven physiological responses and metabolic reorganization in the fuel-biodesulfurizing < em > Rhodococcus qingshengii < /em > IGTS8
Appl Environ Microbiol. 2023 Sep 1:e0082623. doi: 10.1128/aem.00826-23. Online ahead of print.ABSTRACTComparative proteomics and untargeted metabolomics were combined to study the physiological and metabolic adaptations of Rhodococcus qingshengii IGTS8 under biodesulfurization conditions. After growth in a chemically defined medium with either dibenzothiophene (DBT) or MgSO4 as the sulfur source, many differentially produced proteins and metabolites associated with several metabolic and physiological processes were detected including the metabolism of carbohydrates, amino acids, lipids, nucleotides, vitamins, protein synth...
Source: Applied and Environmental Microbiology - September 1, 2023 Category: Microbiology Authors: Julie Zumsteg Aur élie Hirschler Christine Carapito Lo ïc Maurer Claire Villette Dimitri Heintz Christiane Dahl Ashraf El Nayal Vartul Sangal Huda Mahmoud Alain Van Dorsselaer Wael Ismail Source Type: research
Arachidonic acid metabolism CYP450 pathway is deregulated in hepatocellular carcinoma and associated with microvascular invasion
In this study, we investigated the expression of key genes involved in the arachidonic acid metabolism pathway in HCC using a combination of bioinformatics, proteomics and immunohistochemistry analyses. Through a comprehensive analysis of publicly available datasets, clinical HCC tissues, and tissue microarrays, we compared the expression of hepatic arachidonic acid metabolic genes. We observed significant downregulation of cytochrome P450 (CYP450) pathway genes at both the messenger RNA and protein levels in HCC tissues compared to normal liver tissues. Furthermore, we observed a strong correlation between the deregulatio...
Source: Cell Biology International - September 1, 2023 Category: Cytology Authors: Kai Wang Ji-Hua Shi Jie Gao Yaohui Sun Zhihui Wang Xiaoyi Shi Wenzhi Guo Yang Jin Shuijun Zhang Source Type: research
Carbohydrate flow through agricultural ecosystems: Implications for synthesis and microbial conversion of carbohydrates
Biotechnol Adv. 2023 Aug 29:108245. doi: 10.1016/j.biotechadv.2023.108245. Online ahead of print.ABSTRACTCarbohydrates are chemically and structurally diverse biomolecules, serving numerous and varied roles in agricultural ecosystems. Crops and horticulture products are inherent sources of carbohydrates that are consumed by humans and non-human animals alike; however carbohydrates are also present in other agricultural materials, such as soil and compost, human and animal tissues, milk and dairy products, and honey. The biosynthesis, modification, and flow of carbohydrates within and between agricultural ecosystems is inti...
Source: Biotechnology Advances - August 31, 2023 Category: Biotechnology Authors: Kristin E Low Jeffrey P Tingley Leeann Klassen Marissa L King Xiaohui Xing Caitlin Watt Shelley E R Hoover Monika Gorzelak D Wade Abbott Source Type: research
Carbohydrate polymers-based surface modified nano delivery systems for enhanced target delivery to colon cancer - A review
Int J Biol Macromol. 2023 Aug 29:126581. doi: 10.1016/j.ijbiomac.2023.126581. Online ahead of print.ABSTRACTCarbohydrate polymers-based surface-modified nano-delivery systems have gained significant attention in recent years for enhancing targeted delivery to colon cancer. These systems leverage carbohydrate polymers' unique properties, such as biocompatibility, biodegradability, and controlled release. These properties make them suitable candidates for drug delivery applications. Nano-delivery systems loaded with bioactive compounds are well-studied for targeted colorectal cancer delivery. However, those drugs' target rea...
Source: International Journal of Biological Macromolecules - August 31, 2023 Category: Biochemistry Authors: Ibrahim Abdel Aziz Ibrahim Abdullah R Alzahrani Ibrahim M Alanazi Naiyer Shahzad Imran Shahid Alaa Hisham Falemban Mohd Fahami Nur Azlina Palanisamy Arulselvan Source Type: research
Glycemic variability and hypoglycemia before and after Roux-en-Y Gastric Bypass and Sleeve Gastrectomy - A cohort study of females without diabetes
CONCLUSIONS: The lower IG concentration in combination with the higher GV after surgery, might create a lower margin to hypoglycemia. This could help explain the increased occurrence of hypoglycemic episodes after RYGB and SG.PMID:37652806 | DOI:10.1016/j.soard.2023.07.008
Source: Surgery for Obesity and Related Diseases : official journal of the American Society for Bariatric Surgery - August 31, 2023 Category: Surgery Authors: Inger Nilsen Magnus Sundbom Johanna Osterberg Anna Laurenius Agneta Andersson Arvo Haenni Source Type: research
Fermentation patterns of prebiotics fructooligosaccharides-SCFA esters inoculated with fecal microbiota from ulcerative colitis patients
In this study, esters formed by binding of well-known prebiotics, fructooligosaccharides (FOS), with short chain fatty acids (SCFAs) via both enzymatic and chemical methods were evaluated for their impact on the gut microbiota of UC patients. An in vitro human colonic fermentation model was employed to monitor changes in total carbohydrates and SCFAs production during the fermentation of these esters by microbiota from patients with active and remission UC. The results showed that pronounced abundance of [Ruminococcus]_gnavus_group, Escherichia_Shigella, Lachnoclostridium, Klebsiella and other potential pathogens were dete...
Source: Food and Chemical Toxicology - August 31, 2023 Category: Food Science Authors: Weiwen Chen Diming Tan Zixin Yang Jian Tang Weibin Bai Lingmin Tian Source Type: research
