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Management: National Institutes of Health (NIH)
Procedure: Lung Transplant
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Total 16 results found since Jan 2013.
Is low-risk status a surrogate outcome in pulmonary arterial hypertension? An analysis of three randomised trials
Lancet Respir Med. 2023 May 22:S2213-2600(23)00155-8. doi: 10.1016/S2213-2600(23)00155-8. Online ahead of print.ABSTRACTBACKGROUND: Targeting short-term improvements in multicomponent risk scores for mortality in patients with pulmonary arterial hypertension (PAH) could result in improved long-term outcomes. We aimed to determine whether PAH risk scores were adequate surrogates for clinical worsening or mortality outcomes in PAH randomised clinical trials (RCTs).METHODS: We performed an individual participant data meta-analysis of RCTs selected from PAH trials provided by the US Food and Drug Administration (FDA). We calcu...
Source: Respiratory Care - May 25, 2023 Category: Respiratory Medicine Authors: Bryan S Blette Jude Moutchia Nadine Al-Naamani Corey E Ventetuolo Chao Cheng Dina Appleby Ryan J Urbanowicz Jason Fritz Jeremy A Mazurek Fan Li Steven M Kawut Michael O Harhay Source Type: research
Results of Multicenter Phase II Study With Imatinib Mesylate in Allogeneic Recipients With Steroid-Refractory Chronic GVHD
Cell Transplant. 2022 Jan-Dec;31:9636897221113789. doi: 10.1177/09636897221113789.ABSTRACTIn this multicenter phase II study, we evaluated the safety and efficacy of imatinib in patients with steroid-resistant chronic graft-versus-host disease (cGVHD) and evaluated the quality of life (QOL) of the enrolled patients using the Short Form 36 (SF-36) health survey questionnaire. Thirty-six patients who were diagnosed with steroid-refractory cGVHD and treated with imatinib between March 2013 and February 2019 received 100 mg/day of imatinib for 2 weeks. Depending on the patient's condition and investigator's decision, the imati...
Source: Cell Transplantation - July 21, 2022 Category: Cytology Authors: Dong Won Baek Hee Jeong Cho Ju-Hyung Kim Jae Sook Ahn Hyeoung-Joon Kim Sung Nam Lim Jun Won Cheong Sung-Yong Kim Ho Sup Lee Jong Ho Won Ho-Young Yhim Sang Kyun Sohn Joon Ho Moon Source Type: research
AI recognition of patient race in medical imaging: a modelling study
Lancet Digit Health. 2022 May 11:S2589-7500(22)00063-2. doi: 10.1016/S2589-7500(22)00063-2. Online ahead of print.ABSTRACTBACKGROUND: Previous studies in medical imaging have shown disparate abilities of artificial intelligence (AI) to detect a person's race, yet there is no known correlation for race on medical imaging that would be obvious to human experts when interpreting the images. We aimed to conduct a comprehensive evaluation of the ability of AI to recognise a patient's racial identity from medical images.METHODS: Using private (Emory CXR, Emory Chest CT, Emory Cervical Spine, and Emory Mammogram) and public (MIMI...
Source: Cancer Control - May 14, 2022 Category: Cancer & Oncology Authors: Judy Wawira Gichoya Imon Banerjee Ananth Reddy Bhimireddy John L Burns Leo Anthony Celi Li-Ching Chen Ramon Correa Natalie Dullerud Marzyeh Ghassemi Shih-Cheng Huang Po-Chih Kuo Matthew P Lungren Lyle J Palmer Brandon J Price Saptarshi Purkayastha Ayis T Source Type: research
Fight Aging! Newsletter, October 18th 2021
In this study, we therefore analysed the influence of lithium treatment on lifespan and parameters of health during ageing in mice.
To determine the concentration of lithium suitable to be administered in a longitudinal ageing study, we first tested the effects of lithium chloride (LiCl) in doses from 0.01 to 2.79 g LiCl per kg chow. C57Bl/6J mice fed with 1.05-2.79 g/kg LiCL in the diet showed lithium plasma levels between 0.4 and 0.8 mM/l. While plasma levels to 0.4 and 0.8 mM/l are well tolerated by human patients, at doses above 1.44 g LiCl/kg, we observed an obvious dose-dependent polydipsia combined with a dis...
