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Silence and its effects on the autonomic nervous system: A systematic review
Prog Brain Res. 2023;280:103-144. doi: 10.1016/bs.pbr.2023.08.001. Epub 2023 Sep 1.ABSTRACTThis systematic review explores the influence of silence on the autonomic nervous system. The Polyvagal Theory has been used as a reference model to describe the autonomic nervous system by explaining its role in emotional regulation, social engagement, and adaptive physiological responses. PubMed, Scopus, PsycInfo, EMBASE, and Google Scholar were systematically searched up until July 2023 for relevant studies. The literature search yielded 511 results, and 37 studies were eventually included in this review. Silence affects the auton...
Source: Brain Research - September 15, 2023 Category: Neurology Authors: Davide Donelli Davide Lazzeroni Matteo Rizzato Michele Antonelli Source Type: research
Cognitive-exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3 β Pathway
This study aimed to investigate the effects of CEDI and the role of regulation of the lncRNA NEAT1/miR-124-3p on the caveolin-1-PI3K/Akt/GSK3β pathway in CEDI improving cognitive function. Forty 18-month-old natural aging rats were randomly assigned to four groups: exercise training group, cognitive training group, CEDI group, and aging control group, and underwent 12 weeks of intervention. A novel object recognition test was performed to determine the cognitive function, and the hippocampus was separated three days after the behavioral tests for further molecular detection. In an in vitro study, the mouse hippocampal neu...
Source: Brain Research - September 15, 2023 Category: Neurology Authors: Tiancong Li Xue Tao Ruifeng Sun Conglin Han Xiaoling Li Ziman Zhu Wenshan Li Peiling Huang Weijun Gong Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
The value of radiomics model based on ultrasound image features in the differentiation between minimal breast cancer and small benign breast masses
CONCLUSION: The radiomics model based on ultrasound image features has a satisfied predictive ability for small breast masses, and is expected to become a potential tool for the diagnosis of MBC, and it is a zero cost (in terms of patient participation and imaging time).PMID:37712556 | DOI:10.1002/jcu.23556
Source: Clinical Breast Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Shuyi Lyu Meiwu Zhang Baisong Zhang Jiazhen Zhu Libo Gao Yuqin Qiu Liu Yang Yan Zhang Source Type: research
Development of a national deep learning-based auto-segmentation model for the heart on clinical delineations from the DBCG RT nation cohort
CONCLUSIONS: This study demonstrated a deep learning-based auto-segmentation model trained on curated clinical delineations which performs on par with a model trained on dedicated delineations, making it easier to develop multi-institutional auto-segmentation models.PMID:37712509 | DOI:10.1080/0284186X.2023.2252582
Source: Acta Oncologica - September 15, 2023 Category: Cancer & Oncology Authors: Emma Riis Skars ø Lasse Refsgaard Abhilasha Saini Ditte Sloth M øller Ebbe Laugaard Lorenzen Else Maae Karen Andersen Maja Vestm ø Maraldo Marie Louise Milo Tine Bisballe Nyeng Birgitte Vrou Offersen Stine Sofia Korreman Source Type: research
Machine learning to predict outcomes following endovascular abdominal aortic aneurysm repair
CONCLUSIONS: In this data set, machine learning was able to predict 1-year mortality following EVAR using preoperative data and outperformed standard logistic regression models.PMID:37710397 | DOI:10.1093/bjs/znad287
Source: The British Journal of Surgery - September 15, 2023 Category: Surgery Authors: Ben Li Badr Aljabri Raj Verma Derek Beaton Naomi Eisenberg Douglas S Lee Duminda N Wijeysundera Thomas L Forbes Ori D Rotstein Charles de Mestral Muhammad Mamdani Graham Roche-Nagle Mohammed Al-Omran Source Type: research
Development and Validation of Entrustable Professional Activities for Provisionally Registered (Intern) Pharmacists in Australia
CONCLUSION: Fourteen EPAs were validated for use with provisionally registered (intern) pharmacists. To our knowledge, this is the first time that the EQual rubric has been used in the evaluation and validation of pharmacy EPAs.PMID:37714661 | DOI:10.1016/j.ajpe.2022.12.005
Source: American Journal of Pharmaceutical Education - September 15, 2023 Category: Universities & Medical Training Authors: Carmen Abeyaratne Michelle Vienet Kirsten Galbraith Source Type: research
Pharmacy Students Practicing Health Advocate Competency Roles in Workplace-Based Training
CONCLUSION: Pharmacy students construct health advocacy roles in workplace-based training through biomedical-oriented practices with little direct input offered by supervisors. Pharmacy educational outcomes require contemporary updates to health advocacy competency descriptions which offer examples for practical enactment at system-level and recommendations for feedback and assessment.PMID:37714657 | DOI:10.1016/j.ajpe.2023.100118
Source: American Journal of Pharmaceutical Education - September 15, 2023 Category: Universities & Medical Training Authors: Mojan Fazelipour Amninder Dhatt Tom Sun Arwa Nemir Kerry Wilbur Source Type: research
