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Fight Aging! Newsletter, July 17th 2023
In conclusion, the longevity-associated genotype of FLT1 may confer increased lifespan by protecting against mortality risk posed by hypertension. We suggest that FLT1 expression in individuals with longevity genotype boosts vascular endothelial resilience mechanisms to counteract hypertension-related stress in vital organs and tissues. Resistance Exercise Slows the Onset of Pathology in a Mouse Model of Alzheimer's Disease https://www.fightaging.org/archives/2023/07/resistance-exercise-slows-the-onset-of-pathology-in-a-mouse-model-of-alzheimers-disease/ With the caveat that mouse models of Alzheimer's...
Source: Fight Aging! - July 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Multimodeling approach to evaluating the efficacy of layering pharmaceutical and nonpharmaceutical interventions for influenza pandemics
Proc Natl Acad Sci U S A. 2023 Jul 11;120(28):e2300590120. doi: 10.1073/pnas.2300590120. Epub 2023 Jul 3.ABSTRACTWhen an influenza pandemic emerges, temporary school closures and antiviral treatment may slow virus spread, reduce the overall disease burden, and provide time for vaccine development, distribution, and administration while keeping a larger portion of the general population infection free. The impact of such measures will depend on the transmissibility and severity of the virus and the timing and extent of their implementation. To provide robust assessments of layered pandemic intervention strategies, the Cente...
Source: Cancer Control - July 3, 2023 Category: Cancer & Oncology Authors: Pragati V Prasad Molly K Steele Carrie Reed Lauren Ancel Meyers Zhanwei Du Remy Pasco Jorge A Alfaro-Murillo Bryan Lewis Srinivasan Venkatramanan James Schlitt Jiangzhuo Chen Mark Orr Mandy L Wilson Stephen Eubank Lijing Wang Matteo Chinazzi Ana Pastore Y Source Type: research

VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe
CONCLUSIONS: The VACCELERATE Site Network enables a constantly updated Europe-wide mapping of experienced clinical sites interested in executing vaccine trials. The network is already in use as a rapid-turnaround single contact point for the identification of vaccine trials sites in Europe.PMID:37210309 | PMC:PMC10194816 | DOI:10.1016/j.vaccine.2023.05.006
Source: Vaccine - May 20, 2023 Category: Allergy & Immunology Authors: Jon Salmanton-Garc ía Pauline Wipfler Paula Valle-Sim ón Christina Merakou Ioannis Kopsidas Ullrich Bethe Angela Steinbach Orly Spivak Lenka Sou čková Maria Am élia Mendonça Markela Koniordou Margot Hellemans Jesus Fr ías-Iniesta Ruth Joanna Davis Source Type: research

Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules. MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/ Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, prod...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

10 What can we learn from the nervous sequelae of past pandemics?
Dr Mark Honigsbaum, medical historian and senior lecturer, City University of London. A regular contributor to The Observer & The Lancet, the author of five books including The Pandemic Century: One Hundred Years of Panic, Hysteria, and Hubris (New York and London: Norton; Hurst, 2019), The Fever Trail: In Search of the Cure for Malaria (Farrar Straus Giroux, 2002), and Living With Enza: The Forgotten Story of Britain and the Great Flu Pandemic of 1918 (Macmillan, 2009), which was longlisted for the Royal Society science book of the year in 2009. A specialist in the history of pandemics and infectious disease, his acad...
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 14, 2022 Category: Neurosurgery Authors: Honigsbaum, M. Tags: Speakers Short Biographies and Abstracts Source Type: research

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Traditional Chinese medicines as effective agents against influenza virus-induced pneumonia
Biomed Pharmacother. 2022 Sep;153:113523. doi: 10.1016/j.biopha.2022.113523. Epub 2022 Aug 11.ABSTRACTInfluenza virus-induced pneumonia (IVP) is a high morbidity and contagiousness pulmonary infectious disease caused by invasion of the influenza virus into the lower respiratory tract. Currently, the treatment of IVP is mainly based on an anti-influenza virus infection strategy, which includes the use of anti-influenza vaccines and drugs. However, the clinical use of these treatment options is limited as the influenza virus has a high level of variability and drug resistance may occur. Traditional Chinese medicines (TCMs) f...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2022 Category: Drugs & Pharmacology Authors: Mengru Yang Yi Wang Yimin Yue Lanyuan Liang Mingming Peng Mantong Zhao Ying Chen Xia Cao Wei Li Chuanqiu Li Han Zhang Jieyong Du Renxing Zhong Tianyi Xia Zunpeng Shu Source Type: research

An online survey of primary care physicians' knowledge of common respiratory diseases in China
NPJ Prim Care Respir Med. 2022 Aug 19;32(1):28. doi: 10.1038/s41533-022-00289-5.ABSTRACTChina has a huge population with respiratory diseases, these diseases should be managed well in primary care, however, primary care physicians' knowledge level of these diseases were unknown. The aim of the study was to assess primary care physicians' knowledge of asthma, CAP, COPD, and influenza in China. An e-questionnaire was distributed to attendees of respiratory diseases academic conferences in China from July, 2017 to December, 2018. 7391 questionnaires were returned and 4815 valid questionnaires were analyzed, 3802 (79.0%) from ...
Source: Respiratory Care - August 19, 2022 Category: Respiratory Medicine Authors: Zihan Pan Ting Yang Chunhua Chi Yahong Chen Jiping Liao Kewu Huang Si ân Williams Chen Wang Source Type: research

Characteristics and Perceptions Associated with COVID-19 Vaccination Hesitancy among Pregnant and Postpartum Individuals: A Cross-sectional Study
CONCLUSIONS: COVID-19 vaccine hesitancy was frequent among pregnant and postpartum individuals. Those who may face barriers to accessing healthcare services were more likely to report vaccine hesitancy. These results can inform interventions to increase COVID-19 vaccine uptake in pregnancy.PMID:35104382 | DOI:10.1111/1471-0528.17110
Source: BJOG : An International Journal of Obstetrics and Gynaecology - February 1, 2022 Category: OBGYN Authors: Miranda K Kiefer Rebecca Mehl Maged M Costantine Alyson Johnson Jessica Cohen Taryn L Summerfield Mark B Landon Kara M Rood Kartik K Venkatesh Source Type: research

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