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Total 1564 results found since Jan 2013.

Platelet bio-nanobubbles as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics
Conclusions: In summary, platelet membrane-based nanobubbles for targeting acute ischemic lesions were developed as microvascular recanalization nanoformulation for acute ischemic stroke lesion theranostics. This biomimetic PNBs theranostic strategy will be valuable for ischemic stroke patients in the future.
Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Mingxi Li, Yang Liu, Jinpeng Chen, Taotao Liu, Zhuxiao Gu, Jianqiong Zhang, Xiaochun Gu, Gaojun Teng, Fang Yang, Ning Gu Tags: Research Paper Source Type: research

Modulators of microglia activation and polarization in ischemic stroke (Review).
Authors: Jiang CT, Wu WF, Deng YH, Ge JW Abstract Ischemic stroke is one of the leading causes of mortality and disability worldwide. However, there is a current lack of effective therapies available. As the resident macrophages of the brain, microglia can monitor the microenvironment and initiate immune responses. In response to various brain injuries, such as ischemic stroke, microglia are activated and polarized into the proinflammatory M1 phenotype or the anti‑inflammatory M2 phenotype. The immunomodulatory molecules, such as cytokines and chemokines, generated by these microglia are closely associated with s...
Source: Molecular Medicine Reports - April 25, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Diffusion tensor and volumetric magnetic resonance imaging using an MR-compatible hand-induced robotic device suggests training-induced neuroplasticity in patients with chronic stroke.
In this study, we hypothesized that brain mapping using a novel magnetic resonance (MR)-compatible hand device in conjunction with state‑of‑the‑art magnetic resonance imaging (MRI) can serve as a novel biomarker for brain plasticity induced by rehabilitative motor training in patients with chronic stroke. This hypothesis is based on the premises that robotic devices, by stimulating brain plasticity, can assist in restoring movement compromised by stroke‑induced pathological changes in the brain and that these changes can then be monitored by advanced MRI. We serially examined 15 healthy controls and 4 patients wi...
Source: International Journal of Molecular Medicine - August 27, 2013 Category: Molecular Biology Authors: Lazaridou A, Astrakas L, Mintzopoulos D, Khanicheh A, Singhal AB, Moskowitz MA, Rosen B, Tzika AA Tags: Int J Mol Med Source Type: research

Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis.
Abstract A recent genome-wide association study elucidated that 4q25 was implicated in ischemic stroke, but subsequent studies showed inconsistent results. In order to get coincident conclusion, we investigated two SNPs (rs2200733, rs10033464) on chromosome 4q25 in 1,388 stroke patients and 1,629 controls from Chinese Han population and then performed a meta-analysis. Although we failed to detect any association between 4q25 and stroke in our case-control study, meta-analysis revealed that rs2200733 showed association with overall stroke (OR 1.18, 95 % CI 1.08-1.27), but not for rs10033464. Subsequently subgroup ...
Source: Molecular Biology Reports - September 25, 2013 Category: Molecular Biology Authors: Cao YY, Ma F, Wang Y, Wang DW, Ding H Tags: Mol Biol Rep Source Type: research

Reduced release of TNF α and IP-10 after ex vivo blood stimulation with endotoxin is associated with poor outcome after stroke.
CONCLUSIONS: The reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is independently associated with poor outcome after stroke. Our results suggest that the inhibition of both the MyD88-dependent pathway and MyD88-independent pathway of TLR4 signaling in blood cells correlates with an unfavorable prognosis in stroke patients. PMID: 29275013 [PubMed - as supplied by publisher]
Source: Cytokine - December 21, 2017 Category: Molecular Biology Authors: Klimiec E, Kowalska K, Pasinska P, Pera J, Slowik A, Dziedzic T Tags: Cytokine Source Type: research

Hyperforin improves post-stroke social isolation ‑induced exaggeration of PSD and PSA via TGF-β.
In conclusion, the results revealed a previously uncharacterized role of hyperforin in improving post‑stroke social isolation‑induced exaggeration of PSD and PSA and, in turn, promoting hippocampal neurogenesis and cognitive function via TGF‑β. PMID: 30387813 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - November 2, 2018 Category: Molecular Biology Authors: Zhang Y, Yu P, Liu H, Yao H, Yao S, Yuan SY, Zhang JC Tags: Int J Mol Med Source Type: research

Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery
Conclusion: GAT-1 is a key molecular substrate of the effects of EE on network excitability and consequent stroke recovery and can serve as a novel therapeutic target for stroke treatment during the repair phase.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Yuhui Lin, Mengcheng Yao, Haiyin Wu, Feng Wu, Shiying Cao, Huanyu Ni, Jian Dong, Di Yang, Yanyu Sun, Xiaolin Kou, Jun Li, Hui Xiao, Lei Chang, Jin Wu, Yan Liu, Chunxia Luo, Dongya Zhu Tags: Research Paper Source Type: research

