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Total 2417 results found since Jan 2013.

Neurocognitive, Quality of Life, and Behavioral Outcomes for Patients With Covert Stroke After Cardiac Surgery: Exploratory Analysis of Data From a Prospectively Randomized Trial
CONCLUSIONS: More than one-half of patients undergoing cardiac surgery demonstrated covert stroke. In this exploratory analysis, covert stroke was not found to be significantly associated with neurocognitive dysfunction 1 month after surgery; evidence of impaired quality of life, anxiety, or depression, albeit a type II error, cannot be excluded.PMID:34319914 | DOI:10.1213/ANE.0000000000005690
Source: Anesthesia and Analgesia - July 28, 2021 Category: Anesthesiology Authors: Choy Lewis Annabelle Levine Lauren C Balmert Liqi Chen Saadia S Sherwani Alexander J Nemeth Jordan Grafman Rebecca Gottesman Charles H Brown Charles W Hogue Source Type: research

Review article: The role of hypotension in perioperative stroke.
CONCLUSIONS: Unusually low blood pressure will eventually result in neurological damage; however, the threshold and duration at which an association might be found between a perioperative stroke and hypotension have not been well investigated. Thus, the exact role of hypotension in the etiology of perioperative stroke is still largely unknown. PMID: 23239486 [PubMed - as supplied by publisher]
Source: Canadian Journal of Anaesthesia - December 13, 2012 Category: Anesthesiology Authors: Bijker JB, Gelb AW Tags: Can J Anaesth Source Type: research

The THRIVE score strongly predicts outcomes in patients treated with the Solitaire device in the SWIFT and STAR trials
ConclusionsThe THRIVE score strongly predicts clinical outcome and mortality in patients treated with the Solitaire device in the SWIFT and STAR trials. The lack of interaction between THRIVE and procedure‐specific elements such as vessel recanalization or device choice makes the THRIVE score a reasonable candidate for use as a patient selection criterion in stroke clinical trials.
Source: International Journal of Stroke - May 22, 2014 Category: Neurology Authors: Alexander C. Flint, Sean P. Cullen, Vivek A. Rao, Bonnie S. Faigeles, Vitor M. Pereira, Elad I. Levy, Tudor G. Jovin, David S. Liebeskind, Raul G. Nogueira, Reza Jahan, Jeffrey L. Saver, Tags: Research Source Type: research

Perioperative stroke: incidence, etiologic factors, and prevention.
CONCLUSIONS: Recognition of the incidence, risk factors, and causes of perioperative stroke may lead to prevention and proper management. PMID: 28901120 [PubMed - as supplied by publisher]
Source: Minerva Anestesiologica - September 14, 2017 Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research

Effect of Conscious Sedation vs. General Anesthesia on Outcomes in Patients Undergoing Mechanical Thrombectomy for Acute Ischemic Stroke: A Prospective Randomized Clinical Trial
Conclusion: Anesthetic management with GA or CS during MT had no differential impact on the functional outcomes and mortality at discharge or 3 months after stroke in AIS patients, but CS led to more stable hemodynamics and lower incidence of pneumonia.
Source: Frontiers in Neurology - March 23, 2020 Category: Neurology Source Type: research

A prospective observational study of stroke volume responsiveness to a passive leg raise manoeuvre in healthy non‐starved volunteers as assessed by transthoracic echocardiography
Summary Current guidelines for intra‐operative fluid management recommend the use of increments in stroke volume following intravenous fluid bolus administration as a guide to subsequent fluid therapy. To study the physiological premise of this paradigm, we tested the hypothesis that healthy, non‐starved volunteers would develop an increment in their stroke volume following a passive leg raise manoeuvre. Subjects were positioned supine and stroke volume was measured by transthoracic echocardiography at baseline, 30 s, 1 min, 3 min and 5 min after passive leg raise manoeuvre to 45°. Stroke volume was measured at end...
Source: Anaesthesia - March 18, 2014 Category: Anesthesiology Authors: G. E. P. Godfrey, S. W. Dubrey, J. M. Handy Tags: Original Article Source Type: research

The utility of intra‐operative three‐dimensional transoesophageal echocardiography for dynamic measurement of stroke volume
This study included 40 cardiac surgery patients. Haemodynamic variables were measured before and 2 min after haemodynamic interventions, which consisted of phenylephrine 100 μg or ephedrine 5 mg. We used Bland–Altman analysis to assess the agreement between the stroke volume measured by three‐dimensional transoesophageal echocardiography and by the pulmonary artery catheter. Polar‐plot and 4‐quadrant plot analyses were used to assess the trending ability of three‐dimensional transoesophageal echocardiography compared with the pulmonary artery catheter. Bias and percentage error were −1.2 ml and 20%, respec...
Source: Anaesthesia - September 29, 2014 Category: Anesthesiology Authors: K. Suehiro, K. Tanaka, T. Yamada, T. Matsuura, T. Funao, T. Mori, K. Nishikawa Tags: Original Article Source Type: research

