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Therapy: Stem Cell Therapy
Nutrition: Calcium
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Total 1021 results found since Jan 2013.
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
Polysaccharide-Based Composite Hydrogel with Hierarchical Microstructure for Enhanced Vascularization and Skull Regeneration
Biomacromolecules. 2023 Sep 20. doi: 10.1021/acs.biomac.3c00655. Online ahead of print.ABSTRACTCritical-size skull defects caused by trauma, infection, and tumor resection raise great demands for efficient bone substitutes. Herein, a hybrid cross-linked hierarchical microporous hydrogel scaffold (PHCLS) was successfully assembled by a multistep procedure, which involved (i) the preparation of poly(lactic-co-glycolic)/nanohydroxyapatite (PLGA-HAP) porous microspheres, (ii) embedding the spheres in a solution of dopamine-modified hyaluronic acid and collagen I (Col I) and cross-linking via dopamine polyphenols binding to (i)...
Source: Biomacromolecules - September 20, 2023 Category: Biochemistry Authors: Gonggong Lu Xiang Li Peilei Wang Xing Li Yuxiang Wang Jiayi Zhu Alfredo Ronca Ugo D'Amora Wenke Liu Xuhui Hui Source Type: research
The symbiotic effect of osteoinductive extracellular vesicles and mineralized microenvironment on osteogenesis
J Biomed Mater Res A. 2023 Sep 6. doi: 10.1002/jbm.a.37600. Online ahead of print.ABSTRACTThe increasing prevalence of bone-related diseases has raised concern about the need for an osteoinductive and mechanically stronger scaffold-based bone tissue engineering (BTE) alternative. A mineralized microenvironment, similar to the native bone microenvironment, is required in the scaffold to recruit and differentiate local mesenchymal stem cells at the bone defect site. Further, extracellular vesicles (EVs), pre-osteoblasts' secretome, contain osteoinductive cargo and have recently been exploited in bone regeneration. This work ...
Source: Cell Research - September 6, 2023 Category: Cytology Authors: Ketki Holkar Vaijayanti Kale Prasad Pethe Ganesh Ingavle Source Type: research
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Cell Mol Life Sci. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3.ABSTRACTHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. Human ...
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Robert D Johnson Ming Lei John H McVey Patrizia Camelliti Source Type: research
New biograft solution, growth factors and bone regenerative approaches in neurosurgery, dentistry, and orthopedics: a review
Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7653-7664. doi: 10.26355/eurrev_202308_33419.ABSTRACTBone regeneration following surgery, trauma, or any other condition is an autologous process that can fail, necessitating the requirement of novel procedures and materials. Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in spine surgery, orthopedics, and dentistry are facing many challenges and posing clinical concerns. A PubMed, MEDLINE, and Scopus review was carried out to identify all studies dealing with bone regenerative approaches in dent...
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: N Montemurro E Pierozzi A M Inchingolo B Pahwa A De Carlo A Palermo R Scarola G Dipalma M Corsalini A D Inchingolo F Inchingolo B Rapone Source Type: research
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Cell Mol Life Sci. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3.ABSTRACTHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. Human ...
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Robert D Johnson Ming Lei John H McVey Patrizia Camelliti Source Type: research
New biograft solution, growth factors and bone regenerative approaches in neurosurgery, dentistry, and orthopedics: a review
Eur Rev Med Pharmacol Sci. 2023 Aug;27(16):7653-7664. doi: 10.26355/eurrev_202308_33419.ABSTRACTBone regeneration following surgery, trauma, or any other condition is an autologous process that can fail, necessitating the requirement of novel procedures and materials. Recently, significant progress has been made in the research related to regenerative medicine. At the same time, biomedical implants in spine surgery, orthopedics, and dentistry are facing many challenges and posing clinical concerns. A PubMed, MEDLINE, and Scopus review was carried out to identify all studies dealing with bone regenerative approaches in dent...
Source: Pharmacological Reviews - September 5, 2023 Category: Drugs & Pharmacology Authors: N Montemurro E Pierozzi A M Inchingolo B Pahwa A De Carlo A Palermo R Scarola G Dipalma M Corsalini A D Inchingolo F Inchingolo B Rapone Source Type: research
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Cell Mol Life Sci. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3.ABSTRACTHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. Human ...
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Robert D Johnson Ming Lei John H McVey Patrizia Camelliti Source Type: research
Calvaria defect regeneration via human periodontal ligament stem cells and prevascularized scaffolds in athymic rats
CONCLUSION: The hPL pre-culture method is promising to enhance bone regeneration via prevascularized CPC. Novel hPDLSC-hUVEC-CPC-hPL prevascularized construct increased new bone formation and blood vessel density by 4-8 folds over CPC control.CLINICAL SIGNIFICANCE: Novel hPDLSC-hUVEC-hPL-CPC prevascularized construct greatly increased bone and vascular regeneration in vivo and hence is promising for a wide range of craniofacial applications.PMID:37666466 | DOI:10.1016/j.jdent.2023.104690
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Zeqing Zhao Yaxi Sun Qingchen Qiao Michael D Weir Abraham Schneider Radi Masri Christopher D Lynch Ning Zhang Ke Zhang Yuxing Bai Hockin Xu Source Type: research
Maturation of iPSC-derived cardiomyocytes in a heart-on-a-chip device enables modeling of dilated cardiomyopathy caused by R222Q-SCN5A mutation
In conclusion, we demonstrate that in addition to altering cardiac electrophysiology and Na+ current, the R222Q mutation also causes profound sarcomere disruptions and mechanical destabilization. Possible mechanisms for these observations are discussed.PMID:37651922 | DOI:10.1016/j.biomaterials.2023.122255
Source: Biomaterials - August 31, 2023 Category: Materials Science Authors: Marianne Wauchop Naimeh Rafatian Yimu Zhao Wenliang Chen Mark Gagliardi St éphane Massé Brian J Cox Patrick Lai Timothy Liang Shira Landau Stephanie Protze Xiao Dong Gao Erika Yan Wang Kelvin Chan Tung Zachary Laksman Rick Xing Ze Lu Gordon Keller Kumar Source Type: research
Generation of eight hiPSCs lines from two pathogenic variants in CACNA1A using the CRISPR-Cas9 gene editing technology
Stem Cell Res. 2023 Aug 25;71:103193. doi: 10.1016/j.scr.2023.103193. Online ahead of print.ABSTRACTDevelopmental and epileptic encephalopathies (DEEs) are rare severe neurodevelopmental disorders with a cumulative incidence of 1:6.000 live births. Many epileptic conditions arise from single nucleotide variants in CACNA1A (calcium voltage-gated channel subunit alpha1 A), encoding the CaV2.1 calcium channel subunit. Human induced pluripotent stem cells (hiPSCs) are an optimal choice for modeling DEEs, as they can be differentiated in vitro into diverse neuronal subpopulations. Here, we report the generation of hiPSC lines w...
Source: Cell Research - August 31, 2023 Category: Cytology Authors: Paula Rivera-S ánchez Line S øndergaard Methi Wathikthinnakon Helena B D Magnusson Henriette R Frederiksen Freja Aab æk Hammer Reema Taleb Conan Christian Cassidy Mads Tranholm Bruun Zeynep T ümer Bj ørn Holst Charlotte Brasch-Andersen Rikke M øller Source Type: research
