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Procedure: Heart Transplant
Therapy: Stem Cell Therapy
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Total 306 results found since Jan 2013.
Combined Treatment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates
CONCLUSIONS: These results demonstrate the synergistic effect of combining iPSC-derived ECs and CMs for therapy in the postmyocardial infarction heart, enabling a promising strategy toward clinical translation.PMID:37732466 | DOI:10.1161/CIRCULATIONAHA.122.061736
Source: Circulation - September 21, 2023 Category: Cardiology Authors: Yu-Che Cheng Marvin L Hsieh Chen-Ju Lin Cindy M C Chang Ching-Ying Huang Riley Puntney Amy Wu Moy Chien-Yu Ting Darien Zhing Herr Chan Martin W Nicholson Po-Ju Lin Hung-Chih Chen Gina C Kim Jianhua Zhang Jennifer Coonen Puja Basu Heather A Simmons Yen-Wen Source Type: research
Expanding the clinical and immunological phenotypes of PAX1-deficient SCID and CID patients
We described six new patients who demonstrated variable clinical penetrance. Reduced transcriptional activity of pathogenic variants confirmed partial or complete PAX1 deficiency. Thymic aplasia and hypoplasia were associated with impaired T-cell immunity. Corrective treatment was required in 4/6 patients. Hematopoietic stem cell transplantation resulted in poor immune reconstitution with absent naïve T cells, contrasting with the superior recovery of T-cell immunity after thymus transplantation. Normal ex vivo differentiation of PAX1-deficient CD34+ cells into mature T-cell demonstrated the absence of a hematopoietic cel...
Source: Clinical Immunology - September 9, 2023 Category: Allergy & Immunology Authors: Nalan Yakici Alexandra Y Kreins Mehmet Cihangir Catak Royala Babayeva Baran Erman Heather Kenney Hatice Eke Gungor Pablo A Cea Tomoki Kawai Marita Bosticardo Ottavia Maria Delmonte Stuart Adams Yu-Tong Fan Francesca Pala Ayberk Turkyilmaz Evey Howley Aust Source Type: research
Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin
CONCLUSIONS: Long-term cultured mature hiPSC-CMs promoted engraftment, maturation and angiogenesis post-transplantation in infarcted rat hearts. CRYAB, which was highly expressed in D56-CMs, was identified as an angiogenic factor from mature hiPSC-CMs. This study revealed the benefits of long-term culture, which may enhance the therapeutic potential of hiPSC-CMs.PMID:37679796 | DOI:10.1186/s13287-023-03468-4
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Yuki Tanaka Shin Kadota Jian Zhao Hideki Kobayashi Satomi Okano Masaki Izumi Yusuke Honda Hajime Ichimura Naoko Shiba Takeshi Uemura Yuko Wada Shinichiro Chuma Tsutomu Nakada Shugo Tohyama Keiichi Fukuda Mitsuhiko Yamada Tatsuichiro Seto Koichiro Kuwahara Source Type: research
Human myofibroblasts increase the arrhythmogenic potential of human induced pluripotent stem cell-derived cardiomyocytes
Cell Mol Life Sci. 2023 Sep 5;80(9):276. doi: 10.1007/s00018-023-04924-3.ABSTRACTHuman induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have the potential to remuscularize infarcted hearts but their arrhythmogenicity remains an obstacle to safe transplantation. Myofibroblasts are the predominant cell-type in the infarcted myocardium but their impact on transplanted hiPSC-CMs remains poorly defined. Here, we investigate the effect of myofibroblasts on hiPSC-CMs electrophysiology and Ca2+ handling using optical mapping of advanced human cell coculture systems mimicking cell-cell interaction modalities. Human ...
