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Nutrition: Calcium
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Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Vitam Horm. 2023;123:313-383. doi: 10.1016/bs.vh.2022.12.008. Epub 2023 Jun 8.ABSTRACTThe nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex transcriptionally controls genes encoding factors that regulate calcium and phosphate sensing/transport, bone remodeling, immune function, and nervous system maintenance. With the aid of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), 1,25D/VDR primarily participates in an intricate netw...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Mark R Haussler Carol A Haussler Peter W Jurutka Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Vitam Horm. 2023;123:313-383. doi: 10.1016/bs.vh.2022.12.008. Epub 2023 Jun 8.ABSTRACTThe nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex transcriptionally controls genes encoding factors that regulate calcium and phosphate sensing/transport, bone remodeling, immune function, and nervous system maintenance. With the aid of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), 1,25D/VDR primarily participates in an intricate netw...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Mark R Haussler Carol A Haussler Peter W Jurutka Source Type: research
TORC1 mediated regulation of mitochondrial integrity and calcium ion homeostasis by Wat1/mLst8 in S. pombe
Int J Biol Macromol. 2023 Sep 15:126907. doi: 10.1016/j.ijbiomac.2023.126907. Online ahead of print.ABSTRACTThe mTOR complexes play a fundamental role in mitochondrial biogenesis and cellular homeostasis. Wat1, an ortholog of mammalian Lst8 is an important component of TOR complex and is essential for the regulation of downstream signaling. Earlier we reported the role of Wat1 in oxidative stress response. Here, we have shown that the abrogation of wat1 causes respiratory defects and mitochondrial depolarization that leads to a decrease in ATP production. The confocal and electron microscopy in wat1Δ cells revealed the fr...
Source: International Journal of Biological Macromolecules - September 17, 2023 Category: Biochemistry Authors: Simmi Anjum Swati Srivastava Lalita Panigrahi Uzair Ahmad Ansari Arun Kumar Trivedi Shakil Ahmed Source Type: research
Structure-function of DHEA binding proteins
Vitam Horm. 2023;123:587-617. doi: 10.1016/bs.vh.2022.12.002. Epub 2022 Dec 16.ABSTRACTDehydroepiandrosterone (3β-hydroxy-5-androsten-17-one, DHEA) and its sulfated metabolite DHEA-S are the most abundant circulating steroids and are precursors for active sex steroid hormones, estradiol and testosterone. DHEA has a broad range of reported effects in the central nervous system (CNS), cardiovascular system, adipose tissue, kidney, liver, and in the reproductive system. The mechanisms by which DHEA and DHEA-S initiate their biological effects are diverse. DHEA and DHEA-S may directly bind to plasma membrane (PM) receptors, i...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Barbara J Clark Carolyn M Klinge Source Type: research
Sirtuin1 inhibits calcium oxalate crystal-induced kidney injury by regulating TLR4 signaling and macrophage-mediated inflammatory activation
Cell Signal. 2023 Sep 15:110887. doi: 10.1016/j.cellsig.2023.110887. Online ahead of print.ABSTRACTSirtuin1 (Sirt1) activation significantly attenuated calcium oxalate (CaOx) crystal deposition and renal inflammatory injury by regulating renal immune microenvironment. Here, to elucidate the molecular mechanism underlying the therapeutic effects of Sirt1 on macrophage related inflammation and tubular epithelial cells (TECs) necrosis, we constructed a macrophage and CaOx monohydrate (COM)-stimulated tubular cell co-culture system to mimic immune microenvironment in kidney and established a mouse model of CaOx nephrocalcinosi...
Source: Cellular Signalling - September 17, 2023 Category: Cytology Authors: Chen Duan Haoran Liu Xiaoqi Yang Jianhe Liu Yaoliang Deng Tao Wang Jinchun Xing Zhiquan Hu Hua Xu Source Type: research
Genomically anchored vitamin D receptor mediates an abundance of bioprotective actions elicited by its 1,25-dihydroxyvitamin D hormonal ligand
Vitam Horm. 2023;123:313-383. doi: 10.1016/bs.vh.2022.12.008. Epub 2023 Jun 8.ABSTRACTThe nuclear vitamin D receptor (VDR) mediates the actions of its physiologic 1,25-dihydroxyvitamin D3 (1,25D) ligand produced in kidney and at extrarenal sites during times of physiologic and cellular stress. The ligand-receptor complex transcriptionally controls genes encoding factors that regulate calcium and phosphate sensing/transport, bone remodeling, immune function, and nervous system maintenance. With the aid of parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF23), 1,25D/VDR primarily participates in an intricate netw...
Source: Vitamins and Hormones - September 17, 2023 Category: Endocrinology Authors: Mark R Haussler Carol A Haussler Peter W Jurutka Source Type: research
Insight into the mechanism of nutrients removal and response regulation of denitrifying phosphorus removal system under calcium ion stress
This study investigated the effects of calcium ion (Ca2+) on the nutrients removal, nitrogen oxide (N2O) release, microbial community, and quorum sensing in DPR system. Results showed that high accumulation of Ca2+ had a significant impact on the carbon footprint of DPR system. Specifically, N2O release reached 2.11 mg/L under Ca2+ of 150 mg/L, which represented 214.93% increase compared to 0 mg/L of Ca2+. The DPR system demonstrated its adaptability to elevated Ca2+ concentrations by modifying key enzyme activities involved in nitrogen and phosphorus removal, altering the microbial community structure, and adjusting the t...
Source: Bioresource Technology - September 17, 2023 Category: Biotechnology Authors: Cheng Han Hongliang Dai Zechong Guo Guangcan Zhu Bing Li Haq Nawaz Abbasi Xingang Wang Source Type: research
Sirtuin1 inhibits calcium oxalate crystal-induced kidney injury by regulating TLR4 signaling and macrophage-mediated inflammatory activation
Cell Signal. 2023 Sep 15:110887. doi: 10.1016/j.cellsig.2023.110887. Online ahead of print.ABSTRACTSirtuin1 (Sirt1) activation significantly attenuated calcium oxalate (CaOx) crystal deposition and renal inflammatory injury by regulating renal immune microenvironment. Here, to elucidate the molecular mechanism underlying the therapeutic effects of Sirt1 on macrophage related inflammation and tubular epithelial cells (TECs) necrosis, we constructed a macrophage and CaOx monohydrate (COM)-stimulated tubular cell co-culture system to mimic immune microenvironment in kidney and established a mouse model of CaOx nephrocalcinosi...
Source: Cellular Signalling - September 17, 2023 Category: Cytology Authors: Chen Duan Haoran Liu Xiaoqi Yang Jianhe Liu Yaoliang Deng Tao Wang Jinchun Xing Zhiquan Hu Hua Xu Source Type: research
High glucose-induced imbalance of mitochondria-associated ER membranes function promotes RSC96 cell damage
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):138-142. doi: 10.14715/cmb/2023.69.7.22.ABSTRACTTo investigate the effect of high glucose on mitochondrial-related ER membranes (MAMs) in rat Schwann cells (SCs) and the mechanism of cell injury. SCs (RSC96) cells were used as the control group, and RSC96 cells cultured in a high glucose environment for 48 h were set as the experimental group. The level of intracellular calcium was observed by flow cytometry, and ROS levels were detected by DCFH-DA fluorescent probe. The subcellular structure was observed by transmission electron microscopy, focusing on the morphology of mi...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Housheng Fu Jianbing Xu Fei Wang Weifu Wang Zhongyao Wang Source Type: research
Deciphering calcium signals in cells and tissues with tailored probes and models
J Physiol. 2023 Sep 16. doi: 10.1113/JP285037. Online ahead of print.NO ABSTRACTPMID:37715737 | DOI:10.1113/JP285037
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Nicolas Demaurex Source Type: research
Age-related changes in P2Y receptor signalling in mouse cochlear supporting cells
J Physiol. 2023 Sep 16. doi: 10.1113/JP284980. Online ahead of print.ABSTRACTOur sense of hearing depends on the function of a specialised class of sensory cells, the hair cells, which are found in the organ of Corti of the mammalian cochlea. The unique physiological environment in which these cells operate is maintained by a syncitium of non-sensory supporting cells, which are crucial for regulating cochlear physiology and metabolic homeostasis. Despite their importance for cochlear function, the role of these supporting cells in age-related hearing loss, the most common sensory deficit in the elderly, is poorly understoo...
Source: The Journal of Physiology - September 16, 2023 Category: Physiology Authors: Sarah A Hool Jing-Yi Jeng Daniel J Jagger Walter Marcotti Federico Ceriani Source Type: research
Cholesterol homeostasis, mechanisms of molecular pathways, and cardiac health: a current outlook
Curr Probl Cardiol. 2023 Sep 14:102081. doi: 10.1016/j.cpcardiol.2023.102081. Online ahead of print.ABSTRACTThe metabolism of lipoproteins, which regulates the transit of the lipid to and from tissues, is crucial to maintaining cholesterol homeostasis. Cardiac remodeling is referred to as a set of molecular, cellular, and interstitial changes that, following injury, affect the size, shape, function, mass, and geometry of the heart. Acetyl coenzyme A (acetyl CoA), which can be made from glucose, amino acids, or fatty acids, is the precursor for the synthesis of cholesterol. In this article, authors explain concepts behind c...
Source: Atherosclerosis - September 16, 2023 Category: Cardiology Authors: Rajiv Kumar Neelam Chhillar Dhruv Sanjay Gupta Ginpreet Kaur Shailey Singhal Tanya Chauhan Source Type: research
Channeling hope for uranium-induced kidney damage and beyond with TRPML1
Cell Calcium. 2023 Sep 11;115:102799. doi: 10.1016/j.ceca.2023.102799. Online ahead of print.NO ABSTRACTPMID:37716038 | DOI:10.1016/j.ceca.2023.102799
Source: Cell Calcium - September 16, 2023 Category: Cytology Authors: Kirill Kiselyov Source Type: research
