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Total 496 results found since Jan 2013.
Oridonin prevents oxidative stress-induced endothelial injury via promoting Nrf-2 pathway in ischaemic stroke
J Cell Mol Med. 2021 Sep 12. doi: 10.1111/jcmm.16923. Online ahead of print.ABSTRACTOridonin, a natural diterpenoid compound extracted from a Chinese herb, has been proved to exert anti-oxidative stress effects in various disease models. The aim of the present study was to investigate the protective effects of oridonin on oxidative stress-induced endothelial injury in ischaemic stroke. We found oridonin repaired blood-brain barrier (BBB) integrity presented with upregulation of tight junction proteins (TJ proteins) expression, inhibited the infiltration of periphery inflammatory cells and neuroinflammation and thereby redu...
Source: Molecular Medicine - September 13, 2021 Category: Molecular Biology Authors: Lei Li Shu-Qi Cheng Wei Guo Zhen-Yu Cai Yu-Qin Sun Xin-Xin Huang Jin Yang Juan Ji Ya-Yun Chen Yin-Feng Dong Hong Cheng Xiu-Lan Sun Source Type: research
Decreased spasticity of Baishaoluoshi Decoction through the BDNF/TrKB-KCC2 pathway on poststroke spasticity rats
Conclusion
Suppression of spasticity by Baishaoluoshi Decoction in PSS rat models may be correlated with upregulated BDNF/TrKB-KCC2 pathway, which may be a complementary therapeutic strategy for PSS.
Source: NeuroReport - September 3, 2021 Category: Neurology Tags: Cellular, Molecular and Developmental Neuroscience Source Type: research
Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
The RIG-I Signal Pathway Mediated < em > Panax notoginseng < /em > Saponin Anti-Inflammatory Effect in Ischemia Stroke
This study aimed to decipher the underlying molecular target of PNS in the treatment of cerebral ischemia. The oxygen-glucose-deprived (OGD) model of rat brain microvascular endothelial cells (BMECs) was used in this study. The alteration of gene expression in rat BMECs after PNS treatment was measured by microarray and indicated that there were 38 signaling pathways regulated by PNS. Among them, RIG-I receptor and related signaling molecules TNF receptor-associated factor 2 (Traf2) and nuclear factor-kappa B (NF-κB) were significantly suppressed by PNS, which was verified again in OGD-induced BMECs measured by FQ-PCR and...
Source: Evidence-based Complementary and Alternative Medicine - August 31, 2021 Category: Complementary Medicine Authors: Chujun Zhang Sai Zhang Lanxiang Wang Soyeon Kang Jiabao Ma Shihao Liu Yanhong Hu Fan Zhang Tianshi Sun Yixin Dong Tenghui Li Weihong Li Qinghong Du Source Type: research
Dengzhanxixin Injection Ameliorates Cognitive Impairment Through a Neuroprotective Mechanism Based on Mitochondrial Preservation in Patients With Acute Ischemic Stroke
Acute ischemic stroke (AIS) is a global health burden and cognitive impairment is one of its most serious complication. Adequate interventions for AIS may have the potential to improve cognitive outcomes. In the present study, we selected Erigeron breviscapus (Vaniot) Hand.-Mazz. injection (Dengzhanxixin injection, DZXI), a widely used Chinese herbal injection, in contrast to edaravone as the positive control drug to test its potential to ameliorates neurological and cognitive impairments caused by AIS. We performed a 2-week randomized trial with these two drugs in AIS patients presenting mild to moderate cognitive impairm...
Source: Frontiers in Pharmacology - August 30, 2021 Category: Drugs & Pharmacology Source Type: research
A Network Pharmacology Approach for Exploring the Mechanisms of < em > Panax notoginseng < /em > Saponins in Ischaemic Stroke
CONCLUSIONS: The ameliorative effects of PNS against IS were predicted to be associated with the regulation of the IGF1-PI3K-Akt signalling pathway. Ginsenoside Re and ginsenoside Rb1 may play an important role in the treatment of IS.PMID:34434246 | PMC:PMC8382556 | DOI:10.1155/2021/5582782
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2021 Category: Complementary Medicine Authors: Cong Wang Hao Chen Shi-Tang Ma Bin-Bin Mao Yu Chen Hao-Nan Xu Hao Yu Source Type: research
Network pharmacology-based prediction of the active compounds and mechanism of Buyang Huanwu Decoction for ischemic stroke
Exp Ther Med. 2021 Oct;22(4):1050. doi: 10.3892/etm.2021.10484. Epub 2021 Jul 23.ABSTRACTBuyang Huanwu Decoction (BYHWD) is used to promote blood circulation and is widely used in Chinese clinical practice for the treatment and prevention of ischemic cerebral vascular diseases. However, the mechanism and active compounds of BYHWD used to treat ischemic stroke are not well understood. The current study aimed to identify the potential active components of BYHWD and explore its mechanism using network pharmacology and bioinformatics analyses. The compounds of BYHWD were obtained from public databases. Oral bioavailability and...
Source: Experimental and Therapeutic Medicine - August 26, 2021 Category: General Medicine Authors: Kai Wang Lu Lei Jinyi Cao Yi Qiao Ruimin Liang Jialin Duan Zhijun Feng Yi Ding Yang Ma Zhifu Yang Enhu Zhang Source Type: research
A Network Pharmacology Approach for Exploring the Mechanisms of < em > Panax notoginseng < /em > Saponins in Ischaemic Stroke
CONCLUSIONS: The ameliorative effects of PNS against IS were predicted to be associated with the regulation of the IGF1-PI3K-Akt signalling pathway. Ginsenoside Re and ginsenoside Rb1 may play an important role in the treatment of IS.PMID:34434246 | PMC:PMC8382556 | DOI:10.1155/2021/5582782
Source: Evidence-based Complementary and Alternative Medicine - August 26, 2021 Category: Complementary Medicine Authors: Cong Wang Hao Chen Shi-Tang Ma Bin-Bin Mao Yu Chen Hao-Nan Xu Hao Yu Source Type: research
FDA Approves Expanded Peripheral Artery Disease (PAD) Indication for XARELTO ® (rivaroxaban) Plus Aspirin to Include Patients After Lower-Extremity Revascularization (LER) Due to Symptomatic PAD
RARITAN, N.J., August 24, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) has approved an expanded peripheral artery disease (PAD) indication for the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily plus aspirin 100 mg once daily) to include patients following recent lower-extremity revascularization (LER) due to symptomatic PAD. The approval is based on data from the Phase 3 VOYAGER PAD study. With this approval, XARELTO® is the first and only therapy indicated to help reduce the risks of major cardiovascular (CV) events in p...
Source: Johnson and Johnson - August 24, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Effects of Naodesheng tablets on amyloid beta-induced dysfunction: A traditional Chinese herbal formula with novel therapeutic potential in Alzheimer's disease revealed by systems pharmacology
In conclusion, this is the first study to provide a comprehensive systems pharmacology approach to elucidate the potential therapeutic mechanism of NDS tablets for AD treatment. We suggest that the protective effects of NDS in neurodegenerative conditions could be partly attributed to its role in improving synaptic plasticity and inhibiting neuroinflammation via NF-κB signaling pathway inhibition and cAMP/PKA/CREB signaling pathway activation.PMID:34328103 | DOI:10.1016/j.biopha.2021.111916
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 30, 2021 Category: Drugs & Pharmacology Authors: Baoyue Zhang Jun Zhao Pengfei Guo Zhe Wang Lvjie Xu Ailin Liu Guanhua Du Source Type: research
Revealing new therapeutic opportunities in hypertension through network-driven integrative genetic analysis and drug target prediction approach
Gene. 2021 Jul 19:145856. doi: 10.1016/j.gene.2021.145856. Online ahead of print.ABSTRACTEpidemiological studies have established that untreated hypertension (HTN) is a major independent risk factor for developing cardiovascular diseases (CVD), stroke, renal failure, and other conditions. Several important studies have been published to prevent and manage HTN; however, antihypertensive agents' optimal choice remains controversial. Therefore, the present study is undertaken to update our knowledge in the primary treatment of HTN, specifically in the setting of other three important diseases. MicroRNAs (miRNAs) are remarkabl...
Source: Gene - July 22, 2021 Category: Genetics & Stem Cells Authors: Kavita Sharma Prithvi Singh Md Amjad Beg Ravins Dohare Fareeda Athar Mansoor Ali Syed Source Type: research
