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Specialty: Biochemistry
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Total 23 results found since Jan 2013.

Neuroinflammatory biomarkers: From stroke diagnosis and prognosis to therapy.
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger. PMID: 26524637 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - October 30, 2015 Category: Biochemistry Authors: Simats A, García-Berrocoso T, Montaner J Tags: Biochim Biophys Acta Source Type: research

Protective features of peripheral monocytes/macrophages in stroke.
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger. PMID: 26584587 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - November 12, 2015 Category: Biochemistry Authors: Gliem M, Schwaninger M, Jander S Tags: Biochim Biophys Acta Source Type: research

Dendrimer Grafted Albumin Nanoparticles for the Treatment of Post Cerebral Stroke Damages: A Proof of Concept Study
Publication date: Available online 3 September 2019Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Deepak Pradhan, Vishakha Tambe, Nidhi Raval, Piyush Gondalia, Pallab Bhattacharya, Kiran Kalia, Rakesh K. TekadeAbstractStroke is the second largest disease of mortality. The biggest hurdle in designing effective brain drug delivery systems is offered by the blood-brain barrier (BBB), which is highly impermeable to many drugs. Albumin nanoparticles (NP) have gained attention due to their multiple ligand binding sites and long circulatory half-life. Citicoline (CIT) is reported to enhance the acetylcholine secretion i...
Source: Colloids and Surfaces B: Biointerfaces - September 10, 2019 Category: Biochemistry Source Type: research

Knockdown of Nrf2 inhibits angiogenesis by down-regulating VEGF expression through PI3K/Akt signaling pathway in cerebral microvascular endothelial cells under hypoxic conditions.
This study aimed at investigating the effect of NF-E2-related factor 2 (Nrf2) on the angiogenesis of mouse cerebral microvascular endothelial bEnd.3 cells in a hypoxic environment. We found that Nrf2 expression was temporarily increased in hypoxia-induced bEnd.3 cells. Knockdown of Nrf2 inhibited the proliferation, migration as well as tube formation in hypoxia-induced bEnd.3 cells. Meanwhile, VEGF and PI3K/Akt signaling pathways were identified to be regulated by Nrf2 in hypoxia-induced bEnd.3 cells. It was found that silencing of Nrf2 down-regulated the expression levels of NAD(P)H:quinine oxidoreductase-1 (Nqo1), VEGF, ...
Source: Biochemistry and Cell Biology - January 26, 2018 Category: Biochemistry Authors: Huang Y, Mao Y, Li H, Shen G, Nan G Tags: Biochem Cell Biol Source Type: research

Changes and roles of IL-17A, VEGF-A and TNF- α in patients with cerebral infarction during the acute phase and early stage of recovery
CONCLUSION: After cerebral infarction, VEGF-A from the acute phase and IL-17A from the early stage of recovery may be important for nerve protection and repair; TNF-α plays a complex role within 35 days.PMID:35550786 | DOI:10.1016/j.clinbiochem.2022.05.001
Source: Clinical Biochemistry - May 13, 2022 Category: Biochemistry Authors: Panpan Xu Shuting Zhang Xiuli Kan Xianshan Shen Jing Mao Chuanqin Fang Xiaosan Wu Ju Qiu Ping Qu Peijun Qian Mei Shao Tingting Wu Yongfeng Hong Source Type: research

The role of the blood-brain barrier during neurological disease and infection
Biochem Soc Trans. 2023 Mar 17:BST20220830. doi: 10.1042/BST20220830. Online ahead of print.ABSTRACTA healthy brain is protected by the blood-brain barrier (BBB), which is formed by the endothelial cells that line brain capillaries. The BBB plays an extremely important role in supporting normal neuronal function by maintaining the homeostasis of the brain microenvironment and restricting pathogen and toxin entry to the brain. Dysfunction of this highly complex and regulated structure can be life threatening. BBB dysfunction is implicated in many neurological diseases such as stroke, Alzheimer's disease, multiple sclerosis,...
Source: Biochemical Society Transactions - March 17, 2023 Category: Biochemistry Authors: Adjanie Patabendige Damir Janigro Source Type: research

Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosis.
Abstract Platelets are involved in the maintenance of haemostasis but their inappropriate activation leads to thrombosis, a principal trigger for heart attack and ischaemic stroke. Although platelets circulate in isolation, upon activation they accumulate or aggregate together to form a thrombus, where they function in a co-ordinated manner to prevent loss of blood and control wound repair. Previous report (1) indicates that the stability and functions of a thrombus are maintained through sustained, contact-dependent signalling between platelets. Given the role of gap junctions in the co-ordination of tissue respo...
Source: Biochemical Society Transactions - May 27, 2015 Category: Biochemistry Authors: Vaiyapuri S, Flora GD, Gibbins JM Tags: Biochem Soc Trans Source Type: research

Nudging Oligodendrocyte Intrinsic Signaling to Remyelinate and Repair: Estrogen Receptor Ligand Effects
Publication date: Available online 14 January 2016 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Anna J. Khalaj, Jonathan Hasselmann, Catherine Augello, Spencer Moore, Seema K. Tiwari-Woodruff Demyelination in multiple sclerosis (MS) leads to significant, progressive axonal and neuronal degeneration. Currently existing immunosuppressive and immunomodulatory therapies alleviate MS symptoms and slow, but fail to prevent or reverse, disease progression. Restoration of damaged myelin sheath by replenishment of mature oligodendrocytes (OLs) should not only restore saltatory axon conduction, ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - January 15, 2016 Category: Biochemistry Source Type: research

Role of heparin and non heparin binding serpins in coagulation and angiogenesis: A complex interplay.
Abstract Pro-coagulant, anti-coagulant and fibrinolytic pathways are responsible for maintaining haemostatic balance under physiological conditions. Any deviation from these pathways would result in hypercoagulability leading to life threatening diseases like myocardial infarction, stroke, portal vein thrombosis, deep vein thrombosis (DVT) and pulmonary embolism (PE). Angiogenesis is the process of sprouting of new blood vessels from pre-existing ones and plays a critical role in vascular repair, diabetic retinopathy, chronic inflammation and cancer progression. Serpins; a superfamily of protease inhibitors, play ...
Source: Archives of Biochemistry and Biophysics - June 28, 2016 Category: Biochemistry Authors: Bhakuni T, Ali MF, Ahmad I, Bano S, Ansari S, Jairajpuri MA Tags: Arch Biochem Biophys Source Type: research

Neuroprotective Effects of Peptides in the Brain: Transcriptome Approach
AbstractThe importance of studying the action mechanisms of drugs based on natural regulatory peptides is commonly recognized. Particular attention is paid to the peptide drugs that contribute to the restoration of brain functions after acute cerebrovascular accidents (stroke), which for many years continues to be one of the main problems and threats to human health. However, molecular genetic changes in the brain in response to ischemia, as well as the mechanisms of protective effects of peptides, have not been sufficiently studied. This limits the use of neuroprotective peptides and makes it difficult to develop new, mor...
Source: Biochemistry (Moscow) - February 29, 2020 Category: Biochemistry Source Type: research

Nanodomains in cardiopulmonary disorders and the impact of air pollution.
Abstract Air pollution is a major environmental threat and each year about 7 million people reported to die as a result of air pollution. Consequently, exposure to air pollution is linked to increased morbidity and mortality world-wide. Diesel automotive engines are a major source of urban air pollution in the western societies encompassing particulate matter and diesel exhaust particles (DEP). Air pollution is envisioned as primary cause for cardiovascular dysfunction, such as ischemic heart disease, cardiac dysrhythmias, heart failure, cerebrovascular disease and stroke. Air pollution also causes lung dysfunctio...
Source: Biochemical Society Transactions - June 28, 2020 Category: Biochemistry Authors: Cattani-Cavalieri I, Valença SDS, Schmidt M Tags: Biochem Soc Trans Source Type: research

Perlecan, a Modular Instructive Proteoglycan with Diverse Functional Properties.
This study reviewed some new aspects of the modular proteoglycan perlecan, a colossal proteoglycan with a 467 kDa core protein and five distinct functional domains. Perlecan is a heparan sulphate proteoglycan that transiently displays native CS sulphation motifs 4-C-3 and 7-D-4 during tissue morphogenesis these are expressed by progenitor cell populations during tissue development. Perlecan is susceptible to fragmentation by proteases during tissue development and in pathological tissues particularly in domains IV and V. The fragmentation pattern of domain IV has been suggested as a means of grading prostate cancer. Doma...
Source: The International Journal of Biochemistry and Cell Biology - September 14, 2020 Category: Biochemistry Authors: Melrose J Tags: Int J Biochem Cell Biol Source Type: research