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Total 211 results found since Jan 2013.

Transcriptome-based analysis of human peripheral blood reveals regulators of immune response in different viral infections
DiscussionThe identified relationships between some of them and virus-induced alteration of immune functions are new and have not been found earlier, e.g., receptors for autocrine motility factor, insulin, prolactin, angiotensin II, and immunoglobulin epsilon. Modulation of the identified receptors can be investigated as one of therapeutic strategies for the treatment of severe viral infections.
Source: Frontiers in Immunology - September 19, 2023 Category: Allergy & Immunology Source Type: research

Fight Aging! Newsletter, September 18th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reduced SARS-CoV-2 mRNA vaccine immunogenicity and protection in mice with diet-induced obesity and insulin resistance
CONCLUSION: We demonstrate impaired immunity following SARS-CoV-2 mRNA immunization in a murine model of comorbid T2DM and obesity, supporting the need for further research into the basis for impaired anti-SARS-CoV-2 immunity in T2DM and investigation of novel approaches to enhance vaccine immunogenicity among those with metabolic diseases.PMID:37595760 | DOI:10.1016/j.jaci.2023.06.031
Source: Clinical Lung Cancer - August 18, 2023 Category: Cancer & Oncology Authors: Timothy R O'Meara Etsuro Nanishi Marisa E McGrath Soumik Barman Danica Dong Carly Dillen Manisha Menon Hyuk-Soo Seo Sirano Dhe-Paganon Robert K Ernst Ofer Levy Matthew B Frieman David J Dowling Source Type: research

Long COVID-19 and Insulin Autoimmune Syndrome: A Case Report
Clin Ther. 2023 Jul 29:S0149-2918(23)00250-3. doi: 10.1016/j.clinthera.2023.06.026. Online ahead of print.ABSTRACTPURPOSE: To describe a case report of a patient with symptoms associated with metabolic alterations 1 month after having COVID-19.METHODS: Laboratory tests, clinical evaluations, and body composition assessments were performed by specialists.FINDINGS: The patient presented excessive sweating, hot flashes, dizziness, blurred vision, and seizure. Laboratory tests indicated low glucose levels after convulsions (50, 42.7, and 55 mg/dL), high insulin levels (basal, 638 µIU/mL; 2-hour, >1000 µU/mL), and positivi...
Source: Clinical Therapeutics - July 31, 2023 Category: Drugs & Pharmacology Authors: Fernanda Isadora Corona-Meraz Blanca Perla Quintero-Castillo Luis Alexis Hern ández-Palma Andrea Carolina Machado-Sulbaran Source Type: research

New-Onset Fulminant Type 1 Diabetes Following SARS-CoV-2 Protein Subunit Vaccine: A Case Report and Literature Review
We report a rare case of a 39-year-old woman who suffered from severe hyperglycemia and ketoacidosis with normal hemoglobin A1c four days after SARS-CoV-2 protein subunit vaccine, which is consistent with the diagnosis of fulminant type 1 diabetes (FT1D). She received insulin therapy and recovered after 24 days from onset of the symptoms. This is the first case of new-onset FT1D after SARS-CoV-2 protein subunit vaccination and one of only six that developed after any form of SARS-CoV-2 vaccination. We hope to raise awareness of this potential adverse consequence and recommend careful monitoring after vaccination in patient...
Source: J Korean Med Sci - June 20, 2023 Category: General Medicine Authors: Lanhui Huang Min Liang Yuling He Source Type: research

Cardiovascular complications of diabetes: role of non-coding RNAs in the crosstalk between immune and cardiovascular systems
Cardiovasc Diabetol. 2023 May 24;22(1):122. doi: 10.1186/s12933-023-01842-3.ABSTRACTDiabetes mellitus, a group of metabolic disorders characterized by high levels of blood glucose caused by insulin defect or impairment, is a major risk factor for cardiovascular diseases and related mortality. Patients with diabetes experience a state of chronic or intermittent hyperglycemia resulting in damage to the vasculature, leading to micro- and macro-vascular diseases. These conditions are associated with low-grade chronic inflammation and accelerated atherosclerosis. Several classes of leukocytes have been implicated in diabetic ca...
Source: Atherosclerosis - May 24, 2023 Category: Cardiology Authors: Gaia Spinetti Martina Mutoli Simona Greco Federica Riccio Soumaya Ben-Aicha Franziska Kenneweg Amela Jusic David de Gonzalo-Calvo Anne Ya ël Nossent Susana Novella Georgios Kararigas Thomas Thum Costanza Emanueli Yvan Devaux Fabio Martelli Source Type: research

New-Onset Diabetes after COVID-19
J Clin Endocrinol Metab. 2023 May 19:dgad284. doi: 10.1210/clinem/dgad284. Online ahead of print.ABSTRACTThere is evidence suggesting that infection with SARS-CoV-2 can lead to several long-term sequelae including diabetes. This mini-review examines the rapidly evolving and conflicting literature on new-onset diabetes after COVID-19, which we term NODAC. We searched PubMed, MEDLINE, and medRxiv from inception until December 1, 2022 using both MeSH terms and free text words including "COVID-19," "SARS-CoV-2," "diabetes," "hyperglycemia," "insulin resistance," and "pancreatic β-cell." We also supplemented searches by examin...
Source: The Journal of Clinical Endocrinology and Metabolism - May 19, 2023 Category: Endocrinology Authors: Sun H Kim Ipsa Arora Daniel S Hsia William C Knowler Erin LeBlanc Eleftherios Mylonakis Richard Pratley Anastassios G Pittas Source Type: research