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Total 21 results found since Jan 2013.

Statins for women with polycystic ovary syndrome not actively trying to conceive
CONCLUSIONS: The evidence for all main outcomes of this review was of very low certainty. Due to the limited evidence, we are uncertain if statins compared with placebo, or statins plus metformin compared with metformin alone, improve resumption of menstrual regularity. The trial evaluating statin plus OCP versus OCP alone reported neither of our primary outcomes. No other studies reported resumption of spontaneous ovulation. We are uncertain if statins improve hirsutism, acne severity, or testosterone. All trials that measured adverse events reported no significant differences between the groups.PMID:37462232 | PMC:PMC103...
Source: Cochrane Database of Systematic Reviews - July 18, 2023 Category: General Medicine Authors: Ting Xiong Eloise Fraison Eleni Kolibianaki Michael F Costello Christos Venetis Elena B Kostova Source Type: research

Highlights of Cardiovascular Disease Prevention Studies Presented at the 2023 American College of Cardiology Conference
Curr Atheroscler Rep. 2023 Apr 22. doi: 10.1007/s11883-023-01103-4. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: To summarize selected late-breaking science on cardiovascular (CV) disease prevention presented at the 2023 American College of Cardiology (ACC) conference.RECENT FINDINGS: The CLEAR outcomes randomized control trial (RCT) compared bempedoic acid to placebo in patients at high-risk of cardiovascular disease (CVD) or prevalent CVD and statin intolerance for CV outcomes. The YELLOW III was a single-arm study that evaluated the effect of Evolocumab on coronary plaque characteristics in patients with stable coro...
Source: Atherosclerosis - April 22, 2023 Category: Cardiology Authors: Kartik Gupta Isabel Balachandran Jacob Foy Melody Hermel Azka Latif Chayakrit Krittanawong Leandro Slipczuk Farhala Baloch Zainab Samad Salim S Virani Source Type: research

What ’ s On Your Plate? Culinary Medicine as an Innovative Nutrition Education Model
On this episode of the Academic Medicine Podcast, guests Courtney Newman and Jaclyn Albin, MD, join host Toni Gallo to discuss culinary medicine and its role in teaching nutrition, nutrition counseling, and hands-on cooking skills to medical students. The conversation also covers how culinary medicine programs build connections and community and improve the well-being of students, faculty, and patients. This episode is now available through Apple Podcasts, Spotify, and anywhere else podcasts are available. A transcript is below. Read the article discussed in this episode: Newman C, Yan J, Me...
Source: Academic Medicine Blog - February 20, 2023 Category: Universities & Medical Training Authors: amrounds Tags: AM Podcast AM Podcast Transcript Academic Medicine podcast culinary medicine medical education nutrition patient care Source Type: blogs

Pharmacological effects of statins in adult patients with type 2 diabetes mellitus: A protocol for systematic review and meta-analysis
This study will not involve human samples and patient data; hence ethics approval will not be required. The findings will be presented in journal clubs and conferences and published in peer-reviewed journals.PMID:36595825 | PMC:PMC9794268 | DOI:10.1097/MD.0000000000032313
Source: Atherosclerosis - January 3, 2023 Category: Cardiology Authors: Kabelo Mokgalaboni Phiwayinkosi V Dludla Bongani B Nkambule Source Type: research

Fight Aging! Newsletter, February 7th 2022
In this study, we used accelerometer measurements (1) to examine the association of physical activity and mortality in a population-based sample of US adults and (2) to estimate the number of deaths prevented annually with modest increases in moderate-to-vigorous physical activity (MVPA) intensity. This analysis included 4,840 participants. Increasing MVPA by 10, 20, or 30 minutes per day was associated with a 6.9%, 13.0%, and 16.9% decrease in the number of deaths per year, respectively. We estimated that approximately 110,000 deaths per year could be prevented if US adults aged 40 to 85 years or older increased th...
Source: Fight Aging! - February 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 24th 2022
In conclusion, senolytic drugs have shown promising results in the elimination of senescent cells and in alleviating various diseases in animal models. However, in patients, there is a paucity in data on the efficacy and safety of senotherapeutics from clinical trials, including systemic effects and side-effects. In this regard it is important to assess the specificity of senolytics in killing targeted senescent cells and their cytotoxic effects, to identify reliable markers for intervention responses, to elucidate interactions with comorbidities and other drugs, and to standardise administration protocols. FOXO3...
Source: Fight Aging! - January 23, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Statins for asthma.
CONCLUSIONS: The evidence was of very low certainty, so we are unable to draw conclusions about the effectiveness and safety of statins to treat asthma. High-quality RCTs are needed to assess the effect of statins on people with asthma. Well-designed multicentre trials with larger samples and longer duration of treatment are required, which assess outcomes such as adverse events, hospital utilisation and costs, to provide better quality evidence. Future studies that include subgroups of obese people with asthma are also required. PMID: 32668027 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - July 14, 2020 Category: General Medicine Authors: Naing C, Ni H Tags: Cochrane Database Syst Rev Source Type: research

