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Procedure: Transplants

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Total 24 results found since Jan 2013.

Effectiveness and Safety of Autologous Bone Marrow Stromal Cells Transplantation After Ischemic Stroke: A Meta-Analysis.
CONCLUSIONS Although BM-MNCs/MSCs transplantation might generate some benefits in lowering the grade of impairment caused by ischemic stroke, large RCTs are required to further confirm the effectiveness of BM-MSCs/MNCs-based cell therapy and to optimize the conditions require for best therapeutic effects. PMID: 26215395 [PubMed - in process]
Source: Medical Science Monitor - August 1, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Application of Muse Cell Therapy to Stroke.
Authors: Niizuma K, Borlongan CV, Tominaga T Abstract Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. The number of stroke patients is increasing, and stroke represents a serious problem from the viewpoint of the national medical economy. Even with the current sophisticated treatments, more ...
Source: Advances in Experimental Medicine and Biology - November 30, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

A Museum of Stem Cells Points to Muse Cells as Robust Transplantable Cells for Stroke: Review.
Authors: Park YJ, Farooq J, Cho J, Cozene B, Gonzales-Portillo B, Sadanandan N, Saft M, Lee JY, Borlongan CV Abstract Stem cell-based therapy stands as a robust experimental treatment for ischemic stroke. Stem cells derived from fetal, embryonic, and adult tissues serve as potential sources for transplantable cells in the setting of ischemic stroke. However, the search continues for finding an optimal cell line for clinical use. Muse cells, a distinct subset of mesenchymal stem cells found sporadically in the connective tissue of nearly every organ, may be a suitable candidate due to its safety and accessibility. T...
Source: Advances in Experimental Medicine and Biology - November 11, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

Muse Cell: A New Paradigm for Cell Therapy and Regenerative Homeostasis in Ischemic Stroke.
Authors: Kuroda S, Koh M, Hori E, Hayakawa Y, Akai T Abstract Multilineage-differentiating stress enduring (Muse) cells are one of the most promising donor cells for cell therapy against ischemic stroke, because they can differentiate into any type of cells constructing the central nervous system (CNS), including the neurons. They can easily be isolated from the bone marrow stromal cells (BMSCs), which may also contribute to functional recovery after ischemic stroke as donor cells. In this chapter, we concisely review their biological features and then future perspective of Muse cell transplantation for ischemic st...
Source: Advances in Experimental Medicine and Biology - November 30, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Transplantation of hematopoietic stem cells: intra-arterial versus intravenous administration impacts stroke outcomes in a murine model
In this study, we compared the therapeutic potential of intra-arterial versus intravenous injection of bone marrow derived-mononuclear cells (BM-MNCs) and CD133-positive (CD133+) cells in a murine stroke model.
Source: Translational Research - April 17, 2016 Category: Research Authors: Yukiko Kasahara, Kenichi Yamahara, Toshihiro Soma, David M. Stern, Takayuki Nakagomi, Tomohiro Matsuyama, Akihiko Taguchi Source Type: research

Transplantation of neural progenitor cells generated from human urine epithelial cell-derived induced pluripotent stem cells improves neurological functions in rats with stroke.
In this study, we differentiated NPCs from a urine-derived iPSC line (UC-05) which was generated with optimized episomal vectors in a feeder-free culture system. UC-05 can be induced into NPCs efficiently in monolayer cultures using dual SMAD inhibitions, and have the ability to differentiate further into astrocytes and functional neurons in vitro. We then characterized UC-05-derived NPCs upon transplantation into the striatum of adult male rats subjected to transient middle cerebral artery occlusion (tMCAO) reperfusion. While NPCs were grafted into rats 7 days before the MCAO surgery, cells were found to migrate from the ...
Source: Discovery Medicine - July 1, 2020 Category: Research Tags: Discov Med Source Type: research

Prognostic Signature for Human Umbilical Cord Mesenchymal Stem Cell Treatment of Ischemic Cerebral Infarction by Integrated Bioinformatic Analysis
Biomed Res Int. 2022 Dec 13;2022:9973232. doi: 10.1155/2022/9973232. eCollection 2022.ABSTRACTIn recent studies, stem cell-based therapy is a potential new approach in the treatment of stroke. The mechanism of human umbilical cord mesenchymal stem cell (hUMSC) transplantation as one of the new approaches in the treatment of ischemic stroke is still unclear. The aim of this study was to determine the traits of immune responses during stroke progression after treatment with human umbilical cord blood MSCs by bioinformatics, to predict potential prognostic biomarkers that could lead to sex differences, and to reveal potential...
Source: Biomed Res - December 23, 2022 Category: Research Authors: Zhifeng Wen Fangxi Liu Xinyu Lin Shanshan Zhong Xiuchun Zhang Zhike Zhou Jukka Jolkkonen Chang Liu Chuansheng Zhao Source Type: research

