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Specialty: Cardiology
Nutrition: Sodium

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Total 159 results found since Jan 2013.

Effects of Sodium/Glucose Cotransporter 2 (SGLT2) Inhibitors and Combined SGLT1/2 Inhibitors on Cardiovascular, Metabolic, Renal, and Safety Outcomes in Patients with Diabetes: A Network Meta-Analysis of 111 Randomized Controlled Trials
ConclusionsIn patients with T2DM, compared with pure SGLT2 inhibitors, combined SGLT1/2 inhibitors demonstrated a lower risk of myocardial infarction and of stroke, but were associated with a higher risk of diarrhea and severe hypoglycemia.
Source: American Journal of Cardiovascular Drugs - March 22, 2022 Category: Cardiology Source Type: research

Aldosterone and cardiovascular diseases
Cardiovasc Res. 2022 Apr 7:cvac027. doi: 10.1093/cvr/cvac027. Online ahead of print.ABSTRACTAldosterone's role in the kidney and its pathophysiologic actions in hypertension are well known. However, its role or that of its receptor [minieralocorticoid receptor (MR)] in other cardiovascular (CV) disease are less well described. To identify their potential roles in six CV conditions (heart failure, myocardial infarction, atrial fibrillation, stroke, atherosclerosis, and thrombosis), we assessed these associations in four areas: 1) mechanistic studies in rodents and humans; 2) preclinical studies of MR antagonists; 3) clinica...
Source: Atherosclerosis - April 7, 2022 Category: Cardiology Authors: Wasita W Parksook Gordon H Williams Source Type: research

Transitioning to GLP-1 RAs and SGLT2 Inhibitors as the First Choice for Managing Cardiometabolic Risk in Type 2 Diabetes
Abstract  Purpose of ReviewThis forward-looking review summarizes existing evidence from cardiovascular outcome trials on cardiometabolic risk-reduction in type 2 diabetes (T2DM) management, with attention to updating and personalizing recommendations from recent diabetes practice guidelines issued by cardiology societies.Recent FindingsT2DM management has shifted towards cardiometabolic outcome improvement rather than purely glycemic control. According to large clinical trials, sodium-glucose cotransporter-2 inhibitors showed robust results in reducing heart failure (HF) hospitalization and chronic kidney disease (CKD) p...
Source: Current Atherosclerosis Reports - November 24, 2022 Category: Cardiology Source Type: research

Effects of the Sodium-Glucose Cotransporter Inhibitors on Cardiovascular Death and All-Cause Mortality: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Clinical Trials
ConclusionsSodium-glucose cotransporter inhibitors  significantly reduced major adverse cardiovascular events, including hospitalization and all-cause mortality in patients with or without established atherosclerotic cardiovascular disease. We observed a beneficial trend in patients with heart failure with preserved ejection fraction, and no benefi ts in patients with stroke or myocardial infarction.
Source: American Journal of Cardiovascular Drugs - December 27, 2022 Category: Cardiology Source Type: research

Long ‐term outcomes in heart failure with preserved ejection fraction: Predictors of cardiac and non‐cardiac mortality
ConclusionsIn patients with acute decompensated HFpEF, over 5  years of follow-up, nearly of patients died, half from CV and the other half from non-CV causes. CAD and tricuspid regurgitation were associated with CV death. Stroke, kidney disease, lower BMI, and lower sodium were associated with non-CV death. Anaemia and higher age were associated with both ou tcomes.
Source: ESC Heart Failure - March 11, 2023 Category: Cardiology Authors: Angiza Shahim, Marion Hourqueig, Lars H. Lund, Gianluigi Savarese, Emmanuel Oger, Ashwin Venkateshvaran, Lina Benson, Jean ‐Claude Daubert, Cecilia Linde, Erwan Donal, Camilla Hage Tags: Original Article Source Type: research

Glucagon-Like Peptide 1 Receptor Agonists Versus Sodium-Glucose Cotransporter 2 Inhibitors for Atherosclerotic Cardiovascular Disease in Patients With Type 2 Diabetes
Cardiol Res. 2023 Feb;14(1):12-21. doi: 10.14740/cr1459. Epub 2023 Feb 25.ABSTRACTBeyond improving hemoglobin A1c (HbA1c) in adults with type 2 diabetes, glucagon-like peptide 1 receptor agonists (GLP-1RA) have been approved for reducing risk of major adverse cardiovascular events (MACE) with established cardiovascular disease (CVD) or multiple CV risk factors. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) also reduced the risk for the primary composite CV outcome in patients with type 2 diabetes at high risk for CV events. In the American Diabetes Association (ADA) and European Association of Study in Diabetes (EASD)...
Source: Atherosclerosis - March 10, 2023 Category: Cardiology Authors: Hidekatsu Yanai Hiroki Adachi Mariko Hakoshima Hisayuki Katsuyama Source Type: research

The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity
Conclusion: Despite substantial increases in CO and SV, we did not observe any significant change in BP during high sodium intake, neither in morbid obese patients nor in lean individuals.
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Obesity Source Type: research

Reducing Sodium Intake in Children: A Public Health Investment
The antecedents of elevated blood pressure (BP) and its major consequences (cardiovascular disease and stroke) begin in childhood. Higher levels of BP early in life track into adulthood and are associated with subclinical target organ damage in children and adults. Diet behaviors, including the choice of high sodium containing foods, are established during childhood. On average, children, ages 2‐19, consume more than 3,100 mg of sodium per day, with substantially greater sodium intakes in boys than girls. Importantly, studies show that lowering sodium intake in children lowers blood pressure. In view of this evidence, US...
Source: The Journal of Clinical Hypertension - July 1, 2015 Category: Cardiology Authors: Lawrence J. Appel, Alice H. Lichtenstein, Emily A. Callahan, Alan Sinaiko, Linda Van Horn, Laurie Whitsel Tags: Original Paper Source Type: research

Usefulness and Pitfalls in Sodium Intake Estimation: Comparison of Dietary Assessment and Urinary Excretion in Chilean Children and Adults.
CONCLUSIONS: Our results showed that average sodium intake was higher than recommended in both children and adults (WHO ≤2,000mg/d). The sodium intake estimated by dietary assessment correlated with urinary excretion in all subjects, but in obese adults was more inaccurate than in children. Future studies to validate the appropriate test to assess sodium intake by age and nutritional status are warranted. PMID: 27279009 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - June 7, 2016 Category: Cardiology Authors: Campino C, Hill C, Baudrand R, Martínez-Aguayo A, Aglony M, Carrasco CA, Ferrada C, Loureiro C, Vecchiola A, Bancalari R, Grob F, Carvajal CA, Lagos CF, Valdivia C, Tapia-Castillo A, Fuentes CA, Mendoza C, Garcia H, Uauy R, Fardella CE Tags: Am J Hypertens Source Type: research

Cross-Sectional Positive Association of Serum Lipids and Blood Pressure With Serum Sodium Within the Normal Reference Range of 135-145 mmol/L.
CONCLUSIONS: Serum sodium concentration is a cardiovascular risk factor even within the normal reference range. Thus, decreasing sodium to the lower end of the normal range by modification of water and salt intake is a personalizable strategy for decreasing cardiovascular risks. PMID: 28062505 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - December 28, 2016 Category: Cardiology Authors: Gao S, Cui X, Wang X, Burg MB, Dmitrieva NI Tags: Arterioscler Thromb Vasc Biol Source Type: research

Infection CV Risk; Statin Key After Stroke; Sodium Strains the Heart?
(MedPage Today) -- Cardiovascular Daily wraps up the top cardiology news of the week
Source: MedPage Today Cardiovascular - August 4, 2017 Category: Cardiology Source Type: news

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction
Breast cancer radiotherapy increases the risk of heart failure with preserved ejection fraction (HFpEF). Cardiomyocytes are highly radioresistant, but radiation specifically affects coronary microvascular endothelial cells, with subsequent microvascular inflammation and rarefaction. The effects of radiation on left ventricular (LV) diastolic function are poorly characterized. We hypothesized that cardiac radiation exposure may result in diastolic dysfunction without reduced EF. Global cardiac expression of the sodium-iodide symporter (NIS) was induced by cardiotropic gene (adeno-associated virus serotype 9) delivery to 5-w...
Source: AJP: Heart and Circulatory Physiology - August 11, 2017 Category: Cardiology Authors: Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C., Russell, S. J., Redfield, M. M. Tags: RESEARCH ARTICLE Source Type: research

Symptomatic carotid atherosclerosis detection by positron emission tomography imaging
Aim: We investigated whether sodium fluoride (NaF) positron emission tomography (PET) were superior to fluorodeoxyglucose (FDG) PET in the detection of symptomatic carotid artery among stroke patients with carotid artery stenosis.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jeong -Min Kim, Woo Hyun Paik, Byeong Jun Song, Eun Seoung Lee, Kwang -Yeol Park, Ju Won Seok, Oh -Sang Kwon Source Type: research

Detection of symptomatic carotid atherosclerosis from 18F-fluorodeoxyglucose and 18F-sodium fluoride positron emission tomography after stroke: A prospective study
Aim: We investigated whether symptomatic carotid atherosclerosis can be detected by using 18F-fluorodeoxyglucose (FDG) and 18F-sodium fluoride (NaF) positron emission tomography (PET) among cerebral infarction patients.
Source: Atherosclerosis - August 1, 2017 Category: Cardiology Authors: Jeong -Min Kim, Woo Hyun Paik, Byeong Jun Song, Eun Seoung Lee, Kwang -Yeol Park, Ju Won Seok Source Type: research

Recent Insights into Pharmacologic Cardiovascular Risk Reduction in Type 2 Diabetes Mellitus
In conclusion, there is a growing literature which shows that the risk of cardiovascular outcomes can be reduced in most patients wi th diabetes, as outlined in this review.
Source: Cardiovascular Drugs and Therapy - September 4, 2017 Category: Cardiology Source Type: research