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Total 1564 results found since Jan 2013.

Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway
CONCLUSIONS: Summarily, our results support myricetin as a novel neuroprotectant for the prevention or treatment of ischemic stroke via MAPK-ERK signaling pathway.PMID:36611117 | DOI:10.1007/s11033-022-08238-8
Source: Molecular Biology Reports - January 7, 2023 Category: Molecular Biology Authors: Lei Zhang Tai Zhou Qiaorong Ji Li He Yan Lan Lei Ding Li Li Zhongcheng Wang Source Type: research

Stroke and molecular imaging: a focus on FDG-PET
Am J Nucl Med Mol Imaging. 2023 Apr 25;13(2):51-63. eCollection 2023.ABSTRACTStroke is the leading cause of disability worldwide, the second most common cause of dementia and the third leading cause of death. Though the etiology of stroke has been explored extensively, there remains open questions in the scientific and clinical study of stroke. Traditional imaging techniques, such as magnetic resonance imaging and computed tomography, have been applied extensively and remain mainstays in clinical practice. Nevertheless, positron emission tomography has proven to be a powerful molecular imaging tool in exploring the scienti...
Source: Molecular Medicine - May 22, 2023 Category: Molecular Biology Authors: Cyrus Ayubcha Aamir Amanullah Krishna H Patel Eric Teichner Saket Gokhale Ulysses Marquez-Valenzuela Thomas J Werner Abass Alavi Source Type: research

Frequency of angiotensin II type 1 receptor gene polymorphism in Turkish acute stroke patients
This study was performed in acute stroke patients in the Turkish population to determine the frequency of the A1166C polymorphism in the AT1 gene and to examine the role of this polymorphism in acute stroke development. In this study, 257 genomic DNA samples were analysed (from 206 acute stroke patients and 51 healthy individuals). Genomic DNA was prepared from peripheral blood using the salt‐extraction method. The presence of the A1166C polymorphism in the AT1 gene was determined using the polymerase chain reaction (PCR)‐restriction fragment length polymorphism (RFLP) method. PCR products were separated by 2% agarose ...
Source: Journal of Cellular and Molecular Medicine - March 11, 2013 Category: Molecular Biology Authors: Kurt Hulyam, Bayramoglu Aysegul, Gunes Hasan Veysi, Ozbabalik Demet, Degirmenci Irfan, Colak Ertugrul, Cosan Turgut Didem, Bayram Banu, Dikmen Miris Tags: Original Article Source Type: research

Image-guided Pro-angiogenic Therapy in Diabetic Stroke Mouse Models Using a Multi-modal Nanoprobe
Conclusions: The non-invasive imaging method could be used for early and accurate evaluation of the response to pro-angiogenic therapy in diabetic stroke models.
Source: Theranostics - November 15, 2014 Category: Molecular Biology Authors: Ying-Ying Bai, Xihui Gao, Yuan-Cheng Wang, Xin-Gui Peng, Di Chang, Shuyan Zheng, Cong Li, Shenghong Ju Tags: Research Paper Source Type: research

Genetic analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the kidneys.
Abstract Spontaneously hypertensive rats (SHRs) and stroke-prone SHRs (SHRSP) are frequently used as models not only of essential hypertension and stroke, but also of attention-deficit hyperactivity disorder (ADHD). Normotensive Wistar-Kyoto (WKY) rats are normally used as controls in these studies. In the present study, we aimed to identify the genes causing hypertension and stroke, as well as the genes involved in ADHD using these rats. We previously analyzed gene expression profiles in the adrenal glands and brain. Since the kidneys can directly influence the functions of the cardiovascular, endocrine and sy...
Source: International Journal of Molecular Medicine - July 10, 2015 Category: Molecular Biology Authors: Watanabe Y, Yoshida M, Yamanishi K, Yamamoto H, Okuzaki D, Nojima H, Yasunaga T, Okamura H, Matsunaga H, Yamanishi H Tags: Int J Mol Med Source Type: research

Promoting brain remodeling to aid in stroke recovery.
Abstract Endogenous brain repair after stroke involves a set of highly interactive processes, such as angiogenesis, neurogenesis, oligodendrogenesis, synaptogenesis, and axonal outgrowth, which together orchestrate neurological recovery. During the past several years, there have been advances in our understanding of miRNAs and histone deacetylases (HDACs) in brain repair processes after stroke. Emerging data indicate the important role of exosomes for intercellular communication in promoting coupled brain remodeling processes. These advances will likely have a major impact on the development of restorative therapi...
Source: Trends in Molecular Medicine - August 13, 2015 Category: Molecular Biology Authors: Zhang ZG, Chopp M Tags: Trends Mol Med Source Type: research