Low interobserver agreement among subspecialised breast pathologists in evaluating HER2-low breast cancer
CONCLUSIONS: Subspecialised breast pathologists have suboptimal agreement for immunohistochemical evaluation of HLBC using the modified Ki-67 methodology. An urgent need remains for a new assay/algorithm to reliably evaluate HLBC.PMID:37714693 | DOI:10.1136/jcp-2023-209055
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Gulisa Turashvili Yuan Gao Di Andy Ai Abdulwahab M Ewaz Sandra Gjorgova Gjeorgjievski Qun Wang Thi T A Nguyen Chao Zhang Xiaoxian Li Source Type: research
Machine learning- and WGCNA-mediated double analysis based on genes associated with disulfidptosis, cuproptosis and ferroptosis for the construction and validation of the prognostic model for breast cancer
CONCLUSION: Multiplex analysis based on DRGs, CRGs and FRGs correlated strongly with BC, providing new insights for developing clinical prognostic tools and designing immunotherapy regimens for BC patients.PMID:37712959 | DOI:10.1007/s00432-023-05378-7
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Lijun Xu Shanshan Wang Dan Zhang Yunxi Wu Jiali Shan Huixia Zhu Chongyu Wang Qingqing Wang Source Type: research
The value of radiomics model based on ultrasound image features in the differentiation between minimal breast cancer and small benign breast masses
CONCLUSION: The radiomics model based on ultrasound image features has a satisfied predictive ability for small breast masses, and is expected to become a potential tool for the diagnosis of MBC, and it is a zero cost (in terms of patient participation and imaging time).PMID:37712556 | DOI:10.1002/jcu.23556
Source: Clinical Genitourinary Cancer - September 15, 2023 Category: Cancer & Oncology Authors: Shuyi Lyu Meiwu Zhang Baisong Zhang Jiazhen Zhu Libo Gao Yuqin Qiu Liu Yang Yan Zhang Source Type: research
Computed tomography angiography-based radiomics model to identify high-risk carotid plaques
CONCLUSIONS: The combined model of the radiomics features of carotid plaques and PVAT and the traditional CTA features significantly contributes to identifying high-risk carotid plaques compared with traditional CTA model.PMID:37711840 | PMC:PMC10498225 | DOI:10.21037/qims-23-158
Source: Atherosclerosis - September 15, 2023 Category: Cardiology Authors: Chao Chen Wei Tang Yong Chen Wenhan Xu Ningjun Yu Chao Liu Zenghui Li Zhao Tang Xiaoming Zhang Source Type: research
Cognitive-exercise dual-task intervention ameliorates cognitive decline in natural aging rats via inhibiting the promotion of LncRNA NEAT1/miR-124-3p on caveolin-1-PI3K/Akt/GSK3 β Pathway
This study aimed to investigate the effects of CEDI and the role of regulation of the lncRNA NEAT1/miR-124-3p on the caveolin-1-PI3K/Akt/GSK3β pathway in CEDI improving cognitive function. Forty 18-month-old natural aging rats were randomly assigned to four groups: exercise training group, cognitive training group, CEDI group, and aging control group, and underwent 12 weeks of intervention. A novel object recognition test was performed to determine the cognitive function, and the hippocampus was separated three days after the behavioral tests for further molecular detection. In an in vitro study, the mouse hippocampal neu...
Source: Brain Research Bulletin - September 15, 2023 Category: Neurology Authors: Tiancong Li Xue Tao Ruifeng Sun Conglin Han Xiaoling Li Ziman Zhu Wenshan Li Peiling Huang Weijun Gong Source Type: research
The SOFIA pilot study: assessing feasibility and fidelity of coordinated care to reduce excess mortality and increase quality of life in patients with severe mental illness in a general practice setting; a cluster-randomised pilot trial
CONCLUSION: Our findings suggest that delivering the coordinated care program in a fully powered trial in primary care is likely feasible. However, the recruitment methodology requires improvement to ensure sufficient recruitment and minimize selective inclusion.TRIAL REGISTRATION: The date of pilot trial protocol registration was 05/11/2020, and the registration number is NCT04618250.PMID:37715123 | PMC:PMC10504748 | DOI:10.1186/s12875-023-02141-2
Source: Primary Care - September 15, 2023 Category: Primary Care Authors: Katrine Tranberg Alexandra J ønsson Tina Due Volkert Siersma John Brandt Brodersen Kristine Bissenbakker Frederik Martiny Annette Davidsen Pia K ürstein Kjellberg Kevin Doherty Stewart W Mercer Maria Haahr Nielsen Susanne Reventlow Anne M øller Maarten Source Type: research
E-prescription: views and acceptance of general practitioners and pharmacists in Greater Sydney
CONCLUSION: There are many facilitators and barriers to the use of e-prescription. Our findings may inform the future promotion of e-prescription post-COVID-19 pandemic. Further research should focus on consumers' perspectives of e-prescription.PMID:37710390 | DOI:10.1071/PY22240
Source: Primary Care - September 15, 2023 Category: Primary Care Authors: Phyllis Lau Minh Thuan Tran Ricky Yong Kim Alsayed Hashem Alrefae Sangwoo Ryu Jim Chyuan Teh Source Type: research
