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Total 376 results found since Jan 2013.

Intravenous Fat Emulsion Does Not Significantly Alter Clotting Markers in Dabigatran-Treated Blood
AbstractDabigatran etexilate is an oral direct thrombin (Factor IIa) inhibitor approved for patients with atrial fibrillation and for management of risk of deep vein thrombosis and pulmonary embolism. Dabigatran offers advantages over treatment with warfarin, including limited laboratory monitoring. It is equivalent in prevention of stroke and deep vein thrombosis with essentially equivalent complication rates. In contrast to warfarin, reversal of the anticoagulation is less well established. Idarucizumab is available for reversal, however supporting research is mixed; the agent also happens to be quite expensive making av...
Source: Indian Journal of Hematology and Blood Transfusion - June 21, 2020 Category: Hematology Source Type: research

Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients.
Abstract The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collected and used for hematological analyses, fetal hemoglobin quantification, and genotyping of 3.7 kb alpha-thalassemia deletion by GAP-PCR. The frequency of the 3.7 kb alpha-thalassemia deletion in homozygosity was 12.5% and in heterozygosity was 55.0%. An increase in alpha-thalassemia frequency ...
Source: Molecular Biology Reports - July 5, 2020 Category: Molecular Biology Authors: Santos B, Delgadinho M, Ferreira J, Germano I, Miranda A, Arez AP, Faustino P, Brito M Tags: Mol Biol Rep Source Type: research

Predictors of Acute Kidney Injury Following Surgical Valve Replacement
Conclusion Independent predictors of acute kidney injury following valve surgeries include age, hypertension, heart failure, MR, use of ACEi <month, perioperative blood transfusion, and prolonged pump time or inotropic support. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: The Thoracic and Cardiovascular Surgeon - July 24, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Ibrahim, Khalid S. Kheirallah, Khalid A. Mayyas, Fadia A. Alwaqfi, Nizar A. Tags: Original Cardiovascular Source Type: research

Mortality and Morbidity of Surgical Management of Geriatric Ankle Fractures.
DISCUSSION: After controlling for comorbidities (ie, the ASA class), no increased risk is observed for the 30-day mortality or complication rate between geriatric ankle fracture in the 65 to 79 years old and the 80 to 99 years old age groups. LEVEL OF EVIDENCE: Prognostic level III, retrospective study. PMID: 32769723 [PubMed - in process]
Source: The Journal of the American Academy of Orthopaedic Surgeons - August 13, 2020 Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research

Impact of Hematologic Malignancies on Outcome of Cardiac Surgery.
CONCLUSIONS: Although late survival is reduced in patients with hematologic malignancies, early outcomes are generally similar to matched controls. Thus, operation should not be withheld in patients with a diagnosis of hematologic malignancy who would benefit from cardiac procedures. PMID: 32822668 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - August 17, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Nguyen A, Schaff HV, Arghami A, Bagameri G, Cicek MS, Crestanello JA, Daly RC, Greason KL, Pochettino A, Rowse PG, Stulak JM, Lahr BD, Dearani JA, Count TW Tags: Ann Thorac Surg Source Type: research

Trends in Comorbidities and Complications Among Patients Undergoing Inpatient Spine Surgery
Study Design. Retrospective database study. Objective. We sought to identify trends in demographics, comorbidities, and postoperative complications among patients undergoing ACDF and PLF. Summary of Background Data. As demand for anterior cervical discectomy and fusion (ACDF) and posterior lumbar fusion (PLF) surgery continues to increase, it is important to understand changes in the healthcare system and patient populations undergoing these procedures. Methods. We identified 220,520 ACDF and 151,547 PLF surgeries (2006–2016; Premier Healthcare database). Annual proportions or medians were calculated for patie...
Source: Spine - August 28, 2020 Category: Orthopaedics Tags: SURGERY Source Type: research

Intra-and postoperative complications in the treatment of spinal metastases. A multicentre surveillance study from the German Spinal Registry (DWG-Register).
CONCLUSIONS: This analysis provides predictive models for surgeons to identify patients who may benefit from transitional care programmes. Preoperative status, invasiveness, blood loss> 500 ml and blood transfusions are independent predictors associated with higher risk of complication. PMID: 33047579 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgical Sciences - October 15, 2020 Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research

