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Mp284 * chronic renal failure worsens ischemic stroke severity and neurological consequences in mice
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Brazier, F., Assem, M., Henaut, L., Kamel, S., Massy, Z. A., Chillon, J.-M. Tags: CHRONIC KIDNEY DISEASE. PATHOPHYSIOLOGY, PROGRESSION & amp; RISK FACTORS - 2 Source Type: research

Mp343 * the association between serum uric acid and incidence of non-fatal stroke in the ckd population: a longitudinal survey of a nationwide cohort in japan
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Kamei, K., Araumi, A., Watanabe, S., Sato, H., Ichikawa, K., Konta, T., Kubota, I., Iseki, K., Yamagata, K., Fujimoto, S., Tsuruya, K., Narita, I., Moriyama, T., Yugo, S., Asahi, K., Kondo, M., Kasahara, M., Watanabe, T. Tags: CHRONIC KIDNEY DISEASE CLINICAL EPIDEMIOLOGY - 2 Source Type: research

Mp588 * probing risk of stroke and its related factors in elderly dialysis patients
Source: Nephrology Dialysis Transplantation - May 13, 2016 Category: Urology & Nephrology Authors: Han, S. S., Joo, K. W., Han, J. S., Kim, Y. S., Kim, D. K. Tags: DIALYSIS. EPIDEMIOLOGY, OUTCOME RESEARCH, HEALTH SERVICES RESEARCH - 2 Source Type: research

Mortality and Associated Risk Factors in Dialysis Patients with Cardiovascular Disease
Background/Aims: Although dialysis patients have a higher risk of morbidity and mortality related to cardiovascular disease (CVD) than the general population, the mortality and associated risk factors in Asian dialysis patients with CVD have not been well examined. Methods: In this prospective cohort study, mortality and risk factors were investigated in 591 dialysis patients who were recruited from two dialysis centers from May 1, 2009 to May 1, 2014. The Cox proportional hazards regression assessed adjusted differences in mortality risk. A multivariate analysis was also performed, comparing the CVD and non-CVD groups. Re...
Source: Kidney and Blood Pressure Research - July 19, 2016 Category: Urology & Nephrology Source Type: research

Phosphate-Binding Agents in Adults With CKD: A Network Meta-analysis of Randomized Trials
Conclusions There is currently no evidence that phosphate-binder treatment reduces mortality compared to placebo in adults with CKD. It is not clear whether the higher mortality with calcium versus sevelamer reflects whether there is net harm associated with calcium, net benefit with sevelamer, both, or neither. Iron-based binders show evidence of greater phosphate lowering that warrants further examination in randomized trials.
Source: American Journal of Kidney Diseases - July 22, 2016 Category: Urology & Nephrology Source Type: research

Comparative effectiveness of angiotensin receptor blockers vs. angiotensin-converting enzyme inhibitors on cardiovascular outcomes in patients initiating peritoneal dialysis.
CONCLUSION: We identified no significant difference in the risks of CV events or death between users of ARBs vs. ACEIs in patients initiating PD, thus supporting their mostly interchangeable use in this population. PMID: 27485007 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - August 1, 2016 Category: Urology & Nephrology Authors: Shen JI, Saxena AB, Montez-Rath ME, Leng L, Chang TI, Winkelmayer WC Tags: J Nephrol Source Type: research

The blood pressure-salt sensitivity paradigm: pathophysiologically sound yet of no practical value
Sodium plays an important pathophysiological role in blood pressure (BP) values and in the development of hypertension, and epidemiological studies such as the Intersalt Study have shown that the increase in BP occurring with age is determined by salt intake. Recently, a meta-analysis of 13 prospective studies has also shown the close relationship between excess sodium intake and higher risk of stroke and total cardiovascular events. However, the BP response to changing salt intake displayed a marked variability, as first suggested by Kawasaki et al. (The effect of high-sodium and low-sodium intakes on blood pressure and o...
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Galletti, F., Strazzullo, P. Tags: NDT PERSPECTIVES Source Type: research

