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Specialty: Neurology
Procedure: Perfusion

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Total 1377 results found since Jan 2013.

Association of hyperglycemia and computed tomographic perfusion deficits in patients who underwent endovascular treatment for acute ischemic stroke caused by a proximal intracranial occlusion: A subgroup analysis of a randomized phase 3 trial (MR CLEAN)
Hyperglycemia is highly prevalent in patients with acute ischemic stroke and is associated with increased risk of symptomatic intracranial hemorrhage, larger infarct size and unfavorable outcome. Furthermore, glucose may modify the effect of endovascular treatment (EVT) in patients with ischemic stroke. Hyperglycemia might lead to accelerated conversion of penumbra into infarct core. However, it remains uncertain whether hyperglycemia on admission is associated with the size of penumbra or infarct core in acute ischemic stroke.
Source: Journal of the Neurological Sciences - June 30, 2022 Category: Neurology Authors: C.J.B.A. Kersten, A.A.M. Zandbergen, O.A. Berkhemer, J. Borst, M. Haalboom, Y.B.W.E.M. Roos, D.W.J. Dippel, R.J. van Oostenbrugge, A. van der Lugt, W.H. van Zwam, C.B. Majoie, H.M. den Hertog, on behalf of the MR CLEAN investigators Source Type: research

Collateral Flow in Intracranial Atherosclerotic Disease
AbstractIntracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke and transient ischemic attack (TIA) worldwide. The culprit of ICAD is frequently a high-grade intracranial atherosclerotic stenosis (ICAS) pertaining to the infarct territory, and by then, the ICAS is described as symptomatic. A high-grade ICAS may progressively limit cerebral perfusion downstream, demanding collateral compensation. Collateral circulation refers to the pre-existing and dynamic emergence of vascular channels that maintain and compensate for a failing principal vascular route. Collaterals through the Circle of Willis and ...
Source: Translational Stroke Research - June 8, 2022 Category: Neurology Source Type: research

Outcomes of Medical Management Alone for Adult Patients with Cerebral Misery Perfusion Due to Ischemic Moyamoya Disease
Although revascularization surgery is recommended for adult patients with moyamoya disease (MMD) who present with ischemic symptoms due to hemodynamic compromise, the clinical course of such patients who are treated with medical management alone remains unclear. Here, we report outcomes of adult patients with cerebral misery perfusion due to ischemic MMD who received medical management alone.
Source: Journal of Stroke and Cerebrovascular Diseases - June 4, 2022 Category: Neurology Authors: Kuniaki Ogasawara, Shun Uchida, Yosuke Akamatsu, Kohei Chida, Masakazu Kobayashi, Kenji Yoshida, Shunrou Fujiwara, Kazunori Terasaki, Yoshitaka Kubo Source Type: research

Automated CT Perfusion Detection of the Acute Infarct Core in Ischemic Stroke: A Systematic Review and Meta-Analysis
Conclusion: Due to significant heterogeneity and insufficient high-quality studies reporting each outcome, there is insufficient evidence to reliably determine the accuracy of CTP prediction of the infarct core compared to DWI or FLAIR.Cerebrovasc Dis
Source: Cerebrovascular Diseases - June 3, 2022 Category: Neurology Source Type: research

Central Retinal Artery Occlusion: Current Practice, Awareness and Prehospital Delays in Switzerland
ConclusionsCRAO awareness of the general population and physician awareness about the treatment options as well as the non-standardized prehospital organization, seems to be the main reason for the prehospital delays and impedes treating CRAO patients. Educational efforts should be undertaken to improve awareness about CRAO.
Source: Frontiers in Neurology - May 23, 2022 Category: Neurology Source Type: research

A Deep Learning-Based Automatic Collateral Assessment in Patients with Acute Ischemic Stroke
This study aimed to develop a supervised deep learning (DL) model for grading collateral status from dynamic susceptibility contrast magnetic resonance perfusion (DSC-MRP) images from patients with large vessel occlusion (LVO) acute ischemic stroke (AIS) and compare its performance against experts ’ manual grading. Among consecutive LVO-AIS at three medical center sites, DSC-MRP data were processed to generate collateral flow maps consisting of arterial, capillary, and venous phases. With the use of expert readings as a reference, a DL model was developed to analyze collateral status with o utput classified into good and...
Source: Translational Stroke Research - May 21, 2022 Category: Neurology Source Type: research

Endovascular Thrombectomy Reduces Risk of Poor Functional Outcomes in Patients Presenting within 0-6 Hours with Large Ischemic Core Volumes on Computed Tomography Perfusion
Large vessel occlusion (LVO) stroke patients presenting with large ischemic core volumes (LICVs) on acute imaging have worse outcomes compared to those with smaller ischemic core volumes1 However, endovascular thrombectomy (EVT), compared with medical management (MM), may still be beneficial in this population according to a meta-analysis of patient-level data from early window randomized thrombectomy trials1 and a systematic review of patients presenting with LICVs on computed tomography (CT) or computed tomography perfusion (CTP)2
Source: Journal of Stroke and Cerebrovascular Diseases - May 11, 2022 Category: Neurology Authors: Rahul R. Karamchandani, Hongmei Yang, Tanushree Prasad, Dale Strong, Jeremy B. Rhoten, Gary Defilipp, Jonathan Clemente, William R. Stetler, Joe Bernard, Andrew W. Asimos Source Type: research

