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CROI 2023: Neuropsychiatric Complications in People With HIV
Top Antivir Med. 2023 Jun 30;31(4):543-555.ABSTRACTThe 2023 Conference on Retroviruses and Opportunistic Infections (CROI) featured new and impactful findings about neuropsychiatric complications in people with HIV and other infections. Reports included new evidence of (a) the importance of myeloid cells in the pathogenesis of HIV disease in the central nervous system, including as an HIV reservoir; (b) eukaryotic and prokaryotic viruses in cerebrospinal fluid during suppressive antiretroviral therapy; (c) the influence of sex on pathogenesis, including in novel neuropsychiatric biotypes identified by machine learning and ...
Source: Topics in HIV Medicine - September 13, 2023 Category: Infectious Diseases Authors: Albert M Anderson Beau M Ances Scott L Letendre Source Type: research

'Adversarial' search for neural basis of consciousness yields first results
NEW YORK CITY—Amidst rock music , a rap about consciousness, and the calling in of a 25-year-old drunken bet, camps backing two leading theories of how consciousness arises from the brain waited anxiously in a Greenwich village theater on Friday to hear who had won the first round of an ambitious “adversarial collaboration.” Three neutral judges chosen to help design the experiment and evaluate the results gave a qualified victory to advocates of the idea that consciousness is a feature of networks of neurons found at the back of the brain. But the opposing camp is far from ready to c...
Source: Science of Aging Knowledge Environment - June 25, 2023 Category: Geriatrics Source Type: research

‘Adversarial’ search for neural basis of consciousness yields first results
NEW YORK CITY— Amid rock music , a rap about consciousness, and the calling in of a 25-year-old drunken bet, camps backing two leading theories of how consciousness arises from the brain waited anxiously in a Greenwich Village theater on Friday to hear who had won the first round of an ambitious “adversarial collaboration.” On balance, the initial results presented appeared to favor the idea that consciousness is a feature of networks of neurons found at the back of the brain. But the opposing camp is far from ready to concede. It still contends that consciousness emerges within the brain’s “e...
Source: ScienceNOW - June 25, 2023 Category: Science Source Type: news

< sup > 18 < /sup > FFET-PET in children and adolescents with central nervous system tumors: does it support difficult clinical decision-making?
CONCLUSION: [18F]FET-PET may provide important additional information for treatment guidance in pediatric and adolescent patients with CNS tumors.PMID:36670283 | DOI:10.1007/s00259-023-06114-6
Source: Molecular Medicine - January 20, 2023 Category: Molecular Biology Authors: Olivia Kertels J ürgen Krauß Camelia Maria Monoranu Samuel Samnick Alexander Dierks Malte Kircher Milena I Mihovilovic Mirko Pham Andreas K Buck Matthias Eyrich Paul-Gerhardt Schlegel Michael C Fr ühwald Brigitte Bison Constantin Lapa Source Type: research

Roche provides update on Alzheimer ’s Prevention Initiative study evaluating crenezumab in autosomal dominant Alzheimer’s disease
Crenezumab did not slow or prevent cognitive decline in people with a specific genetic mutation which causes early-onset Alzheimer ’s diseaseFor more than a decade Roche has been working in collaboration with Banner Alzheimer ’s Institute, the University of Antioquia in Colombia and the National Institute on Aging on this pioneering prevention studyInitial data will be presented at the upcoming Alzheimer ' s Association International ConferenceBasel, 16 June 2022 - Roche (SIX: RO, ROG; OTCQX: RHHBY), together with Banner Alzheimer ’s Institute, today announced results from the Alzheimer’s Prevention Initiative (API...
Source: Roche Media News - June 16, 2022 Category: Pharmaceuticals Source Type: news

Fight Aging! Newsletter, February 14th 2022
In conclusion, this first examination of the effects of age and the ageing process on the small intestinal microbiome demonstrates that the duodenal microbiome changes with increasing age, with significant decreases in duodenal microbial diversity due to increased prevalence of phylum Proteobacteria, particularly coliforms and anaerobic taxa. Given the key roles of small intestinal microbes in nutrient absorption and host metabolism, these changes may be clinically relevant for human health during the ageing process. Naked Mole Rats Exhibit Minimal Cardiac Aging https://www.fightaging.org/archives/2022/02/naked...
Source: Fight Aging! - February 13, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, January 3rd 2022
In this study, we showed that the iPaD (inducing Plagl2 and anti-Dyrk1a) lentivirus substantially rejuvenated the proliferative and neurogenic potential of NSCs in the aged brain. Clonal analysis by a sparse labeling approach as well as transcriptome analysis indicated that iPaD can rejuvenate aged NSCs (19-21 mo of age) to a level comparable with those at 1 or 2 months of age and successfully improved cognition of aged mice. Once rejuvenated and activated by iPaD, aged dormant NSCs can generate, on average, 4.9 neurons but very few astrocytes in 3-week tracing. Furthermore, these activated NSCs were maintained for ...
Source: Fight Aging! - January 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Contemporary options and future perspectives: three examples highlighting the challenges in testicular cancer imaging
ConclusionFurther efforts should be made to refine imaging for TGCT patients, which is of high relevance for the guidance of treatment decisions as well as the associated treatment burdens and oncological outcomes.
Source: World Journal of Urology - November 15, 2021 Category: Urology & Nephrology Source Type: research

Computed tomography for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease
CONCLUSIONS: In the clinical pathway for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease, CT has roles as a confirmatory test for hepatocellular carcinoma lesions, and for staging assessment. We found that using CT in detecting hepatocellular carcinoma of any size and stage, 22.5% of people with hepatocellular carcinoma would be missed, and 8.7% of people without hepatocellular carcinoma would be unnecessarily treated. For resectable hepatocellular carcinoma, we found that 28.6% of people with resectable hepatocellular carcinoma would improperly not be resected, while 8% of people without hep...
Source: Cochrane Database of Systematic Reviews - October 6, 2021 Category: General Medicine Authors: Tin Nadarevic Vanja Giljaca Agostino Colli Mirella Fraquelli Giovanni Casazza Damir Miletic Davor Štimac Source Type: research

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