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Total 1564 results found since Jan 2013.

TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention.
Authors: Wang Q, Liu N, Ni YS, Yang JM, Ma L, Lan XB, Wu J, Niu JG, Yu JQ Abstract Ischemic stroke has a high lethality rate worldwide, and novel treatments are limited. Calcium overload is considered to be one of the mechanisms of cerebral ischemia. Transient receptor potential melastatin 2 (TRPM2) is a reactive oxygen species (ROS)-sensitive calcium channel. Cerebral ischemia-induced TRPM2 activation triggers abnormal intracellular Ca2+ accumulation and cell death, which in turn causes irreversible brain damage. Thus, TRPM2 has emerged as a new therapeutic target for ischemic stroke. This review provides data on ...
Source: Channels - January 21, 2021 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

Overexpression of EphB4 promotes neurogenesis, but inhibits neuroinflammation in mice with acute ischemic stroke
In conclusion, this study contributes to the current understanding of the mechanisms of EphB4 in exerting neurorestorative effects and may recommend a potential new strategy for ischemic stroke treatment.PMID:34476505 | DOI:10.3892/mmr.2021.12396
Source: Molecular Medicine Reports - September 3, 2021 Category: Molecular Biology Authors: Jin Wang Zun Zhang Shaojing Fu Xiaojie Li Xinhui Li Shaobin Wang Lihe Yuan Source Type: research

Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network
In this study, a total of 30 participants were recruited, including 10 controls, 10 patients with AF and 10 patients with AF and stroke (AF + STROKE). Differentially expressed genes (DEGs) were identified, and functional annotation of DEGs, comparative toxicogenomic database analysis associated with cardiovascular diseases, and predictions of miRNAs of hub genes were performed. Using RT-qPCR, biological process and support vector machine neural networks, numerous DEGs were found to be related to AF. HBG1, SNCA and GYPB were found to be upregulated in the AF group. Higher expression of hub genes in AF and AF + STROKE groups...
Source: J Cell Mol Med - February 9, 2022 Category: Molecular Biology Authors: Xiang Wang Xuyang Meng Lingbing Meng Ying Guo Yi Li Chenguang Yang Zuowei Pei Jiahan Li Fang Wang Source Type: research

MiR-203a-3p/153-3p improves cognitive impairments induced by ischemia/reperfusion via blockade of SRC-mediated MAPK signaling pathway in ischemic stroke
In this study, the rat model of middle cerebral artery occlusion (MCAO) and the cell model of oxygen and glucose deprivation/reperfusion (OGD/R) were applied to investigate the possible role of the microRNA in ischemic stroke. MCAO/R and OGD/R caused the downregulation of miR-203a-3p and miR-153-3p, the upregulation of SRC. SRC was identified to be a common target for miR-203a-3p and miR-153-3p. Both miR-203a-3p and miR-153-3p inhibited SRC expression at the mRNA and protein levels. miR-203a-3p and miR-153-3p improved the cognitive deficits through targeting SRC. Moreover, miR-203a-3p and miR-153-3p relieved the apoptosis,...
Source: Chemico-Biological Interactions - March 20, 2022 Category: Molecular Biology Authors: Yamei Li Bo Peng Yi Li Airu Huang Yinian Peng Qian Yu Yufeng Li Source Type: research

Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke (Review)
Int J Mol Med. 2022 Jun;49(6):74. doi: 10.3892/ijmm.2022.5130. Epub 2022 Apr 8.ABSTRACTPost‑ischemic neuroinflammation induced by the innate local immune response is a major pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of mortality and disability worldwide. NLR family pyrin domain containing (NLRP)3 inflammasome crucially mediates post‑ischemic inflammatory responses via its priming, activation and interleukin‑1β release during hypoxic‑ischemic brain damage. Mitochondrial dysfunctions are among the main hallmarks of several brain diseases, including ischemic stroke. In th...
Source: International Journal of Molecular Medicine - April 14, 2022 Category: Molecular Biology Authors: Xiaolu Zhang Wenyun Zeng Yue Zhang Qun Yu Miao Zeng Jiali Gan Wenlan Zhang Xijuan Jiang Huhu Li Source Type: research

Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia
This study aimed to evaluate whether genetic polymorphism is associated with an increased risk of infection, specifically post-stroke aspiration pneumonia. Blood samples were obtained from a total of 206 post-stroke participants (males, n = 136; mean age, 63.8 years). Genotyping was performed for catechol-O-methyltransferase (rs4680, rs165599), dopamine receptors (DRD1; rs4532, DRD2; rs1800497, DRD3; rs6280), brain-derived neurotrophic factor (rs6265), apolipoprotein E (rs429358, rs7412), and the interleukin-1 receptor antagonist gene (rs4251961). The subjects were stratified into two groups, aged < 65 (young) and â...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Hae-Yeon Park Hyun-Mi Oh Tae-Woo Kim Youngkook Kim Geun-Young Park Hyemi Hwang Sun Im Source Type: research

The study of serum C-reactive protein, Serum cystatin C, and carbohydrate antigen 125 in patients with acute ischemic stroke
Cell Mol Biol (Noisy-le-grand). 2022 May 31;68(5):89-95. doi: 10.14715/cmb/2022.68.5.12.ABSTRACTStroke is the most common, deadly, and complicating neurological disease. Many studies have shown that the levels of some acute inflammatory reactants in people with ischemic stroke are higher than average. Therefore, in this study, three acute inflammatory reactants, i.e., C-reactive protein, Serum cystatin C, and carbohydrate antigen 125, were evaluated in patients with acute ischemic stroke to consider the association between these serums with intra and extra-cerebral vessels stenosis. In this cross-sectional study, 90 patien...
Source: Cellular and Molecular Biology - August 27, 2022 Category: Molecular Biology Authors: Xiaoqian Lin Chunyu Yu Hongmei Ding Xiuping Ma Fengning Guo Dan Chen Youmin Fan Source Type: research

Single Nucleotide Polymorphisms May Increase the Risk of Aspiration Pneumonia in Post-Stroke Patients with Dysphagia
This study aimed to evaluate whether genetic polymorphism is associated with an increased risk of infection, specifically post-stroke aspiration pneumonia. Blood samples were obtained from a total of 206 post-stroke participants (males, n = 136; mean age, 63.8 years). Genotyping was performed for catechol-O-methyltransferase (rs4680, rs165599), dopamine receptors (DRD1; rs4532, DRD2; rs1800497, DRD3; rs6280), brain-derived neurotrophic factor (rs6265), apolipoprotein E (rs429358, rs7412), and the interleukin-1 receptor antagonist gene (rs4251961). The subjects were stratified into two groups, aged < 65 (young) and â...
Source: Current Issues in Molecular Biology - August 25, 2022 Category: Molecular Biology Authors: Hae-Yeon Park Hyun-Mi Oh Tae-Woo Kim Youngkook Kim Geun-Young Park Hyemi Hwang Sun Im Source Type: research