Association between serum homocysteine and arterial stiffness in patients with Behçet’s disease
Publication date: Available online 16 July 2019Source: The Egyptian RheumatologistAuthor(s): Amany R. El-Najjar, ahmed A. elsammakAbstractAim of the workTo study the effects of serum homocysteine (Hcy) on arterial wall properties, as a contributing risk factor for arterial atherosclerosis and thrombosis.Patients and methodsFifty Behçet's disease (BD) patients (M/F:37/13; age:34.8 ± 8.5 years) along with 50 healthy controls (M/F:32/18; age:31.9 ± 8.1 years) matched for age, sex, blood pressure, heart rate, height, total cholesterol and glucose levels were included. All were recruited Zagazig...
Source: The Egyptian Rheumatologist - July 17, 2019 Category: Rheumatology Source Type: research

Depression in rheumatoid arthritis patients: Screening for a frequent yet underestimated comorbidity
This study included 200 consecutive adult RA patients. Clinical and laboratory investigations were performed. PROs including tender and swollen joint count, patient’s estimated pain, patient global assessment (PGA), validated Arabic version of the health assessment questionnaire (HAQ-A) as well as physician global assessment were considered. The disease activity score (DAS28) and simplified erosion narrowing score (SENS) were calculated. Patient health questionnaire-9 (PHQ-9) was used to detect depression.ResultsThe patients’ mean age was 41.3 ± 11.9 years and disease duration 6.6 ± 4.9...
Source: The Egyptian Rheumatologist - July 13, 2019 Category: Rheumatology Source Type: research

Polyarteritis nodosa (PAN) associated with familial Mediterranean fever (FMF): An unusual case presentation and a review of the literature
ConclusionIncreased awareness of such clinical association of PAN and FMF and early management may improve the disease outcome. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - July 9, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: July 2019Source: The Egyptian Rheumatologist, Volume 41, Issue 3Author(s): (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - July 3, 2019 Category: Rheumatology Source Type: research

Risk factors for cataracts in a cohort of Egyptian systemic lupus erythematosus patients
This study was undertaken to evaluate cataract risk factors in Egyptian systemic lupus erythematosus (SLE) patients.Patients and methodsA cohort of 150 consecutive adult SLE patients was included. None of the patients was diabetic or had cataract before steroids treatment for SLE. Detailed medical and ophthalmological histories were taken. Thorough clinical examination was performed with assessment of SLE disease activity index (SLEDAI) and systemic lupus international collaborating clinics damage index (SLICC DI), along with routine blood tests. Slit lamp examination was done to assess the anterior segment of the eye espe...
Source: The Egyptian Rheumatologist - July 3, 2019 Category: Rheumatology Source Type: research

Bone mineral density and bone remodelling in Tunisian patients with ankylosing spondylitis: A cross-sectional study
Publication date: Available online 29 June 2019Source: The Egyptian RheumatologistAuthor(s): Afef Feki, Hela Fourati, Imen Sellami, Zouhour Gassara, Achraf Ghorbel, Mariam Ezzeddine, Hedi Kallel Mohamed, Fatma Ayadi, Rim Akrout, Sofien BakloutiAbstractAim of the workTo assess the bone turnover markers and bone mineral density (BMD) in ankylosing spondylitis (AS) patients and to evaluate their association with clinical variables.Patients and methodsForty-seven AS patients were compared with 47 matched control. Clinical features and inflammatory parameters were assessed. C-terminal telopeptide fragments of type I collagen (C...
Source: The Egyptian Rheumatologist - June 30, 2019 Category: Rheumatology Source Type: research

Predictive significance of CXCL8, CXCL10 and CXCL16 in juvenile idiopathic and rheumatoid arthritis Iraqi patients
ConclusionsCXCL8 and CXCL10 are potential predictors of JIA and RA. CXCL10 is a more significant predictor. The CXCL16 was not found to have such impact and it might be of value in a subgroup of seropositive RA patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - June 15, 2019 Category: Rheumatology Source Type: research

