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Pretreatment Advanced Imaging in Patients with Stroke Treated with IV Thrombolysis: Evaluation of a Multihospital Data Base BRAIN
CONCLUSIONS: Use of advanced imaging is increasing in patients treated with IV thrombolysis. While there were differences in outcomes among imaging groups, the clinical effect of advanced imaging remains unclear.
Source: American Journal of Neuroradiology - March 13, 2014 Category: Radiology Authors: McDonald, J. S., Fan, J., Kallmes, D. F., Cloft, H. J. Tags: BRAIN Source Type: research

Successful outcome after endovascular thrombolysis for acute ischemic stroke with basis on perfusion-diffusion mismatch after 24 h of symptoms onset.
CONCLUSIONS: We report the case of a successful thrombolytic therapy following AIS performed more than 24 h after the initial symptoms based on the presence of a perfusion-diffusion mismatch. This report is expected to stimulate the development of future prospective studies with special focus on the role of perfusion-diffusion mismatch in patient selection for treatment of AIS, especially in those presenting outside the traditional time window. PMID: 27313971 [PubMed]
Source: Surgical Neurology International - June 19, 2016 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Acute Ischemic Stroke in a Child Successfully Treated with Thrombolytic Therapy and Mechanical Thrombectomy
We present the case of a 4-year-old boy with complex congenital heart disease, admitted 30 min after sudden onset of an aphasia and right hemiplegia, scoring 14 on the Pediatric National Institutes of Health Stroke Scale (PedNIHSS). Non-contrast brain computed tomography (CT) showed no evidence of acute ischemia. CT angiogram demonstrated a thrombus in the M1 segment of the left middle cerebral artery. Intravenous recombinant tissue plasminogen activator (rTPA) was infused 3.5 h after onset of symptoms. An improvement was observed in the hour after rTPA, with a PedNIHSS score of 7. Digital subtraction angiography was perfo...
Source: Case Reports in Neurology - February 8, 2019 Category: Neurology Source Type: research

An Optimal Animal Model of Ischemic Stroke Established by Digital Subtraction Angiography-Guided Autologous Thrombi in Cynomolgus Monkeys
ConclusionOur study may provide an optimal non-human primate model for an in-depth study of the pathogenesis and treatment of focal cerebral ischemia.
Source: Frontiers in Neurology - April 25, 2022 Category: Neurology Source Type: research

Emergent Angioplasty and Stent Placement Recanalization Without Thrombolysis in Acute Middle Cerebral Artery Occlusions
This study evaluated the feasibility, efficacy, and safety of intracranial artery recanalization for acute middle cerebral artery (MCA) occlusion using emergent angioplasty and stent placement without thrombolysis. All patients from a retrospectively collected database who met the inclusion criteria and were treated with an intracranial stent for acute MCA occlusion were included. Treatment comprised angioplasty and stenting without interventional thrombolytic therapy. Recanalization was assessed by angiography immediately after stent placement based on the Thrombolysis in Myocardial Infarction (TIMI) score. Complications ...
Source: Journal of Stroke and Cerebrovascular Diseases - December 12, 2011 Category: Neurology Authors: Xin-Bin Guo, Lai-Jun Song, Sheng Guan Tags: Original Articles Source Type: research

Shear-Activated Nanoparticle Aggregates Combined With Temporary Endovascular Bypass to Treat Large Vessel Occlusion Basic Sciences
Conclusions— A novel intra-arterial, nanoparticle-based thrombolytic therapy combined with TEB achieves high rates of complete recanalization. Moreover, this approach reduces vascular trauma as compared with stent-retriever thrombectomy.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Marosfoi, M. G., Korin, N., Gounis, M. J., Uzun, O., Vedantham, S., Langan, E. T., Papa, A.-L., Brooks, O. W., Johnson, C., Puri, A. S., Bhatta, D., Kanapathipillai, M., Bronstein, B. R., Chueh, J.-Y., Ingber, D. E., Wakhloo, A. K. Tags: Animal Models of Human Disease, Angiography, Treatment, Cerebrovascular Disease/Stroke Basic Sciences Source Type: research

