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Drug: Melatonin
Nutrition: Iron
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Total 63 results found since Jan 2013.
Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model
Biosci Rep. 2023 Sep 20:BSR20230128. doi: 10.1042/BSR20230128. Online ahead of print.ABSTRACTFerroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the ...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Moumita Saha Sanjib Das Krishnendu Manna Krishna Das Saha Source Type: research
Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2023 Sep 15:S0891-5849(23)00636-6. doi: 10.1016/j.freeradbiomed.2023.09.012. Online ahead of print.ABSTRACTFerroptosis is a novel form of cell death that plays a critical role in the pathological and physiological processes of early brain injury following subarachnoid hemorrhage. Melatonin, as the most potent endogenous antioxidant, has shown strong protective effects against pathological changes following subarachnoid hemorrhage, but its impact on ferroptosis induced by subarachnoid hemorrhage remains unexplored. In our study, we established a subarachnoid hemorrhage model in male SD rats. We found th...
Source: Free Radical Biology and Medicine - September 17, 2023 Category: Biology Authors: Sheng-Ji Ma Chen Li Cong Yan Nan Liu Guang-You Jiang Hong-Rui Yang Hao-Chen Yan Ji-Yi Li Huai-Lei Liu Cheng Gao Source Type: research
Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling
CONCLUSIONS: We proposed that MT attenuated SONFH by inhibiting ferroptosis through the regulation of GDF15, and supplementation with exogenous MT might be a promising method for the treatment of SONFH.PMID:37400902 | DOI:10.1186/s13287-023-03371-y
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Wenming Li Wenhao Li Wei Zhang Hongzhi Wang Lei Yu Peng Yang Yi Qin Minfeng Gan Xing Yang Lixin Huang Yuefeng Hao Dechun Geng Source Type: research
Therapeutic potential of melatonin in the intervertebral disc degeneration through inhibiting the ferroptosis of nucleus pulpous cells
This study demonstrated that CM from the LPS-stimulated RAW264.7 macrophages promoted the NP cell injury. MLT alleviated the CM-induced NP cell injury partly through inhibiting ferroptosis. The findings support the role of ferroptosis in the pathogenesis of IDD, and suggest that MLT may serve as a potential therapeutic approach for clinical treatment of IDD.PMID:37329158 | DOI:10.1111/jcmm.17818
Source: J Cell Mol Med - June 17, 2023 Category: Molecular Biology Authors: Xinyu Dou Yunlong Ma Qipeng Luo Chunyu Song Meijuan Liu Xiao Liu Donglin Jia Shuiqing Li Xiaoguang Liu Source Type: research
Exogenous melatonin enhances Cd stress tolerance in Platycladus orientalis seedlings by improving mineral nutrient uptake and oxidative stress
Ecotoxicol Environ Saf. 2023 Feb 6;252:114619. doi: 10.1016/j.ecoenv.2023.114619. Online ahead of print.ABSTRACTThe development of agriculture and industry has led to a gradual increase in the levels of cadmium (Cd) in the soil, which, due to its high mobility in soil, makes Cd deposition in plants a serious threat to the health of animals and humans. The important role of melatonin (MT) in regulating plant growth and adaptation to environmental stress has become a pertinent research topic, but the mechanisms of action of MT in Cd-stressed Platycladus orientalis seedlings are unclear. Here, we investigated the mitigation m...
Source: Ecotoxicology and Environmental Safety - February 8, 2023 Category: Environmental Health Authors: Chun Ou Wenhui Cheng Zelu Wang Xiamei Yao Shengmei Yang Source Type: research
Melatonin Repairs Osteoporotic Bone Defects in Iron-Overloaded Rats through PI3K/AKT/GSK-3 < em > β < /em > /P70S6k Signaling Pathway
In conclusion, melatonin enhanced the osteogenic ability of iron overload-induced MC3T3-E1 cells by activating the PI3K/AKT/GSK-3β/P70S6k signaling pathway and promoting the healing of iron overload-induced osteoporotic bone defects in rats.PMID:36703914 | PMC:PMC9873465 | DOI:10.1155/2023/7718155
Source: Molecular Medicine - January 27, 2023 Category: Molecular Biology Authors: Maoxian Ren Hedong Liu Wenkai Jiang Zhi Zhou Xuewei Yao Zhiyi Liu Nengfeng Ma Bing Chen Min Yang Source Type: research
Direct and Indirect Effects of Blue Light Exposure on Skin: A Review of Published Literature
The growing use of electronic devices and other artificial light sources in recent decades has changed the pattern of exposure to blue light (400 –500 nm). Although some progress has been made in the study of the biological effects of blue light on the skin, many questions in this field remain unexplored. The aim of this article was to review the currently available evidence on the deleterious effects of blue light on the skin, as well as t he methods and strategies designed to protect from the detrimental effects of blue light. PubMed and ProQuest databases were searched in January 2022. Search results were supplemented...
Source: Skin Pharmacology and Physiology - August 31, 2022 Category: Dermatology Source Type: research