Prospective study of IL-18 and risk of MI and stroke in men and women aged 60-79years: A nested case-control study.
CONCLUSIONS: Circulating IL-18 levels were strongly associated with a range of established and novel risk factors but were not independently associated with risk of MI or stroke in our study. PMID: 23207179 [PubMed - as supplied by publisher]
Source: Cytokine - November 30, 2012 Category: Molecular Biology Authors: Jefferis BJ, Whincup PH, Welsh P, Wannamethee SG, Rumley A, Ebrahim S, Lawlor DA, Lowe GD Tags: Cytokine Source Type: research

The apoptotic actions of platelets in acute ischemic stroke.
Abstract Stroke is a disease that affects the blood vessels that supply blood to the brain. Although platelets are implicated in the pathophysiology of stroke the mechanism is still not clear and there antiplatelet agents available for the prevention and treatment of stroke. We herein examined the relationship between the potential cytokine, TNF-α platelet activation and apoptosis in acute ischemic stroke patients. We selected 60 patients (mean age 57.9 ± 10.2 years) who had not taken any antiplatelet drugs for 14 days. A group of 45 participants (mean age 51.05 ± 9.07 years) were selected as the control...
Source: Molecular Biology Reports - September 22, 2013 Category: Molecular Biology Authors: Cevik O, Adiguzel Z, Baykal AT, Somay G, Sener A Tags: Mol Biol Rep Source Type: research

Neuroinflammatory biomarkers: From stroke diagnosis and prognosis to therapy
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - October 31, 2015 Category: Molecular Biology Source Type: research

Functional characterization of a mouse model for central post-stroke pain
Conclusions These results suggest that the evoked hypersensitivity observed in central post-stroke pain is causally linked to on-going neuronal activity in the lateral thalamus.
Source: Molecular Pain - March 7, 2016 Category: Molecular Biology Authors: Gritsch, S., Bali, K. K., Kuner, R., Vardeh, D. Tags: Original Article Source Type: research

Multilocus analysis of the association of polymorphic variants of inflammation genes with ischemic stroke in Russians.
Abstract Carriage frequencies of alleles and genotypes of polymorphic loci of inflammation genes (49A>G CTLA4, 41G>A and 87C>T PDE4D, -590C>T IL4, -308A>G TNF, 252G>A LTA, 874A>T IFNG, -509С>Т, 869T>C and 915G>C TGFB1) were determined in a sample of 200 patients diagnosed with ischemic stroke and in the control group similar in gender and age (146 individuals), all ethnic Russians. The positive association of the allele PDE4D*87C (р = 0.028) and genotype TGFB1*-509Т/Т (р = 0.02) carriage with ischemic stroke was shown. The association of the disease with the carriage of the alle...
Source: Molekuliarnaia Biologiia - June 30, 2016 Category: Molecular Biology Authors: Titov BV, Matveeva NA, Martynov MY, Favorova OO Tags: Mol Biol (Mosk) Source Type: research

CCR2-dependent monocytes/macrophages exacerbate acute brain injury but promote functional recovery after ischemic stroke in mice
Conclusion: CCR2-dependent monocytes/macrophages are a double-edged sword; they worsen acute brain injury, but are essential for neurological recovery by promoting anti-inflammatory macrophage polarization.
Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Weirong Fang, Xuan Zhai, Dong Han, Xiaoxing Xiong, Tao Wang, Xun Zeng, Shucheng He, Rui Liu, Masaaki Miyata, Baohui Xu, Heng Zhao Tags: Research Paper Source Type: research

Connectivity map identifies luteolin as a treatment option of ischemic stroke by inhibiting MMP9 and activation of the PI3K/Akt signaling pathway.
This study aimed to explore potential new drugs in the treatment of ischemic stroke by Connectivity Map (CMap) and to determine the role of luteolin on ischemic stroke according to its effects on matrix metalloproteinase-9 (MMP9) and PI3K/Akt signaling pathway. Based on published gene expression data, differentially expressed genes were obtained by microarray analysis. Potential compounds for ischemic stroke therapy were obtained by CMap analysis. Cytoscape and gene set enrichment analysis (GSEA) were used to discover signaling pathways connected to ischemic stroke. Cell apoptosis and viability were, respectively, evaluate...
Source: Molecular Medicine - March 24, 2019 Category: Molecular Biology Authors: Luo S, Li H, Mo Z, Lei J, Zhu L, Huang Y, Fu R, Li C, Huang Y, Liu K, Chen W, Zhang L Tags: Exp Mol Med Source Type: research

Hyaluronic acid and Regenerative medicine: New insights into the stroke therapy.
Abstract Stroke is known as one of very important public health problems which are related to a societal burden and tremendous economic. It has been showed, there are few therapeutic approaches in the treatment of this disease. In this regard, present therapeutic platforms aim to obtain neuroprotection, reperfusion, and neurorecovery. Among these therapies, regenerative medicine-based therapies have been appeared as new ways in stroke therapy. Hyaluronic acid (HA) is a new candidate which could be applied as regerenative medicine-based therapy in the treatment of stroke. HA is a glycosaminoglycan which is formed o...
Source: Current Molecular Medicine - March 24, 2020 Category: Molecular Biology Authors: Shahi M, Mohammadnejad D, Karimipour M, Rasta SH, Rahbarghazi R, Elahi AA Tags: Curr Mol Med Source Type: research