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Specialty: Epidemiology
Infectious Disease: COVID-19

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Total 23 results found since Jan 2013.

Serious neurological adverse events following immunization against SARS-CoV-2: a narrative review of the literature
Ther Adv Drug Saf. 2023 May 21;14:20420986231165674. doi: 10.1177/20420986231165674. eCollection 2023.ABSTRACTAmid the coronavirus disease 2019 (COVID-19) pandemic, massive immunization campaigns became the most promising public health measure. During clinical trials, certain neurological adverse effects following immunization (AEFIs) were observed; however, acceptable safety profiles lead to emergency authorization for the distribution and use of the vaccines. To contribute to pharmacovigilance and lessen the potential negative impact that vaccine hesitancy would have on immunization programs, we conducted a review of the...
Source: Adv Data - May 24, 2023 Category: Epidemiology Authors: Sara Eslait-Olaciregui Kevin Llin ás-Caballero David Pati ño-Manjarrés Thomas Urbina-Ariza Juan Fernando Cediel-Becerra Camilo Alberto Dom ínguez-Domínguez Source Type: research

Stroke Mortality Among Black and White Adults Aged ≥35 Years Before and During the COVID-19 Pandemic - United States, 2015-2021
MMWR Morb Mortal Wkly Rep. 2023 Apr 21;72(16):431-436. doi: 10.15585/mmwr.mm7216a4.ABSTRACTStroke is the fifth leading cause of death and a leading cause of long-term disability in the United States (1). Although stroke death rates have declined since the 1950s, age-adjusted rates remained higher among non-Hispanic Black or African American (Black) adults than among non-Hispanic White (White) adults (1,2). Despite intervention efforts to reduce racial disparities in stroke prevention and treatment through reducing stroke risk factors, increasing awareness of stroke symptoms, and improving access to treatment and care for s...
Source: MMWR Morb Mortal Wkl... - April 21, 2023 Category: Epidemiology Authors: Quanhe Yang Xin Tong Linda Schieb F átima Coronado Robert Merritt Source Type: research

Prevalence and Mortality Risk of Neurological Disorders during the COVID-19 Pandemic: An Umbrella Review of the Current Evidence
Conclusion: Our results show that the preva lence and mortality risk may increase in some neurological diseases during the COVID-19 pandemic. Future studies should elucidate the precise mechanisms for the link between COVID-19 and neurological diseases, determine which patient characteristics predispose them to neurological diseases, and cons ider potential global patient management.
Source: Neuroepidemiology - April 12, 2023 Category: Epidemiology Source Type: research

Hospitalisation rate and mortality among people with and without diabetes during the COVID-19 pandemic year 2020
AbstractMost studies reported reduced health care use among people with diabetes during the COVID-19 pandemic. This may be due to restricted medical services or people avoiding health care services because they fear being infected with COVID-19 in health care facilities. The aim of our study was to analyse hospitalisation and mortality in people with and without diabetes in Germany during the COVID-19 pandemic year 2020 compared to 2017 –2019. The data were sourced from a German statutory health insurance company covering 3.2 million people. We estimated age-sex standardised rates of mortality, all-cause hospitalisation,...
Source: European Journal of Epidemiology - June 8, 2022 Category: Epidemiology Source Type: research

Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies
ConclusionThis review summarizes modifiable factors for intervention (e.g. smoking, obesity and inflammatory factors) and proteomic signatures (e.g. OAS1 and IL-6) that could help identify drugs for treating COVID-19.
Source: International Journal of Epidemiology - April 20, 2022 Category: Epidemiology Source Type: research

Impact of COVID-19 lockdowns on hospital presentations and admissions in the context of low community transmission: evidence from time series analysis in Melbourne, Australia
Conclusions Our analyses suggest citizens were willing and able to present with life-threatening conditions during Melbourne’s lockdowns, and that switching to telemedicine did not cause widespread spill-over from primary care into ED. During a pandemic, lockdowns may not inhibit appropriate hospital attendance where rates of infectious disease are low.
Source: Journal of Epidemiology and Community Health - March 10, 2022 Category: Epidemiology Authors: Collyer, T. A., Athanasopoulos, G., Srikanth, V., Tiruvoipati, R., Matthews, C., Mcinnes, N., Menon, S., Dowling, J., Braun, G., Krivitsky, T. A., Cooper, H., Andrew, N. E. Tags: COVID-19 Original research Source Type: research

Dexamethasone sensitizes to ferroptosis by glucocorticoid receptor-induced dipeptidase-1 expression and glutathione depletion
Sci Adv. 2022 Feb 4;8(5):eabl8920. doi: 10.1126/sciadv.abl8920. Epub 2022 Feb 2.ABSTRACTDexamethasone is widely used as an immunosuppressive therapy and recently as COVID-19 treatment. Here, we demonstrate that dexamethasone sensitizes to ferroptosis, a form of iron-catalyzed necrosis, previously suggested to contribute to diseases such as acute kidney injury, myocardial infarction, and stroke, all of which are triggered by glutathione (GSH) depletion. GSH levels were significantly decreased by dexamethasone. Mechanistically, we identified that dexamethasone up-regulated the GSH metabolism regulating protein dipeptidase-1 ...
Source: Adv Data - February 2, 2022 Category: Epidemiology Authors: Anne von M ässenhausen Nadia Zamora Gonzalez Francesca Maremonti Alexia Belavgeni Wulf Tonnus Claudia Meyer Kristina Beer Monica T Hannani Arthur Lau Mirko Peitzsch Paul Hoppenz Sophie Locke Triantafyllos Chavakis Rafael Kramann Daniel A Muruve Christian Source Type: research

Sexual orientation-related disparities in health conditions that elevate COVID-19 severity
CONCLUSIONS: Findings largely corroborated patterns among the general US population. Further research is needed to determine if these disparities translate to poorer COVID-19 outcomes for individuals with minoritized sexual orientation.PMID:34785397 | DOI:10.1016/j.annepidem.2021.11.006
Source: Annals of Epidemiology - November 17, 2021 Category: Epidemiology Authors: Kristine E Lynch Jillian C Shipherd Elise Gatsby Benjamin Viernes Scott L DuVall John R Blosnich Source Type: research

Reduction in Acute Stroke Admissions during the COVID-19 Pandemic: Data from a National Stroke Registry
Conclusion: The marked decrease in admissions for acute stroke and TIA, occurring at a time of a relatively low burden of COVID-19, is of great concern. Public awareness campaigns are needed as patients reluctant to seek urgent stroke care are deprived of lifesaving procedures and secondary prevention treatments.Neuroepidemiology
Source: Neuroepidemiology - July 8, 2021 Category: Epidemiology Source Type: research

Characteristics, Management, and Case-Fatality of Patients Hospitalized for Stroke with a Diagnosis of COVID-19 in France
Conclusion: Patients hospitalized for stroke with a concomitant COVID-19 diagnosis had a higher inhospital and 3 months case-fatality rates compared to patients hospitalized for stroke without a COVID-19 diagnosis. Further research is needed to better understand the excess of mortality related to these cases.Neuroepidemiology
Source: Neuroepidemiology - June 24, 2021 Category: Epidemiology Source Type: research