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Drug: Lortab
Nutrition: Antidoxidants
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Total 768 results found since Jan 2013.
Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice
Biol Trace Elem Res. 2023 Sep 13. doi: 10.1007/s12011-023-03845-3. Online ahead of print.ABSTRACTOverdose of acetaminophen (paracetamol), a widely used non-prescriptive analgesic and antipyretic medication, is one of the main causes of drug-induced acute liver failure around the world. Oxidative stress contributes to this hepatotoxicity. Antioxidants are known to protect the liver from oxidative stress. Selenium, a potent antioxidant, is a commonly used micronutrient. Here, we evaluated the protective effect of selenium on acetaminophen-induced hepatotoxicity. Treating Wistar albino mice with sodium selenite (1 mg/kg) befo...
Source: Biological Trace Element Research - September 13, 2023 Category: Biology Authors: Mylanayakanahosahalli Chandrashekar Indumathi Kamatam Swetha Kandahalli Venkataranganayaka Abhilasha Shiva Siddappa Shivamadhaiah Manjula Kumar Govinda Keerthi Prasad Chu-Huang Chen Gopal Kedihithlu Marathe Source Type: research
Layer-by-layer reinforced-mediated sustained-release nanoantioxidants for long-lasting prevention against drug-induced liver injury
Colloids Surf B Biointerfaces. 2023 Aug 1;230:113489. doi: 10.1016/j.colsurfb.2023.113489. Online ahead of print.ABSTRACTDrug-induced liver injury (DILI) is a commonly encountered and diagnostically complex etiology of acute liver failure, characterized by early indications of hepatic oxidative stress. The most economical approach for DILI treatment is effective and durable oxidative stress prevention. Herein, we propose a long-lasting nanoantioxidant called PDA-Zn-BAI NPs characterized by sustained-release of baicalein (a natural antioxidant) for the long-lasting prevention of DILI. It is constructed using dopamine as an ...
Source: Colloids and Surfaces - August 14, 2023 Category: Biotechnology Authors: Peng Tang Huiyin Wu Mengru Wang Yongpeng Wang Ruihan Zhang Xingjie Zhang Xiaoli Li Bin Liang Weilie Xiao Source Type: research
Tangeretin and 4'-demethyltangeretin prevent damage to mouse hepatocytes from oxidative stress by activating the Nrf2-related antioxidant pathway via an epigenetic mechanism
In this study we examined the effects of tangeretin (TAN), a common citrus PMF, and its metabolite 4'-demethyltangeretin (4'-OH-TAN) on activation of the Nrf2 antioxidant system in mouse AML-12 hepatocytes through regulation by epigenetic mechanisms. The ability of TAN and 4'-OH-TAN to inhibit APAP-induced hepatotoxicity was also evaluated. The results showed that TAN and 4'-OH-TAN significantly increased the mRNA and protein levels of Nrf2 and Nrf2-mediated antioxidant and detoxifying enzymes (UGT1A, HO-1, and NQO1) in AML-12 cells. TAN and 4'-OH-TAN also suppressed protein expression of histone deacetylases (HDACs) and D...
Source: Chemico-Biological Interactions - July 30, 2023 Category: Molecular Biology Authors: Zheng-Yuan Su Jen-Chun Chien Yen-Chen Tung Tien-Yuan Wu Jie-An Liao Guor-Jien Wei Source Type: research
Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study
CONCLUSION: The results of this study support the significant hepatoprotective effect of SLB nanoliposomes against acetaminophen-induced toxicity depending on the route of administration.PMID:37506470 | DOI:10.1016/j.bbrc.2023.07.045
Source: Cell Research - July 28, 2023 Category: Cytology Authors: Fatemeh Gheybi Alireza Khooei Azam Hoseinian Maham Doagooyan Kebria Houshangi Mahmoud Reza Jaafari Arash Papi Zahra Khoddamipour Amirhossein Sahebkar Seyedeh Hoda Alavizadeh Source Type: research
Excessive N-acetylcysteine exaggerates glutathione redox homeostasis and apoptosis during acetaminophen exposure in Huh-7 human hepatoma cells
Biochem Biophys Res Commun. 2023 Jul 20;676:66-72. doi: 10.1016/j.bbrc.2023.07.023. Online ahead of print.ABSTRACTAcetaminophen (APAP) hepatotoxicity is one of the biggest drawbacks of this relatively safe and widely used drug. In addition to its hepatotoxicity, APAP also cause comparable levels of toxicity on human hepatoma cells. Here we show activation of the intrinsic caspase-9/3 pathway of apoptosis followed by gasdermin E (GSDME) cleavage and subsequent ballooning in APAP (10 mM, 72 h)-treated Huh-7 human hepatocarcinoma cells. N-acetylcysteine (NAC), an antioxidant currently used as an antidote for APAP overdose, do...
Source: Biochemical and Biophysical Research communications - July 24, 2023 Category: Biochemistry Authors: Toshihiko Aki Hiroki Tanaka Takeshi Funakoshi Kana Unuma Koichi Uemura Source Type: research
The effects of subtoxic dose of acetaminophen combined with exercise on the liver of rats
Physiol Res. 2023 Jul 14;72(3):383-392.ABSTRACTRegular physical exercise is beneficial to the body. Acute exercise causes oxidant stress in many tissues including the liver by creating an unbalanced status between oxidant and antioxidant levels. Analgesic drugs are commonly consumed to reduce the pain after exercise. Acetaminophen (APAP), commonly used as an over-the-counter analgesic, can cause hepatotoxicity. The aim of this study was to investigate the effect and underlying mechanisms of APAP at subtoxic dose, which is given after the acute and exhaustive exercise on the rat livers. Male Wistar rats weighing 200-250 g w...
Source: Physiological Research - July 14, 2023 Category: Physiology Authors: I Aksu M Kiray C Gencoglu A Tas O Acikgoz Source Type: research
Xanthohumol protect against acetaminophen-induced hepatotoxicity via Nrf2 activation through the AMPK/Akt/GSK3 β pathway
CONCLUSION: Thus, xanthohumol exerted a hepatoprotective effect by inhibiting oxidative stress and mitochondrial dysfunction through the AMPK/Akt/GSK3β/Nrf2 antioxidant pathway.PMID:37406514 | DOI:10.1016/j.biopha.2023.115097
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2023 Category: Drugs & Pharmacology Authors: Laiyu Zhu Xiaoye Fan Chunyuan Cao Kailiang Li Wenli Hou Xinxin Ci Source Type: research