Source: Cellular and Molecular Life Sciences : CMLS - September 5, 2023 Category: Cytology Authors: Robert D Johnson Ming Lei John H McVey Patrizia Camelliti Source Type: research
Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes
Stem Cell Res Ther. 2023 Aug 30;14(1):228. doi: 10.1186/s13287-023-03470-w.ABSTRACTIn the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts. However, mass production of hiPSC-CMs remains challenging, limiting their translational potential in regenerative medicine. Therefore, multiple strategies including cell cycle regulators, small molecules, co-culture systems, and epigenetic modifiers have been used to improve the proliferation of hiPSC-CMs. On the other hand, the immaturity of these proliferat...
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Hao Yang Yuan Yang Fedir N Kiskin Mengcheng Shen Joe Z Zhang Source Type: research
Research progress on cardiac tissue construction of mesenchymal stem cells for myocardial infarction
This study shows that MSCs have wide clinical applications in the treatment of AMI, suggesting improved myocardial tissue creation. A broader clinical application prospect will be explored and developed to improve the survival rate of MSC transplants and myocardial vascularization.PMID:37612870 | DOI:10.2174/1574888X18666230823091017
Source: Current Stem Cell Research and Therapy - August 24, 2023 Category: Stem Cells Authors: Guo-Dong Yang Da-Shi Ma Chun-Ye Ma Yang Bai Source Type: research
Amending the injured heart by in vivo reprogramming
Curr Opin Genet Dev. 2023 Aug 16;82:102098. doi: 10.1016/j.gde.2023.102098. Online ahead of print.ABSTRACTIschemic heart injury causes death of cardiomyocyte (CM), formation of a fibrotic scar, and often adverse cardiac remodeling, resulting in chronic heart failure. Therapeutic interventions have lowered myocardial damage and improved heart function, but pharmacological treatment of heart failure has only shown limited progress in recent years. Over the past two decades, different approaches have been pursued to regenerate the heart, by transplantation of newly generated CMs derived from pluripotent stem cells, generation...
Source: Current Opinion in Genetics and Development - August 18, 2023 Category: Genetics & Stem Cells Authors: Xuejun Yuan Thomas Braun Source Type: research
Human amnion-derived mesenchymal stem cells improve subclinical hypothyroidism by immunocompetence mediating apoptosis inhibition on thyroid cells in aged mice
This study was designed to investigate whether human amnion-derived mesenchymal stem cells (hAMSC) could effect on immune regulation, apoptosis inhibition of thyroid cells, thyroid function, blood lipid levels, and heart function. In addition, qualified hAMSCs were intravenously injected into aged female SCH mice via the tail vein on day 0 and day 10. The levels of thyroid hormone and blood lipids as well as cardiac function, serum immunological indexes, and apoptosis of thyroid cells were then analyzed on day 5, 10, 15, and 20; meanwhile, the quantity of Th1, Th2, Th17, and Treg immune cells in peripheral blood was evalua...
Source: Cell Research - August 12, 2023 Category: Cytology Authors: Chuyu Li Qiang Rui Xiaohan Dong Song Ning Jing Zhou Huimin Wu Chunyan Jiang Yugui Cui Jiayin Liu Jun Jiang Lianju Qin Source Type: research
Xenograft of human pluripotent stem cell-derived cardiac lineage cells on zebrafish embryo heart
Biochem Biophys Res Commun. 2023 Jun 14:S0006-291X(23)00795-7. doi: 10.1016/j.bbrc.2023.06.040. Online ahead of print.ABSTRACTCardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) are a promising cell source for regenerative medicine and drug discovery. However, the use of animal models for studying human cardiomyocytes derived from hiPSCs in vivo is limited and challenging. Given the shared properties between humans and zebrafish, their ethical advantages over mammalian models, and their immature immune system that is rejection-free against xenografted human cells, zebrafish provide a suitable alternat...
Source: Biochemical and Biophysical Research communications - August 2, 2023 Category: Biochemistry Authors: Mika Takahi Riko Taira Jo Onozuka Haruka Sunamura Akiko Kondow Koji Nakade Kenichi Nakashima Iori Sato Yohei Hayashi Chinmoy Patra Kiyoshi Ohnuma Source Type: research
