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Total 61 results found since Jan 2013.
Structural Integrity of Normal Appearing White Matter and Sex-Specific Outcomes After Acute Ischemic Stroke Brief Report
Background and Purpose—Women have worse poststroke outcomes than men. We evaluated sex-specific clinical and neuroimaging characteristics of white matter in association with functional recovery after acute ischemic stroke.Methods—We performed a retrospective analysis of acute ischemic stroke patients with admission brain MRI and 3- to 6-month modified Rankin Scale score. White matter hyperintensity and acute infarct volume were quantified on fluid-attenuated inversion recovery and diffusion tensor imaging MRI, respectively. Diffusivity anisotropy metrics were calculated in normal appearing white matter contralateral to...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Mark R. Etherton, Ona Wu, Pedro Cougo, Anne-Katrin Giese, Lisa Cloonan, Kaitlin M. Fitzpatrick, Allison S. Kanakis, Gregoire Boulouis, Hasan H. Karadeli, Arne Lauer, Jonathan Rosand, Karen L. Furie, Natalia S. Rost Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Brief Reports Source Type: research
Demographic, Clinical, and Radiologic Predictors of Neurologic Deterioration in Patients with Acute Ischemic Stroke
One-third of patients with acute ischemic stroke develop early neurologic worsening, which is associated with increased mortality and long-term functional disability. We investigated the predictive factors for neurologic deterioration in patients with acute ischemic stroke within 1 week of onset. We retrospectively investigated 643 patients who were admitted within 2 days of acute ischemic stroke between April 2007 and March 2010. Neurologic deterioration was defined as an increase of 4 points or more in the National Institutes of Health Stroke Scale (NIHSS) score within 1 week of admission. We retrieved data on demograph...
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2011 Category: Neurology Authors: Nobukazu Miyamoto, Yasutaka Tanaka, Yuji Ueno, Miyako Kawamura, Yoshiaki Shimada, Ryota Tanaka, Nobutaka Hattori, Takao Urabe Tags: Original Articles Source Type: research
The Determinants of Dementia After Stroke (DEDEMAS) Study: protocol and pilot data
This study will provide insights into the mechanisms of poststroke dementia and hold the potential to identify novel diagnostic markers and targets for preventive therapies. The study is registered at http://www.clinicaltrials.gov (NCT01334749) and will be extended as a multicenter study starting 2013.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Frank A. Wollenweber, Vera Zietemann, Axel Rominger, Christian Opherk, Anna Bayer‐Karpinska, Andreas Gschwendtner, Lisa Coloma Andrews, Katharina Bürger, Marco Duering, Martin Dichgans Tags: Protocols Source Type: research
Intrathecal Injection of Allogenic Bone Marrow-Derived Mesenchymal Stromal Cells in Treatment of Patients with Severe Ischemic Stroke: Study Protocol for a Randomized Controlled Observer-Blinded Trial
AbstractMesenchymal stromal cells (MSCs) can differentiate into multiple tissues. Preclinical studies have shown that MSC-based therapy is a potential new treatment approach for ischemic stroke. These results support the urgent need for further studies of MSC transplantation in the treatment of ischemic stroke in humans. Here, we develop a prospective, randomized, controlled, observer-blinded phase II trial to assess the clinical safety, feasibility, and therapeutic mechanisms of allogenic bone marrow-derived MSCs (BM-MSCs) by intrathecal infusion in the treatment of patients with cerebral infarction within the middle cere...
Source: Translational Stroke Research - May 23, 2018 Category: Neurology Source Type: research
Frequency and Predictors of Dysphagia in Patients With Recent Small Subcortical Infarcts Brief Report
Background and Purpose—Detailed data on the occurrence of swallowing dysfunction in patients with recent small subcortical infarcts (RSSI) in the context of cerebral small vessel disease are lacking. This prompted us to assess the frequency of and risk factors for dysphagia in RSSI patients.Methods—We identified all inpatients with magnetic resonance imaging–confirmed RSSI between January 2008 and February 2013. Demographic and clinical data were extracted from our stroke database, and magnetic resonance imaging scans were reviewed for morphological changes. Dysphagia was determined according to the Gugging Swallowin...
