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Infectious Disease: Tuberculosis
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Total 35529 results found since Jan 2013.
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages
J Cell Biol. 2023 Dec 4;222(12):e202303066. doi: 10.1083/jcb.202303066. Epub 2023 Sep 22.ABSTRACTPeroxisomes are organelles involved in many metabolic processes including lipid metabolism, reactive oxygen species (ROS) turnover, and antimicrobial immune responses. However, the cellular mechanisms by which peroxisomes contribute to bacterial elimination in macrophages remain elusive. Here, we investigated peroxisome function in iPSC-derived human macrophages (iPSDM) during infection with Mycobacterium tuberculosis (Mtb). We discovered that Mtb-triggered peroxisome biogenesis requires the ESX-1 type 7 secretion system, criti...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Enrica Pellegrino Beren Aylan Claudio Bussi Antony Fearns Elliott M Bernard Natalia Athanasiadi Pierre Santucci Laure Botella Maximiliano G Gutierrez Source Type: research
Malawi: First Lady Shares Malawi's Success in TB Fight in New York
[Nyasa Times] Malawi'S First Lady Monica Chakwera has shared the successes of Malawi in fighting against tuberculosis (TB) in the country during the End Tuberculosis Innovation Summit held alongside the UN General Assembly (UNGA).
Source: AllAfrica News: Tuberculosis - September 21, 2023 Category: Infectious Diseases Tags: Health and Medicine Malawi Southern Africa Tuberculosis Source Type: news
Distinct healthcare utilization profiles of high healthcare use tuberculosis survivors: A latent class analysis
DiscussionOur findings suggest that foreign-born high healthcare-use TB survivors in a high-resource setting may be categorized into distinct profiles to help guide the development of person-centred care strategies targeting the long-term health impacts TB survivors face.
Source: PLoS One - September 21, 2023 Category: Biomedical Science Authors: Kamila Romanowski Source Type: research
Global Epidemiology of Nontuberculous Mycobacterial Pulmonary Disease
Nontuberculous mycobacterial (NTM) isolation and pulmonary disease (NTM-PD) have continued to increase in most regions of the world, driven mainly by Mycobacterium avium. Single-center studies also support increasing trends as well as a persistent burden of undiagnosed NTM among persons suspected of having tuberculosis (TB), in countries with moderate-to-high TB prevalence. Cumulative exposure to water and soil presents an increased risk to susceptible hosts, and trace metals in water supply are recently recognized risk factors. Establishing standard case definitions for subnational and national surveillance systems with m...
Source: Clinics in Chest Medicine - September 21, 2023 Category: Respiratory Medicine Authors: D. Rebecca Prevots, Julia E. Marshall, Dirk Wagner, Kozo Morimoto Source Type: research
South Africa: 'The Only Good TB Bacillus Is a Dead One', Says UCT's Prof Valerie Mizrahi
[spotlight] World-leading tuberculosis researcher Professor Valerie Mizrahi was 35 when her mother Etty started losing weight and coughing furiously. After healthcare professionals in Johannesburg failed to accurately diagnose her, it was a doctor in Plettenberg Bay who told Etty: "The good news is you don't have lung cancer, the bad news is that you have tuberculosis (TB)."
Source: AllAfrica News: Health and Medicine - September 20, 2023 Category: African Health Tags: Health and Medicine South Africa Southern Africa Tuberculosis Source Type: news
Phenolic Substitution in Fidaxomicin: A Semisynthetic Approach to Antibiotic Activity Across Species
Chembiochem. 2023 Sep 20:e202300570. doi: 10.1002/cbic.202300570. Online ahead of print.ABSTRACTFidaxomicin (Fdx) is a natural product antibiotic with potent activity against Clostridioides difficile and other Gram-positive bacteria such as Mycobacterium tuberculosis. Only few Fdx derivatives have been synthesized and examined for their biological activity in the 50 years since its discovery. Fdx has a well-studied mechanism of action, namely inhibition of the bacterial RNA polymerase. Yet, the targeted organisms harbor different target protein sequences, which poses a challenge for the rational development of new semisynt...
Source: Chembiochem - September 20, 2023 Category: Biochemistry Authors: Erik Jung Anastassia Kraimps Silvia Dittmann Tizian Griesser Jordan Costafrolaz Yves Mattenberger Simon Jurt Patrick H Viollier Peter Sander Susanne Sievers Karl Gademann Source Type: research
Severe Vitamin D Deficiency as a Risk Factor in Newly Diagnosed Tuberculosis Patients: Comparative Study on Inhabitants of High Altitude Region
Conclusions: Vitamin D levels are significantly low in tuberculosis pati ents and severe VDD independently contributes to developing tuberculosis infection.