Filling Defect of Ipsilateral Transverse Sinus in Acute Large Artery Occlusion
ConclusionFilling defect of the ipsilateral transverse sinus was associated with edema expansion and an unfavorable outcome irrespective of the baseline arterial collateral status in patients with acute LAO, indicating that FDITS may be an important stroke-related prognostic imaging marker.
Source: Frontiers in Neurology - May 10, 2022 Category: Neurology Source Type: research

Hypoperfusion Intensity Ratio is Associated with Stroke Mechanism in Patients Undergoing Mechanical Thrombectomy
Hypoperfusion Intensity Ratio (HIR), defined as Tmax>10s/Tmax>6s on computed tomography perfusion (CTP), and stroke mechanisms have been independently correlated with angiographic collaterals and patient outcomes. Slowly developing atherosclerotic stenosis may foster collateral development, whereas cardioembolic occlusion may occur before collaterals mature. We hypothesized that favorable HIR is associated with large artery atherosclerosis (LAA) stroke mechanism and good clinical outcome.
Source: Journal of Stroke and Cerebrovascular Diseases - May 9, 2022 Category: Neurology Authors: Ahmad A. Ballout, Richard B Libman, Julia R. Schneider, Marc S. Ayoub, Jason J. Wang, Athos Patsalides, Jeffrey M Katz Source Type: research

Caveolin-1 Promoted Collateral Vessel Formation in Patients With Moyamoya Disease
ConclusionThis study indicated that Cav-1 may be a potential driver to promote angiogenesis and collateral formation after bypass surgery in patients with MMD, providing a better understanding of MMD pathophysiology and potential non-surgical targets of MMD.
Source: Frontiers in Neurology - April 26, 2022 Category: Neurology Source Type: research

An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys
ConclusionOur study may provide an optimal non-human primate model for an in-depth study of the pathogenesis and treatment of focal cerebral ischemia.
Source: Frontiers in Neurology - April 25, 2022 Category: Neurology Source Type: research

CT Perfusion Maps Improve Detection of M2-MCA Occlusions in Acute Ischemic Stroke
A growing body of literature supports mechanical thrombectomy-based endovascular therapy for M2-MCA occlusions in eligible patients with acute ischemic stroke (AIS).1 –5 This is because endovascular treatment for M2-MCA occlusions is technically feasible and leads to improved patient outcomes, despite a potential increased risk of hemorrhage.4,5 Not uncommonly, these patients undergo a single or multi-phase CT angiogram (CTA) study for LVO detection. In patient s who present in the late stroke window (6–24 h since last known normal), the CT Perfusion (CTP) study is generally performed along with a CTA study to aid in patient triage.
Source: Journal of Stroke and Cerebrovascular Diseases - April 14, 2022 Category: Neurology Authors: Girish Bathla, Ravishankar Pillenahalli Maheshwarappa, Neetu Soni, Minako Hayakawa, Sarv Priya, Edgar Samaniego, Santiago Ortega-Gutierrez, Colin P. Derdeyn Source Type: research

Therapeutic Induction of Collateral Flow
AbstractTherapeutic induction of collateral flow as a means to salvage tissue and improve outcome from acute ischemic stroke is a promising approach in the era in which endovascular therapy is no longer time-dependent but collateral-dependent. The importance of collateral flow enhancement as a therapeutic for acute ischemic stroke extends beyond those patients with large amounts of salvageable tissue. It also has the potential to extend the time window for reperfusion therapies in patients who are ineligible for endovascular thrombectomy. In addition, collateral enhancement may be an important adjuvant to neuroprotective a...
Source: Translational Stroke Research - April 13, 2022 Category: Neurology Source Type: research

Large Vessel Occlusion Sites Affect Agreement Between Outputs of Three Computed Tomography Perfusion Software Packages
Computed tomography perfusion (CTP) data are important for hyperacute stroke decision making. Available comparisons between outputs of different CTP software packages show variable outcomes. Evaluation for factors associated with agreement between the volume estimates is limited. We assessed for differences in core and penumbra volume estimates of three CTP software packages – AutoMIStar, RAPID, and Vitrea – and analyzed factors associated with agreement between the volume estimates.
Source: Journal of Stroke and Cerebrovascular Diseases - April 13, 2022 Category: Neurology Authors: Peter S.W. Park, Robbie Chan, Channa Senanayake, Stanley Tsui, Alun Pope, Helen M. Dewey, Philip M.C. Choi Source Type: research

Evaluation of T2-FLAIR combined with ASL on the collateral circulation of acute ischemic stroke
ConclusionThe T2-FLAIR sequence combined with ASL can more accurately assess the blood flow changes in the IP area, the open state of collateral circulation, and the clinical prognosis.
Source: Neurological Sciences - April 6, 2022 Category: Neurology Source Type: research