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Periventricular White Matter Lesions as a Prognostic Factor of Swallowing Function in Older Patients with Mild Stroke

AbstractOlder patients with stroke have poor functional prognosis compared to younger patients. Patients with stroke who have severe white matter (WM) lesions have been reported to have poor functional prognosis such as cognitive dysfunction, increased propensity for falling, and gait and balance problems. The aim of this study was to determine whether WM lesions exert negative effects on swallowing function in older patients with mild stroke. We conducted a retrospective analysis of 63 patients aged  >65  years who had a National Institutes of Health Stroke Scale score ≤5 and who underwent videofluoroscopic swallowing examination after their first stroke. Linear regression analysis showed that oral transit time tended to increase as Fazekas grade increased (p = 0.003). In addition, inadequate mastication was related to the presence of lesions in the left hemisphere (p = 0.039). The presence of penetration could also be predicted by Fazekas grade (p = 0.015). Our findings suggest that WM lesions observed in brain magnetic resonance imaging scans can impact swallowing problems in older patients with mild stroke, regardless of initial stroke severity or other factors associated with lesion location. Accordingly, our data indicate that WM lesio ns are a predictive factor by which patients can be stratified into favorable or unfavorable outcomes with respect to dysphagia.
Source: Dysphagia - Category: Speech Therapy Source Type: research

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ConclusionThis work shows the extent of bias in cerebrospinal fluid flow quantification due to radiofrequency saturation effects. This clinical relevance of this error was presented with respect to shunt responsiveness among normal pressure hydrocephalus patients. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
Source: Magnetic Resonance in Medicine - Category: Radiology Authors: Tags: Full Paper Source Type: research
AbstractPurposeQuantitative assessment of white matter hyperintensities (WMH) on structural Magnetic Resonance Imaging (MRI) is challenging. It is important to harmonise results from different software tools considering not only the volume but also the signal intensity. Here we propose and evaluate a metric of white matter (WM) damage that addresses this need.MethodsWe obtained WMH and normal-appearing white matter (NAWM) volumes from brain structural MRI from community dwelling older individuals and stroke patients enrolled in three different studies, using two automatic methods followed by manual editing by two to four o...
Source: Neuroradiology - Category: Radiology Source Type: research
ABSTRACT BACKGROUND AND PURPOSEThe susceptibility vessel sign (SVS) on magnetic resonance imaging (MRI) is related to thrombus location, composition, and size in acute stroke. No previous study has determined its inter‐MRI scanner variability. We aimed to compare the diagnostic accuracy in‐vitro of four different MRI scanners for the characterization of histologic thrombus composition. METHODSThirty‐five manufactured thrombi analogs of different composition that were histologically categorized as fibrin‐dominant, mixed, or red blood cell (RBC)‐dominant were scanned on four different MRI units with T2* sequence. N...
Source: Journal of Neuroimaging - Category: Radiology Authors: Tags: Experimental Laboratory Research Source Type: research
Conclusion The results demonstrate that changes after a stroke in both intrinsic and network-based structurofunctional correlations at rest are correlated with motor function, underscoring the importance of residual structural connectivity in cortical networks.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Updated to include comment from Aspect Imaging The FDA today granted 510(k) clearance to Aspect Imaging‘s Embrace Neonatal magnetic resonance imaging device, which it touted as the 1st MRI device specifically designed for neonatal brain and head imaging. The Embrace Neonatal MRI system is designed specifically for imaging neonatal heads, and can be used on nenonates with a head circumference of up to 38 cm and a weight between 1 and 4.5 kg, according to an FDA release. The system includes a temperature-controlled incubator which can be placed directly into the MRI system to reduce movement. “The vision of Aspec...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Food & Drug Administration (FDA) Imaging Regulatory/Compliance Aspect Imaging Source Type: news
AbstractFactors that can facilitate early identification of individuals at risk of dysphagia such as stroke location are potentially of great benefit. The aim of this study was to examine the role of hemisphere and lesion location in assessing dysphagia pattern and airway invasion as identified through the use of validated, standardized interpretation measures for the videofluoroscopic swallowing study. Consecutive patients (N = 80) presenting with stroke symptoms who had a first-time acute ischemic stroke confirmed on diffusion-weighted magnetic resonance imaging (DW-MRI) scan participated. Three swallowing outc...
Source: Dysphagia - Category: Speech-Language Pathology Source Type: research
Background and Purpose—We assessed whether the presence, number, and distribution of cerebral microbleeds (CMBs) on pre-intravenous thrombolysis MRI scans of acute ischemic stroke patients are associated with an increased risk of intracerebral hemorrhage (ICH) or poor functional outcome.Methods—We performed an individual patient data meta-analysis, including prospective and retrospective studies of acute ischemic stroke treated with intravenous tissue-type plasminogen activator. Using multilevel mixed-effects logistic regression, we investigated associations of pre-treatment CMB presence, burden (1, 2–4, ...
Source: Stroke - Category: Neurology Authors: Tags: Magnetic Resonance Imaging (MRI), Prognosis, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research
Conclusions—OEF ratios on QSM-OEF images at 7 Tesla showed a good correlation with those on PET-OEF images in patients with unilateral steno-occlusive internal carotid artery/middle cerebral artery lesions, suggesting that noninvasive OEF measurement by MRI can be a substitute for PET.
Source: Stroke - Category: Neurology Authors: Tags: Hemodynamics, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research
The FDA today granted 510(k) clearance to Aspect Imaging‘s Embrace Neonatal magnetic resonance imaging device, which it touted as the 1st MRI device specifically designed for neonatal brain and head imaging. The Embrace Neonatal MRI system is designed specifically for imaging neonatal heads, and can be used on nenonates with a head circumference of up to 38 cm and a weight between 1 and 4.5 kg, according to an FDA release. The system includes a temperature-controlled incubator which can be placed directly into the MRI system to reduce movement. The system allows for urgent access to the neonates if necessary, with th...
Source: Mass Device - Category: Medical Devices Authors: Tags: 510(k) Food & Drug Administration (FDA) Imaging Regulatory/Compliance Aspect Imaging Source Type: news
ABSTRACT BACKGROUND AND PURPOSEBlood–brain barrier (BBB) disruption detected on magnetic resonance imaging (MRI) in acute ischemic stroke as a hyperintense acute reperfusion marker (HARM) is associated with upregulation of matrix metalloproteinase‐9 (MMP‐9). Although activated leukocytes, including monocytes, are the main source of MMPs, limited data exist to support relationship between leukocyte activation and BBB disruption in patients with acute ischemic stroke. The goal of this study is to investigate the relationship between neutrophils, lymphocytes, and monocytes with BBB disruption detected as HARM (+) in...
Source: Journal of Neuroimaging - Category: Radiology Authors: Tags: Short Communication Source Type: research
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