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Total 177 results found since Jan 2013.

Effective treatment of intractable diseases using nanoparticles to interfere with vascular supply and angiogenic process
AbstractAngiogenesis is a vital biological process involving blood vessels forming from pre-existing vascular systems. This process contributes to various physiological activities, including embryonic development, hair growth, ovulation, menstruation, and the repair and regeneration of damaged tissue. On the other hand, it is essential in treating a wide range of pathological diseases, such as cardiovascular and ischemic diseases, rheumatoid arthritis, malignancies, ophthalmic and retinal diseases, and other chronic conditions. These diseases and disorders are frequently treated by regulating angiogenesis by utilizing a va...
Source: European Journal of Medical Research - November 4, 2022 Category: Research Source Type: research

Air pollution and headache disorders
Divyani Garg, Man Mohan Mehndiratta, Mohammad Wasay, Vasundhara AggarwalAnnals of Indian Academy of Neurology 2022 25(7):35-40 Air pollution, the most prevalent form of pollution worldwide, is associated with a wide range of neurological disorders, including neurodegenerative conditions, stroke, autism, depression, and developmental delay. There is accumulating evidence on the association between air pollution and headache disorders, especially migraine. Many classical and non-classical air pollutants have been associated with headache, including particulate matter, nitrogen dioxide, sulfur dioxide, ozone, carbon monoxide...
Source: Annals of Indian Academy of Neurology - September 7, 2022 Category: Neurology Authors: Divyani Garg Man Mohan Mehndiratta Mohammad Wasay Vasundhara Aggarwal Source Type: research

Targeting organic cation transporters at the blood-brain barrier to treat ischemic stroke in rats
Exp Neurol. 2022 Jul 26:114181. doi: 10.1016/j.expneurol.2022.114181. Online ahead of print.ABSTRACTDrug discovery and development for stroke is challenging as evidenced by few drugs that have advanced beyond a Phase III clinical trial. Memantine is a N-methyl-d-aspartate (NMDA) receptor antagonist that has been shown to be neuroprotective in various preclinical studies. We have identified an endogenous BBB uptake transport system for memantine: organic cation transporters 1 and 2 (Oct1/Oct2). Our goal was to evaluate Oct1/Oct2 as a required BBB mechanism for memantine neuroprotective effects. Male Sprague-Dawley rats (200...
Source: Experimental Neurology - July 29, 2022 Category: Neurology Authors: Joshua A Stanton Erica I Williams Robert D Betterton Thomas P Davis Patrick T Ronaldson Source Type: research

Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function
Conclusions Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. Further work is needed to determine the domains of cognition most affected by decreased secretory clearance and the mechanisms of these associations.
Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Lidgard, B., Bansal, N., Zelnick, L. R., Hoofnagle, A., Chen, J., Colaizzo, D., Dobre, M., Mills, K. T., Porter, A. C., Rosas, S. E., Sarnak, M. J., Seliger, S., Sondheimer, J., Tamura, M. K., Yaffe, K., Kestenbaum, B., the CRIC Study Investigators, The C Tags: Chronic Kidney Disease Source Type: research

Handheld two-stroke engines as an important source of personal VOC exposure for olive farm workers
Environ Sci Pollut Res Int. 2022 Jun 14. doi: 10.1007/s11356-022-21378-5. Online ahead of print.ABSTRACTPersonal exposure to volatile organic compounds (VOCs) is mainly associated with indoor exposures; however, elevated short-term exposures may also occur during ambient activities. Handheld two-stroke gasoline-powered engines have widespread use in agriculture, but so far, no studies have been conducted on the potential health risks due to the inhalation of emitted VOCs. A one-week passive sampling has been conducted on olive farm workers during the harvesting season to monitor personal exposure levels to VOCs. The first ...
Source: Environmental Science and Pollution Research International - June 14, 2022 Category: Environmental Health Authors: Akif Ar ı Pelin Ert ürk Arı Soner Özenç İlhan Eftade O Gaga Source Type: research

Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study
CONCLUSION: From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates. A statistically significant association between concomitant use of these medications and cardiovascular adverse events could not be identified.PRIMARY FUNDING SOURCE: Ib Mogens Kristiansens Almene Fond and Helsefonden.PMID:35436155 | DOI:10.7326/M21-3445
Source: Annals of Internal Medicine - April 18, 2022 Category: Internal Medicine Authors: Anders Holt Paul Blanche Aksel Karl Georg Jensen Nina Nouhravesh Deepthi Rajan Mads Hashiba Jensen Mohammed El-Sheikh Anne-Marie Schjerning Morten Schou Gunnar Gislason Christian Torp-Pedersen Patricia McGettigan Morten Lamberts Source Type: research

A Review on the Arylpiperazine Derivatives as Potential Therapeutics for the Treatment of Various Neurological Disorders
Curr Drug Targets. 2022 Jan 17. doi: 10.2174/1389450123666220117104038. Online ahead of print.ABSTRACTNeurological disorders are disease conditions related to the neurons and central nervous system (CNS). Any kind of structural, electrical, biochemical and functional abnormalities in neurons can lead to various types of disorders like Alzheimer's disease (AD), depression, Parkinson's disease (PD), epilepsy, stroke, etc. Currently available medicines are symptomatic and do not treat the disease state. Thus, novel CNS active agents with the potential of complete treatment of an illness are highly desired. A range of small or...
Source: Epilepsy Curr - March 21, 2022 Category: Neurology Authors: Bhupinder Kumar Naveen Kumar Amandeep Thakur Vijay Kumar Rakesh Kumar Vinod Kumar Source Type: research