Risk factors and outcomes of myocardial injury after non-cardiac surgery in high-risk patients who underwent radical cystectomy
Radical cystectomy is considered the standard treatment for patients with muscle-invasive bladder tumors and has high postoperative complication rates among urological surgeries. High-risk patients, defined as those ≥45 years of age with history of coronary artery disease, stroke, or peripheral artery disease or those ≥65 years of age, can have a higher incidence of cardiac complications. Therefore, we evaluated the incidence, risk factors, and outcomes of myocardial injury after non-cardiac surgery (MINS) in high-risk patients who underwent radical cystectomy. This retrospective observational study analyzed 248 high-...
Source: Medicine - October 23, 2020 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Iron deficiency does not impair the outcome after elective coronary artery bypass and aortic valve procedures
ConclusionsThe majority of patients undergoing elective CABG or SAVR suffer from ID;  however, we found no significant differences in regard to MACCE and postoperative morbidity between ID and non‐ID patients.
Source: Journal of Cardiac Surgery - December 20, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Moritz B. Immohr, Yukiharu Sugimura, Hug Aubin, Philipp Rellecke, Udo Boeken, Artur Lichtenberg, Payam Akhyari Tags: ORIGINAL ARTICLE Source Type: research

Preoperative anemia and complications after surgery for pelvic organ prolapse: an analysis of the national surgical quality improvement program database
ConclusionsPreoperative anemia is associated with an increased risk of adverse postoperative outcomes in women having surgery for pelvic organ prolapse.
Source: International Urogynecology Journal - April 24, 2021 Category: OBGYN Source Type: research

Right anterior mini thoracotomy approach for isolated aortic valve replacement: Early outcomes at a Canadian center
ConclusionThe sternum-sparing RAMT approach can be safely integrated into surgical practice as a minimally invasive alternative for isolated AVR, and can reduce postoperative bleeding and narcotic requirements.
Source: Journal of Cardiac Surgery - May 18, 2021 Category: Cardiovascular & Thoracic Surgery Authors: Ali Fatehi Hassanabad, Nader Aboelnazar, Andrew Maitland, Daniel D Holloway, Corey Adams, William D T Kent Tags: ORIGINAL ARTICLE Source Type: research

Low Grip Strength Associated with Clinical Outcomes after Total Hip Arthroplasty - A Prospective Case-Control Study
CONCLUSIONS: Clinicians should be encouraged to include GS assessment in their evaluation of patients who planned to undergo THA in order to optimize the treatment of high-risk individuals.PMID:34080763 | DOI:10.1111/os.13007
Source: Hand Surgery - June 3, 2021 Category: Surgery Authors: Gong Long Chen Chao Tan Ming-Sheng Yi Ping Source Type: research

Perioperative outcomes of goal-directed versus conventional fluid therapy in radical cystectomy with enhanced recovery protocol
ConclusionStroke volume variation guided goal-directed fluid therapy is safe in radical cystectomy without compromising the renal function. It is associated with less intra- and perioperative fluid infusion; however, no association with hospital stay, 90-day complication or readmission rates were noted.
Source: International Urology and Nephrology - June 4, 2021 Category: Urology & Nephrology Source Type: research

Low Grip Strength Associated with Clinical Outcomes after Total Hip Arthroplasty - A Prospective Case-Control Study
CONCLUSIONS: Clinicians should be encouraged to include GS assessment in their evaluation of patients who planned to undergo THA in order to optimize the treatment of high-risk individuals.PMID:34080763 | DOI:10.1111/os.13007
Source: Hand Surgery - June 3, 2021 Category: Surgery Authors: Gong Long Chen Chao Tan Ming-Sheng Yi Ping Source Type: research

Perioperative safety of simultaneous off-pump coronary artery bypass grafting with non-cardiac surgery of moderate-to-severe severity
Background To evaluate the perioperative safety of simultaneous off-pump coronary artery bypass grafting (OPCABG) with non-cardiac surgery. Methods From September 2013 to January 2019, patients who underwent OPCABG surgery in the Department of Cardiology, Peking University First Hospital were included in this retrospective study. A total of 54 patients who underwent simultaneous surgery were defined as simultaneous surgery group. A total of 108 patients who had recently undergone isolated OPCABG surgery, and had similar vascular reconstruction methods were selected for matching, and these patients were defined a...
Source: Coronary Artery Disease - July 27, 2021 Category: Cardiology Tags: CABG Source Type: research