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Specialty: Allergy & Immunology

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Total 749 results found since Jan 2013.

Promoted Generation of T Helper 1-Like Regulatory T Cells After Transient Middle Cerebral Artery Occlusion in Type-2 Diabetic Mice
CONCLUSION: The generation of Th1-like Tregs was promoted in the brains of type 2 diabetic mice after stroke. Our study reveals significant Treg plasticity in diabetic stroke.Abbreviations: Foxp3: forkhead box P3; IFN-γ: interferon-γ; IL-10: interleukin-10; IL-12: interleukin-12; MCAO: middle cerebral artery occlusion; PBS: phosphate-buffered saline; STAT1: Signal transducer and activator of transcription 1; STAT5: Signal transducer and activator of transcription 1; T-bet: T-box expressed in T cells; TGF-β: transforming growth factor-β; Th1: T helper 1; TNF-α: tumor necrosis factor-α; Tregs: regulatory T cells. Foxp3...
Source: Immunological Investigations - April 19, 2023 Category: Allergy & Immunology Authors: Lei Jian Yanqi Hu Mingjie Gao Long Shu Source Type: research

BRG1 alleviates microglial activation by promoting the KEAP1-NRF2/HO-1 signaling pathway and minimizing oxidative damage in cerebral ischemia-reperfusion
Int Immunopharmacol. 2023 May 10;119:110201. doi: 10.1016/j.intimp.2023.110201. Online ahead of print.ABSTRACTBRG1 is a key factor in the process of apoptosis and oxidative damage; however, its role in the pathophysiology of ischemic stroke is unclear. Here, we discovered that during middle cerebral artery occlusion (MCAO) reperfusion in mice, microglia were significantly activated in the cerebral cortex of the infarct area, and BRG1 expression was increased in the mouse MCAO/R model, peaking at 4 days. In microglia subjected to OGD/R, BRG1 expression increased and peaked at 12 h after reoxygenation. After ischemic stroke,...
Source: International Immunopharmacology - May 12, 2023 Category: Allergy & Immunology Authors: Kongwei Guo Yanxing Shang Zhao Wang Yu Li Jinliang Chen Baofeng Zhu Dongmei Zhang Jianrong Chen Source Type: research

Brainstem Infarction in Immunodeficiency Identified as Adenosine Deaminase 2 Deficiency: Case Report
ConclusionWe present the case of a young adult with diagnosis of DADA2 as a cause for recurrent strokes due to vasculitis. This stroke etiology is rare but should be considered as a cause of recurrent stroke of unknown origin in young patients to avoid a disabling disease course by disease-specific treatment options.
Source: Journal of Clinical Immunology - June 12, 2023 Category: Allergy & Immunology Source Type: research

Pharmacological Upregulation of Microglial Lipid Droplet Alleviates Neuroinflammation and Acute Ischemic Brain Injury
In this study, we observed increased LDs accumulation in microglia at the acute stage of ischemic stroke by immunofluorescence and flow cytometry. Transcriptomic analysis indicated that microglia accumulated with LDs were associated with inflammation and phagocytosis. Both inflammatory activation and phagocytosis of tissue debris in microglia could contribute to LDs formation. Moreover, through specific LDs depletion and overload experiments by pharmacological approaches, we proposed that LDs was critical for the maintenance of anti-inflammatory properties of microglia. Furthermore, Atglistatin, a specific adipose triglyce...
Source: Inflammation - July 14, 2023 Category: Allergy & Immunology Source Type: research

Plasma levels of mannan‐binding lectin (MBL)‐associated serine proteases (MASPs) and MBL‐associated protein in cardio‐ and cerebrovascular diseases
Summary Growing evidence suggests a prominent role of the complement system in the pathogenesis of cardio‐ and cerebrovascular diseases (CVD). Mannan‐binding lectin‐associated serine proteases (MASPs) MASP‐1 and MASP‐2 of the complement lectin pathway contribute to clot formation and may represent an important link between inflammation and thrombosis. MBL‐associated protein MAp44 has shown cardio‐protective effects in murine models. However, MAp44 has never been measured in patients with CVD and data on MASP levels in CVD are scarce. Our aim was to investigate for the first time plasma levels of MAp44 and MAS...
Source: Clinical and Experimental Immunology - February 25, 2013 Category: Allergy & Immunology Authors: Vera Frauenknecht, Steffen Thiel, Line Storm, Niklaus Meier, Marcel Arnold, Jean‐Paul Schmid, Hugo Saner, Verena Schroeder Tags: Original Article Source Type: research

Icariin attenuates cerebral ischemia-reperfusion injury through inhibition of inflammatory response mediated by NF-κB, PPARα and PPARγ in rats.
Abstract Icariin (ICA), an active flavonoid extracted from Chinese medicinal herb Epimedii, has been reported to exhibit many pharmacological effects including alleviating brain injury. However, little is known about the protection of ICA on ischemic stroke. Hence, this study was designed to investigate the neuroprotective effect of ICA and explore its underlying mechanisms on ischemic stroke induced by cerebral ischemia-reperfusion (I/R) injury in rats. The animals were pretreated with ICA at doses of 10, 30mg/kg twice per day for 3 consecutive days followed by cerebral I/R injury induced by middle cerebral arter...
Source: International Immunopharmacology - December 8, 2015 Category: Allergy & Immunology Authors: Xiong D, Deng Y, Huang B, Yin C, Liu B, Shi J, Gong Q Tags: Int Immunopharmacol Source Type: research

Salvianolic Acid B Ameliorates Cerebral Ischemia/Reperfusion Injury Through Inhibiting TLR4/MyD88 Signaling Pathway
ABSTRACT Ischemic stroke can activate multiple transcription factors and cause inflammatory reactions, which involve pattern recognition receptors with immunostimulatory effects. Toll-like receptor 4 (TLR4) is one of the receptors related to innate immunity and several inflammatory reactions. The promising anti- inflammatory activity of salvianolic acid B (SAB) had been previously reported, but its effect on ischemic stroke remains unknown. An oxygen-glucose deprivation and reoxygenation (OGD/R) model in vitro and a middle cerebral artery occlusion (MCAO) model in vivo were used in this paper, and the results show...
Source: Inflammation - June 1, 2016 Category: Allergy & Immunology Source Type: research

An integrated epidemiological and neural net model of the warfarin effect in managed care patients.
CONCLUSION: Enrichment methodology improves the statistical discrimination of meaningful endpoints when used in a health records-based analysis. PMID: 28572740 [PubMed - in process]
Source: Clinical Pharmacology: Advances and Applications - June 4, 2017 Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research

Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway
Publication date: November 2017 Source:Molecular Immunology, Volume 91 Author(s): Juan Peng, Xian Deng, Wei Huang, Ji-hua Yu, Jian-xiong Wang, Jie-ping Wang, Shi-bin Yang, Xi Liu, Li Wang, Yun Zhang, Xiang-Yu Zhou, Hui Yang, Yan-Zheng He, Fang-yuan Xu Recent studies found that irisin, a newly discovered skeletal muscle-derived myokine during exercise, is also synthesized in various tissues of different species and protects against neuronal injury in cerebral ischemia. The NOD-like receptor pyrin 3 (NLRP3) inflammasome play an important role in detecting cellular damage and mediating inflammatory responses to aseptic tissu...
Source: Molecular Immunology - October 1, 2017 Category: Allergy & Immunology Source Type: research

Blood Cell-Bound C4d as a Marker of Complement Activation in Patients With the Antiphospholipid Syndrome
In conclusion the detection of complement activation products on circulating erythrocytes and platelets using a highly sensitive and specific assay further supports the view that APS is a complement-mediated disorder. Increased EC4d and PC4d percentages are associated with the active inflammatory disease in SLE. It is difficult to translate this finding to APS which is a non-acute inflammatory disorder. We failed to find an association with both the classification and non-classification criteria, including thrombocytopenia. However, we believe that this sensitive tool to evaluate complement activation may offer more inform...
Source: Frontiers in Immunology - April 11, 2019 Category: Allergy & Immunology Source Type: research

Immunoreactive Cells After Cerebral Ischemia
The immune system is rapidly activated after ischemic stroke. As immune cells migrate and infiltrate across the blood-brain barrier into the ischemic region, a cascade of cellular and molecular biological reactions occur, involving migrated immune cells, resident glial cells, and the vascular endothelium. These events regulate infarction evolution and thus influence the outcome of ischemic stroke. Most immune cells exert dual effects on cerebral ischemia, and some crucial cells may become central targets in ischemic stroke treatment and rehabilitation.
Source: Frontiers in Immunology - November 25, 2019 Category: Allergy & Immunology Source Type: research

Assessment of pre-specified adverse events following varicella vaccine: A population-based self-controlled risk interval study.
CONCLUSIONS: We detected a small risk of incidental pneumonia associated with varicella vaccine in the 6th week after immunization. There was no increase in the risk of other pre-specified adverse events. PMID: 32046891 [PubMed - as supplied by publisher]
Source: Vaccine - February 7, 2020 Category: Allergy & Immunology Authors: Liu CH, Yeh YC, Huang WT, Chie WC, Chan KA Tags: Vaccine Source Type: research

CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia.
CONCLUSIONS: CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia. CKLF1/CCR5 axis may be a useful target for stroke therapy. PMID: 32446198 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - May 19, 2020 Category: Allergy & Immunology Authors: Chen C, Chu SF, Ai QD, Zhang Z, Chen NH Tags: Int Immunopharmacol Source Type: research

Up-regulating lncRNA OIP5-AS1 protects neuron injury against cerebral hypoxia-ischemia induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p.
CONCLUSION: Up-regulating lncRNA OIP5-AS1 protects neuron injury against MCAO/R induced inflammation and oxidative stress in microglia/macrophage through activating CTRP3 via sponging miR-186-5p. PMID: 33516048 [PubMed - as supplied by publisher]
Source: International Immunopharmacology - January 27, 2021 Category: Allergy & Immunology Authors: Chen Y, Liu W, Chen M, Sun Q, Chen H, Li Y Tags: Int Immunopharmacol Source Type: research