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Overcoming the Challenges in the Development and Implementation of Artificial Intelligence in Radiology: A Comprehensive Review of Solutions Beyond Supervised Learning
Korean J Radiol. 2023 Aug 28. doi: 10.3348/kjr.2023.0393. Online ahead of print.ABSTRACTArtificial intelligence (AI) in radiology is a rapidly developing field with several prospective clinical studies demonstrating its benefits in clinical practice. In 2022, the Korean Society of Radiology held a forum to discuss the challenges and drawbacks in AI development and implementation. Various barriers hinder the successful application and widespread adoption of AI in radiology, such as limited annotated data, data privacy and security, data heterogeneity, imbalanced data, model interpretability, overfitting, and integration wit...
Source: Korean J Radiol - September 19, 2023 Category: Radiology Authors: Gil-Sun Hong Miso Jang Sunggu Kyung Kyungjin Cho Jiheon Jeong Grace Yoojin Lee Keewon Shin Ki Duk Kim Seung Min Ryu Joon Beom Seo Sang Min Lee Namkug Kim Source Type: research

Evaluating Prognostic Value of Dynamics of Circulating Lactate Dehydrogenase in Colorectal Cancer Using Modeling and Machine Learning
Clin Pharmacol Ther. 2023 Sep 19. doi: 10.1002/cpt.3052. Online ahead of print.ABSTRACTPre-treatment serum lactate dehydrogenase (LDH) levels have been associated with poor prognosis in several types of cancer, including metastatic colorectal cancer (mCRC). However, very few models link survival to longitudinal LDH measured repeatedly over time during treatment. We investigated the prognostic value of on-treatment LDH dynamics in mCRC. Using data from two large Phase III studies (2L and 3L+ mCRC settings, n = 824 and 210, respectively), we found that integrating longitudinal LDH data with baseline risk factors significantl...
Source: Clinical Pharmacology and Therapeutics - September 19, 2023 Category: Drugs & Pharmacology Authors: Haolun Ding Min Yuan Yaning Yang Manish Gupta Xu Steven Xu Source Type: research

Learning Language, Un/Learning Empathy in Medical School
This article considers the ways in which empathy for patients and related solidarity with communities may be trained out of medical students during medical school. The article focuses especially on the pre-clinical years of medical school, those that begin with orientation and initiation events such as the White Coat Ceremony. The ethnographic data for the article come from field notes and recordings from my own medical training as well as hundreds of hours of observant participation and interviews with medical students over the past several years. Exploring the framework of language socialization, I argue that learning th...
Source: Culture, Medicine and Psychiatry - September 19, 2023 Category: Psychiatry Authors: Seth M Holmes Source Type: research

Linking Clinic With Classroom in Intensive Focused Preservice Education on Augmentative and Alternative Communication
CONCLUSION: This study suggests the significance of compulsory fieldwork embedded in the AAC training as evidenced by the graduate students' subjective perception of competence and preparedness in AAC services following the AAC course.PMID:37724941 | DOI:10.1044/2023_AJSLP-23-00020
Source: American Journal of Speech-Language Pathology - September 19, 2023 Category: Speech-Language Pathology Authors: Sojung Kim Yu-Kyong Choe Source Type: research

Acupuncture Improves Synaptic Plasticity of SAMP8 Mice through the RhoA/ROCK Pathway
CONCLUSION: Acupuncture can improve synaptic plasticity by inhibiting the abnormal activation of the RhoA/ROCK pathway, and improve the spatial learning and memory ability of AD, so as to achieve the purpose of treating AD.PMID:37723951 | DOI:10.2174/1567205020666230828095826
Source: Current Alzheimer Research - September 19, 2023 Category: Neurology Authors: Bohong Kan Zhengjia Dong Zhenyu Tang Lan Zhao Zhen Li Source Type: research

Evaluating Prognostic Value of Dynamics of Circulating Lactate Dehydrogenase in Colorectal Cancer Using Modeling and Machine Learning
Clin Pharmacol Ther. 2023 Sep 19. doi: 10.1002/cpt.3052. Online ahead of print.ABSTRACTPre-treatment serum lactate dehydrogenase (LDH) levels have been associated with poor prognosis in several types of cancer, including metastatic colorectal cancer (mCRC). However, very few models link survival to longitudinal LDH measured repeatedly over time during treatment. We investigated the prognostic value of on-treatment LDH dynamics in mCRC. Using data from two large Phase III studies (2L and 3L+ mCRC settings, n = 824 and 210, respectively), we found that integrating longitudinal LDH data with baseline risk factors significantl...
Source: Clinical Colorectal Cancer - September 19, 2023 Category: Cancer & Oncology Authors: Haolun Ding Min Yuan Yaning Yang Manish Gupta Xu Steven Xu Source Type: research

Role of registered dietitians in nasoenteric feeding tube placement
Nutr Clin Pract. 2023 Sep 19. doi: 10.1002/ncp.11071. Online ahead of print.ABSTRACTProvision of enteral nutrition (EN) in hospitalized patients is an integral part of clinical care. For various reasons, including but not limited to delayed enteral access placement and EN initiation, it is becoming more prevalent for registered dietitians (RDs) to place feeding tubes in various clinical settings. Although numerous RDs have expanded their practice by learning this skill, many remain hesitant about adding feeding tube placement to their scope of responsibilities. Feeding tube placement is within RDs' scope of practice. The r...
Source: Nutrition in Clinical Practice - September 19, 2023 Category: Nutrition Authors: Maryam Yeganehjoo Jennifer Johanek Source Type: research

Reconsidering a Global Agency for Medical Education: Back to the Drawing Board?
This article proposes a more democratic and equitable means by which a global organization for medical education might choose its priority areas, and a more inclusive method by which it could engage the medical education community worldwide. It concludes by hypothesizing about the future of global representation and priority-setting, and outlines a series of principles that could form the basis for a reimagined agency that would have the potential to become a force for empowerment and global justice in medical education.PMID:37724805 | DOI:10.1080/10401334.2023.2259363
Source: Teaching and Learning in Medicine - September 19, 2023 Category: Universities & Medical Training Authors: Mohammed Ahmed Rashid Thirusha Naidu Dawit Wondimagegn Cynthia Whitehead Source Type: research

Construction of a novel cancer-associated fibroblast-related signature to predict clinical outcome and immune response in colon adenocarcinoma
Aging (Albany NY). 2023 Sep 16;15. doi: 10.18632/aging.205032. Online ahead of print.ABSTRACTThe interaction between the tumour and the surrounding microenvironment determines the malignant biological behaviour of the tumour. Cancer-associated fibroblasts (CAFs) coordinate crosstalk between cancer cells in the tumour immune microenvironment (TIME) and are extensively involved in tumour malignant behaviours, such as immune evasion, invasion and drug resistance. Here, we performed differential and prognostic analyses of genes associated with CAFs and constructed CAF-related signatures (CAFRs) to predict clinical outcomes in ...
Source: Aging - September 19, 2023 Category: Biomedical Science Authors: Lei Zheng Jiale Zhang Yingquan Ye Zhangpeng Shi Yi Huang Mengmeng Zhang Zhongxuan Gui Ping Li Huanlong Qin Weijie Sun Mei Zhang Source Type: research

Efficacy of a music-based intervention in a preclinical model of traumatic brain injury: An initial foray into a novel and non-pharmacological rehabilitative therapy
Exp Neurol. 2023 Sep 17:114544. doi: 10.1016/j.expneurol.2023.114544. Online ahead of print.ABSTRACTTraumatic brain injury (TBI) causes neurobehavioral and cognitive impairments that negatively impact life quality for millions of individuals. Because of its pernicious effects, numerous pharmacological interventions have been evaluated to attenuate the TBI-induced deficits or to reinstate function. While many such pharmacotherapies have conferred benefits in the laboratory, successful translation to the clinic has yet to be achieved. Given the individual, medical, and societal burden of TBI, there is an urgent need for alte...
Source: Experimental Neurology - September 19, 2023 Category: Neurology Authors: Eleni H Moschonas Tyler S Ranellone Vincent J Vozzella Piper L Rennerfeldt Corina O Bondi Ellen M Annas Rachel A Bittner Dana M Tamura Rithika I Reddy Rithik R Eleti Jeffrey P Cheng Jessica M Jarvis Ericka L Fink Anthony E Kline Source Type: research

Aortic Annulus Detection Based on Deep Learning for Transcatheter Aortic Valve Replacement Using Cardiac Computed Tomography
CONCLUSION: Our deep learning framework was feasible to detect the 3D complex structure of the aortic annulus plane using cardiac CT for TAVR. The performance of our algorithms was higher than other convolutional neural networks.PMID:37724499 | PMC:PMC10506901 | DOI:10.3346/jkms.2023.38.e306
Source: J Korean Med Sci - September 19, 2023 Category: General Medicine Authors: Yongwon Cho Soojung Park Sung Ho Hwang Minseok Ko Do-Sun Lim Cheol Woong Yu Seong-Mi Park Mi-Na Kim Yu-Whan Oh Guang Yang Source Type: research

Measuring Clinical Preparedness After Residency Training: Development of a New Instrument
CONCLUSIONS: To learn about the possible impact of length of training, we developed a novel approach to assess preparedness for independent clinical practice of family medicine residency graduates.PMID:37725776 | DOI:10.22454/FamMed.2023.973082
Source: Famly Medicine - September 19, 2023 Category: Primary Care Authors: Patricia A Carney Annie Ericson Colleen Conry James C Martin Alan B Douglass M Patrice Eiff Source Type: research

Resident Involvement in Curricular and Clinical Practice Change and Satisfaction With Training According to Length of Training in Family Medicine
CONCLUSIONS: Four-year residents were involved in a greater number of quality improvement projects and had a more diverse profile of involvement than those in 3-year residency programs. Involvement in practice and curricular change and the learning environment were associated with greater levels of resident satisfaction with training in both 3-year and 4-year programs.PMID:37725772 | DOI:10.22454/FamMed.2023.346131
Source: Famly Medicine - September 19, 2023 Category: Primary Care Authors: Jennifer Romeu Patricia A Carney Annie Ericson Nicholas Weida Jennifer Somers Bethany Picker Suki Tepperberg Richard A Young Source Type: research

Enhancing Medical Students' Understanding of Team-Based Care to Address Social Determinants of Health: A Case-Based Experience
CONCLUSIONS: Our students reported that a case-based experience coupled with a small-group debriefing was an effective method for teaching them how to use a team-based approach to address social determinants of health.PMID:37725770 | DOI:10.22454/FamMed.2023.914274
Source: Famly Medicine - September 19, 2023 Category: Primary Care Authors: Jennifer D Taylor Jalysa King Source Type: research

Assessing Educational and Attitudinal Outcomes of a Student Learner Experience Focused on Homelessness
CONCLUSIONS: Improvements from time point 1 to 2 demonstrated the value of didactic learning, while further improvements from time point 2 to 3 demonstrated the added benefit of hands-on experiential learning. Our study illustrates the potential educational benefits that a PNP provides to medical students who may encounter or care for this population during their careers.PMID:37725769 | DOI:10.22454/FamMed.2023.112960
Source: Famly Medicine - September 19, 2023 Category: Primary Care Authors: Drupad Annapureddy Shannon Teaw Pooja Kumar William M Turlington Ethan Wang Shelley Speed Nora Gimpel Source Type: research