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The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions.
Abstract
The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, ra...
Source: Diabetes Care - November 25, 2014 Category: Endocrinology Authors: Hamman RF, Bell RA, Dabelea D, D'Agostino RB, Dolan L, Imperatore G, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Pihoker C, Rodriguez BL, Saydah S, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research
Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes.
PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research
A novel fast Fourier transform accelerated off-grid exhaustive search method for cryo-electron microscopy fitting
This paper presents a novel fast Fourier transform (FFT)-based exhaustive search method extended to off-grid translational and rotational degrees of freedom. The method combines the advantages of the FFT-based exhaustive search, which samples all the conformations of a system under study on a grid, with a local optimization technique that guarantees to find the nearest optimal off-grid conformation. The method is demonstrated on a fitting problem and can be readily applied to a docking problem. The algorithm first samples a scoring function on a six-dimensional grid of size N6 using the FFT. This operation has an asymptoti...
Source: Journal of Applied Crystallography - June 26, 2017 Category: Physics Authors: Hoffmann, A. Perrier, V. Grudinin, S. Tags: cryo-EM fitting fast Fourier transform FFT exhaustive search off-grid search trust-region problem research papers Source Type: research
Prevalence of Diabetes Mellitus in U.S. Youth in 2009: The SEARCH for Diabetes in Youth Study.
ConclusionDiabetes mellitus, one of the leading chronic diseases in childhood, affects over 190,000 (1 out of 433) youth less than age 20 years in the US, with racial and ethnic disparities seen in diabetes prevalence, overall and by diabetes type.
PMID: 24041677 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 16, 2013 Category: Endocrinology Authors: Pettitt DJ, Talton J, Dabelea D, Divers J, Imperatore G, Lawrence JM, Liese AD, Linder B, Mayer-Davis EJ, Pihoker C, Saydah SH, Standiford DA, Hamman RF, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research
Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-Up Cohort: A pilot study.
CONCLUSIONSDPN prevalence among youth with type 2 diabetes approached rates reported in adult populations with diabetes. Our findings suggest not only that youth with diabetes are at risk for DPN but also that many already show measurable signs of DPN.
PMID: 24144652 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 21, 2013 Category: Endocrinology Authors: Jaiswal M, Lauer A, Martin CL, Bell RA, Divers J, Dabelea D, Pettitt DJ, Saydah S, Pihoker C, Standiford DA, Rodriguez BL, Pop-Busui R, Feldman EL, for The SEARCH For Diabetes In Youth Study Group Tags: Diabetes Care Source Type: research
Complementary, Alternative, and Other Noncomplete Decongestive Therapy Treatment Methods in the Management of Lymphedema: A Systematic Search and Review
Conclusions: No interventions were ranked as “recommended for practice” based on the Putting Evidence into Practice guidelines. Two treatment modalities in 3 studies were ranked as “likely to be effective” in reducing LE or in managing secondary LE complications. Consideration should be given that many of the PAMs demonstrate long-standing support within the literature, with broad parameters for therapeutic application and benefit for secondary conditions associated with LE. However, further investigation as to their individual contributory value and the factors that contribute to their efficacy, specific to LE, h...
Source: PM and R - September 20, 2013 Category: Rehabilitation Authors: Julia R. Rodrick, Ellen Poage, Ausanee Wanchai, Bob R. Stewart, Janice N. Cormier, Jane M. Armer Tags: Analytical Review: Systematic Search Source Type: research
Factors influencing time to case registration for youth with type 1 and type 2 diabetes: SEARCH for Diabetes in Youth Study.
CONCLUSIONS: These findings highlight the need for continued childhood diabetes surveillance to identify future trends and influences on changes in prevalence and incidence.
PMID: 27664849 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - August 31, 2016 Category: Epidemiology Authors: Crume TL, Hamman RF, Isom S, Talton J, Divers J, Mayer-Davis EJ, Zhong VW, Liese AD, Saydah S, Standiford DA, Lawrence JM, Pihoker C, Dabelea D, SEARCH for Diabetes in Youth Study Group Tags: Ann Epidemiol Source Type: research
Obesity, risk of biochemical recurrence, and prostate ‐specific antigen doubling time after radical prostatectomy: results from the SEARCH database
ConclusionWhile we confirmed that higher BMI was associated with BCR, we found no link between BMI and PSADT at the time of recurrence. Our data suggest obese men do not have more aggressive recurrences. Future studies are needed to test whether obesity predicts response to salvage therapies.
Source: BJU International - November 16, 2018 Category: Urology & Nephrology Authors: Stephen J. Freedland,
Brandee L. Branche,
Lauren E. Howard,
Robert J. Hamilton,
William J. Aronson,
Martha K. Terris,
Matthew R. Cooperberg,
Christopher L. Amling,
Christopher J. Kane,
On behalf of the SEARCH Database Study Group Tags: Original Article Source Type: research
Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community.
This study describes principles commonly applied to authorship order decisions within the medical education community and educators' opinions about the significance of authorship order. Approach: A questionnaire was developed to ascertain current practices related to authorship decisions. Sixteen items were rated in terms of frequency of actual use and the desirability of the practice using a 4-point rating scale: 1 (never), 2 (sometimes), 3 (often), and 4 (always). Additional questions addressed the perceived significance of authorship order. The last set of questions provided information about respondents' personal and c...
Source: Teaching and Learning in Medicine - December 15, 2018 Category: Universities & Medical Training Authors: Authorship Order in Medical Education Publications: In Search of Practical Guidance for the Community. Tags: Teach Learn Med Source Type: research
Assessment pf physical fitness of 8 and 9-year-old children from Szczecin,Poland, involved in the obesity prevention program - pilot study.
CONCLUSION: The fact of unsatisfactory physical fitness and excess body weight in children from Szczecin is unsettling. There is ceratainly a need for preventive measures in the broad sense.
PMID: 30300427 [PubMed - in process]
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 11, 2018 Category: Endocrinology Authors: Ratajczak J, Raducha D, Horodnicka-Józwa A, Kilian A, Demiaszkiewicz M, Bartoszewicz K, Jackowski T, Szmit-Domagalska J, Biczysko-Mokosa A, Marcinkiewicz K, Adamczyk T, Gapińska I, Walczak M, Petriczko E Tags: Pediatr Endocrinol Diabetes Metab Source Type: research
A 10-year study of Alternaria and Cladosporium in two Polish cities (Szczecin and Cracow) and relationship with the meteorological parameters
Abstract
Alternaria and Cladosporium spores belong to the most frequent and allergenic particles in bioaerosol in the temperate climate. The investigation of Alternaria and Cladosporium spore concentrations was performed in two cities in Poland, Szczecin and Cracow, in 2004–2013. The meteorological parameters taken to assess their impact on fungal spores were average, maximum and minimum temperature, relative humidity and average wind velocity. In order to reveal whether changes in dynamics of spore seasons are driven by meteorological conditions, ordination methods were applied. Canonical corresp...
Source: Aerobiologia - November 14, 2015 Category: Environmental Health Source Type: research
Reporting rates for cervical screening in the Szczecin Region during the period 2007-2010.
The objective of the study was analysis of the reporting rates for cervical screening in the Szczecin Region during the period 2007-2010. Statistical data were analyzed obtained from: the Central (Poznań) and Regional (Szczecin, Olsztyn) Coordination Centre for the Programme of Prophylaxis and Early Detection of Cervical Cancer of the Medical Prophylaxis Computer Information System (SIMP), and Oncology Centre in Warsaw. All collected data were subjected to the statistical analyses. The West Pomeranian Voivodeship, with reporting rates for cervical test of about 30% (women aged 25-59) occupies the second or third position ...
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 31, 2012 Category: Environmental Health Authors: Owoc A, Cveijć R, Koprowicz A, Sygit K, Fronczak A, Bojar I Tags: Ann Agric Environ Med Source Type: research
Atrial fibrillation and stroke - Coexistence and attitude to preventive therapy on the basis of Szczecin and Szczecin region patients.
The objective of the study was to evaluate the frequency of coexistence of non-valvular AF and IS during the acute stroke and to analyze the attitude of AF patients to treatment. The study included 3712 successive patients presenting either an IS or a transient ischemic attack. The analysis revealed a significant increase in the rate of patients with AF and IS in the years 2010-2013 (31.9%) compared with 2002-2005 (20.2%). A rise in the proportion of AF and IS patients was recorded over the course of consecutive years in group II. The proportion of newly detected AF cases during hospital stay differed significantly between...
Source: Neurologia i Neurochirurgia Polska - December 14, 2014 Category: Neurology Authors: Gołąb-Janowska M, Meller A, Kotlęga D, Bajer-Czajkowska A, Nowacki P Tags: Neurol Neurochir Pol Source Type: research
Seasonal variation of iGanoderma/i spore concentrations in urban and suburban districts of the city of Szczecin, Poland.
This study indicates that a single measuring site in the city centre insufficiently reflected the dynamics and level of Ganoderma spore concentration in peripheral districts.
PMID: 25780819 [PubMed - in process]
Source: Annals of Agricultural and Environmental Medicine : AAEM - February 24, 2015 Category: Environmental Health Authors: Grinn-Gofroń A, Strzelczak A, Przestrzelska K Tags: Ann Agric Environ Med Source Type: research
Seasonal variation of Ganoderma spore concentrations in urban and suburban districts of the city of Szczecin, Poland.
This study indicates that a single measuring site in the city centre insufficiently reflected the dynamics and level of Ganoderma spore concentration in peripheral districts.
PMID: 25780819 [PubMed - indexed for MEDLINE]
Source: Annals of Agricultural and Environmental Medicine : AAEM - December 15, 2015 Category: Environmental Health Authors: Grinn-Gofroń A, Strzelczak A, Przestrzelska K Tags: Ann Agric Environ Med Source Type: research
