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Infectious Disease: HIV AIDS
Drug: Insulin

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Total 55 results found since Jan 2013.

Amino acid metabolism dysregulation associated with inflammation and insulin resistance in HIV-infected individuals with metabolic disorders
In this study, we performed targeted metabolomic analyses on 64 patients with HIV/AIDS and 21 healthy controls. Twenty-four amino acids and selected intermediate metabolites in the serum were quantitatively detected using high-performance liquid chromatography-tandem mass spectrometry, and characteristic changes and metabolic pathways were analyzed in HIV-infected patients with different degrees of abnormal glucose and lipid metabolism. Spearman's partial correlation was used to analyze the association between amino acids, biochemical parameters, and inflammatory cytokines. The results showed that the main metabolic pathwa...
Source: Amino Acids - September 19, 2023 Category: Biochemistry Authors: Jing Zhang Yanfang Chen Mingli Wang Liuting Zhong Linghua Li Zhongwen Yuan Shangrong Zou Source Type: research

Dolutegravir use over 48 weeks is not associated with worsening insulin resistance and pancreatic beta cell function in a cohort of HIV-infected Ugandan adults
CONCLUSION: We demonstrated insignificant changes in both insulin resistance and pancreatic beta cell function in clinically stable young adult Ugandan PWH on dolutegravir for 48 weeks. We add to the body of evidence demonstrating glucose metabolic safety of dolutegravir in ART naïve patients. Ugandan guidelines should reconsider restricting DTG initiation in ART naive adults at high risk for diabetes.PMID:37689695 | DOI:10.1186/s12981-023-00564-6
Source: AIDS Research and Therapy - September 9, 2023 Category: Infectious Diseases Authors: Frank Mulindwa Barbara Castelnuovo Nele Brusselaers Martin Nabwana Robert Bollinger Allan Buzibye Eva Laker Agnes Odongpiny Ronald Kiguba Jean-Marc Schwarz Source Type: research

HIV infection in adult Ugandans with new-onset type 2 diabetes: exploring its influence on the anthropometric and metabolic profile
CONCLUSION: In our study population, HIV infection was not associated with increased adiposity, pancreatic beta-cell function, and insulin resistance. Large prospective studies are needed to investigate the effect of HIV on the pathogenesis of type 2 diabetes in adult Ugandans.PMID:37596620 | PMC:PMC10439581 | DOI:10.1186/s12981-023-00553-9
Source: AIDS Research and Therapy - August 18, 2023 Category: Infectious Diseases Authors: Davis Kibirige Isaac Sekitoleko Noela Owarwo Irene Andia-Biraro William Lumu Source Type: research

Auto adaptation of closed-loop insulin delivery system using continuous reward functions and incremental discretization
Comput Methods Biomech Biomed Engin. 2023 Aug 7:1-12. doi: 10.1080/10255842.2023.2241945. Online ahead of print.ABSTRACTSeveral closed or hybrid loop controllers for Blood Glucose (BG) regulation, which are also known as Artificial Pancreas (AP) Systems or Automated Insulin Delivery systems (AIDs), are in development worldwide. Most AIDs are designed and evaluated for short-term performance, with a particular emphasis on the post-meal period. However, if controllers are not adapted properly to account for variations in physiology that affect Insulin Sensitivity (IS), the AIDs may perform inadequately. In this work, the per...
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 7, 2023 Category: Biomedical Engineering Authors: Maria Cecilia Serafini Nicolas Rosales Fabricio Garelli Source Type: research

An aerobic exercise intervention to improve metabolic health among people living with HIV with at-risk alcohol use: the ALIVE-Ex research study protocol
CONCLUSIONS: The proposed intervention will also have the potential to be scalable to promote lifestyle changes among PLWH, particularly in underserved communities.PMID:37296413 | DOI:10.1186/s12981-023-00530-2
Source: AIDS Research and Therapy - June 9, 2023 Category: Infectious Diseases Authors: Liz Simon Stefany D Primeaux Danielle E Levitt Brianna Bourgeois Neil M Johannsen Adrianna Peters Jameel Ahmed Richard H Marshall Alexandra H Fairchild Tekeda F Ferguson Patricia E Molina Source Type: research

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Thioredoxin Interacting Protein Inhibitors In Diabetes Mellitus: A Critical Review
Curr Drug Res Rev. 2023 Feb 14. doi: 10.2174/2589977515666230214101808. Online ahead of print.ABSTRACTDiabetes Mellitus (DM)is one of the highest contributors to global mortality, exceeding numbers of even the three major infectious diseases in the world, namely Tuberculosis, HIV AIDS, and Malaria. DM is characterised by increased serum levels of glucose caused by a loss of beta cells of the pancreatic islets, responsible for the secretion of insulin. Upon accumulation of data via a wide array of literature surveys, it has been found that Thioredoxin Interacting Protein (TXNIP)presents itself as a vital factor in controlli...
Source: Cell Research - February 14, 2023 Category: Cytology Authors: Ayushi Kar P Balamurugan J Darshini A K Swaroop Jubie Selvaraj Source Type: research

Class II two-peptide lanthipeptide proteases: exploring LicTP for biotechnological applications
Appl Microbiol Biotechnol. 2023 Feb 10. doi: 10.1007/s00253-023-12388-5. Online ahead of print.ABSTRACTThe enzymatic machinery involved in the biosynthesis of lantibiotic is an untapped source of proteases with different specificities. Lanthipeptide biosynthesis requires proteolysis of specific target sequences by known proteases, which are encoded by contiguous genes. Herein, the activity of lichenicidin A2 (LicA2) trimming proteases (LicP and LicT) was investigated in vivo. Firstly, the impact of some residues and the size of the peptide were evaluated. Then followed trials in which LicA2 leader was evaluated as a tag to...
Source: Applied Microbiology and Biotechnology - February 10, 2023 Category: Microbiology Authors: Joana C Barbosa Eva M ösker Raquel Faria Roderich D S üssmuth S ónia Mendo T ânia Caetano Source Type: research

Fight Aging! Newsletter, January 16th 2023
Conclusions Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue Assessment of Somatic Mosaicism as a Biomarker of Aging The Gut Microbiome of Centenarians https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/ The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other fu...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs