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Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Clinical phenotypes and quality of life to define post-COVID-19 syndrome: a cluster analysis of the multinational, prospective ORCHESTRA cohort
EClinicalMedicine. 2023 Jul 21;62:102107. doi: 10.1016/j.eclinm.2023.102107. eCollection 2023 Aug.ABSTRACTBACKGROUND: Lack of specific definitions of clinical characteristics, disease severity, and risk and preventive factors of post-COVID-19 syndrome (PCS) severely impacts research and discovery of new preventive and therapeutics drugs.METHODS: This prospective multicenter cohort study was conducted from February 2020 to June 2022 in 5 countries, enrolling SARS-CoV-2 out- and in-patients followed at 3-, 6-, and 12-month from diagnosis, with assessment of clinical and biochemical features, antibody (Ab) response, Variant o...
Source: Cell Research - September 1, 2023 Category: Cytology Authors: Elisa Gentilotti Anna G órska Adriana Tami Roy Gusinow Massimo Mirandola Jes ús Rodríguez Baño Zaira R Palacios Baena Elisa Rossi Jan Hasenauer Iris Lopes-Rafegas Elda Righi Natascia Caroccia Salvatore Cataudella Zeno Pasquini Thomas Osmo Lidia Del Pi Source Type: research

Protection against COVID-19 hospitalisation conferred by primary-series vaccination with AZD1222 in non-boosted individuals: first vaccine effectiveness results of the European COVIDRIVE study and meta-regression analysis
We report a prespecified interim analysis of primary-series AZD1222 (ChAdOx1 nCoV-19) VE.METHODS: Seven Study Contributors in Europe collected data on individuals aged ≥18 years who were hospitalised with severe acute respiratory infection (June 1st, 2021-September 5th, 2022) and eligible for COVID-19 vaccination prior to hospitalisation. In this test-negative case-control study, individuals were defined as test-positive cases or test-negative controls (SARS-CoV-2 RT-PCR) and were either fully vaccinated (two AZD1222 doses, 4-12 weeks apart, completed ≥14 days prior to symptom onset; no booster doses) or unvaccinated (...
Source: Herpes - August 7, 2023 Category: Infectious Diseases Authors: Wilhelmine Meeraus Leonie de Munter Christen M Gray Akshat Dwivedi Chlo é Wyndham-Thomas Mario Ouwens Wendy Hartig-Merkel Laura Drikite Griet Rebry Antonio Carmona Anke L Stuurman Thi Yen Chi Nguyen Guillermo Mena Ainara Mira-Iglesias Giancarlo Icardi Su Source Type: research

Long-running ProMED email service for alerting world to disease outbreaks is in trouble
The first news about the COVID-19 pandemic came not from a government or a scientific publication, but in an email from a disease-alert system called ProMED . This fateful missive in December 2019 about a few cases of a mysterious pneumonia in Wuhan, China, is just one example of how physicians and public health experts around the world have used the 30-year-old, free service to share real-time information about local disease outbreaks with tens of thousands of subscribers. But ProMED is now on life support. Much of its work came to a screeching halt yesterday when 21 of its 38 paid editors and moderators went o...
Source: Science of Aging Knowledge Environment - August 4, 2023 Category: Geriatrics Source Type: research

Vietnam's Evolving Healthcare System: Notable Successes and Significant Challenges
Cureus. 2023 Jun 14;15(6):e40414. doi: 10.7759/cureus.40414. eCollection 2023 Jun.ABSTRACTFrom regional and rural grassroots to a nationwide level, Vietnam has established a four-tiered hierarchical healthcare system, comprising national, provincial, district, and commune healthcare centers. Over the last three decades, alongside increasing provision of universal health insurance coverage and cutting healthcare expenditure, the country has demonstrated its dedication to preventative medicine and health promotion. Recent investment in research, development, and production has led to "homegrown" vaccines for SARS-CoV-2 now u...
Source: Rural Remote Health - July 17, 2023 Category: Rural Health Authors: Nguyen K Quan Andrew W Taylor-Robinson Source Type: research

Immune response after two doses of the BNT162b2 COVID-19 vaccine and risk of SARS-CoV-2 breakthrough infection in Tyrol, Austria: an open-label, observational phase 4 trial
Lancet Microbe. 2023 Jun 21:S2666-5247(23)00107-6. doi: 10.1016/S2666-5247(23)00107-6. Online ahead of print.ABSTRACTBACKGROUND: Correlates of protection could help to assess the extent to which a person is protected from SARS-CoV-2 infection after vaccination (so-called breakthrough infection). We aimed to clarify associations of antibody and T-cell responses after vaccination against COVID-19 with risk of a SARS-CoV-2 breakthrough infection and whether measurement of these responses enhances risk prediction.METHODS: We did an open-label, phase 4 trial in two community centres in the Schwaz district of the Federal State o...
Source: Cancer Control - June 24, 2023 Category: Cancer & Oncology Authors: Lisa Seekircher Zolt án Bánki Janine Kimpel Annika R össler Helena Sch äfer Barbara Falkensammer David Bante Lukas Forer Sebastian Sch önherr Shieldvacc-2 Study Group Teresa Harthaller Magdalena Sacher Cornelia Ower Lena Tschiderer Hanno Ulmer Floria Source Type: research

Investigating Bacteria ’ s CRISPR Defense System to Improve Human Health
Credit: Adrian Sanchez Gonzales. The earliest Andrew Santiago-Frangos, Ph.D., remembers being interested in science was when he was about 8 years old. He was home sick and became engrossed in a children’s book that explained how some bacteria and viruses cause illness. To this day, his curiosity about bacteria persists, and he’s making discoveries about CRISPR—a system that helps bacteria defend against viruses—as a postdoctoral researcher and NIGMS-funded Maximizing Opportunities for Scientific and Academic Independent Careers (MOSAIC) scholar at Montana State University (MSU) in Bozeman. Becoming a Biologist...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 31, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Bacteria Cellular Processes COVID-19 DNA Profiles Source Type: blogs

Importance of Balanced Attention Toward Coronavirus Disease 2019 and Neglected Tropical Diseases
Yonsei Med J. 2023 Jun;64(6):351-358. doi: 10.3349/ymj.2022.0656.ABSTRACTCoronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, has been spreading since 2019, causing a worldwide pandemic. Amid the COVID-19 pandemic, tuberculosis, AIDS, and malaria have adversely affected the quality of life of patients and killed millions of people. In addition, COVID-19 continues to impede the delivery of health services, including those for the control of neglected tropical diseases (NTDs). Furthermore, NTDs have been reported as possible co-pathogens among patients infected with COVID-19. However, studies regarding parasitic co-inf...
Source: Yonsei Medical Journal - May 25, 2023 Category: Universities & Medical Training Authors: Ju Yeong Kim Singeun Oh Moonsoo Yoon Tai-Soon Yong Source Type: research