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Total 19 results found since Jan 2013.
Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells.
Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Major U.S. geological survey aims to uncover minerals critical for batteries and microchips
From the air, Maine is a uniform sea of green: Forests cover 90% of the state. But beneath the foliage and the dirt lies an array of geological terrains that is far more diverse, built from the relics of volcanic islands that collided with North America hundreds of millions of years ago.
Two years ago, sensor-laden aircraft began to survey these geochemically rich terrains for precious minerals. Researchers spotted an anomalous signal streaming out of Pennington Mountain, 50 kilometers from the Canadian border. State geologists bushwhacked through the paper mill–bound pine forests, taking rock samples. They
event...
Source: Science of Aging Knowledge Environment - June 1, 2023 Category: Geriatrics Source Type: research
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Weekly Australian Health IT Links – 1 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----Quite a lot this week – especially regarding the NBN and Labor trying to regain control of what it is actually for – service provision – and not making a huge profit – in their view. Love the new Minister has ambitions to be maximally photogenic and not a ‘techie’!Otherwise all sorts of fun things!-----https://www.ausd...
Source: Australian Health Information Technology - August 1, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
‘Voyager on steroids.’ Mission would probe mysterious region beyond our Solar System
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Before embarking on his Ph.D., Ralph McNutt had never been east of the Mississippi River. But soon after the young Texan arrived at the Massachusetts Institute of Technology (MIT) in the fall of 1975, he found himself on a voyage to the edge of the Solar System—and beyond. Casting around for a research assistantship, he ended up in the office of plasma physicist Herbert Bridge, a towering figure in ...
Source: Science of Aging Knowledge Environment - July 28, 2022 Category: Geriatrics Source Type: research
Fight Aging! Newsletter, January 18th 2021
In this study, Desferal, deferoxamine mesylate for injection, which is approved for the treatment of acute iron intoxication and chronic iron overload, was used to explore the beneficial effects on preventing aging-induced bone loss and mitigating dysfunction of aged BMSCs. High-dose Desferal significantly prevented bone loss in aged rats. Compared with controls, the ex vivo experiments showed that short-term Desferal administration could promote the potential of BMSC growth and improve the rebalance of osteogenic and adipogenic differentiation, as well as rejuvenate senescent BMSCs and revise the expression of stemness/se...
Source: Fight Aging! - January 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, July 22nd 2019
This study elucidates the potential to use mitochondria from different donors (PAMM) to treat UVR stress and possibly other types of damage or metabolic malfunctions in cells, resulting in not only in-vitro but also ex-vivo applications.
Gene Therapy in Mice Alters the Balance of Macrophage Phenotypes to Slow Atherosclerosis Progression
https://www.fightaging.org/archives/2019/07/gene-therapy-in-mice-alters-the-balance-of-macrophage-phenotypes-to-slow-atherosclerosis-progression/
Atherosclerosis causes a sizable fraction of all deaths in our species. It is the generation of fatty deposits in blood vessel...
Source: Fight Aging! - July 21, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exploring the Potential Role of Moonlighting Function of the Surface-Associated Proteins From Mycobacterium bovis BCG Moreau and Pasteur by Comparative Proteomic
In this study, the proteomic profile of the surface-associated proteins from M. bovis BCG Moreau was compared to the BCG Pasteur reference strain. The methodology used was 2DE gel electrophoresis combined with mass spectrometry techniques (MALDI-TOF/TOF), leading to the identification of 115 proteins. Of these, 24 proteins showed differential expression between the two BCG strains. Furthermore, 27 proteins previously described as displaying moonlighting function were identified, 8 of these proteins showed variation in abundance comparing BCG Moreau to Pasteur and 2 of them presented two different domain hits. Moonlighting ...
Source: Frontiers in Immunology - April 25, 2019 Category: Allergy & Immunology Source Type: research
Methylobacterium extorquens RSH Enzyme Synthesizes (p)ppGpp and pppApp in vitro and in vivo, and Leads to Discovery of pppApp Synthesis in Escherichia coli
This study of the RSHMex enzyme activity is the first direct biochemical demonstration that an RSH enzyme is capable of synthesizing a nucleotide derivative other than (p)ppGpp, i.e., pppApp. This is shown in vitro with the RSHMex1-352 protein (Figures 3, 4), as well as in vivo with E. coli cells induced to express full-length RSHMex and with wild type M. extorquens AM1 cells (Figure 6). Moreover, we demonstrate pppApp accumulation in wild type E. coli cells, which points to a possible new player in bacterial stringent response.
In this work, it became evident to us that there may be a need to re-evaluate RSH nomenclature...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research
Impact of ROS-Induced Damage of TCA Cycle Enzymes on Metabolism and Virulence of Salmonella enterica serovar Typhimurium
Discussion
Reactive oxygen species (ROS) are generated intrinsically in bacteria (i) by the respiratory chain, (ii) by indirect action of antibiotics, or (iii) are produced by phagocytes combating pathogens. ROS damage DNA and other macromolecules, resulting in growth restriction and/or killing of bacteria. We elucidate how oxidative stress-induced metabolic perturbations of the primary metabolism reduce bacterial viability and facilitate clearance of pathogens. For the analysis of long-term exposition of STM to ROS we used a mutant strain defective in both cytosolic SODs. Since all three types of ROS should accumulate in...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research
The RstAB System Impacts Virulence, Motility, Cell Morphology, Penicillin Tolerance and Production of Type II Secretion System-Dependent Factors in the Fish and Human Pathogen Photobacterium damselae subsp. damselae
This study establishes RstAB as a major regulator of virulence and diverse cellular functions in P. damselae subsp. damselae.
Introduction
Two-component signal transduction systems enable bacteria to sense environmental stimuli and transfer this information across the cytoplasmic membrane to the cytoplasm (Stock et al., 2000). Such systems consist of a membrane-embedded protein kinase which acts as a sensory component, and its cognate response regulator, a cytoplasmic transcriptional factor. When the sensory component of the pair is stimulated by a specific signal, it autophosphorylates a histidine residue and then...
Source: Frontiers in Microbiology - April 23, 2019 Category: Microbiology Source Type: research
A Rapid Antimicrobial Susceptibility Test for Determining Yersinia pestis Susceptibility to Doxycycline by RT-PCR Quantification of RNA Markers
This study was supported by the Israel Institute for Biological Research, Ness Ziona, Israel.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Acknowledgments
We thank Dr. Vered Caspi (Ben-Gurion University) for assisting with the bioinformatics and statistical analyses of the Agilent DNA microarray results.
Supplementary Material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00754/full#s...
Source: Frontiers in Microbiology - April 15, 2019 Category: Microbiology Source Type: research
Living at the Extremes: Extremophiles and the Limits of Life in a Planetary Context
Nancy Merino1,2,3, Heidi S. Aronson4, Diana P. Bojanova1, Jayme Feyhl-Buska1, Michael L. Wong5,6, Shu Zhang7 and Donato Giovannelli2,8,9,10*
1Department of Earth Sciences, University of Southern California, Los Angeles, CA, United States
2Earth-Life Science Institute, Tokyo Institute of Technology, Tokyo, Japan
3Biosciences and Biotechnology Division, Physical and Life Sciences Directorate, Lawrence Livermore National Lab, Livermore, CA, United States
4Department of Biology, University of Southern California, Los Angeles, CA, United States
5Department of Astronomy – Astrobiology Program, University of Was...
Source: Frontiers in Microbiology - April 14, 2019 Category: Microbiology Source Type: research
Identification of a nth-Like Gene Encoding an Endonuclease III in Campylobacter jejuni
In this study, a BER homolog encoded by cj0595c (named nth) in C. jejuni was analyzed for endonuclease III activity and for its role in maintaining genomic stability. It was found that inactivation of nth resulted in elevated frequencies of spontaneous fluoroquinolone-resistant (FQR) and oxidative stress resistant (OXR) mutants, compared with the wild-type strain in C. jejuni. Sequencing analysis of the FQR and OXR mutants revealed that the elevated mutation rates were associated with C → T or G → A transition in gyrA (FQR mutants) or perR (for OXR mutants). In an in vitro assay, a purified recombinant C. jej...
Source: Frontiers in Microbiology - April 9, 2019 Category: Microbiology Source Type: research
