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Infectious Disease: Influenza

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Total 16445 results found since Jan 2013.

Impact of Influenza Infection Among Adult and Pediatric Populations With Hematologic Malignancy and hematopoietic Stem Cell Transplant: A Systematic Review and Meta-Analysis
This study systematically reviewed and summarized the outcomes of influenza infection as to in-hospital influenza-related mortality, development of lower respiratory tract infection and acute respiratory distress syndrome, need for hospitalization, intensive care unit admission, and mechanical ventilation.METHODS: We conducted a systematic search of literature using the PubMed and EMBASE databases for articles published from January 1989 through January 19, 2020, reporting laboratory-confirmed influenza in patients of any age with hematologic malignancies and HSCT. Time from transplantation was not included in the search c...
Source: Clinical Therapeutics - April 4, 2021 Category: Drugs & Pharmacology Authors: Eleftheria Atalla Markos Kalligeros Evangelia K Mylona Maria Tsikala-Vafea Fadi Shehadeh Joanna Georgakas Eleftherios Mylonakis Source Type: research

1,2,4-Triazolo1,5-apyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors
Eur J Med Chem. 2021 Apr 26;221:113494. doi: 10.1016/j.ejmech.2021.113494. Online ahead of print.ABSTRACTIn the search for new anti-influenza virus (IV) compounds, we have identified the 1,2,4-triazolo[1,5-a]pyrimidine (TZP) as a very suitable scaffold to obtain compounds able to disrupt IV RNA-dependent RNA polymerase (RdRP) PA-PB1 subunits heterodimerization. In this work, in order to acquire further SAR insights for this class of compounds and identify more potent derivatives, we designed and synthesized additional series of analogues to investigate the role of the substituents around the TZP core. To this aim, we devel...
Source: European Journal of Medicinal Chemistry - May 7, 2021 Category: Chemistry Authors: Maria Chiara Pismataro Tommaso Felicetti Chiara Bertagnin Maria Giulia Nizi Anna Bonomini Maria Letizia Barreca Violetta Cecchetti Dirk Jochmans Steven De Jonghe Johan Neyts Arianna Loregian Oriana Tabarrini Serena Massari Source Type: research

Evinacumab for the treatment of homozygous familial hypercholesterolemia
Expert Rev Clin Pharmacol. 2022 Feb 26. doi: 10.1080/17512433.2022.2047934. Online ahead of print.ABSTRACTINTRODUCTION: Hypercholesterolemia is mainly caused by abnormal lipoprotein metabolism and can increase the risk of cardiovascular disease. Angiopoietin-like protein 3 (ANGPTL3) can increase low-density lipoprotein cholesterol (LDL-C) and other lipids by inhibiting lipoprotein lipase activity. Evinacumab is a monoclonal antibody against ANGPTL3, it can decrease levels of LDL-C and has shown potential benefit in patients with homozygous familial hypercholesterolemia (HoFH).AREAS COVERED: A comprehensive literature searc...
Source: Pharmacological Reviews - February 28, 2022 Category: Drugs & Pharmacology Authors: Yanli Gao Baoqi Zhang Junyi Yang Source Type: research

Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - August 23, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon.-----h...
Source: Australian Health Information Technology - August 23, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Updates and an artificial album cover
As regular readers will know, I’ve been running the Sciencebase site since July 1999. Its precursor, Elemental Discoveries, had various homes on the web from December 1995 until that fateful summer. There are almost 4000 articles in the archives, so it’s quite a hefty site for a one-man show. Anyway, having played around with various website options in the last couple of weeks, I’ve finally done a proper spring clean, got rid of some very out-of-date articles and updated others that were worth keeping. I’ve upgraded security and performance stuff so the site should load much faster than ever before...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 1, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Sciencebase Source Type: blogs

How has the flu virus infected the Web? 2010 influenza and vaccine information available on the Internet
Conclusions: We found that the majority of the websites providing information on flu vaccination were pro/neutral and gave sufficient information. We suggest that antivaccinationist information may have been spread by a different route, such as via Web 2.0 tools, which may be more prone to the dissemination of "viral" information.The page ranking analysis revealed the crucial role of search engines regarding access to information on the Internet.
Source: BMC Public Health - Latest articles - January 29, 2013 Category: Consumer Health News Authors: Loredana CovoloSilvia MascarettiAnna CaruanaGrazia OrizioLuigi CaimiUmberto Gelatti Source Type: research