Prehypertensive treatment with losartan, however not amlodipine, leads to long‑term effects on blood pressure and reduces the risk of stroke in spontaneously hypertensive stroke‑prone rats.
Authors: Zhang L, He D, Lin J Abstract The current study investigated the efficacy of losartan and amlodipine in protecting spontaneously hypertensive stroke‑prone (SHRSP) rats against the risk of stroke. SHRSP rats were administered losartan, amlodipine or the vehicle for 6 weeks. There were no significant differences in systolic blood pressure (SBP) in rats treated with losartan or amlodipine, however, following drug withdrawal, rats treated with losartan maintained reduced SBP for a longer time compared with rats treated with amlodipine. In addition, rats treated with losartan exhibited thinner vascular walls...
Source: Molecular Medicine Reports - December 11, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Enhanced Neuroprotection of Ischemic Stroke Based on Liposomal Drug Delivery System Loading a Novel Uncoupler of Ischemia-induced nNOSPSD- 95
In this study, ZL006 was loaded effectively into liposomes to improve the solubility and bioavailability. The particle size of ZL006-loaded liposomes (LPs) was about 115.5 nm with acceptable polydispersity index. The in vitro release profiles indicated that ZL006 could keep sustained release from LPs for more than 48 h. The results of pharmacokinetics study proved that the mean residence time of LPs group was 1.5-fold (P
Source: Current Signal Transduction Therapy - December 21, 2015 Category: Molecular Biology Source Type: research

Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice
This study investigated the effect of post-stroke, direct AT2-receptor (AT2R) stimulation with the non-peptide AT2R-agonist compound 21 (C21) on infarct size, survival and neurological outcome after middle cerebral artery occlusion (MCAO) in mice and looked for potential underlying mechanisms. C57/BL6J or AT2R-knockout mice (AT2-KO) underwent MCAO for 30 min followed by reperfusion. Starting 45 min after MCAO, mice were treated once daily for 4 days with either vehicle or C21 (0.03 mg/kg ip). Neurological deficits were scored daily. Infarct volumes were measured 96 h post-stroke by MRI. C21 significantly improved surv...
Source: Journal of Molecular Medicine - March 16, 2016 Category: Molecular Biology Source Type: research

Sodium tanshinone IIA sulfonate improves inflammation, aortic endothelial cell apoptosis, disseminated intravascular coagulation and multiple organ damage in a rat heat stroke model.
Authors: Chen F, Li H, Zhu G, Chen X, Tang Z Abstract The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS. In the HS groups, the ra...
Source: Molecular Medicine Reports - May 13, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

MicroRNA-125a-3p is involved in early behavioral disorders in stroke-afflicted rats through the regulation of Cadm2.
In conclusion, miR‑125a is involved in the behavioral disorder of animal models of MCAO by regulation of Cadm2. PMID: 29039453 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - October 10, 2017 Category: Molecular Biology Authors: Liu Y, Li Y, Ren Z, Si W, Li Y, Wei G, Zhao W, Zhou J, Tian Y, Chen D Tags: Int J Mol Med Source Type: research

mTOR is involved in stroke-induced seizures and the anti-seizure effect of mild hypothermia.
Authors: Yang GS, Zhou XY, An XF, Liu XJ, Zhang YJ, Yu D Abstract Stroke is considered an underlying etiology of the development of seizures. Stroke leads to glucose and oxygen deficiency in neurons, resulting in brain dysfunction and injury. Mild hypothermia is a therapeutic strategy to inhibit stroke‑induced seizures, which may be associated with the regulation of energy metabolism of the brain. Mammalian target of rapamycin (mTOR) signaling and solute carrier family 2, facilitated glucose transporter member (GLUT)‑1 are critical for energy metabolism. Furthermore, mTOR overactivation and GLUT‑1 deficiency...
Source: Molecular Medicine Reports - February 28, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Combined treatment of sodium ferulate, n ‐butylidenephthalide, and ADSCs rehabilitates neurovascular unit in rats after photothrombotic stroke
AbstractThe remodelling of structural and functional neurovascular unit (NVU) becomes a central therapeutic strategy after cerebral ischaemic stroke. In the present study, we investigated the effect of combined therapy of sodium ferulate (SF),n‐butylidenephthalide (BP) and adipose‐derived stromal cells (ADSCs) to ameliorate the injured NVU in the photochemically induced thrombotic stroke in rats. After solely or combined treatment, the neovascularization, activation of astrocytes, neurogenesis, expressions of vascular endothelial grow th factor (VEGF) and claudin‐5 were assessed by immunohistochemical or immunofluore...
Source: Journal of Cellular and Molecular Medicine - November 12, 2018 Category: Molecular Biology Authors: Yong ‐Hua Zhao, Nai‐Wei Liu, Chien‐Chih Ke, Bo‐Wen Liu, Yi‐An Chen, Cheng Luo, Qian Zhang, Zhen‐Yan Xia, Ren‐Shyan Liu Tags: ORIGINAL ARTICLE Source Type: research