Pro: Reducing salt intake at population level: is it really a public health priority?
A reduction in salt intake reduces blood pressure, stroke and other cardiovascular events, including chronic kidney disease, by as much as 23% (i.e. 1.25 million deaths worldwide). It is effective in both genders, any age, ethnic group, and in high-, medium- and low-income countries. Population salt reduction programmes are both feasible and effective (preventive imperative). Salt reduction programmes are cost-saving in all settings (high-, middle- and low-income countries) (economic imperative). Public health policies are powerful, rapid, equitable and cost-saving (political imperative). The important shift in public heal...
Source: Nephrology Dialysis Transplantation - September 1, 2016 Category: Urology & Nephrology Authors: Cappuccio, F. P. Tags: POLAR VIEWS IN NEPHROLOGY Source Type: research

Cognitive Impairment in Advanced Chronic Kidney Disease: The Canadian Frailty Observation and Interventions Trial.
CONCLUSIONS: Our study uncovered a high rate of unrecognized cognitive impairment in an advanced CKD population. This impairment is global, affecting all aspects of cognition and is likely vascular in nature. The longitudinal trajectory of cognitive function and its effect on dialysis decision-making and outcomes deserves further study. PMID: 27798938 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - October 31, 2016 Category: Urology & Nephrology Authors: Foster R, Walker S, Brar R, Hiebert B, Komenda P, Rigatto C, Storsley L, Prasad B, Bohm C, Tangri N Tags: Am J Nephrol Source Type: research

Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study
Conclusions High Lp(a) concentrations and LMW apo(a) isoforms are risk predictors for all-cause mortality and death due to infection in haemodialysis patients with diabetes mellitus. These associations are modified by age.
Source: Nephrology Dialysis Transplantation - November 1, 2016 Category: Urology & Nephrology Authors: Kollerits, B., Drechsler, C., Krane, V., Lamina, C., März, W., Dieplinger, H., Ritz, E., Wanner, C., Kronenberg, F., for the German Diabetes and Dialysis Study Investigators Tags: Chronic Kidney Disease Source Type: research

Dry weight assessment by combined ultrasound and bioimpedance monitoring in low cardiovascular risk hemodialysis patients: a randomized controlled trial
ConclusionsThis study shows that a LUS –bioimpedance-guided dry weight adjustment protocol, as compared to clinical evaluation, does not reduce all-cause mortality and/or CVE in HD patients. A fluid management protocol based on bioimpedance with LUS on indication might be a better strategy.
Source: International Urology and Nephrology - December 6, 2016 Category: Urology & Nephrology Source Type: research

Antiplatelet agents in hemodialysis.
In conclusion, since CRF patients are one of the groups at highest risk for atherosclerotic events, it could be reasonable to use aspirin in HD patients. However, the bleeding risk in HD patients needs to be strongly evaluated, especially before starting dual AA treatment. PMID: 27928736 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - December 7, 2016 Category: Urology & Nephrology Authors: Migliori M, Cantaluppi V, Scatena A, Panichi V Tags: J Nephrol Source Type: research

Cognitive Impairment and Structural Neuroimaging Abnormalities Among Patients with Chronic Kidney Disease
Conclusion: Dialysis modality showed no association with cognitive impairment, although hemodialysis patients had more severe neuroimaging abnormalities. For the whole group, white matter hyperintensity, and ventricular and hippocampal atrophy, were independently associated with global cognitive impairment in chronic kidney disease patients.Kidney Blood Press Res 2016;41:986-996
Source: Kidney and Blood Pressure Research - December 17, 2016 Category: Urology & Nephrology Source Type: research

Warfarin Initiation, Atrial Fibrillation, and Kidney Function:  Comparative Effectiveness and Safety of Warfarin in Older Adults With Newly Diagnosed Atrial Fibrillation
Conclusions Among older adults with AF, warfarin therapy initiation was associated with a significantly lower 1-year risk for the composite outcome across all strata of kidney function. The risk for major bleeding associated with warfarin use was increased only among those with eGFRs of 60 to 89mL/min/1.73m2.
Source: American Journal of Kidney Diseases - December 18, 2016 Category: Urology & Nephrology Source Type: research

Faster rate of blood volume change in pediatric hemodialysis patients impairs cardiac index
ConclusionThe cardiac index and stroke volume decreased significantly during the HD session. Patients with larger blood volume changes during the first 2  h of HD and at 4 h showed a significant decrease in cardiac index that did not recover at the completion of the HD treatment. Rate of fluid removal was the only significant risk factor for compromised cardiac index during HD. Conventional methods currently used for assisting fluid removal in HD ar e inadequate to assess hemodynamic changes.
Source: Pediatric Nephrology - January 1, 2017 Category: Urology & Nephrology Source Type: research

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