Source: International Journal of Preventive Medicine - September 20, 2023 Category: International Medicine & Public Health Source Type: research
Nigeria: First Lady Seeks Improved Advocacy On TB, HIV/Aids in Children
[Premium Times] Mrs Tinubu was one of the panellists who spoke on strategies to advance global health standards and investments towards effectively financing the eradication of tuberculosis.
Source: AllAfrica News: HIV-Aids and STDs - September 20, 2023 Category: Infectious Diseases Tags: HIV-Aids and STDs Children and Youth Health and Medicine Nigeria West Africa Source Type: news
Upfront tofacitinib in patients with biological-na ïve ulcerative colitis – An Indian multicentric experience
ConclusionUpfront tofacitinib is effective in biologic-na ïve Indian patients with moderate-severe UC. Further randomized studies are required to validate the study findings.Graphical abstract
Source: Indian Journal of Gastroenterology - September 20, 2023 Category: Gastroenterology Source Type: research
Impact of COVID-19 pandemic on Tuberculosis and HIV services in Ghana: An interrupted time series analysis
ConclusionThis study demonstrated that the COVID-19 pandemic negatively impacted TB case notifications and HIV testing and counselling services, However, ART initiation was generally not impacted during the first year of the pandemic. Proactive approaches aimed at actively finding the thousands of individuals with TB who were missed in 2020 and increasing HIV testing and counselling and subsequent treatment initiations should be prioritised.
Source: PLoS One - September 20, 2023 Category: Biomedical Science Authors: Eric Osei Source Type: research
'Pure price-gouging': Advocates celebrate price drop of critical TB test but say Big Pharma needs to do more
Every 20 seconds, someone dies of tuberculosis. But health advocates and experts hope that a newly announced reduction in the cost of TB testing might change that.
Source: CBC | Health - September 19, 2023 Category: Consumer Health News Tags: News/Health Source Type: news
Antibiotics Destroy Memories?
Even in my earliest days of practicing medicine, I was never a big fan of prescribing antibiotics – except, of course, in cases of extreme or life-threatening infections.
Because even back then, I was concerned about the damage these drugs could cause to your gut.
That’s because trillions of microscopic bacteria – some that protect against certain diseases and some that can cause disease – live in your microbiome and exist in a delicate balance with each other.
The problem is that antibiotics can’t distinguish between so-called “good” bacteria and the “bad” ones causing the infection.
These drugs kill eve...
Source: Al Sears, MD Natural Remedies - September 19, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Source Type: news
Upfront tofacitinib in patients with biological-na ïve ulcerative colitis - An Indian multicentric experience
CONCLUSION: Upfront tofacitinib is effective in biologic-naïve Indian patients with moderate-severe UC. Further randomized studies are required to validate the study findings.PMID:37726491 | DOI:10.1007/s12664-023-01434-9
Source: Herpes - September 19, 2023 Category: Infectious Diseases Authors: Suprabhat Giri Sukanya Bhrugumalla Abhishek Kamuni Debakanta Mishra Girish Kumar Pati Dhiraj Agrawal Govind Verma Rohit Wagh Shamshersingh Chauhan Meghraj Ingle Sanjay Chandnani Shubham Jain Pravin M Rathi Akash Shukla Aditya Kale Source Type: research
AHL score for predicting mortality risk in patients with pulmonary tuberculosis
Chest. 2023 Sep 17:S0012-3692(23)05434-X. doi: 10.1016/j.chest.2023.09.008. Online ahead of print.ABSTRACTBACKGROUND: A clinically applicable mortality-risk prediction system for pulmonary tuberculosis may improve treatment outcomes, but no easy-to-calculate and accurate score has yet been reported. We aimed to construct a simple and objective disease-severity score for patients with pulmonary tuberculosis.RESEARCH QUESTION: Does a clinical score consisting of simple objective factors predict the mortality risk of patients with pulmonary tuberculosis?STUDY DESIGN AND METHODS: The dataset from our previous prospective study...
Source: Chest - September 19, 2023 Category: Respiratory Medicine Authors: Takeshi Osawa Masato Watanabe Kozo Morimoto Takashi Yoshiyama Shuichi Matsuda Keiji Fujiwara Koji Furuuchi Masafumi Shimoda Masashi Ito Tatsuya Kodama Fumiko Uesugi Masao Okumura Yoshiaki Tanaka Yuka Sasaki Hideo Ogata Hajime Goto Shoji Kudoh Ken Ohta Source Type: research
