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Procedure: Gastroschisis Repair

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Total 40 results found since Jan 2013.

Long-term T cell responses in the brain after an ischemic stroke.
Authors: Selvaraj UM, Stowe AM Abstract Stroke, which occurs during a loss of blood flow to the brain, is a global disease that accounts for 10% of yearly mortality. But stroke is also a leading cause of long-term adult disability, with recovery continuing for months to years after initial stroke onset. This long-term functional recovery from stroke encompasses changes in neuronal structure and function, and occurs throughout the post-stroke brain. Much less understood is whether the adaptive immune cells that infiltrated the brain during acute post-stroke neuroinflammation remain long-term, and if their presence s...
Source: Discovery Medicine - January 28, 2018 Category: Research Tags: Discov Med Source Type: research

Stroke induces a rapid adaptive autoimmune response to novel neuronal antigens.
Authors: Ortega SB, Noorbhai I, Poinsatte K, Kong X, Anderson A, Monson NL, Stowe AM Abstract Stroke affects millions of people worldwide every year. Despite this prevalence, mechanisms of long-term injury and repair within the ischemic brain are still understudied. Sterile inflammation occurs in the injured brain after stroke, with damaged tissue exposing central nervous system (CNS)-derived antigen that could initiate potential autoimmune responses. We used a standard immunology-based recall response assay for murine immune cells, isolated from the cervical lymph nodes and spleen after transient stroke, to determ...
Source: Discovery Medicine - June 26, 2015 Category: Research Tags: Discov Med Source Type: research

Ischemic stroke and intestinal flora: an insight into brain –gut axis
AbstractStroke is a type of cerebrovascular disease that significantly endangers human health and lowers quality of life. This understandably places a heavy burden on society and families. In recent years, intestinal flora has attracted increasing attention from scholars worldwide, and its association with ischemic stroke is becoming a hot topic of research amongst researchers in field of stroke. After suffering from a stroke, intestinal microbial dysbiosis leads to increased intestinal permeability and activation of the intestinal immune system, which in turn leads to ectopic intestinal bacteria and pro-inflammatory cells...
Source: European Journal of Medical Research - May 25, 2022 Category: Research Source Type: research

Application of Muse Cell Therapy to Stroke.
Authors: Niizuma K, Borlongan CV, Tominaga T Abstract Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. The number of stroke patients is increasing, and stroke represents a serious problem from the viewpoint of the national medical economy. Even with the current sophisticated treatments, more ...
Source: Advances in Experimental Medicine and Biology - November 30, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Global trends and hotspots in research on acupuncture for stroke: a bibliometric and visualization analysis
This study aimed to characterize the global publications and analyze the trends of acupuncture for stroke in the past 40  years. We identified 1157 publications from the Web of Science Core Collection. The number of publications grew slowly in the first three decades from 1980 until it started to grow after 2010, with significant growth in 2011–2012 and 2019–2020. China, the USA, and South Korea are the top three countries in this field, and China has formed good internal cooperative relations. Early studies focused on the clinical efficacy of acupuncture for stroke. In the last five years, more emphasis has been plac...
Source: European Journal of Medical Research - September 21, 2023 Category: Research Source Type: research

Adipose tissue-derived stem cells in stroke treatment: from bench to bedside.
Authors: Gutiérrez-Fernández M, Rodríguez-Frutos B, Otero-Ortega L, Ramos-Cejudo J, Fuentes B, Díez-Tejedor E Abstract More recently, growing interests have brought cell therapy to the forefront of promising new approaches towards efficacious treatment for stroke. Of all cell-types, adipose tissue-derived mesenchymal stem cells (AD-MSC) are considered good candidates for stroke treatment because of their abundance and easy harvesting without invasive surgery from healthy donors. A wide number of experimental studies have demonstrated the potential of AD-MSC administration for improving functional deficits and h...
Source: Discovery Medicine - November 14, 2014 Category: Research Tags: Discov Med Source Type: research

Systematic Analysis of RNA Regulatory Network in Rat Brain after Ischemic Stroke.
In this study, we simultaneously interrogate the expression profiles of lncRNAs, miRNAs, and mRNAs changes during focal ischemia induced by transient middle cerebral artery occlusion. A set of 1924 novel lncRNAs were identified and may involve brain injury and DNA repair as revealed by coexpression network analysis. Furthermore, many short interspersed elements (SINE) mediated lncRNA:mRNA duplexes were identified, implying that lncRNAs mediate Staufen1-mediated mRNA decay (SMD) which may play a role during focal ischemia. Moreover, based on the competitive endogenous RNA (ceRNA) hypothesis, a stroke regulatory ceRNA networ...
Source: Biomed Res - March 10, 2018 Category: Research Authors: Liu J, Zhang KS, Hu B, Li SG, Li Q, Luo YP, Wang Y, Deng ZF Tags: Biomed Res Int Source Type: research

Mechanisms and challenges in translational stroke research
Translating basic science advances into clinical meaning has been challenging for stroke research. This does not, however, mean that the investigation of basic mechanisms is irrelevant. Translation is difficult because the underlying mechanisms are complex and ill-defined. The original focus on neuroprotection has now evolved into a broader consideration of the role of non-neuronal cells in stroke pathophysiology. The neurovascular unit may provide a conceptual framework within which interactions between neural, glial, and vascular cells comprise a basis for function and dysfunction in the central nervous system. Important...
Source: Journal of Investigative Medicine - March 21, 2016 Category: Research Authors: Lo, E. H., Ning, M. Tags: Editor's choice Experimental biology symposia Source Type: research

SI – CROSSTALK: Mitochondrial‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 22, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

Mitochondrial ‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 21, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

Mitochondrial –nuclear p53 trafficking controls neuronal susceptibility in stroke
AbstractStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and apopt osis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which control protein localization, stability, and proapoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis through both tra...
Source: IUBMB Life - March 2, 2021 Category: Research Authors: Angeles Almeida, Irene S ánchez‐Morán, Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research

Efficacy of Balloon Guide Catheter-Assisted Thrombus Repair in Stroke Treatment: A Retrospective Survey in China
CONCLUSION: We showed that BGC shortened the procedural time and increased the rate of the successful FP. We recommend that BGC could be considered the preferred technique for endovascular intervention in stroke.PMID:36212711 | PMC:PMC9534624 | DOI:10.1155/2022/4278048
Source: Biomed Res - October 10, 2022 Category: Research Authors: Qiang Li Tengfei Zhou Yingkun He Min Guan Zhaoshuo Li Liheng Wu Changming Wen Haibo Wang Guang Feng Ziliang Wang Liangfu Zhu Tianxiao Li Source Type: research