Source: Stroke - December 22, 2016 Category: Neurology Authors: Simon Fandler, Thomas Gattringer, Sebastian Eppinger, Kathrin Doppelhofer, Daniela Pinter, Kurt Niederkorn, Christian Enzinger, Joanna M. Wardlaw, Franz Fazekas Tags: Magnetic Resonance Imaging (MRI), Complications, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research
REVASCAT: a randomized trial of revascularization with SOLITAIRE FR® device vs. best medical therapy in the treatment of acute stroke due to anterior circulation large vessel occlusion presenting within eight‐hours of symptom onset
REVASCAT is a prospective, multicenter, randomized trial seeking to establish whether subjects meeting following main inclusion criteria: age 18‐80, baseline National Institutes of Health Stroke Scale ≥6, evidence of intracranial internal carotid artery or proximal (M1 segment) middle cerebral artery occlusion, Alberta Stroke Program Early Computed Tomography score of >7 on non‐contrast CT or >6 on diffusion‐weighted magnetic resonance imaging , ineligible for or with persistent occlusion after intravenous alteplase and procedure start within 8 hours from symptom onset, have higher rates of favorable outcome ...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Carlos A. Molina, Angel Chamorro, Àlex Rovira, Angeles Miquel, Joaquin Serena, Luis San Roman, Tudor G. Jovin, Antoni Davalos, Erik Cobo Tags: Protocols Source Type: research
Fluid-Attenuated Inversion Recovery Vascular Hyperintensity Topography, Novel Imaging Marker for Revascularization in Middle Cerebral Artery Occlusion Clinical Sciences
In this study, we aimed to investigate the association between FVH topography or FVH-Alberta Stroke Program Early CT Score (ASPECTS) pattern and outcome in acute M1-middle cerebral artery occlusion patients with endovascular treatment.Methods—We included acute M1-middle cerebral artery occlusion patients treated with endovascular therapy (ET). All patients had diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery before ET. Distal FVH-ASPECTS was evaluated according to distal middle cerebral artery-ASPECT area (M1–M6) and acute DWI lesion was also reviewed. The presence of FVH inside and outside DWI-...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Liu, D., Scalzo, F., Rao, N. M., Hinman, J. D., Kim, D., Ali, L. K., Saver, J. L., Sun, W., Dai, Q., Liu, X., Liebeskind, D. S. Tags: Magnetic Resonance Imaging (MRI), Revascularization, Ischemic Stroke Original Contributions Source Type: research
5-Fluorouracil–induced Leukoencephalopathy with Acute Stroke-like Presentation Fulfilling Criteria for Recombinant Tissue Plasminogen Activator Therapy
A 61-year-old man underwent systemic chemotherapy with intravenous infusion of nedaplatin and 5-fluorouracil. On the day after the final drug administration, he suddenly experienced difficulty in speaking followed by left-sided weakness. His National Institutes of Health Stroke Scale score was 12. A computed tomographic scan of the brain performed 4 hours after symptom onset revealed no abnormalities. Because all eligibility criteria were fulfilled, he immediately underwent intravenous recombinant tissue plasminogen activator therapy. He recovered from neurologic complications on day 14. An initial magnetic resonance imagi...
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Ryuta Kinno, Yoshitaka Kii, Masanobu Uchiyama, Yoshiyuki Owan, Takahiro Yamazaki, Toshiya Fukui Tags: Case Reports Source Type: research
A Genetic Variant of miR-34a Contributes to Susceptibility of Ischemic Stroke Among Chinese Population
This study was supported by National Natural Science Foundation of China (Nos. 81560552, 81260234), Natural Science Foundation of Guangxi Zhuang Autonomous Region (CN) (2017JJA180826), Innovation Project of Guangxi Graduate Education (CN) (201601009) and Key Laboratory Open Project Fund of Guangxi Zhuang Autonomous Region (CN) (kfkt20160064).
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Supplementary Material
The Supplementary Material for this article can be fou...
