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Infectious Disease: Coronavirus

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Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2: A Case Series Quantitative Systematic Review
Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July 1, 2020. We found a myriad of clinical features, but we were able to describe common characteristics: previously healthy school-aged children, persistent fever and gastrointestinal symptoms, lymphopenia, and high inflammatory markers. Clinical syndromes such as myocarditis and Kawasaki disease were present in o...
Source: Pediatric Emergency Care - January 1, 2021 Category: Emergency Medicine Tags: Special Features Source Type: research

Hospital Mortality and Resource Implications of Hospitalisation with COVID-19 in London, UK: A Prospective Cohort Study.
Conclusions: COVID-19 is associated with a high burden of mortality for patients treated on the ward and the ICU and required substantial reconfiguration of critical care services. This has significant implications for planning and resource utilisation. PMID: 33564474 [PubMed]
Source: Critical Care Research and Practice - February 12, 2021 Category: Intensive Care Tags: Crit Care Res Pract Source Type: research

Validation of a Crisis Standards of Care Model for Prioritization of Limited Resources During the Coronavirus Disease 2019 Crisis in an Urban, Safety-Net, Academic Medical Center*
In this study, we sought to retrospectively validate this protocol to cohorts of critically ill patients from our hospital. DESIGN: We applied our hospital-adopted guidelines, which defined severe and major chronic conditions as those associated with a greater than 50% likelihood of 1- and 5-year mortality, respectively, to a critically ill patient population. We investigated mortality for the same intervals. SETTING: An urban safety-net hospital ICU. PATIENTS: All adults hospitalized during April of 2015 and April 2019 identified through a clinical database search. INTERVENTIONS: None. MEASU...
Source: Critical Care Medicine - September 27, 2021 Category: Emergency Medicine Tags: Clinical investigations Source Type: research

Transmission and Risk Factors of COVID-19 among Health Care Workers
Semin Respir Crit Care Med DOI: 10.1055/s-0043-1766118Coronavirus disease 2019 (COVID-19) poses a significant occupational risk factor to health care workers (HCWs). As in previous events, this occupational risk amplifies and compounds the adverse impact of the pandemic. We conducted a narrative review summarizing risk factors associated with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) transmission in HCWs. We searched for original observational studies (including case-control, cross-sectional, prospective and retrospective cohorts) using PubMed, Scopus, and Google Scholar. A total of 22 articles were revi...
Source: Seminars in Respiratory and Critical Care Medicine - April 4, 2023 Category: Respiratory Medicine Authors: Alghader, Majdi R.M. Valvi, Damaskini de la Hoz, Rafael E. Tags: Review Article Source Type: research

Characteristics, treatment, outcomes and cause of death of invasively ventilated patients with COVID-19 ARDS in Milan, Italy.
Conclusions: Despite multiple advanced critical care interventions, COVID-19 ARDS was associated with prolonged ventilation and high short term mortality. Older age and pre-admission hypertension were key mortality risk factors. Trial registration: ClinicalTrials.gov identifier: NCT04318366. PMID: 32353223 [PubMed - as supplied by publisher]
Source: Critical Care and Resuscitation - May 1, 2020 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Understanding critical care in the ICU: then and now PODCAST
“I write this as a caregiver, patient educator, and clinical researcher. The coronavirus pandemic has shone a spotlight on intensive care units (ICUs).   Due to the rapid and continued increase in critical illness from COVID-19 infection, discussions about capacity and specialized equipment have become commonplace. Terms such as ventilators, ECMO, PPE, emergency use authorization, and […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - December 23, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Patient COVID-19 coronavirus Critical Care Infectious Disease Source Type: blogs

Coronavirus disease 2019 respiratory failure: what is the best supportive care for patients who require ICU admission?
Purpose of review Currently, there is no cure for SARS-CoV-2 infection, yet hospital mortality rates for COVID-19 have improved over the course of the pandemic and may be due in part to improved supportive care in the ICU. This review highlights the evidence for and against various ICU supportive therapies for the treatment of critically ill patients with COVID-19. Recent findings Early in the pandemic, there was great interest in novel ICU supportive care, both for the benefit of the patient, and the safety of clinicians. With a few exceptions (e.g. prone ventilation of nonintubated patients), clinicians abando...
Source: Current Opinion in Critical Care - September 3, 2021 Category: Nursing Tags: SEVERE INFECTIONS: Edited by Andre C. Kalil Source Type: research

Factors associated with unmet pediatric health care needs during the coronavirus pandemic
To examine risk factors for unmet pediatric health care needs during the coronavirus pandemic in a national sample of US children under 17  years of age.
Source: Journal of Pediatric Nursing - September 19, 2023 Category: Nursing Authors: Maya Tabet, Russell S. Kirby, Pamela Xaverius Source Type: research

Saturation of critical care capacity and mortality in patients with the novel coronavirus (COVID-19) in Italy
Publication date: Available online 23 May 2020Source: Trends in Anaesthesia and Critical CareAuthor(s): Edoardo Mannucci, Giovanni Antonio Silverii, Matteo Monami
Source: Trends in Anaesthesia and Critical Care - May 23, 2020 Category: Anesthesiology Source Type: research

Providing respiratory and ventilation care in the face of shifting evidence: current opinion in critical care
Purpose of review To review the clinical problem and noninvasive treatments of hypoxemia in critically-ill patients with coronavirus disease 2019 pneumonia and describe recent advances in evidence supporting bedside decision making. Recent findings High-flow nasal oxygen and noninvasive ventilation, along with awake prone positioning are potentially helpful therapies for acute hypoxemic respiratory failure. High-flow nasal oxygen therapy has been widely implemented as a form of oxygen support supported by prepandemic randomized controlled trials showing possible benefit over noninvasive ventilation. Given the sh...
Source: Current Opinion in Critical Care - November 3, 2022 Category: Nursing Tags: ICU EXPERIENCES FROM COVID 19: Edited by Luigi Camporota Source Type: research

Research in the context of coronavirus disease 2019: Considerations for critical care environments
Disasters and public health emergencies, such as coronavirus disease 2019 (COVID-19), by their very nature, overwhelm the operational capacity of health services to provide their normal level and array of services. From a health service perspective, this may include any event that results in the need for a health service to adapt their business as usual practices in an attempt to restore and maintain the normal day-to-day health services and standards of care.1 This is of importance as the inability to provide normal operational capacity results in increased morbidity and mortality for those patients in the health service ...
Source: Australian Critical Care - June 30, 2020 Category: Nursing Authors: Jamie Ranse Tags: Editorial Source Type: research

Fast reshaping of intensive care unit facilities in a large metropolitan hospital in Milan, Italy: facing the COVID-19 pandemic emergency
Authors: Zangrillo A, Beretta L, Silvani P, Colombo S, Scandroglio AM, Dell’Acqua A, Fominskiy E, Landoni G, Monti G, Azzolini ML, Monaco F, Oriani A, Belleti A, Sartorelli M, Pallanch O, Saleh O, Sartini C, Nardelli P, Lombardi G, Morselli F, Scquizzato T, Frontera A, Ruggeri A, Scotti R, Assanelli A, Dagna L, Rovere-Querini P, Castagna A, Scarpellini P, Di Napoli D, Ambrosio A, Ciceri F, Tresoldi M Abstract At the end of 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak spread from China all around the world, causing thousands of deaths. In Italy, the hardest hit region was Lombard...
Source: Critical Care and Resuscitation - April 2, 2020 Category: Intensive Care Tags: Crit Care Resusc Source Type: research

Fight Against COVID-19 Aided by Sepsis Researchers
Spike proteins on the surface of a coronavirus. Credit: David Veesler, University of Washington. Since the start of the COVID-19 pandemic, researchers from many areas of biomedical science have worked together to learn how this new disease affects the human body, how to prevent its spread, and how to treat it. Severe cases of COVID-19 and cases of sepsis share many symptoms. Sepsis is the body’s overactive and extreme response to an infection. It’s unpredictable and can progress rapidly. Without prompt treatment, it can lead to tissue damage, organ failure, and death. Sepsis has similarities with some cases of COVI...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 13, 2021 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Injury and Illness COVID-19 Infectious Diseases Research Roundup Scientific Process Sepsis Source Type: blogs

Comparative Analysis of Pediatric COVID-19 Infection in Southeast Asia, South Asia, Japan, and China
This study aims to identify risk factors for severe COVID-19 disease among children in the region. This is an observational study of children with COVID-19 infection in hospitals contributing data to the Pediatric Acute and Critical Care COVID-19 Registry of Asia. Laboratory-confirmed COVID-19 cases were included in this registry. The primary outcome was severity of COVID-19 infection as defined by the World Health Organization (WHO) (mild, moderate, severe, or critical). Epidemiology, clinical and laboratory features, and outcomes of children with COVID-19 are described. Univariate and multivariable logistic regression mo...
Source: The American Journal of Tropical Medicine and Hygiene - June 15, 2021 Category: Tropical Medicine Authors: Judith Ju Ming Wong Qalab Abbas Soo Lin Chuah Ririe Fachrina Malisie Kah Min Pon Tomohiro Katsuta Hongxing Dang Pei Chuen Lee Muralidharan Jayashree Rehena Sultana Quratulain Maha Chin Seng Gan Naoki Shimizu Feng Xu Swee Fong Tang Luming Shi Jan Hau Lee K Source Type: research