New Books Party: books received this week | @GrrlScientist
This week, I tell you about a treasure trove of excellent science books, including books about evolution, pterosaurs, birds, human sexuality, HIV/AIDS and chemistry.Below the jump, I mention the books that I received recently in the mail as gifts or as review copies, or that I purchased somewhere. These are the books that I may review in more depth later, either here or in print somewhere in the world. When I get new books, I like to share them with people. Unfortunately, you are all so far away, so I cannot host a book party in my crib where you can look then over, so I'll do the next best thing. I'll host a book party on...
Source: Guardian Unlimited Science - July 5, 2013 Category: Science Authors: GrrlScientist Tags: Blogposts guardian.co.uk Science Source Type: news

Virus Variation Resource--recent updates and future directions
Virus Variation (http://www.ncbi.nlm.nih.gov/genomes/VirusVariation/) is a comprehensive, web-based resource designed to support the retrieval and display of large virus sequence datasets. The resource includes a value added database, a specialized search interface and a suite of sequence data displays. Virus-specific sequence annotation and database loading pipelines produce consistent protein and gene annotation and capture sequence descriptors from sequence records then map these metadata to a controlled vocabulary. The database supports a metadata driven, web-based search interface where sequences can be selected using...
Source: Nucleic Acids Research - December 28, 2013 Category: Research Authors: Brister, J. R., Bao, Y., Zhdanov, S. A., Ostapchuck, Y., Chetvernin, V., Kiryutin, B., Zaslavsky, L., Kimelman, M., Tatusova, T. A. Tags: IV. Viruses, bacteria, protozoa and fungi Source Type: research

Neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis.
CONCLUSIONS: We were unable to identify any randomised controlled trials or quasi-randomised controlled trials on the efficacy of neuraminidase inhibitors for the treatment of influenza infection in people with cystic fibrosis. The absence of high level evidence for the effectiveness of these interventions emphasises the need for well-designed, adequately powered, randomised controlled clinical trials. PMID: 24515341 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - February 10, 2014 Category: Journals (General) Authors: Jagannath VA, Asokan GV, Fedorowicz Z, Lee TW Tags: Cochrane Database Syst Rev Source Type: research

Wikipedia May Predict The Next Global Health Crisis
Scientists may one day be able to predict epidemics simply by analyzing what people are searching on the Internet. Researchers at the Los Alamos National Laboratory in New Mexico found that a surge in Wikipedia traffic for certain disease-related articles predicted the large-scale spread of illnesses in several world locations, sometimes as long as 28 days before official spikes were recorded. The findings were published online Thursday in PLOS Computational Biology. Unlike Google flu trends, which uses search data to reflect where outbreaks are happening, the Wikipedia analysis can predict an outbreak. Nicholas Generou...
Source: Healthy Living - The Huffington Post - November 17, 2014 Category: Consumer Health News Source Type: news

Using Google Trends to estimate the incidence of influenza-like illness in Argentina.
Abstract The aim of this study was to find a model to estimate the incidence of influenza-like illness (ILI) from the Google Trends (GT) related to influenza. ILI surveillance data from 2012 through 2013 were obtained from the National Health Surveillance System, Argentina. Internet search data were downloaded from the GT search engine database using 6 influenza-related queries: flu, fever, cough, sore throat, paracetamol, and ibuprofen. A Poisson regression model was developed to compare surveillance data and internet search trends for the year 2012. The model's results were validated using surveillance data for ...
Source: Cadernos de Saude Publica - April 1, 2015 Category: Global & Universal Authors: Orellano PW, Reynoso JI, Antman J, Argibay O Tags: Cad Saude Publica Source Type: research

Benefits of using heterologous polyclonal antibodies and potential application to new and undertreated infectious pathogens.
CONCLUSIONS: Polyclonal antibodies have been successfully applied to rabies, envenomation and intoxication. Polyclonal production provides an exciting opportunity to revolutionise the prognosis of both longstanding neglected tropical diseases as well as emerging infectious threats to humans. PMID: 26802604 [PubMed - as supplied by publisher]
Source: Vaccine - January 20, 2016 Category: Allergy & Immunology Authors: Dixit R, Herz J, Dalton R, Booy R Tags: Vaccine Source Type: research

Can Google Searches Predict the Popularity and Harm of Psychoactive Agents?
Conclusions: Our data correlate well with the results from a multicriteria decision analysis of drug harms in the United Kingdom. We showed that Google search data can be a valuable source of information to assess the popularity of and harm caused by psychoactive agents and may help in monitoring drug use trends.
Source: Journal of Medical Internet Research - February 25, 2016 Category: Journals (General) Authors: Wojciech JankowskiMarcin Hoffmann Source Type: research