• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Effectiveness and durability of BNT162b2 vaccine against hospital and emergency department admissions due to SARS-CoV-2 omicron sub-lineages BA.1 and BA.2 in a large health system in the USA: a test-negative, case-control study
This study is registered at ClinicalTrials.gov, NCT04848584, and is ongoing.FINDINGS: Of 65 813 total admissions during the study period, we included 16 994 in our analyses, of which 7435 were due to BA.1, 1056 were due to BA.2, and 8503 were not due to SARS-CoV-2. In adjusted analyses, two-dose vaccine effectiveness was 40% (95% CI 27 to 50) for hospitalisation and 29% (18 to 38) for emergency department admission against BA.1 and 56% (31 to 72) for hospitalisation and 16% (-5 to 33) for emergency department admission against BA.2. Three-dose vaccine effectiveness was 79% (74 to 83) for hospitalisation and 72% (67 to 77) ...
Source: Respiratory Care - October 10, 2022 Category: Respiratory Medicine Authors: Sara Y Tartof Jeff M Slezak Laura Puzniak Vennis Hong Timothy B Frankland Fagen Xie Bradley K Ackerson Srinivas R Valluri Luis Jodar John M McLaughlin Source Type: research

The Virus Hunters Trying to Prevent the Next Pandemic
Nobody saw SARS-CoV-2 coming. In the early days of the pandemic, researchers were scrambling to collect samples from people who had mysteriously developed fevers, coughs, and breathing problems. Pretty soon, they realized that the disease-causing culprit was a new virus humans hadn’t seen before. And the world, lacking a coordinated global response, was unprepared. Some countries acted quickly to develop tests for the novel coronavirus, while others with fewer resources were left behind. With a virus oblivious to national borders, and with travel between countries and continents more common than it had been in previo...
Source: TIME: Health - August 1, 2022 Category: Consumer Health News Authors: Alice Park and Video by Andrew D. Johnson Tags: Uncategorized Disease Frontiers of Medicine 2022 healthscienceclimate Source Type: news

The Addis Declaration on Immunization: A binding reminder of the political support needed to achieve universal immunization in Africa
Vaccine. 2022 Jul 21:S0264-410X(22)00843-X. doi: 10.1016/j.vaccine.2022.06.073. Online ahead of print.ABSTRACTWhile African countries have improved access to immunization since the start of the millennium, progress has stagnated in the last few years. One in five African children is not vaccinated with life-saving vaccines, and recent outbreaks of vaccine-preventable diseases (VPDs) including yellow fever, measles, and meningitis, among others point to gaps in immunization coverage as well as disease surveillance. In 2017, African Heads of State endorsed the Addis Declaration on Immunization (ADI) at the 28th African Union...
Source: Vaccine - July 25, 2022 Category: Allergy & Immunology Authors: Richard M Mihigo Joseph C Okeibunor Fahmy Karmal Helena O'Malley Natasha Godinho Linda Okero Alain N Poy Ouma Onyango Niamh Fitzgerald Source Type: research

Etiological and epidemiological features of acute meningitis or encephalitis in China: a nationwide active surveillance study
Lancet Reg Health West Pac. 2022 Jan 3;20:100361. doi: 10.1016/j.lanwpc.2021.100361. eCollection 2022 Mar.ABSTRACTBACKGROUND: Acute meningitis or encephalitis (AME) results from a neurological infection causing high case fatality and severe sequelae. AME lacked comprehensive surveillance in China.METHODS: Nation-wide surveillance of all-age patients with AME syndromes was conducted in 144 sentinel hospitals of 29 provinces in China. Eleven AME-causative viral and bacterial pathogens were tested with multiple diagnostic methods.FINDINGS: Between 2009 and 2018, 20,454 AME patients were recruited for tests. Based on 9,079 pat...
Source: Herpes - January 17, 2022 Category: Infectious Diseases Authors: Li-Ping Wang Yang Yuan Ying-Le Liu Qing-Bin Lu Lu-Sha Shi Xiang Ren Shi-Xia Zhou Hai-Yang Zhang Xiao-Ai Zhang Xin Wang Yi-Fei Wang Sheng-Hong Lin Cui-Hong Zhang Meng-Jie Geng Jun Li Shi-Wen Zhao Zhi-Gang Yi Xiao Chen Zuo-Sen Yang Lei Meng Xin-Hua Wang Ai- Source Type: research

The impact of childhood pneumococcal conjugate vaccine immunisation on all-cause pneumonia admissions in Hong Kong: A 14-year population-based interrupted time series analysis
Vaccine. 2021 Apr 12:S0264-410X(21)00406-0. doi: 10.1016/j.vaccine.2021.03.090. Online ahead of print.ABSTRACTBACKGROUND: Nine years after the introduction of pneumococcal conjugate vaccine (PCV) in the United States, Hong Kong (HK) introduced the vaccine to its universal childhood immunisation programme in 2009. We aimed to assess the impact of childhood PCV immunisation on all-cause pneumonia (ACP) admissions among the overall population of HK.METHODS: In this population-based interrupted time series analysis, we used territory-wide population-representative electronic health records in HK to evaluate the vaccine impact....
Source: Vaccine - April 16, 2021 Category: Allergy & Immunology Authors: Qiuyan Yu Xue Li Min Fan Hong Qiu Angel Y S Wong Linwei Tian Celine S L Chui Philip H Li Lauren K W Lau Esther W Chan William B Goggins Patrick Ip Terry Y Lum Ivan F N Hung Benjamin J Cowling Ian C K Wong Mark Jit Source Type: research

Effect of a 2+1 schedule of ten-valent versus 13-valent pneumococcal conjugate vaccine on pneumococcal carriage: Results from a randomised controlled trial in Vietnam
This study aimed to determine if PCV10 and PCV13 have a differential effect on pneumococcal carriage, a secondary outcome of the trial. We also describe the serotype distribution among unvaccinated participants.TRIAL REGISTRATION: ClinicalTrials.gov NCT01953510.FINDINGS: Compared with unvaccinated controls, a 2+1 schedule of PCV10 reduced PCV10-type carriage by 45-62% from pre-booster through to 24 months of age, and a 2+1 schedule of PCV13 reduced PCV13-type carriage by 36-49% at 12 and 18 months of age. Compared directly with each other, there were few differences between the vaccines in their impact on carriage. Vaccine...
Source: Vaccine - March 22, 2021 Category: Allergy & Immunology Authors: Beth Temple Monica Larissa Nation Vo Thi Trang Dai Jemima Beissbarth Kathryn Bright Eileen Margaret Dunne Jason Hinds Pham Thi Hoan Jana Lai Cattram Duong Nguyen Belinda Daniela Ortika Thanh V Phan Ho Nguyen Loc Thuy Nguyen Trong Toan Doan Y Uyen Catherin Source Type: research

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Exploring the Potential Role of Moonlighting Function of the Surface-Associated Proteins From Mycobacterium bovis BCG Moreau and Pasteur by Comparative Proteomic
In this study, the proteomic profile of the surface-associated proteins from M. bovis BCG Moreau was compared to the BCG Pasteur reference strain. The methodology used was 2DE gel electrophoresis combined with mass spectrometry techniques (MALDI-TOF/TOF), leading to the identification of 115 proteins. Of these, 24 proteins showed differential expression between the two BCG strains. Furthermore, 27 proteins previously described as displaying moonlighting function were identified, 8 of these proteins showed variation in abundance comparing BCG Moreau to Pasteur and 2 of them presented two different domain hits. Moonlighting ...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research