E-036 age, stroke severity, use of stent retrievers, general anesthesia, and hemorrhagic conversion may predict outcome in stroke patients who undergo successful intra-arterial therapy
ConclusionAge, NIHSS score, use of stent retrievers, mode of anesthesia, and symptomatic ICH might affect functional outcome in stroke patients who achieve successful recanalization via intra-arterial therapy. Prospective studies, or a meta-analysis of sub-groups in the recently published prospective trials are needed to confirm the association between those factors, or others, and functional outcome. Identification of such predictors might help in screening acute stroke patients for intra-arterial therapy.DisclosuresM. Noufal: None. J. Mankad: None. D. Shirilla: None. A. Lakraj: None. J. Cox: None. A. Sattar: None. W. Wal...
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Noufal, M., Mankad, J., Shirilla, D., Lakraj, A., Cox, J., Sattar, A., Wally, W., Sallowm, Y., Lynch, J., Zaidat, O. Tags: SNIS 12th Annual Meeting Electronic Poster Abstracts Source Type: research

Effect of stroke volume variation‐directed fluid management on blood loss during living‐donor right hepatectomy: a randomised controlled study
Summary Reducing blood loss is beneficial in living liver donor hepatectomy. Although it has been suggested that maintaining a low central venous pressure is important, it is known that low stroke volume variation may be associated with increased blood loss. Therefore, we compared the effect on blood loss of 40 patients randomly assigned to a high stroke volume variation group (maintaining 10–20% of stroke volume variation) vs 38 patients in a control group (maintaining < 10% stroke volume variation) during living‐donor right hepatectomy. Mean (SD) blood loss during donor hepatectomy was significantly lower in the ...
Source: Anaesthesia - July 28, 2015 Category: Anesthesiology Authors: S.‐S. Choi, I.‐G. Jun, S.‐S. Cho, S.‐K. Kim, G.‐S. Hwang, Y.‐K. Kim Tags: Original Article Source Type: research

Mechanical Thrombectomy Is Now the Gold Standard for Acute Ischemic Stroke: Implications for Routine Clinical Practice
Background: This review aims to summarize the findings of the recently published randomized controlled studies which provide overwhelming evidence in support of mechanical thrombectomy for acute ischemic stroke with large artery occlusion. The five studies, Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN), Endovascular Revascularization with Solitaire Device versus Best Medical Therapy in Anterior Circulation Stroke within 8 h (REVASCAT), Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE), Solitaire™ FR as Primary Tr...
Source: Interventional Neurology - September 18, 2015 Category: Neurology Source Type: research

Endovascular reperfusion therapies for acute ischemic stroke: dissecting the evidence.
Authors: Tsivgoulis G, Safouris A, Krogias C, Arthur AS, Alexandrov AV Abstract Ischemic stroke is a major cause of death and disability and intravenous thrombolysis has been the only approved acute reperfusion therapy (RT) for many years. Seven randomized-controlled clinical trials (RCTs) evaluating the safety and efficacy of endovascular therapy in patients with acute ischemic stroke (AIS) due to emergent large vessel occlusion (ELVO) have been recently published. These studies have changed the treatment paradigm by establishing mechanical thrombectomy (MT) as the most effective acute stroke therapy for improving...
Source: Expert Review of Neurotherapeutics - March 20, 2016 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Intravenous Treatment with a Long-Chain Omega-3 Lipid Emulsion Provides Neuroprotection in a Murine Model of Ischemic Stroke – A Pilot Study
by Dirk Berressem, Konrad Koch, Nicole Franke, Jochen Klein, Gunter P. Eckert Single long-chain omega-3 fatty acids (e.g. docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA)) are known for their neuroprotective properties associated with ischemic stroke. This pilot study aimed to test the effectiveness of an acute treatment with a long-chain omega-3 lipid emulsion (Om egaven 10%®, OGV) that contains fish oil (DHA 18 mg/ml; EPA 21 mg/ml) and α-tocopherol (0.2 mg/ml) in a transient middle cerebral artery occlusion (MCAO) model of ischemic stroke in mice. For this purpose, female CD-1 mice were anesthetized and subje...
Source: PLoS One - November 29, 2016 Category: Biomedical Science Authors: Dirk Berressem Source Type: research

Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms.
Abstract Heat stroke is characterilized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose of quercetin (30 mg/kg) or vehicle (normal saline 1 ml/kg) was administered to the experimental groups of rats. Additional injection was administered immediately after the onset of heat stroke. Immedi...
Source: Chemico-Biological Interactions - January 15, 2017 Category: Molecular Biology Authors: Lin X, Lin CH, Zhao T, Zuo D, Ye Z, Liu L, Lin MT Tags: Chem Biol Interact Source Type: research

Role of anesthesia in endovascular stroke therapy
Purpose of review: Recent randomized clinical trials have demonstrated strong efficacy of endovascular therapy (EVT) for acute ischemic stroke (AIS) from large vessel occlusions; in the USA alone, tens of thousands of patients annually may benefit. The impact of the type of anesthesia used during mechanical thrombectomy on patient outcomes remains controversial. This review discusses the current literature on the effects of anesthesia type on patient outcome following endovascular stroke therapy. Recent findings: EVT is the standard of treatment for intracranial large vessel occlusions. Recent studies show that general an...
Source: Current Opinion in Anaesthesiology - September 7, 2017 Category: Anesthesiology Tags: NEUROANESTHESIA: Edited by Federico Bilotta Source Type: research