Preoperative Statin Therapy for Atrial Fibrillation and Renal Failure after Cardiac Surgery
Conclusion Current but sparse evidence reveals that statin pretreatment is associated with a higher rate of postoperative renal failure compared with control therapy but is ineffective to substantially reduce postoperative AF. Given the relevant heterogeneity among included studies, statin pretreatment cannot be generally recommended. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: The Thoracic and Cardiovascular Surgeon - June 6, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Kuhn, Elmar W. Liakopoulos, Oliver J. Choi, Yeong-Hoon Rahmanian, Parwis Eghbalzadeh, Kaveh Slottosch, Ingo Deppe, Antje Christin Wahlers, Thorsten C.W. Tags: Original Cardiovascular Source Type: research

Fight Aging! Newsletter, March 2nd 2020
In conclusion, the recently demonstrated protective effects of NMN treatment on neurovascular function can be attributed to multifaceted sirtuin-mediated anti-aging changes in the neurovascular transcriptome. Our present findings taken together with the results of recent studies using mitochondria-targeted interventions suggest that mitochondrial rejuvenation is a critical mechanism to restore neurovascular health and improve cerebral blood flow in aging. Wnt/β-Catenin Signaling as a Point of Intervention to Spur Greater Neural Regeneration https://www.fightaging.org/archives/2020/02/wnt-%ce%b2-catenin-signali...
Source: Fight Aging! - March 1, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 12th 2019
We examined 9293 individuals from the Copenhagen General Population Study using nuclear magnetic resonance spectroscopy measurements of total cholesterol, free- and esterified cholesterol, triglycerides, phospholipids, and particle concentration. Fourteen subclasses of decreasing size and their lipid constituents were analysed: six subclasses were very low-density lipoprotein (VLDL), one intermediate-density lipoprotein (IDL), three low-density lipoprotein (LDL), and four subclasses were high-density lipoprotein (HDL). Remnant lipoproteins were VLDL and IDL combined. Mean nonfasting cholesterol concentration was 72â...
Source: Fight Aging! - August 11, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hepatic late adverse effects after antineoplastic treatment for childhood cancer.
CONCLUSIONS: The prevalence of hepatic late adverse effects among studies with an adequate outcome definition varied considerably from 1% to 53%. Evidence suggests that radiotherapy involving the liver, higher BMI, chronic viral hepatitis and longer follow-up time or older age at follow-up increase the risk of hepatic late adverse effects. In addition, there may be a suggestion that busulfan, thioguanine, hepatic surgery, higher alcohol intake (>14 units per week), metabolic syndrome, use of statins, non-Hispanic white ethnicity, and older age at cancer diagnosis increase the risk of hepatic late adverse effects. High-q...
Source: Cochrane Database of Systematic Reviews - April 14, 2019 Category: General Medicine Authors: Mulder RL, Bresters D, Van den Hof M, Koot BG, Castellino SM, Loke YKK, Post PN, Postma A, Szőnyi LP, Levitt GA, Bardi E, Skinner R, van Dalen EC Tags: Cochrane Database Syst Rev Source Type: research

Fight Aging! Newsletter, March 4th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - March 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 21st 2019
In this study, scientists screened cells from old animals to identify any RBPs that change upon aging. The screening showed that one particular protein, Pumilio2 (PUM2), was highly induced in old animals. PUM2 binds mRNA molecules containing specific recognition sites. Upon its binding, PUM2 represses the translation of the target mRNAs into proteins. Using a systems genetics approach, the researchers then identified a new mRNA target that PUM2 binds. The mRNA encodes for a protein called Mitochondrial Fission Factor (MFF), and is a pivotal regulator of mitochondrial fission - a process by which mitochondria break u...
Source: Fight Aging! - January 20, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Role of PCSK9 Inhibitors in the Treatment of Hypercholesterolemia.
CONCLUSION: The PCSK9 inhibitor drug class is an effective LDL-C lowering option for patients with the highest risk of CVD events and high LDL-C despite the use of statin therapy. For more widespread use, significant cost reductions are needed. PMID: 29667842 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - April 1, 2018 Category: Drugs & Pharmacology Authors: Patel RS, Scopelliti EM, Olugbile O Tags: Ann Pharmacother Source Type: research

Fight Aging! Newsletter, September 11th 2017
This study developed the first procedure for the removal of epithelium from the lung airway with the full preservation of vascular epithelium, which could be applied in vivo to treat diseases of lung epithelium. Whole lung scaffolds with an intact vascular network may also allow for recellularization using patient-specific cells and bioengineering of chimeric lungs for transplantation. In addition to the clinical potential, lung scaffolds lacking an intact epithelial layer but with functional vascular and interstitial compartments may also serve as a valuable physiological model for investigating (i) lung development, (ii)...
Source: Fight Aging! - September 10, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs