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Drug: Lithium
Therapy: Stem Cell Therapy

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Total 37 results found since Jan 2013.

Selectivity of cation transport across lipid membranes by the antibiotic salinomycin
Biochim Biophys Acta Biomembr. 2023 Jun 3:184182. doi: 10.1016/j.bbamem.2023.184182. Online ahead of print.ABSTRACTThe ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding, the data on its ion selectivity, although being critical for its therapeutic activity, are rather scarce. In the present work, we studied the ability of salinomycin to exert cation/H+-exchange across artificial bilayer lipid membranes (BLM) by measuring electrical potential on planar BLM in the presence of a protonophore and fluorescence responses of the...
Source: Biochimica et Biophysica Acta - June 5, 2023 Category: Biochemistry Authors: Tatyana I Rokitskaya Alexander M Firsov Ljudmila S Khailova Elena A Kotova Yuri N Antonenko Source Type: research

Hydrogel microenvironment contributes to chemical-induced differentiation of mesenchymal stem cells: single-cell infrared microspectroscopy characterization
Anal Bioanal Chem. 2023 May 16. doi: 10.1007/s00216-023-04746-z. Online ahead of print.ABSTRACTStem cell microenvironment plays vital roles in directing cell proliferation and differentiation. Due to the tiny biochemical changes in the early stage of stem cell development, technical challenges to characterize the potential effects of environmental signals remain. In this work, we have introduced synchrotron radiation-based Fourier transform infrared microspectroscopy to evaluate the synergistic effects of physical and chemical factors on stem cell differentiation at the single-cell level. By using principal component analy...
Source: Analytical and Bioanalytical Chemistry - May 16, 2023 Category: Chemistry Authors: Jiang Qian Yadi Wang Xueling Li Junhong L ü Source Type: research

Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Evaluation of in vivo lithium chloride effects as a GSK3- β inhibitor on human adipose derived stem cells differentiation into oligodendrocytes and re-myelination in an animal model of multiple sclerosis
Mol Biol Rep. 2022 Dec 17. doi: 10.1007/s11033-022-08181-8. Online ahead of print.NO ABSTRACTPMID:36526850 | DOI:10.1007/s11033-022-08181-8
Source: Molecular Biology Reports - December 16, 2022 Category: Molecular Biology Authors: Sahar Ghosouri Mitra Soleimani Mohammad Bakhtiari Nazem Ghasemi Source Type: research

Species-Based Differences in Mechanical Properties, Cytocompatibility, and Printability of Methacrylated Collagen Hydrogels
Biomacromolecules. 2022 Nov 23. doi: 10.1021/acs.biomac.2c00985. Online ahead of print.ABSTRACTCollagen methacrylation is a promising approach to generate photo-cross-linkable cell-laden hydrogels with improved mechanical properties. However, the impact of species-based variations in amino acid composition and collagen isolation method on methacrylation degree (MD) and its subsequent effects on the physical properties of methacrylated collagen (CMA) hydrogels and cell response are unknown. Herein, we compared the effects of three collagen species (bovine, human, and rat), two collagen extraction methods (pepsin digestion a...
Source: Biomacromolecules - November 23, 2022 Category: Biochemistry Authors: Sarah M Ali Nashaita Y Patrawalla Nilabh S Kajave Alan B Brown Vipuil Kishore Source Type: research

Knockdown of CDC20 promotes adipogenesis of bone marrow-derived stem cells by modulating β-catenin
CONCLUSIONS: Our findings showed that CDC20 knockdown enhanced adipogenesis of hBMSC and mBMSCs adipogenesis in vitro and in vivo. CDC20 regulates both adipogenesis and osteogenesis of BMSCs, and might lead to the development of new therapeutic targets for "fatty bone" and osteoporosis.PMID:36056439 | DOI:10.1186/s13287-022-03062-0
Source: Cell Research - September 2, 2022 Category: Cytology Authors: Yangge Du Yunsong Liu Yongsheng Zhou Ping Zhang Source Type: research

The binary combined toxicity of lithium, lead, and manganese on the proliferation of murine neural stem cells using two different models
In conclusion, our study highlights the complexity of the mixtures' interaction patterns and the possible neuroprotective effect of Li under certain conditions. In the future, more research on different levels of metal mixtures, especially Li metal, is necessary to evaluate their underlying interactions and contribute to establishing risk assessment systems.PMID:35976582 | DOI:10.1007/s11356-022-22433-x
Source: Environmental Science and Pollution Research International - August 17, 2022 Category: Environmental Health Authors: Huan Luo Jiayi Li Bo Song Bing Zhang Yixi Li Zhijun Zhou Xiuli Chang Source Type: research

Fight Aging! Newsletter, August 8th 2022
In conclusion, aging research will benefit from a better definition of how specific regulators map onto age-dependent change, considered on a phenotype-by-phenotype basis. Resolving some of these key questions will shed more light on how tractable (or intractable) the biology of aging is. Does Acarbose Extend Life in Short Lived Species via Gut Microbiome Changes? https://www.fightaging.org/archives/2022/08/does-acarbose-extend-life-in-short-lived-species-via-gut-microbiome-changes/ Acarbose is one of a few diabetes medications shown to modestly slow aging in short-lived species. Researchers here take a ...
Source: Fight Aging! - August 7, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs