• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Cisplatin with veliparib or placebo in metastatic triple-negative breast cancer and BRCA mutation-associated breast cancer (S1416): a randomised, double-blind, placebo-controlled, phase 2 trial
Lancet Oncol. 2023 Jan 6:S1470-2045(22)00739-2. doi: 10.1016/S1470-2045(22)00739-2. Online ahead of print.ABSTRACTBACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors are effective in germline BRCA1 or BRCA2 (BRCA1/2) mutation-associated metastatic breast cancer. However, studies evaluating PARP inhibitors plus platinum-based chemotherapy in germline BRCA1/2-wildtype triple-negative breast cancer are scarce. A large proportion of germline BRCA1/2-wildtype triple-negative breast cancer shows homologous recombination deficiency (HRD), resulting in a BRCA-like phenotype that might render sensitivity to PARP inhibitors. T...
Source: Ann Oncol - January 9, 2023 Category: Cancer & Oncology Authors: Eve Rodler Priyanka Sharma William E Barlow Julie R Gralow Shannon L Puhalla Carey K Anders Lori Goldstein Debu Tripathy Ursa A Brown-Glaberman Thu-Tam Huynh Christopher S Szyarto Andrew K Godwin Harsh B Pathak Elizabeth M Swisher Marc R Radke Kirsten M T Source Type: research

Metabolic Regulation of Inflammation and Its Resolution: Current Status, Clinical Needs, Challenges, and Opportunities
J Immunol. 2021 Dec 1;207(11):2625-2630. doi: 10.4049/jimmunol.2100829.ABSTRACTMetabolism and inflammation have been viewed as two separate processes with distinct but critical functions for our survival: metabolism regulates the utilization of nutrients, and inflammation is responsible for defense and repair. Both respond to an organism's stressors to restore homeostasis. The interplay between metabolic status and immune response (immunometabolism) plays an important role in maintaining health or promoting disease development. Understanding these interactions is critical in developing tools for facilitating novel preventa...
Source: Journal of Immunology - November 23, 2021 Category: Allergy & Immunology Authors: Pushpa Tandon Natalie D Abrams Danielle M Carrick Preethi Chander Johanna Dwyer Rebecca Fuldner Gallya Gannot Maren Laughlin George McKie Mercy PrabhuDas Anju Singh Shang-Yi Anne Tsai Merriline M Vedamony Chiayeng Wang Christina H Liu Source Type: research

Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice. To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The National Heart, Lung, and Blood Institute-funded Production Assistance for Cellular Therapies (PACT) program: Eighteen years of cell therapy
Clin Transl Sci. 2021 Jul 19. doi: 10.1111/cts.13102. Online ahead of print.ABSTRACTThe Production Assistance for Cellular Therapies (PACT) Program, is funded and supported by the US Department of Health and Human Services' National Institutes of Health (NIH) National Heart Lung and Blood Institute (NHLBI) to advance development of somatic cell and genetically modified cell therapeutics in the areas of heart, lung, and blood diseases. The program began in 2003, continued under two competitive renewals, and ended June 2021. PACT has supported cell therapy product manufacturing, investigational new drug enabling preclinical ...
Source: Clinical Lung Cancer - July 21, 2021 Category: Cancer & Oncology Authors: Ashraf El Fiky Laarni Ibenana Robert Anderson Joshua M Hare Aisha Khan Adrian P Gee Cliona Rooney David H McKenna Joseph Gold Linda Kelley Martha S Lundberg Lisbeth A Welniak Robert Lindblad Source Type: research

Molecular analysis identifies key differences in lungs of cystic fibrosis patients
A team of researchers from UCLA, Cedars-Sinai and the Cystic FibrosisFoundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.The catalog,described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis.“This new research has provided us with valuable insights into the cellular makeup of both healthy and ...
Source: UCLA Newsroom: Health Sciences - May 7, 2021 Category: Universities & Medical Training Source Type: news

Fight Aging! Newsletter, August 24th 2020
We report that electrical stimulation (ES) stimulation of post-stroke aged rats led to an improved functional recovery of spatial long-term memory (T-maze), but not on the rotating pole or the inclined plane, both tests requiring complex sensorimotor skills. Surprisingly, ES had a detrimental effect on the asymmetric sensorimotor deficit. Histologically, there was a robust increase in the number of doublecortin-positive cells in the dentate gyrus and SVZ of the infarcted hemisphere and the presence of a considerable number of neurons expressing tubulin beta III in the infarcted area. Among the genes that were unique...
Source: Fight Aging! - August 23, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

12 Innovations That Will Change Health Care and Medicine in the 2020s
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - October 25, 2019 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized HealthSummit19 technology Source Type: news

Experimental Analysis of Viral –Host Interactions
Experimental Analysis of Viral–Host Interactions Joseph Gillen and Aleksandra Nita-Lazar* Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States Viral and pathogen protein complexity is often limited by their relatively small genomes, thus critical functions are often accomplished by complexes of host and pathogen proteins. This requirement makes the study of host–pathogen interactions critical for the understanding of pathogenicity and virology. This review article discusses proteomic methods that offer a...
Source: Frontiers in Physiology - April 10, 2019 Category: Physiology Source Type: research

Can Nicotinamide Riboside Help Prevent Alzheimer's?
The supplement nicotinamide riboside (NR) – a form of vitamin B3 – prevented neurological damage and improved cognitive and physical function in a new mouse model of Alzheimer’s disease.byAlzheimer's Reading RoomThe results of the study, conducted by researchers at the National Institute on Aging (NIA) part of the National Institutes of Health,suggest a potential new target for treating Alzheimer ’s disease.What is the Difference Between Alzheimer ’s and DementiaCompound prevents neurological damage, shows cognitive benefits in mouse model of Alzheimer ’s diseaseSubscribe to the Alzheimer's Reading - This is a ...
Source: Alzheimer's Reading Room, The - February 14, 2018 Category: Neurology Tags: alzheimer's research Alzheimers Dementia Alzheimers Prevention alzheimers treatment prevent alzheimers science vitamins Source Type: blogs

Fight Aging! Newsletter, May 30th 2016
This study expands on the idea that loss of Y, already a known risk factor for cancer, could be a predictive biomarker for a wider range of poor health outcomes, specifically Alzheimer's. Why loss of Y can be linked to an increased risk for disease remains unclear, but the authors speculate it has to do with reduced immune system performance. The researchers looked at over 3,000 men to ascertain whether there was any predictive association between loss of Y in blood cells and Alzheimer's disease. The participants came from three long-term studies that could provide regular blood samples: the European Alzheimer's Dis...
Source: Fight Aging! - May 29, 2016 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs