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Aortic Transgraft Hemorrhage after Intravenous Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke
Conclusions: Our analysis provides reassurance regarding the risk of IV tPA therapy in patients undergoing aortic graft replacement.
Source: Journal of Stroke and Cerebrovascular Diseases - August 4, 2014 Category: Neurology Authors: Tomohiro Kawano, Katsufumi Kajimoto, Masahiro Higashi, Kenji Minatoya, Kazunori Toyoda, Kazuyuki Nagatsuka Tags: Original Articles Source Type: research

First Ischemic Stroke in Sickle-Cell Disease: Are There Any Adult Specificities? Brief Reports
Conclusions— First-ever IS occurring in adults with SCD has specificities that justify further studies conducted in adults with SCD to improve understanding and management.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Calvet, D., Bernaudin, F., Gueguen, A., Hosseini, H., Habibi, A., Galacteros, F., Bartolucci, P. Tags: Acute Cerebral Infarction Brief Reports Source Type: research

Gastrointestinal Bleeding in Acute Ischemic Stroke: Recent Trends from the Fukuoka Stroke Registry
Background: Gastrointestinal (GI) hemorrhage is a potentially serious complication of acute stroke, but its incidence appears to be decreasing. The aim of this study was to elucidate the etiology of GI bleeding and its impact on clinical outcomes in patients with acute ischemic stroke in recent years. Methods: Using the database of the Fukuoka Stroke Registry, 6,529 patients with acute ischemic stroke registered between June 2007 and December 2012 were included in this study. We recorded clinical data including any previous history of peptic ulcer, prestroke drug history including the use of antiplatelets, anticoagulants, ...
Source: Cerebrovascular Diseases Extra - November 7, 2014 Category: Neurology Source Type: research

The Way Forward: Challenges and Opportunities in Pediatric Stroke
The past two decades have seen a remarkable increase in publications on pediatric stroke, reflecting increased awareness of its impact on childhood health. The results of the Stroke Prevention Trial in Sickle Cell Anemia (STOP), published in 1998, which showed that chronic blood transfusion decreased the risk of stroke in high risk children with sickle cell anemia by 92%, revolutionized the care of children with sickle cell anemia 1 and highlighted the importance of primary stroke prevention. Surgical revascularization is used increasingly to decrease the risk of ischemic and hemorrhagic stroke in children with moyamoya ce...
Source: Pediatric Neurology - December 9, 2015 Category: Neurology Authors: Catherine Amlie-Lefond, Michael JRivkin, Neil Friedman, Timothy Bernard, Michael Morgan Dowling, Gabrielle deVeber Tags: Perspectives in Pediatric Neurology Source Type: research

Ischemic Stroke Related to Severe Iron-Deficiency Anemia in Adults May Benefit from Blood Transfusion (P01.232)
CONCLUSIONS: Prevalence of IDA is 1-20%; it is 3.9% in our AIS population and is often related to untreated uterine bleeding. As described in the pediatric population, severe IDA may be an underlying mechanism of ischemic stroke in adults, therefore, efforts must be undertaken to identify and treat the cause of the anemia. While patients with AIS and severe IDA may receive TPA, blood transfusion may be considered as an adjuvant therapy.Supported by: SPOTRIAS P50 NS044227 & NIH Training Grant 5T 32NS0077412-12.Disclosure: Dr. Choi has nothing to disclose. Dr. Sanchez-Rotunno has nothing to disclose. Dr. Gonzales has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Choi, E., Sanchez-Rotunno, M., Gonzales, N. Tags: P01 Cerebrovascular Disease I Source Type: research

Intravenous Tissue Plasminogen Activator for an Ischemic Stroke with Occult Double Primary Cancer
Discussion: Although systemic thrombolysis with tPA for ischemic stroke in patients with advanced-stage cancer may be performed relatively safely, optimal post-thrombolysis management is important to prevent the complications.Case Rep Neurol 2014;6:238-242
Source: Case Reports in Neurology - November 7, 2014 Category: Neurology Source Type: research

Role of Surgery in the Management of Brain Arteriovenous Malformations: Prospective Cohort Study Clinical Sciences
Conclusions— Most of the ruptured and unruptured low and middle-grade bAVMs (Spetzler–Ponce A and B) can be surgically treated with a low risk of permanent morbidity and a high likelihood of preventing future hemorrhage. Our results do not apply to Spetzler–Ponce C bAVMs.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Korja, M., Bervini, D., Assaad, N., Morgan, M. K. Tags: Cerebrovascular disease/stroke, Clinical Studies, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Pathology of Stroke Clinical Sciences Source Type: research

Report of cold agglutinins in a patient with acute ischemic stroke
Conclusion: We report here the first case of cerebral infarction probably due to the cold agglutinin disease. The underlying mechanism of cold agglutinins in the pathogenesis of acute ischemic stroke needs to be investigated further.
Source: BMC Neurology - October 30, 2015 Category: Neurology Authors: Haiqiang JinWei SunYongan SunYining HuangYunchuang Sun Source Type: research

Nonaneurysmal Subarachnoid Hemorrhage in Sickle Cell Disease: Description of a Case and a Review of the Literature
We describe the case of an 18-year-old female affected by HbSS genotype SCD presenting with reversible cerebral vasoconstriction syndrome (RCVS) as well as features of posterior reversible encephalopathy syndrome and convexity subarachnoid hemorrhage (SAH) after transfusion of red blood cells. We reviewed the existing literature dealing with SCD, blood transfusion, and hemorrhagic strokes. To our knowledge, this case presentation is unique with convexity SAH predominantly attributable to a RCVS spectrum disorder occurring in the setting of a recent blood transfusion in an adolescent female with SCD. As this case illustrate...
Source: The Neurologist - June 28, 2018 Category: Neurology Tags: Case Report/Case Series Source Type: research

Non-invasive imaging of oxygen extraction fraction in adults with sickle cell anaemia
Sickle cell anaemia is a monogenetic disorder with a high incidence of stroke. While stroke screening procedures exist for children with sickle cell anaemia, no accepted screening procedures exist for assessing stroke risk in adults. The purpose of this study is to use novel magnetic resonance imaging methods to evaluate physiological relationships between oxygen extraction fraction, cerebral blood flow, and clinical markers of cerebrovascular impairment in adults with sickle cell anaemia. The specific goal is to determine to what extent elevated oxygen extraction fraction may be uniquely present in patients with higher le...
Source: Brain - February 25, 2016 Category: Neurology Authors: Jordan, L. C., Gindville, M. C., Scott, A. O., Juttukonda, M. R., Strother, M. K., Kassim, A. A., Chen, S.-C., Lu, H., Pruthi, S., Shyr, Y., Donahue, M. J. Tags: Original Articles Source Type: research

In Context News in brief
Stroke and silent cerebral infarcts are common in children with sickle cell anaemia. Although the incidence of silent cerebral infarcts can be reduced with regular blood transfusions, it is unknown whether regular transfusions can prevent the recurrence of an infarct (stroke or new or enlarged silent cerebral infarction). In a multicentre, randomised, single-blind, controlled trial of 196 children aged 5 to 15 years with sickle cell anaemia who had silent cerebral infarcts, 6 of 99 (6%) children who received transfusion therapy had an end-point event (one had stroke and five had new or enlarged silent cerebral infarcts) ov...
Source: Lancet Neurology - September 16, 2014 Category: Neurology Authors: The Lancet Neurology Tags: In Context Source Type: research

Clinical Features and Risk Factors of Mortality in Patients with Posterior Reversible Encephalopathy Syndrome
CONCLUSIONS: Our results indicate that PRES could be considered as a sign of a very high-risk patient. We also demonstrated that heart failure and stroke were independent risk factors for death in patients with PRES; moreover, pregnancy was a protective factor.PMID:36419591 | PMC:PMC9678458 | DOI:10.1155/2022/9401661
Source: Behavioural Neurology - November 24, 2022 Category: Neurology Authors: Hong-Wei Cui Ru-Yi Lei Bo-Ai Zhang Source Type: research

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