Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function

Conclusions
Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. Further work is needed to determine the domains of cognition most affected by decreased secretory clearance and the mechanisms of these associations.

Source: Journal of the American Society of Nephrology : JASN - June 30, 2022 Category: Urology & Nephrology Authors: Lidgard, B., Bansal, N., Zelnick, L. R., Hoofnagle, A., Chen, J., Colaizzo, D., Dobre, M., Mills, K. T., Porter, A. C., Rosas, S. E., Sarnak, M. J., Seliger, S., Sondheimer, J., Tamura, M. K., Yaffe, K., Kestenbaum, B., the CRIC Study Investigators, The C Tags: Chronic Kidney Disease Source Type: research