Source: Fight Aging! - October 17, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Molecular analysis identifies key differences in lungs of cystic fibrosis patients
A team of researchers from UCLA, Cedars-Sinai and the Cystic FibrosisFoundation has developed a first-of-its-kind molecular catalog of cells in healthy lungs and the lungs of people with cystic fibrosis.The catalog,described today in the journal Nature Medicine, reveals new subtypes of cells and illustrates how the disease changes the cellular makeup of the airways. The findings could help scientists in their search for specific cell types that represent prime targets for genetic and cell therapies for cystic fibrosis.“This new research has provided us with valuable insights into the cellular makeup of both healthy and ...
Source: UCLA Newsroom: Health Sciences - May 7, 2021 Category: Universities & Medical Training Source Type: news
Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries
Lancet Respir Med. 2021 Mar 31:S2213-2600(21)00077-1. doi: 10.1016/S2213-2600(21)00077-1. Online ahead of print.ABSTRACTBACKGROUND: Lung transplantation is a life-saving treatment for patients with end-stage lung disease; however, it is infrequently considered for patients with acute respiratory distress syndrome (ARDS) attributable to infectious causes. We aimed to describe the course of disease and early post-transplantation outcomes in critically ill patients with COVID-19 who failed to show lung recovery despite optimal medical management and were deemed to be at imminent risk of dying due to pulmonary complications.ME...
Source: Respiratory Care - April 3, 2021 Category: Respiratory Medicine Authors: Ankit Bharat Tiago N Machuca Melissa Querrey Chitaru Kurihara Rafael Garza-Castillon Samuel Kim Adwaiy Manerikar Andres Pelaez Mauricio Pipkin Abbas Shahmohammadi Mindaugas Rackauskas Suresh Rao Kg K R Balakrishnan Apar Jindal Lara Schaheen Samad Hashimi Source Type: research
Vaccines, Antibodies and Drug Libraries. The Possible COVID-19 Treatments Researchers Are Excited About
In early April, about four months after a new, highly infectious coronavirus was first identified in China, an international group of scientists reported encouraging results from a study of an experimental drug for treating the viral disease known as COVID-19.
It was a small study, reported in the New England Journal of Medicine, but showed that remdesivir, an unapproved drug that was originally developed to fight Ebola, helped 68% of patients with severe breathing problems due to COVID-19 to improve; 60% of those who relied on a ventilator to breathe and took the drug were able to wean themselves off the machines after 18...
Source: TIME: Health - April 14, 2020 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news
12 Innovations That Will Change Health Care and Medicine in the 2020s
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace.
No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - October 25, 2019 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized HealthSummit19 technology Source Type: news
He ’s the First African American to Receive a Face Transplant. His Story Could Change Health Care
Robert Chelsea turned down the first face he was offered. It was a fine face, one that could have taken him off the transplant waiting list after just a couple months. But Chelsea—severely disfigured after a catastrophic car accident five years earlier—was in no hurry. He’d gotten used to tilting his head back so food and water wouldn’t fall out of his nearly lipless mouth. He knew how to respond compassionately to children who stared in shock and fear. The face, offered in May 2018, had belonged to a man with skin that was much fairer than what remained of Chelsea’s—so light that Chelse...
Source: TIME: Health - October 24, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Healthcare Source Type: news
Informatics and Computational Methods in Natural Product Drug Discovery: A Review and Perspectives
Joseph D. Romano1,2,3,4 and Nicholas P. Tatonetti1,2,3,4*
1Department of Biomedical Informatics, Columbia University, New York, NY, United States
2Department of Systems Biology, Columbia University, New York, NY, United States
3Department of Medicine, Columbia University, New York, NY, United States
4Data Science Institute, Columbia University, New York, NY, United States
The discovery of new pharmaceutical drugs is one of the preeminent tasks—scientifically, economically, and socially—in biomedical research. Advances in informatics and computational biology have increased productivity at many ...
Source: Frontiers in Genetics - April 29, 2019 Category: Genetics & Stem Cells Source Type: research
Top Companies in Genomics
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics!
The amazing journey of genome sequencing
Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing it. ...
Source: The Medical Futurist - May 30, 2017 Category: Information Technology Authors: nora Tags: Genomics Personalized Medicine AI artificial intelligence bioinformatics cancer DNA dna testing DTC gc3 genetic disorders genetics genome sequencing personal genomics precision medicine Source Type: blogs
