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Specialty: Rheumatology

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Total 576 results found since Jan 2013.

A comparison of patients' and physicians' assessments of disease activity using the Swedish version of the Systemic Lupus Activity Questionnaire.
CONCLUSION: We confirm that the SLAQ can be used to monitor disease activity. However, the discrepancy between patients' and physicians' assessments was greater for patients with short versus long disease duration. We encourage further use of the SLAQ, but would like to develop a shorter version which would be valuable in modern, partly web-based, clinical care. PMID: 28293972 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - March 14, 2017 Category: Rheumatology Authors: Pettersson S, Svenungsson E, Gustafsson J, Möller S, Gunnarsson I, Welin Henriksson E Tags: Scand J Rheumatol Source Type: research

Are ankylosing spondylitis, psoriatic arthritis and undifferentiated spondyloarthritis associated with an increased risk of cardiovascular events? A prospective nationwide population-based cohort study
To investigate the risk of first-time acute coronary syndrome (ACS), stroke and venous thromboembolism (VTE) in patients with ankylosing spondylitis (AS), psoriatic arthritis (PsA) and undifferentiated spondyl...
Source: Arthritis Research and Therapy - May 18, 2017 Category: Rheumatology Authors: Karin Bengtsson, Helena Forsblad-d ’Elia, Elisabeth Lie, Eva Klingberg, Mats Dehlin, Sofia Exarchou, Ulf Lindström, Johan Askling and Lennart T. H. Jacobsson Source Type: research

Longterm Outcome of Patients with Primary Antiphospholipid Syndrome: A Retrospective Multicenter Study.
CONCLUSION: Despite therapy, a high proportion of patients experienced new thrombotic events and organ damage, while evolution toward CTD was infrequent. PMID: 28572466 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - June 3, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Subclinical myocardial dysfunction by tissue Doppler echocardiography in primary antiphospholipid syndrome: Preliminary results
Conclusion The present study demonstrated subclinical myocardial dysfunction using TDI in asymptomatic PAPS patients. TDI is non-invasive and cost effective. Prospective studies including a large number of participants in order to confirm these preliminary data are needed.
Source: The Egyptian Rheumatologist - June 20, 2017 Category: Rheumatology Source Type: research

Rheumatoid arthritis-specific cardiovascular risk scores are not superior to general risk scores: a validation analysis of patients from seven countries
Conclusion. The QRISK2, EULAR multiplier and ERS-RA algorithms did not predict CVD risk more accurately in patients with RA than CVD risk calculators developed for the general population.
Source: Rheumatology - March 8, 2017 Category: Rheumatology Source Type: research

Recent advances in childhood vasculitis
Purpose of review: The review aims to summarize the recent findings in vasculitis that may have an impact in our understanding or management of these diseases. Recent findings: We are learning more about monogenic diseases that closely mimic the pediatric vasculitides. Deficiency of adenosine deaminase 2 can present with a polyarteritis nodosa (PAN)-like picture and should be included in the differential of all pediatric cases of PAN with a family history or in cases with early stroke, or in cases resistant to conventional therapy. Mutations in tumor necrosis factor α-induced protein 3 results in a disease that can prese...
Source: Current Opinion in Rheumatology - July 27, 2017 Category: Rheumatology Tags: PEDIATRIC AND HERITABLE DISORDERS: Edited by Polly J. Ferguson Source Type: research

Assessment of intracranial vessels in association with carotid atherosclerosis and brain vascular lesions in rheumatoid arthritis
Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthy control subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging ...
Source: Arthritis Research and Therapy - September 26, 2017 Category: Rheumatology Authors: Csaba Ol áh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki and Zoltán Szekanecz Tags: Research article Source Type: research

Deficiency of Adenosine Deaminase 2 (DADA2), an Inherited Cause of Polyarteritis Nodosa and a Mimic of Other Systemic Rheumatologic Disorders
AbstractPurpose of ReviewA new autoinflammatory disease, deficiency of adenosine deaminase 2 (DADA2), caused by mutations in theCECR1 gene, was first reported in 2014. This review aims to update progress in defining, treating, and understanding this multi-faceted disorder.Recent FindingsDADA2 was first described in patients with systemic inflammation, mild immune deficiency, and vasculopathy manifested as recurrent stroke or polyarteritis nodosa (PAN). More than 125 patients have now been reported, and the phenotype has expanded to include children and adults presenting primarily with pure red cell aplasia (PRCA), or with ...
Source: Current Rheumatology Reports - October 5, 2017 Category: Rheumatology Source Type: research

Central Nervous System Manifestations of Antiphospholipid Syndrome
Neurologic manifestations are common in patients with antiphospholipid antibodies and include stroke, seizures, dementia, cognitive dysfunction, chorea, migraine, psychosis, and demyelinating disease. Many of these disorders mimic their idiopathic counterparts, yet treatment for antiphospholipid antibody –associated disease can be quite different compared with treatment of CNS disease not associated with these antibodies. For patients with antiphospholipid antibody–associated neurologic disease, anticoagulation or immunosuppressive therapy or both may significantly improve their symptoms. Thus, one should have a high i...
Source: Rheumatic Disease Clinics of North America - October 21, 2017 Category: Rheumatology Authors: Jonathan Graf Source Type: research

Evolution of Risk Factors for Atherosclerotic Cardiovascular Events in Systemic Lupus Erythematosus: A Longterm Prospective Study.
CONCLUSION: The relative importance of atherosclerotic risk factors is significantly differentiated over time in SLE. Disease-related factors seem to dominate CV risk during the early stages while traditional factors, partially related to corticosteroid treatment, play a significant role later in the disease course. PMID: 29093154 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - November 3, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Effect of long-term hydroxychloroquine on vascular events in patients with systemic lupus erythematosus: a database prospective cohort study
ConclusionLong-term HCQ appears to have no vascular protective effect in patients with SLE.
Source: Rheumatology - September 27, 2017 Category: Rheumatology Source Type: research

Atherosclerosis in systemic lupus erythematosus
Publication date: Available online 16 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Sara Croca, Anisur Rahman Cardiovascular disease (CVD), comprising coronary heart disease and stroke, is one of the most important causes of death in patients with systemic lupus erythematosus (SLE). The risks of developing both clinical CVD and sub-clinical atherosclerosis are increased in patients with SLE. This increase is not fully explained by traditional cardiovascular risk factors such as smoking, hypertension and elevated cholesterol, and it is believed that immune dysfunction also contribute...
Source: Best Practice and Research Clinical Rheumatology - December 5, 2017 Category: Rheumatology Source Type: research

Central nervous system vasculitis presenting as an ischaemic stroke in a young woman with systemic sclerosis
A 29-year-old woman with diffuse cutaneous SSc for 7 years presented with the acute onset of right hemiparesis. She had a regular pulse of 90/min and blood pressure 126/84 mmHg. Power in the right arm and leg was initially 4/5 but rapidly worsened to 3/5 in the leg with a positive Babinski sign.
Source: Rheumatology - July 12, 2017 Category: Rheumatology Source Type: research

Large Artery Dysfunction in Primary Antiphospholipid Syndrome
Conclusions The higher b/a ratio in APL patients suggests decreased distensibility of large arteries and may be why APL patients are at higher risk for cardiovascular events. The d/a ratio, that is considered a marker of small vessel vascular resistance, was not different than controls. Further studies are needed to evaluate vascular factors that predispose APL patients to atherosclerotic events.
Source: JCR: Journal of Clinical Rheumatology - December 24, 2017 Category: Rheumatology Tags: Original Articles Source Type: research