Angiogram-negative subarachnoid hemorrhage after intravenous thrombolysis in a patient with acute ischemic stroke
We describe a patient with SAH immediately after thrombolytic therapy.
Source: Journal of Stroke and Cerebrovascular Diseases - March 18, 2017 Category: Neurology Authors: Kyung-Hee Cho, Jae-Gyum Kim, Sungwook Yu, Kyung-Hee Cho Source Type: research

Early ST-segment elevation acute myocardial infarction after thrombolytic therapy for acute ischemic stroke: A case report
We report a case of STEMI occurring 40 minutes after thrombolytic therapy for AIS and discuss the possible mechanisms and therapeutic approaches. Patient concerns: A 87-year-old woman with a history of arterial hypertension was admitted for acute onset of right-sided limb weakness 2 hours before arrival at the emergency department. Forty minutes after intravenous recombinant tissue plasminogen activator (i.v. rtPA) administration for AIS, STEMI occurred (signaled by a third-degree atrioventricular block). Diagnoses: The diagnoses were AIS and STEMI. Coronary angiography confirmed right coronary artery occlusion. ...
Source: Medicine - December 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Intracranial Aneurysms After Intravenous Thrombolysis in Patient with Atrial Myxoma: A Case Study
We administered intravenous thrombolytic therapy to a 51-year-old female patient with a 101-min stroke onset. The patient was unconscious during the manifestation of symptoms. Computed tomography angiography examination of the intracranial artery at the time of admission suggested that the left middle cerebral artery was occluded. The patient regained consciousness after the intravenous thrombolytic treatment was administered. On an urgent cerebral angiography, it was revealed that the recanalization of the left middle cerebral artery was successful.
Source: Journal of Stroke and Cerebrovascular Diseases - March 23, 2020 Category: Neurology Authors: Zhizhang Li, Xushen Xu, Liang Hu, Hongxian Sun, Yunhua Yue Tags: Case Report Source Type: research

Ipsilateral Vocal Cord Paralysis After Acute Anterior Ischemic Stroke
CONCLUSION: Our case is a rare case of transient ipsilateral vocal cord paralysis associated with anterior unilateral cerebral ischemia. The paralysis resolved with improvement of the cerebral ischemic penumbra.PMID:33635769 | DOI:10.7812/TPP/20.104
Source: The Permanente journal - February 26, 2021 Category: General Medicine Authors: Khalid Sawalha Ahmed Abd Elazim Omar Hussein Source Type: research

The Case Files: Traumatic Carotid Dissection
By Hsiao, Jonie MD   A 30-year-old man who was right-hand dominant presented 10 days after sustaining left-sided face and head trauma from a fall from a skateboard at an unknown speed. He lost consciousness for several seconds, and initially developed a headache with nausea and vomiting. A non-contrast head CT performed at another hospital done two days after the incident was reportedly negative.   He now presents primarily with concerns about the appearance of his left eye. He has notable anisocoria and a droopy eyelid. His left pupil is notably smaller, 2 mm, compared with the right eye, 5 mm. Both are reactive. The re...
Source: The Case Files - June 4, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research

Collateral Score Complements Clot Location in Predicting the Outcome of Intravenous Thrombolysis BRAIN
CONCLUSIONS: A proximal occlusion in the anterior circulation is associated with poorer collateral status compared with a more distal occlusion. Both the clot location and collateral score are important and independent predictors of favorable clinical outcome of hyperacute stroke treated with intravenous thrombolysis. The location of the clot is a stronger determinant of the outcome than the collateral score.
Source: American Journal of Neuroradiology - October 8, 2014 Category: Radiology Authors: Saarinen, J. T., Rusanen, H., Sillanpaa, N. Tags: BRAIN Source Type: research

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