Methods of Preventing Tissue Ischemia
Nitric oxide (NO) plays an important role as a major intrinsic vasodilator, and increases blood flow to tissues and organs. Disruption of this process leads to peripheral vascular disease, ischemic heart disease, stroke, diabetes, and many more significant diseases. Researchers at the NIH have discovered that the matrix protein thrombospondin-1 blocks the beneficial effects of NO, and prevents it from dilating blood vessels and increasing blood flow to organs and tissues. Additionally, the inventors discovered that this regulation requires interaction with thrombospondin-1's cell receptor CD47. Murine studies revealed that...
Source: NIH OTT Licensing Opportunities - August 1, 2008 Category: Research Authors: admin Source Type: research

ApoA-1 Mimetic Peptides Promoting Lipid Efflux from Cells for Treatment of Vascular Disorders
This invention involves ApoA-1 mimetic peptides with multiple amphipathic alpha-helical domains that promote lipid efflux from cells and are useful in the treatment and prevention of dyslipidemic, inflammatory and vascular disorders. IND-enabling studies for one of the peptides, named Fx-5A, are completed in preparation for an IND filing at the FDA, to be followed by a Phase I clinical trial planned for 2017. Disorders amenable to treatment with the peptides include hyperlipidemia, hyperlipoproteinemia, hypercholesterolemia, HDL deficiency, hypertriglyceridemia, apoA-I deficiency, acute coronary syndrome, angina pectoris, ...
Source: NIH OTT Licensing Opportunities - February 1, 2008 Category: Research Authors: ajoyprabhu3 Source Type: research

Review of the Current Knowledge on the Role of Stem Cell Transplantation in Neurorehabilitation.
Abstract The management involving stem cell (SC) therapy along with physiotherapy offers tremendous chance for patients after spinal cord injury (SCI), traumatic brain injury (TBI), stroke, etc. However, there are still only a limited number of reports assessing the impact of stem cells (SCs) on the rehabilitation process and/or the results of the simultaneous use of SC and rehabilitation. Additionally, since there is still not enough convincing evidence about the effect of SCT on humans, e.g., in stroke, there have been no studies conducted concerning rehabilitation program formation and expected outcomes. It has...
Source: Biomed Res - April 3, 2019 Category: Research Authors: Kamelska-Sadowska AM, Wojtkiewicz J, Kowalski IM Tags: Biomed Res Int Source Type: research

Regulatory systems in bone marrow for hematopoietic stem/progenitor cells mobilization and homing.
Abstract Regulation of hematopoietic stem cell release, migration, and homing from the bone marrow (BM) and of the mobilization pathway involves a complex interaction among adhesion molecules, cytokines, proteolytic enzymes, stromal cells, and hematopoietic cells. The identification of new mechanisms that regulate the trafficking of hematopoietic stem/progenitor cells (HSPCs) cells has important implications, not only for hematopoietic transplantation but also for cell therapies in regenerative medicine for patients with acute myocardial infarction, spinal cord injury, and stroke, among others. This paper reviews ...
Source: Biomed Res - July 16, 2013 Category: Research Authors: Alvarez P, Carrillo E, Vélez C, Hita-Contreras F, Martínez-Amat A, Rodríguez-Serrano F, Boulaiz H, Ortiz R, Melguizo C, Prados J, Aránega A Tags: Biomed Res Int Source Type: research

Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases.
In this report, we reviewed evidence for the neuroprotective efficacy of NTs in animal models, highlighting outstanding technical challenges and discussing more recent attempts to harness the neuroprotective capacity of endogenous NTs using small molecule inducers and cell transplantation. PMID: 24818146 [PubMed - as supplied by publisher]
Source: Biomed Res - May 15, 2014 Category: Research Authors: Cai J, Hua F, Yuan L, Tang W, Lu J, Yu S, Wang X, Hu Y Tags: Biomed Res Int Source Type: research

Neuroprotective effects of systemic cerebral endothelial cell transplantation in a rat model of cerebral ischemia.
Authors: Moon JH, Na JY, Lee MC, Choi KH, Lee JK, Min JJ, Kim KT, Park JT, Park MS, Kim HS Abstract Human cerebral microvascular endothelial cell line (hCMEC)/D3 cells, which are from a stable clonal cell line of human immortalized cerebral endothelial cells, were intra-arterially transplanted through the common carotid artery in a rat model of photochemical-induced cerebral ischemia. Their therapeutic effects on infarct size, blood-brain barrier (BBB) breakdown, and outcome were examined. The hCMEC/D3 cells were genetically modified with the firefly luciferase gene for in vivo imaging post-transplantation. Transpl...
Source: American Journal of Translational Research - June 29, 2016 Category: Research Tags: Am J Transl Res Source Type: research