Potential effectiveness of exenatide in experimentally-induced osteoporosis
ConclusionExenatide has a potential prophylactic and therapeutic role in the management postmenopausal osteoporosis. The non-inferiority of exenatide to vitamin D in treatment of osteoporosis is deduced. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - June 15, 2019 Category: Rheumatology Source Type: research

Evaluation of red blood cell distribution width in patients with psoriatic arthritis
Publication date: Available online 12 June 2019Source: The Egyptian RheumatologistAuthor(s): Cem Ozisler, Sevinc Can SandikciAbstractAim of the workTo evaluate the red blood cell distribution width (RDW) values in psoriatic arthritis (PsA) patients and to study the relationship between these values and disease activation.Patients and methodsForty seven patients with PsA and 56 age- and sex matched healthy controls were included in this study. Laboratory test results of both groups were retrospectively collected from medical records; these included levels for white blood cell count, hemoglobin, platelet, RDW, erythrocyte se...
Source: The Egyptian Rheumatologist - June 13, 2019 Category: Rheumatology Source Type: research

Ocular surface involvement in patients with rheumatoid arthritis: Relation with disease activity and duration
ConclusionOcular manifestations are significant in patients with RA. The most common ocular manifestation is dry eye. Ocular manifestations are significantly associated with the disease duration and should be expected regardless of disease activity in RA patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - June 4, 2019 Category: Rheumatology Source Type: research

Duration till diagnosis and clinical profile of Sjögren’s syndrome: Data from real clinical practice in a single-center cohort
ConclusionsThe median duration till diagnosis of SS is prolonged. Patients with symptoms of OOD at disease onset had significantly prolonged duration till diagnosis. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - June 2, 2019 Category: Rheumatology Source Type: research

Vitamin D deficiency and treatment in Iraqi patients with primary fibromyalgia syndrome
ConclusionVitamin D deficiency is common in FMS patients and it is associated with worsening of symptoms. Vitamin D supplementation in deficient FMS patients is associated with significant improvement. Screening of FMS patients for hypovitaminosis D is recommended. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - May 31, 2019 Category: Rheumatology Source Type: research

IgA nephropathy associated with axial spondyloarthritis responding to treatment by etanercept: A case report
ConclusionEtanercept may be a potentially effective option for treating IgA nephropathy associated with axial SpA. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - May 22, 2019 Category: Rheumatology Source Type: research

Assessment of fatigue and functional impairment in patients with rheumatic diseases
ConclusionsFatigue and functional impairment are common in rheumatic diseases and strongly related to disease activity and severity. Good control of fatigue and functional impairment can be achieved through early control of disease activity and severity. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - May 13, 2019 Category: Rheumatology Source Type: research

Secondary amenorrhea in a cohort of Egyptian systemic lupus erythematosus patients
ConclusionCyclophosphamide is not the only key-player for the development of secondary amenorrhea in SLE; other factors as the shorter disease duration, presence of autoantibodies and major organ involvements may be implicated. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - May 8, 2019 Category: Rheumatology Source Type: research

Is leptin receptor gene (Gln223Arg) polymorphism associated with disease susceptibility and severity in patients of primary knee osteoarthritis?
This study was conducted to detect the existence of genetic association between Knee osteoarthritis (KOA) susceptibility and severity; and LEPR (Gln223Arg) single nucleotide polymorphism (SNP).Patients and methods73 primary KOA patients and 73 matched healthy controls were studied. Kellgren Laurence (K/L) radiographic grading system, Western Ontario and McMaster Universities Arthritis Index (WOMAC) score and Visual Analogue Scale (VAS) were used to assess the severity of KOA. LEPR Gln223Arg SNP (rs1137101) was genotyped in KOA patients and controls using polymerase chain reaction-restriction fragment length polymorphism (P...
Source: The Egyptian Rheumatologist - May 7, 2019 Category: Rheumatology Source Type: research

Association of interleukin-17 with peripheral spondyloarthropathic changes detected by musculoskeletal ultrasound in psoriatic patients
Publication date: Available online 2 May 2019Source: The Egyptian RheumatologistAuthor(s): Ehsan K. Elsayed, Hanan M. El-Saadany, Nashwa N. Elfar, Radwa M. El-Khouly, Samah Hamdi Almaidany, Rasha A. GaberAbstractAim of the workTo evaluate potential role of musculoskeletal ultrasound (MSUS) in detection of early peripheral spondyloarthropathic changes in psoriatic patients correlating these changes with serum interleukin-17 (IL-17) level.Patients and methodsStudy included 52 psoriatic patients and 30 matched healthy controls. Patients were assessed by modified Ritchie articular index (mRAI) and modified health assessment qu...
Source: The Egyptian Rheumatologist - May 3, 2019 Category: Rheumatology Source Type: research

Is it useful to measure serum ferritin level in systemic lupus erythematosus patients?
Publication date: Available online 25 April 2019Source: The Egyptian RheumatologistAuthor(s): Nada M. Gamal, Tayseer M. Khedr, Nadia M. Ismail, Heba Ramadan, Eman R. BadawyAbstractBackgroundSerum ferritin is elevated due to various conditions as inflammation and malignancy and could be up regulated in systemic lupus erythematosus (SLE).Aim of workTo evaluate serum ferritin level in SLE patients and correlate it with different clinical and laboratory parameters as well as disease activity.Patients and methodsThe study was carried out on 46 SLE patients and 20 matched controls. SLE Disease Activity Index (SLEDAI) was assesse...
Source: The Egyptian Rheumatologist - April 26, 2019 Category: Rheumatology Source Type: research

Primary biliary cholangitis in patients with systemic sclerosis: Unmasking the true face of Reynold's syndrome
This study aimed to evaluate the relationship between SSc and PBC, and also associated antibodies.Patients and methodsIn this study, 128 SSc patients with diffuse cutaneous (dcSSc n = 59) and limited cutaneous (lcSSc n = 69) subtypes were enrolled. PBC was diagnosed with any 2 of the following: cholestasis based on alkaline phosphatase elevation, presence of AMA and histologic evidence of destruction of interlobular bile ducts and nonsuppurative destructive cholangitis.ResultsThe mean age of the patients was 54.8 ± 13.2 years and disease duration 2.4 ± 1.4 years and they were 106 (82.8%) f...
Source: The Egyptian Rheumatologist - April 25, 2019 Category: Rheumatology Source Type: research

The incremental value of ultrasound in detection of subclinical peripheral enthesitis in patients with spondyloarthritis
ConclusionUltrasonography is superior to clinical examination in detection of enthesitis in SpA patients with good sensitivity and specificity. Enthesitis is common in upper limbs as it is in lower limbs; pathological findings and predictive values of calcifications and erosions were high at entheses of upper limbs especially supraspinatus. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 25, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: April 2019Source: The Egyptian Rheumatologist, Volume 41, Issue 2Author(s): (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 23, 2019 Category: Rheumatology Source Type: research

Diagnostic value and clinical significance of anti-carbamylated protein (anti-CarP) antibodies in Egyptian patients with rheumatoid arthritis
Publication date: Available online 22 April 2019Source: The Egyptian RheumatologistAuthor(s): Samar R. Mohamed, Nanis O. Neseem, Shereen S. Metwally, Basma A. El-KadyAbstractAim of the workThe study was performed to assess the diagnostic potential of anti-carbamylated proteins (anti-CarP) antibodies in Egyptian patients with RA and their relation to clinical manifestations, laboratory findings and radiological damage.Patients and methodsThe study involved 90 RA patients and 90 matched healthy controls. Disease activity score (DAS28) and health assessment questionnaire (HAQ) were assessed. Plain x-ray hands and feet were pe...
Source: The Egyptian Rheumatologist - April 23, 2019 Category: Rheumatology Source Type: research

Juvenile-onset mixed connective tissue disease associated with macrophage activation syndrome: A case with refractory Raynaud’s phenomenon
ConclusionMCTD may present with a myriad of rheumatic manifestations and in association with MAS the diagnosis and management may be challenging. Refractory Raynauds’ phenomenon may remarkably improve on transthoracic sympathectomy. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 16, 2019 Category: Rheumatology Source Type: research

Anti-neutrophil cytoplasmic antibody (ANCA)-associated scleritis: A diagnostic challenge and outcome
ConclusionANCA-associated vasculitis can have atypical ocular presentation and can be clinically misdiagnosed as conjunctivitis. Long term visual and systemic complications can be prevented with early detection and prompt immunosuppressive treatment. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 14, 2019 Category: Rheumatology Source Type: research

Lymphopenia in systemic lupus erythematosus patients: Is it more than a laboratory finding?
ConclusionLymphopenia is a common finding in SLE patients and was significantly associated with lupus nephritis, complement consumption, higher steroid doses and cyclophosphamide administration. Lymphopenia might be a promising marker for renal involvement in SLE. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - April 14, 2019 Category: Rheumatology Source Type: research

Nail fold capillaroscopic changes in Egyptian patients with psoriatic arthritis in comparison to rheumatoid arthritis
Publication date: Available online 8 April 2019Source: The Egyptian RheumatologistAuthor(s): Adel M. Ali, Sherin M. Hamza, Fatma M. Aboud, Nouran M. El-ShahatAbstractIntroductionNailfold capillaroscopy (NFC) is simple technique for assessment of the microvascular changes recognized in both diseases can be used in helping the differential diagnosis.Aim of the workTo determine the nailfold capillaroscopic changes in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) patients and their relation to disease activity.Patients and methodsTwenty PsA and 20 RA patients were studied. Disease activity score (DAS28) was assessed....
Source: The Egyptian Rheumatologist - April 9, 2019 Category: Rheumatology Source Type: research

Elevated Cytomegalovirus and Epstein-Barr virus burden in rheumatoid arthritis: A true pathogenic role or just a coincidence
Publication date: Available online 2 April 2019Source: The Egyptian RheumatologistAuthor(s): Rasha H. Bassyouni, Reham A. Dwedar, Eman M. Ezzat, Raghda N. Marzaban, Maha Hamdy Nassr, Laila RashidAbstractBackgroundCytomegalovirus (CMV) and Epstein-Barr virus (EBV) have created great interest as their immunomodulatory action and latent forms could play a role in the advance of autoimmune diseases.Aim of the workTo investigate the viral load of CMV and EBV in the serum of rheumatoid arthritis (RA) patients’ and study their association with the clinical and laboratory profiles.Patients and methodsThe study included 50 RA...
Source: The Egyptian Rheumatologist - April 3, 2019 Category: Rheumatology Source Type: research

Does the use of electronic devices provoke the carpal tunnel syndrome (CTS) symptoms and functional impairment? A cross-sectional study
ConclusionThere was no significant association between the patterns of electronic devices use and CTS symptoms. The high prevalence of CTS symptoms necessitates awareness programs, especially among the young population. Although this work did not prove the association, further studies with confirmatory clinical testing are recommended. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - March 19, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: January 2019Source: The Egyptian Rheumatologist, Volume 41, Issue 1Author(s): (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - March 17, 2019 Category: Rheumatology Source Type: research

Calcaneal intraosseous lipoma: A rare cause of heel pain
ConclusionCalcaneal lipoma should be mentioned as a forerunner among the differential diagnoses of persistent heel pain and promptly dealt with for a promising outcome. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - February 7, 2019 Category: Rheumatology Source Type: research

Role of syndecan-1 (CD138) in Egyptian systemic lupus erythematosus patients with lupus nephritis: Relation to disease activity
Publication date: Available online 28 January 2019Source: The Egyptian RheumatologistAuthor(s): Randa F. Salam, Noha M. Khalil, Alshaimaa R. Alnaggar, Osama Mohamady, Amina Maher, Laila Ahmed RashidAbstractBackgroundSyndecan-1, a transmemebrane heparan-sulfate glycoprotein, is predominantly expressed by plasma cells and is readily shed and released under certain pathologic conditions and remains biologically active to plasma cells behaviour.Aim of the workTo assess the level of syndecan-1 in relation to lupus nephritis (LN) and systemic lupus erythematosus (SLE) activity.Patients and methodsThe study included 60 SLE patien...
Source: The Egyptian Rheumatologist - January 29, 2019 Category: Rheumatology Source Type: research

Hyponatremia in systemic lupus erythematosus patients: Relation to disease activity and fatigue
Publication date: Available online 17 January 2019Source: The Egyptian RheumatologistAuthor(s): Mohja A. El-Badawy, Amira R. El-Mahdi, Dalia A. El-Sherbiny, Somia A.H. BawadyAbstractAim of the workTo investigate the relation of hyponatremia to disease activity and fatigue in systemic lupus erythematosus (SLE) patients.Patients and methodsThe present study included 30 SLE patients with hyponatremia and 70 with normal serum sodium (Na) level. SLE disease activity index and the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue score were assessed.ResultsThe gender, age and disease duration of SLE patients with ...
Source: The Egyptian Rheumatologist - January 18, 2019 Category: Rheumatology Source Type: research

Risk factors for osteonecrosis severity among Egyptian systemic lupus erythematosus patients: Magnetic resonance imaging (MRI) staging
Publication date: Available online 7 January 2019Source: The Egyptian RheumatologistAuthor(s): Sherin M.H. Hamza, Nermine Samy, Takwa B. Younes, Amal I.A. OthmanAbstractAim of the workTo determine the risk factors of bilateral and severe (advanced) osteonecrosis femoral head (ONFH) as assessed by magnetic resonance imaging (MRI) staging in Egyptian SLE patients.Patients and methodsSixty SLE patients were studied and subdivided into two groups according to the presence or absence of symptomatic osteonecrosis. Full medical history, musculoskeletal examination, laboratory and serologic tests were done to all patients. SLE dis...
Source: The Egyptian Rheumatologist - January 8, 2019 Category: Rheumatology Source Type: research

Sonographic synovitis in primary knee osteoarthritis patients and its relation to biomarkers of inflammation and oxidative stress
Publication date: Available online 21 December 2018Source: The Egyptian RheumatologistAuthor(s): Riham Ahmed, Marwa Hassan, Nema SolimanAbstractAim of the workTo determine the relation between knee synovitis detected by ultrasound (US) and biomarkers of inflammation and oxidative stress in primary knee osteoarthritis (KOA) patients.Patients and methodsThe study included 40 patients with primary KOA and 40 age and sex matched control. Patients were evaluated using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Laboratory investigations included high-sensitivity C-reactive protein (hsCRP), matr...
Source: The Egyptian Rheumatologist - December 21, 2018 Category: Rheumatology Source Type: research

Unilateral versus bilateral primary knee osteoarthritis: Relation to the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), C-reactive protein and radiological assessment in Egyptian patients
Publication date: Available online 21 December 2018Source: The Egyptian RheumatologistAuthor(s): Hanan M. FathiAbstractAim of the workTo study the differences between unilateral and bilateral knee osteoarthritis (KOA) patients in relation to the Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), C-reactive protein (CRP) and radiological assessment.Patients and methodsThe study included 80 primary KOA patients subgrouped into those with unilateral or bilateral condition according to the X-ray. WOMAC scale and body mass index (BMI), waist (WC) and thigh (TC) circumferences were measured. The CRP and lipid pr...
Source: The Egyptian Rheumatologist - December 21, 2018 Category: Rheumatology Source Type: research

Arterial aneurysms in Behçet’s disease patients: Frequency, clinical characteristics and long-term outcome
ConclusionArterial aneurysms are common in Egyptian BD patients mostly males. Increased awareness of the rheumatologists and including appropriate imaging techniques for early detection of AA in BD are mandatory. Early detection and prompt treatment with immunosuppressives may improve the disease outcome. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 21, 2018 Category: Rheumatology Source Type: research

Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) syndrome in an elderly Spanish patient: Ruling-out polymyalgia rheumatica and management
ConclusionRS3PE could be diagnosed even without polyarthritis and successfully treated by low dose steroids after excluding any related malignancy. Excluding PMR is important to avoid exposing the patient to unwanted higher steroid doses. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - December 20, 2018 Category: Rheumatology Source Type: research

