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Total 12 results found since Jan 2013.

Fight Aging! Newsletter, September 11th 2023
This article reviews the current regulatory role of miR-7 in inflammation and related diseases, including viral infection, autoimmune hepatitis, inflammatory bowel disease, and encephalitis. It expounds on the molecular mechanism by which miR-7 regulates the occurrence of inflammatory diseases. Finally, the existing problems and future development directions of miR-7-based intervention on inflammation and related diseases are discussed to provide new references and help strengthen the understanding of the pathogenesis of inflammation and related diseases, as well as the development of new strategies for clinical interventi...
Source: Fight Aging! - September 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 24th 2023
In this study, we tested the hypothesis that periodontal disease (PD) as a source of infection alters inflammatory activation and Aβ phagocytosis by the microglial cells. Experimental PD was induced using ligatures in C57BL/6 mice for 1, 10, 20, and 30 days to assess the progression of PD. Animals without ligatures were used as controls. Ligature placement caused progressive periodontal disease and bone resorption that was already significant on day 1 post-ligation and continued to increase until day 30. The severity of periodontal disease increased the frequency of activated microglia in the brains on day 30 by 36...
Source: Fight Aging! - July 23, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Estimation of COVID-19 patient numbers using artificial neural networks based on air pollutant concentration levels
Environ Sci Pollut Res Int. 2022 May 10. doi: 10.1007/s11356-022-20231-z. Online ahead of print.ABSTRACTThe dilemma between health concerns and the economy is apparent in the context of strategic decision making during the pandemic. In particular, estimating the patient numbers and achieving an informed management of the dilemma are crucial in terms of the strategic decisions to be taken. The Covid-19 pandemic presents an important case in this context. Sustaining the efforts to cope with and to put an end to this pandemic requires investigation of the spread and infection mechanisms of the disease, and the factors which f...
Source: Environmental Science and Pollution Research International - May 10, 2022 Category: Environmental Health Authors: G ülşen Aydın Keskin Şenay Çetin Doğruparmak Kadriye Erg ün Source Type: research

Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases. Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

12 Innovations That Will Change Health Care and Medicine in the 2020s
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - October 25, 2019 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized HealthSummit19 technology Source Type: news

Validation of a Device for the Ambulatory Monitoring of Sleep Patterns: A Pilot Study on Parkinson's Disease
This study aims to validate an ambulatory circadian monitoring (ACM) device for the detection of sleep and wake states and apply it to the evaluation of sleep quality in patients with Parkinson disease (PD). A polysomnographic validation study was conducted on a group of patients with different sleep disorders in a preliminary phase, followed by a pilot study to apply this methodology to PD patients. The ACM device makes it possible to estimate the main sleep parameters very accurately, as demonstrated by: (a) the lack of significant differences between the mean values detected by PSG and ACM in time in bed (TIB), total sl...
Source: Frontiers in Neurology - April 10, 2019 Category: Neurology Source Type: research

China Is Building The Ultimate Technological Health Paradise. Or Is It?
How could a country keep around 1.4 billion people healthy when the system struggles with corruption, lack of resources and an aging population? China, the emerging giant with a strong central leadership fostering technology and innovation, places its bets on artificial intelligence, telemedicine, cloud-based hospitals, and WeChat. While that could sound like an ultimate technological paradise, the question is, what are they going to do with the vast amount of data or to what interests are they going to leverage their state of the art A.I. systems? Generally, how will we speak about digital health in China: a healthcare dy...
Source: The Medical Futurist - February 19, 2019 Category: Information Technology Authors: nora Tags: Artificial Intelligence in Medicine Bioethics Future of Medicine Medical Professionals Patients Policy Makers AI chatbot china digital digital health Healthcare Innovation smartphone technology telehealth telemedicine Source Type: blogs

Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics. Exercise versus the Hallmarks of Aging https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/ The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, July 17th 2017
This study aimed to estimate associations between combined measurements of BMI and waist-to-hip ratio (WHR) with mortality and incident coronary artery disease (CAD). This study followed 130,473 UK Biobank participants aged 60-69 years (baseline 2006-2010) for 8.3 years (n = 2974 deaths). Current smokers and individuals with recent or disease-associated (e.g., from dementia, heart failure, or cancer) weight loss were excluded, yielding a "healthier agers" group. Ignoring WHR, the risk of mortality for overweight subjects was similar to that for normal-weight subjects. However, among normal-weight subjects, mortalit...
Source: Fight Aging! - July 16, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Stephen Emmott Q&A: 'Windfarms are not the answer to our problems'
The author of Ten Billion on how we might avert a population catastrophe, his attempts to replicate photosynthesis, and why G8 leaders ought to wear tiesWatch Stephen Emmott reading extracts from his book. Reading this on mobile? Click hereWhy have scientists and politicians been slow and reluctant to confront population growth?It might be useful to first distinguish between growth and behaviour. The problem is less the current number of us in itself (yet) but more the way the majority of the 7 billion of us live and consume. This is principally the cause of almost every global problem we face. Critically, every one of the...
Source: Guardian Unlimited Science - June 29, 2013 Category: Science Authors: Tim Adams Tags: Energy Population World news Food Technology Physics Energy efficiency Energy research Ethical and green living Q & amp;As The Observer Environment Science Source Type: news