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Therapy: Dialysis
Nutrition: Potassium
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Total 204 results found since Jan 2013.
Relationship between urinary potassium excretion, serum potassium levels, and cardiac injury in non-dialysis chronic kidney disease: KoreaN cohort study for Outcome in patients With Chronic Kidney Disease (KNOW-CKD)
Br J Nutr. 2023 Sep 11:1-21. doi: 10.1017/S0007114523002064. Online ahead of print.ABSTRACTAlthough the cardiovascular benefits of an increased urinary potassium excretion have been suggested, little is known about the potential cardiac association of urinary potassium excretion in patients with chronic kidney disease (CKD). In addition, whether the cardiac association of urinary potassium excretion was mediated by serum potassium levels has not been studied yet. We reviewed the data of 1,633 patients from a large-scale multicenter prospective Korean study (2011-2016). Spot urinary potassium to creatinine ratio was used as...
Source: The British Journal of Nutrition - September 11, 2023 Category: Nutrition Authors: Hyang Ki Min Su Ah Sung Ji Yong Jung Yun Kyu Oh Kyu Beck Lee Sue K Park Kook-Hwan Oh Curie Ahn Sung Woo Lee Source Type: research
Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites
CONCLUSION: Our data suggest a novel electrolyte-based mechanism of immunosuppression in malignant ascites of patients with peritoneal carcinomatosis. We show for the first time that the immunosuppression of NK cytotoxicity in coculture assays is correlated to patient poor survival. Therapeutic application of sodium channel inhibitors may provide new means for restoring immune cell activity in ascites or similar electrolyte imbalanced environments.PMID:37684704 | DOI:10.1186/s13046-023-02798-8
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Antonio Hrvat Mathias Schmidt Bernd Wagner Denise Zwanziger Rainer Kimmig Lothar Volbracht Sven Brandau Nina Mallmann-Gottschalk Source Type: research
DIALIZE China: A Phase IIIb, Randomized, Placebo-Controlled Study to Reduce Predialysis Hyperkalemia With Sodium Zirconium Cyclosilicate in Chinese Patients
Clin Ther. 2023 Jun 27:S0149-2918(23)00153-4. doi: 10.1016/j.clinthera.2023.04.014. Online ahead of print.ABSTRACTPURPOSE: The DIALIZE China study (Reduce Incidence of Pre-Dialysis Hyperkalaemia With Sodium Zirconium Cyclosilicate in Chinese Subjects) (NCT04217590) evaluated sodium zirconium cyclosilicate (SZC) for the management of hyperkalemia in Chinese patients undergoing hemodialysis.METHODS: In the double-blind, Phase IIIb DIALIZE China study, Chinese adults with kidney failure and predialysis hyperkalemia (predialysis serum potassium [sK+] concentration >5.4 mmol/L after the long interdialytic interval [LIDI] and...
Source: Clinical Therapeutics - June 29, 2023 Category: Drugs & Pharmacology Authors: Zhaohui Ni Renhua Lu Xudong Xu Xueyan Bian Zhihong Zhou Junwei Yang Qun Luo Menghua Chen Chaosheng Chen Xiuli Sun Lei Yu Qiang He Hong Jiang Weijie Yuan Yi Li Rong Zhou Jianqin Wang Xinzhou Zhang Li Zuo Xiangwen Meng Zhiren Chang June Zhao Peter Wessman P Source Type: research
Comparison of effectiveness and safety of sodium polystyrene sulfonate and sodium zirconium cyclosilicate for treatment of hyperkalemia in hospitalized patients
CONCLUSION: One of the largest comparisons of SPS and SZC conducted to date, this study demonstrated the effectiveness and safety of both agents. While a statistically greater reduction in serum potassium was observed with use of SPS, there was significant dosing variability among agents that limited the ability to directly compare specific doses. Further investigation is needed to determine the optimal dose of each agent for acute hyperkalemia management. This data will inform clinical decisions about the choice of potassium binder for acute hyperkalemia.PMID:37335862 | DOI:10.1093/ajhp/zxad137
Source: American Journal of Health-System Pharmacy : AJHP - June 19, 2023 Category: Drugs & Pharmacology Authors: Eileen Sullivan Melanie Ruegger Ian Dunne Neil Sutaria William F Towers Source Type: research
Predialysis trajectories of estimated GFR and concurrent trends of Chronic Kidney Disease-relevant biomarkers
CONCLUSION: Using longitudinal data, we delineated the changes in CKD biomarkers with disease progression. The results provide information to clinicians and clues to elucidate the mechanism of CKD progression.PMID:37324405 | PMC:PMC10265358 | DOI:10.1177/20406223231177291
Source: Adv Data - June 16, 2023 Category: Epidemiology Authors: Hsiao-Mei Tsao Tai-Shuan Lai Yu-Hsiang Chou Shuei-Liong Lin Yung-Ming Chen Source Type: research
Combined aerobic and resistance exercise in maintenance hemodialysis patients: A meta-analysis
Semin Dial. 2023 Jun 14. doi: 10.1111/sdi.13162. Online ahead of print.ABSTRACTExercise brings many benefits to patients undergoing maintenance hemodialysis (MHD), but the effect of combined aerobic and resistance exercise remains unclear. English and Chinese databases (PubMed, Cochrane Library, Embase, Web of Science, CNKI, VIP, Wan Fang, and CBM) were searched from inception to January 2023 to retrieve qualified randomized controlled trials. The literature selection, data extraction, and risk of bias assessment of included studies were conducted independently by two reviewers. Meta-analysis was performed using RevMan 5.3...
Source: Seminars in Dialysis - June 14, 2023 Category: Urology & Nephrology Authors: Yixiu Liu Xiju Luo Siyan Deng Jing Chen Lu Zhang Ying Huang Huagang Hu Source Type: research
Electrolytes Play a Role in Detecting Cisplatin-Induced Kidney Complications and May Even Prevent Them-Retrospective Analysis
Conclusions: We report that an average of 15% of patients with electrolyte abnormalities develop renal toxicity and reduced function. Moreover, electrolytes may serve as an early indicator for renal damage as part of chemotherapy complication. This indication represents 15% of renal toxicity cases. Changes in electrolyte levels have been reported with cisplatin. Specifically, it has been linked to hypomagnesemia, hypocalcemia and hypokalemia. This study will help reduce the risk of dialysis or the need for kidney transplant. It is also important to manage any underlying conditions and control patients' intake of electrolyt...
Source: Cancer Control - May 27, 2023 Category: Cancer & Oncology Authors: Bahauddeen M Alrfaei Abdulaziz O Almutairi Alaa A Aljohani Hajar Alammar Abdulaziz Asiri Yahya Bokhari Feda S Aljaser Manal Abudawood Majed Halwani Source Type: research
Discontinuation of Renin-Angiotensin-Aldosterone System Inhibitors Secondary to Hyperkalemia Translates into higher Cardiorenal Outcomes
CONCLUSION: RAASi discontinuation after hyperkalemia was associated with worsened mortality, which may underscore the benefits of continuing RAASi among patients with CKD.PMID:37231821 | DOI:10.1159/000531102
Source: American Journal of Nephrology - May 26, 2023 Category: Urology & Nephrology Authors: Jaejin An Hui Zhou Liang Ni Teresa N Harrision Rong Wei Abiy Agiro Yasmin Ghanshyam Brahmbhatt Yemmie Oluwatosin Craig Schilling John J Sim Source Type: research