Neuropathic pain in Egyptian patients with primary knee osteoarthritis: Relationship with functional status and radiological severity
Publication date: Available online 19 December 2018Source: The Egyptian RheumatologistAuthor(s): Abdullah Radwan, Ahmed BoraiAbstractAim of the workThe present study was conducted to identify the frequency of neuropathic pain (NP) and its relationship with functional status and radiological severity in a series of Egyptian patients with primary knee osteoarthritis (OA).Patients and methodsThe study included 165 patients with primary KOA. Visual analogue scale (VAS)-pain was estimated and the Western Ontario and McMaster (WOMAC) Universities osteoarthritis index was used for assessment of pain, stiffness and physical functi...
Source: The Egyptian Rheumatologist - December 19, 2018 Category: Rheumatology Source Type: research

Hazards of pulse steroid use in a cohort of Egyptian lupus nephritis patients
Publication date: Available online 14 December 2018Source: The Egyptian RheumatologistAuthor(s): AbdelAzeim M. Elhefny, Hanan M. Farouk, Noran O. El-Azizi, Amr A. Elzaher, Elham S. MohammedAbstractBackgroundPulse methylprednisolone is a tool for rapid immunosuppression in systemic lupus erythematosus (SLE) patients with life-threatening manifestations.Aim of the workTo assess the effect of the frequent use of high-dose pulse steroids on renal response and to detect any associated hazards in lupus nephritis (LN) patients with a disease duration>3 years.Patients and methodsMedical records of 90 Egyptian LN patients were...
Source: The Egyptian Rheumatologist - December 15, 2018 Category: Rheumatology Source Type: research

Serum pentraxin 3 levels in rheumatoid arthritis patients and its association with disease activity
Publication date: Available online 26 November 2018Source: The Egyptian RheumatologistAuthor(s): Mohammadreza Jafari-Nakhjavani, Amir Ghorbanihaghjo, Elyar Pourghassem, Sima Abediazar, Tala Pourlak, Aida MalekmahdaviAbstractAim of the workThis work aimed to evaluate serum pentraxin 3 (PTX3) levels in rheumatoid arthritis (RA) patients and to study the association with the disease activity.Patients and methodsSixty RA patients and 26 matched controls were included. In patients, clinical examination was performed and disease activity score (DAS28) assessed. Serum PTX3, rheumatoid factor (RF), anti-cyclic citrullinated peptid...
Source: The Egyptian Rheumatologist - November 27, 2018 Category: Rheumatology Source Type: research

Diagnostic potential of metastasis-associated-lung-adenocarcinoma-transcript-1 (MALAT-1) and TNFα and hnRNPL related immunoregulatory long non-coding RNA (THRIL) in systemic lupus erythematosus patients: Relation to disease activity
ConclusionMALAT-1 and THRIL may be potential diagnostic biomarkers for SLE and only MALAT-1 may be valuable in detecting disease activity. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 23, 2018 Category: Rheumatology Source Type: research

Diagnostic potential of ultrasound in systemic lupus erythematosus patients with joint involvement: Relation to anticyclic citrullinated peptide (anti-CCP), disease activity and functional status
Publication date: Available online 22 November 2018Source: The Egyptian RheumatologistAuthor(s): Rasha A. Abdel-Magied, Hanaa A.S. AbuOmar, Lamia H. Ali, Huda Talaat, Faten I. MohamedAbstractAim of the work: To assess the pattern of joint involvement in systemic lupus erythematosus (SLE) patients by ultrasound (US) and to detect their relation with clinical, laboratory, disease activity and functional status. Patients and methods: Thirty SLE patients and 20 controls were included. SLE disease activity index (SLEDAI-2k) and health assessment questionnaire-disability index (HAQ-DI) were assessed. Anti-cyclic citrullinated pe...
Source: The Egyptian Rheumatologist - November 23, 2018 Category: Rheumatology Source Type: research

Influence of +299G>A and +62G˃A resistin gene promoter variants on cardiovascular risk in Egyptian women with systemic lupus erythematosus
Publication date: Available online 19 November 2018Source: The Egyptian RheumatologistAuthor(s): Nearmeen M. Rashad, Reem M. Allam, Dina Said, Ayman E. Ali, Nesreen M. Mohy, Hala G. AbomandourAbstractBackgroundCardiovascular diseases (CVDs) are major causes of morbidity and mortality in systemic lupus erythematosus (SLE) patients. Resistin is an inflammatory adipocytokine associated with insulin resistance and an increased risk of CVD.Aim of the workTo study the possible role of resistin (RETN) +299A>G and +62G˃A gene polymorphisms in the development of CVDs among Egyptian SLE patients and their impact on cardio metabo...
Source: The Egyptian Rheumatologist - November 21, 2018 Category: Rheumatology Source Type: research

Increased serum and synovial levels of midkine are associated with radiological progression in primary knee osteoarthritis patients
ConclusionOsteoarthritis patients have significantly elevated serum and synovial levels of midkine that were correlated with functional status assessed with WOMAC index and obviously associated with radiological progression on MSUS suggesting that it could be a useful marker to reflect OA severity and implies a possible role in the disease pathogenesis. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 16, 2018 Category: Rheumatology Source Type: research

Screening for latent tuberculosis infection prior to biologic therapy in patients with chronic immune-mediated inflammatory diseases (IMID): Interferon-gamma release assay (IGRA) versus tuberculin skin test (TST)
ConclusionsTST and IGRA have a low agreement. Both tests should be included in the strategy to diagnose LTBI prior to biologic therapy in IMID patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 16, 2018 Category: Rheumatology Source Type: research

Werner syndrome in two case reports: The wild and the tame systemic sclerosis mimics
ConclusionThis close mimic with systemic sclerosis might mask cases of Werner syndrome in developing countries where no genetic screening is readily available. The cases are illustrative for the confusion that may arise with systemic sclerosis and the difficulty in making the diagnosis in mild cases. Therefore, these descriptions are of clinical value to clinicians treating such patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - November 12, 2018 Category: Rheumatology Source Type: research

Toll-like receptor (TLR9) -1486 T/C (rs187084) gene polymorphism in Egyptian patients with rheumatoid arthritis
ConclusionTLR9 gene polymorphism -1486 T/C is associated with the increased RA susceptibility in Egyptian patients. (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - October 29, 2018 Category: Rheumatology Source Type: research

Cross cultural adaptation and validation of an Arabic version of selected PROMIS measures for use in rheumatoid arthritis patients
Publication date: Available online 22 October 2018Source: The Egyptian RheumatologistAuthor(s): Geilan A. Mahmoud, Hanaa M. Rady, Abdallah M. MostafaAbstractAim of the workTo cross culturally adapt and validate an Arabic version of selected patient reported outcome information system (PROMIS) measures for use in rheumatoid arthritis (RA).Patients and MethodsOne-hundred RA patients were recruited. They were asked to complete a validated Arabic health assessment questionnaire (HAQ), visual analogue scale (VAS) of patient global assessment (PGA) and the translated Arabic version of selected PROMIS measures for use in RA. The ...
Source: The Egyptian Rheumatologist - October 24, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: October 2018Source: The Egyptian Rheumatologist, Volume 40, Issue 4Author(s): (Source: The Egyptian Rheumatologist)
Source: The Egyptian Rheumatologist - October 11, 2018 Category: Rheumatology Source Type: research

Serum ferritin level as a marker of disease activity and renal involvement in Egyptian children with juvenile systemic lupus erythematosus
Publication date: Available online 20 September 2018Source: The Egyptian RheumatologistAuthor(s): Samia Salah-El-Din Mahmoud, Doaa Ghaith, Yomna Farag, Bishoy IbrahimAbstractIntroductionFerritin is an acute-phase reactant that is elevated in several autoimmune disorders. Serum ferritin levels have been correlated with disease activity scores of juvenile systemic lupus erythematosus (JSLE). Furthermore, enhanced levels of ferritin have also been described in lupus nephritis (LN).Aim of the workTo evaluate serum ferritin as a cheap and available marker of disease activity and renal involvement in Egyptian children with JSLE....
Source: The Egyptian Rheumatologist - September 22, 2018 Category: Rheumatology Source Type: research