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Specialty: Biochemistry
Drug: Lortab
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Total 74 results found since Jan 2013.
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study
CONCLUSION: The results of this study support the significant hepatoprotective effect of SLB nanoliposomes against acetaminophen-induced toxicity depending on the route of administration.PMID:37506470 | DOI:10.1016/j.bbrc.2023.07.045
Source: Biochemical and Biophysical Research communications - July 28, 2023 Category: Biochemistry Authors: Fatemeh Gheybi Alireza Khooei Azam Hoseinian Maham Doagooyan Kebria Houshangi Mahmoud Reza Jaafari Arash Papi Zahra Khoddamipour Amirhossein Sahebkar Seyedeh Hoda Alavizadeh Source Type: research
Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets
In conclusion, platelets from healthy donors represents a population of cells easily available, which can be routinely used in studies assessing mitochondrial drug toxicity. Whether these results can be recapitulated in patients treated with these medications is worth further investigation as potential peripheral biomarker of drug overdose.PMID:37486451 | DOI:10.1007/s11010-023-04814-z
Source: Molecular and Cellular Biochemistry - July 24, 2023 Category: Biochemistry Authors: Alina Maria Be ţiu Rodica Lighezan Vlad Florian Avram Danina Mirela Muntean Eskil Elm ér Lucian Petrescu Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
Dose-dependent effects of acetaminophen and ibuprofen on mitochondrial respiration of human platelets
In conclusion, platelets from healthy donors represents a population of cells easily available, which can be routinely used in studies assessing mitochondrial drug toxicity. Whether these results can be recapitulated in patients treated with these medications is worth further investigation as potential peripheral biomarker of drug overdose.PMID:37486451 | DOI:10.1007/s11010-023-04814-z
Source: Molecular and Cellular Biochemistry - July 24, 2023 Category: Biochemistry Authors: Alina Maria Be ţiu Rodica Lighezan Vlad Florian Avram Danina Mirela Muntean Eskil Elm ér Lucian Petrescu Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
Novel ruthenium-doped vanadium carbide/polymeric nanohybrid sensor for acetaminophen drug detection in human blood
Int J Biol Macromol. 2023 Jun 10:125329. doi: 10.1016/j.ijbiomac.2023.125329. Online ahead of print.ABSTRACTThe use of advanced electroactive catalysts enhances the performance of electrochemical biosensors in real-time biomonitoring and has received much attention owing to its excellent physicochemical and electrochemical possessions. In this work, a novel biosensor was developed based on the electrocatalytic activity of functionalized vanadium carbide (VC) material, including VC@ruthenium (Ru), VC@Ru-polyaniline nanoparticles (VC@Ru-PANI-NPs) as non-enzymatic nanocarriers for the fabrication of modified screen-printed el...
Source: International Journal of Biological Macromolecules - June 12, 2023 Category: Biochemistry Authors: Murugesan Duraisamy Mari Elancheziyan Muthusankar Eswaran Sivarasan Ganesan Anees A Ansari Govindaraj Rajamanickam Siew Ling Lee Pei-Chien Tsai Yi-Hsun Chen Vinoth Kumar Ponnusamy Source Type: research
Acetaminophen exposure alters the DNA methylation pattern of Mugilogobius chulae, along with the changes in the Nrf2-Keap1 signaling pathway
Comp Biochem Physiol C Toxicol Pharmacol. 2023 May 13:109655. doi: 10.1016/j.cbpc.2023.109655. Online ahead of print.ABSTRACTDNA methylation can dynamically regulate multiple physiological processes in organisms in response to changes of the external environment. The effects of acetaminophen (APAP) on DNA methylation in aquatic organisms and its toxic mechanisms is an interesting issue. In the present study, Mugilogobius chulae (Approximately 225 individual), a small benthic native fish, were employed to assess the toxic effects of APAP-exposure on non-target organisms. First, under APAP exposure (0.5 μg/L and 500 μg/L) ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - May 15, 2023 Category: Biochemistry Authors: Tianli Tang Yimeng Wang Chao Wang Yufei Zhao Xiangping Nie Source Type: research
Design, synthesis and anti-inflammatory activity of diterpenoid alkaloids and non-steroidal anti-inflammatory drug hybrids based on molecular hybridization strategy
In this study, we synthesized 25 diterpenoid alkaloid derivatives with NSAIDs, organized into four series. Among these derivatives, lappaconitine derivative 1e demonstrated the strongest inhibition of lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells with minimal cytotoxicity. Additionally, 1e effectively suppressed the inflammatory response induced by carrageenan in vivo, with a swelling rate of only 1%. This anti-inflammatory potency was found to be significantly superior to that of naproxen. The molecular docking analysis revealed that the binding affinity of 1e was scored as -10.3 kcal/mol, suggesting t...
Source: Fitoterapia - May 10, 2023 Category: Biochemistry Authors: Ming-Hao Guo Peng Wen Yao Xiao Wan-Sheng Ji Xian-Li Zhou Feng Gao Lian-Hai Shan Source Type: research
8-methoxypsoralen protects against acetaminophen-induced liver injury by antagonising Cyp2e1 in mice
This study aimed to investigate the effect and mechanism of 8-methoxypsoralen (8-MOP) on acetaminophen (APAP)-induced hepatotoxicity in mice. The study found that one hour after intraperitoneal injection of 300 mg/kg APAP, treatment with 40 mg/kg,80 mg/kg and 120 mg/kg 8-MOP could reduce serum transaminase level and histopathological liver necrosis area. Elevated mRNA expression of liver inflammatory mediators caused by excessive APAP was also reversed. 8-MOP significantly reduced APAP-induced hepatotoxicity dose-dependently, and the highest therapeutic dose of 8-MOP (120 mg/kg) had no harmful effects on the liver. Cocktai...
Source: Archives of Biochemistry and Biophysics - April 30, 2023 Category: Biochemistry Authors: Shasha Liu Ruohan Cheng Hui He Kunming Ding Rongmi Zhang Yuanyuan Chai Qinwei Yu Xin Huang Luyong Zhang Zhenzhou Jiang Source Type: research
Comparisons of physicochemical features and hepatoprotective potentials of unprocessed and processed polysaccharides from Polygonum multiflorum Thunb
This study also proposed a new hypothesis that the significant increase of polysaccharide content in processed PM may be another reason that the product PM causes less liver injury.PMID:36871693 | DOI:10.1016/j.ijbiomac.2023.123901
Source: International Journal of Biological Macromolecules - March 5, 2023 Category: Biochemistry Authors: Ying Wang Jianbo Yang Hongyu Jin Donglin Gu Qi Wang Yue Liu Ke Zan Jing Fan Rong Wang Feng Wei Shuangcheng Ma Source Type: research