Source: Frontiers in Physiology - April 23, 2019 Category: Physiology Source Type: research
Acute Stroke Diagnosis
Am Fam Physician. 2022 Jun 1;105(6):616-624.ABSTRACTStroke accounts for significant morbidity and mortality and is the fifth leading cause of death in the United States, with direct and indirect costs of more than $100 billion annually. Expedient recognition of acute neurologic deficits with appropriate history, physical examination, and glucose testing will help diagnose stroke and rule out mimicking presentations. The National Institutes of Health Stroke Scale should be used to determine stroke severity and to monitor for evolving changes in clinical presentation. Initial neuroimaging is used to differentiate between isc...
Source: American Family Physician - June 15, 2022 Category: Primary Care Authors: Edwin Y Choi Gilberto A Nieves Darrell Edward Jones Source Type: research
Perfusion computed tomography in patients with stroke thrombolysis
<span class="paragraphSection"><div class="boxTitle">Abstract</div>See Saver (doi:<strong><a href="article.aspx?volume=&page=">10.1093/awx020<span></span></a></strong>) for a scientific commentary on this article.Stroke shortens an individual’s disability-free life. We aimed to assess the relative prognostic influence of pre- and post-treatment perfusion computed tomography imaging variables (e.g. ischaemic core and penumbral volumes) compared to standard clinical predictors (such as onset-to-treatment time) on long-term stroke disability in patients undergoing th...
Source: Brain - December 30, 2016 Category: Neurology Source Type: research
A pediatric institutional acute stroke protocol improves timely access to stroke treatment
AimWe aimed to evaluate whether an institutional acute stroke protocol (ASP) could accelerate the diagnosis and secondary treatment of pediatric stroke.
MethodWe initiated an ASP in 2005. We compared 209 children (125 males, 84 females; median age 4.8y, interquartile range [IQR] 1.2–9.3y, range 0.09–17.7y) diagnosed with arterial ischemic stroke ‘pre‐protocol’ (1992–2004) to 112 children (60 males, 52 females; median age 5.8y, IQR 1.0–11.4y, range 0.08–17.7y) diagnosed ‘post‐protocol’ (2005–2012) for time‐to‐diagnosis, mode of diagnostic imaging, and time‐to‐treatment with antithrombotic med...
Source: Developmental Medicine and Child Neurology - July 31, 2016 Category: Child Development Authors: Melissa Shack, Andrea Andrade, Priyanka P Shah ‐Basak, Manohar Shroff, Mahendranath Moharir, Ivanna Yau, Rand Askalan, Daune MacGregor, Mubeen F Rafay, Gabrielle A deVeber Tags: Original Article Source Type: research
Periventricular White Matter Lesions as a Prognostic Factor of Swallowing Function in Older Patients with Mild Stroke
AbstractOlder patients with stroke have poor functional prognosis compared to younger patients. Patients with stroke who have severe white matter (WM) lesions have been reported to have poor functional prognosis such as cognitive dysfunction, increased propensity for falling, and gait and balance problems. The aim of this study was to determine whether WM lesions exert negative effects on swallowing function in older patients with mild stroke. We conducted a retrospective analysis of 63 patients aged >65 years who had a National Institutes of Health Stroke Scale score ≤5 and who underwent videofluoroscopic swallo...
Source: Dysphagia - March 27, 2017 Category: Speech Therapy Source Type: research
Acute Ischemic Stroke.
Authors: Rossi UG, Ierardi AM, Cariati M
Abstract
A 77-year-old woman with a history of hypertension developed acute onset of aphasia and right hemiplegia and hemisensory loss. She was urgently referred to emergency department. Cerebral multidetector computed tomographic angiography (MD-CTA) revealed an acute ischemic stroke due to the occlusion of the left middle cerebral artery (Figure 1). Since the symptoms started three hours previously, the patient was candidate for mechanical thrombectomy. The patient then performed a selective digital subtraction angiography (DSA) of the left internal carotid artery that con...
Source: Acta Neurologica Taiwanica - February 1, 2020 Category: Neurology Tags: Acta Neurol Taiwan Source Type: research
