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Drug: Coumadin

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Total 209 results found since Jan 2013.

Clinical pre ‐test of a computerised antithrombotic risk assessment tool for stroke prevention in atrial fibrillation patients: giving consideration to NOACs
ConclusionsAccording to this decision support tool, both warfarin and NOACs are viable treatment options in majority of the patients, but there is a scope for better rationalization of therapy.
Source: Journal of Evaluation in Clinical Practice - June 6, 2016 Category: Journals (General) Authors: Yishen Wang, Beata Bajorek Tags: Original Article Source Type: research

Clinical pre‐test of a computerised antithrombotic risk assessment tool for stroke prevention in atrial fibrillation patients: giving consideration to NOACs
ConclusionsAccording to this decision support tool, both warfarin and NOACs are viable treatment options in majority of the patients, but there is a scope for better rationalization of therapy.
Source: Journal of Evaluation in Clinical Practice - May 31, 2016 Category: Journals (General) Authors: Yishen Wang, Beata Bajorek Tags: Original Article Source Type: research

WITHDRAWN: Antiplatelet agents versus control or anticoagulation for heart failure in sinus rhythm.
CONCLUSIONS: At present there is little evidence from long term RCTs to recommend the use of antiplatelet therapy to prevent thromboembolism in patients with heart failure in sinus rhythm. A possible interaction with ACE inhibitors may reduce the efficacy of aspirin, although this evidence is mainly from retrospective analyses of trial cohorts and two RCTs. There is also no current evidence to support the use of oral anticoagulation (when compared to aspirin/clopidogrel) in patients with heart failure in sinus rhythm. Anticoagulation/antiplatelet therapy should be reserved for heart failure patients with other comorbiditie...
Source: Cochrane Database of Systematic Reviews - May 2, 2016 Category: Journals (General) Authors: Lip GY, Wrigley BJ, Pisters R Tags: Cochrane Database Syst Rev Source Type: research

A review of the role of anticoagulation for patients with infective endocarditis and embolic stroke
Key Clinical Message Stroke is a common embolic complication of infective endocarditis. The most important treatment to prevent stroke in endocarditis is the initiation of antibiotic therapy. It is unclear whether the initiation of de novo anticoagulation (i.e, warfarin) in patients with infective endocarditis is beneficial, since there are no large or randomized controlled trials in this area. However, this case report suggests, despite the limited evidence, that anticoagulation in this patient caused no harm and could suggest a hint of possible benefit. Stroke is a common embolic complication of infective endocarditis. ...
Source: Clinical Case Reports - April 12, 2016 Category: Journals (General) Authors: Arfah Hazel Preston, Stefan Williams, Judy Archer Tags: Case Report Source Type: research

The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study
Publication date: Available online 4 April 2016 Source:The Lancet Author(s): Ziad Hijazi, Jonas Oldgren, Johan Lindbäck, John H Alexander, Stuart J Connolly, John W Eikelboom, Michael D Ezekowitz, Claes Held, Elaine M Hylek, Renato D Lopes, Agneta Siegbahn, Salim Yusuf, Christopher B Granger, Lars Wallentin Background The benefit of oral anticoagulation in atrial fibrillation is based on a balance between reduction in ischaemic stroke and increase in major bleeding. We aimed to develop and validate a new biomarker-based risk score to improve the prognostication of major bleeding in patients with atrial fib...
Source: The Lancet - April 4, 2016 Category: Journals (General) Source Type: research

Comment Can biomarkers balance stroke and bleeding risk?
Age and previous stroke, together with other clinical risk factors (often summarised in the CHA2DS2VASc score), identify patients with atrial fibrillation at high risk for stroke. Dose-adjusted warfarin prevents ischaemic strokes, prolongs life, and maintains autonomy in such patients.1,2 Hence, oral anticoagulation is currently recommended for all patients with atrial fibrillation with two of the CHA2DS2VASc risk factors, and should be considered in those with one of them.1,2 Although even reinitiation of anticoagulation after an intracerebral bleed seems to be associated with improved outcomes,3,4 bleeding is a major rea...
Source: LANCET - April 3, 2016 Category: Journals (General) Authors: Paulus Kirchhof, Larissa Fabritz Tags: Comment Source Type: research

Migrating susceptibility vessel sign in posterior circulation stroke
A 95-year-old woman with atrial fibrillation was admitted with acute onset of disturbed consciousness. On admission, neurological deficits rapidly improved and completely disappeared. The prothrombin time-international normalized ratio (PT-INR) was 1.4 although she was medicated with warfarin (2.5 mg/day). Brain magnetic resonance (MR) imaging with diffusion-weighted imaging (DWI) findings on admission were normal, but MR angiography (MRA) detected basilar-top occlusion and susceptibility-weighted imaging (SWI) confirmed the susceptibility vessel sign at the basilar top (Fig.
Source: The American Journal of Medicine - March 11, 2016 Category: Journals (General) Authors: Teppei Komatsu, Hidetaka Mitsumura, Satoshi Matsushima, Yasuyuki Iguchi Tags: Clinical Communication to the Editor Source Type: research

Migrating Susceptibility Vessel Sign in Posterior Circulation Stroke
A 95-year-old woman with atrial fibrillation was admitted with acute onset of disturbed consciousness. On admission, neurological deficits rapidly improved and completely disappeared. The prothrombin time –international normalized ratio was 1.4 although she was medicated with warfarin (2.5 mg/day). Brain magnetic resonance (MR) imaging with diffusion-weighted imaging (DWI) findings on admission were normal, but MR angiography (MRA) detected basilar-top occlusion, and susceptibility-weighted imaging (SWI) confirmed the susceptibility vessel sign at the basilar top (Figure, A and E).
Source: The American Journal of Medicine - March 10, 2016 Category: Journals (General) Authors: Teppei Komatsu, Hidetaka Mitsumura, Satoshi Matsushima, Yasuyuki Iguchi Tags: AJM online Source Type: research

Clinical Results of Left Atrial Appendage Closure with Watchman Device in Patients with Atrial Fibrillation.
CONCLUSION: The result of the present study showed that percutaneous LAA occlusion with the Watchman device was feasible and safe. The successfulness of the procedures and periprocedural complications were similar to standard in literature. PMID: 26638585 [PubMed - in process]
Source: Journal of the Medical Association of Thailand = Chotmaihet thangphaet - December 20, 2015 Category: Journals (General) Tags: J Med Assoc Thai Source Type: research

Antithrombotic therapy in patients with combined coronary heart disease and atrial fibrillation.
CONCLUSION: In each clinical scenario, the risks of coronary artery or stent thrombosis in CHD and risks of stroke in AF need to be carefully balanced against the risks of bleeding. We make recommendations for management based on the evidence which is available at this time and indicate the many gaps which are currently being addressed by randomised clinical trials. PMID: 26658287 [PubMed - as supplied by publisher]
Source: Panminerva Medica - December 15, 2015 Category: Journals (General) Tags: Panminerva Med Source Type: research

Primary Care Atrial Fibrillation Service: outcomes from consultant-led anticoagulation assessment clinics in the primary care setting in the UK
Conclusions Systematic identification of patients with AF with high stroke-risk and consultation in PCAF consultant-led clinics effectively delivers oral anticoagulation to high-risk patients with AF in the community.
Source: BMJ Open - December 9, 2015 Category: Journals (General) Authors: Das, M., Panter, L., Wynn, G. J., Taylor, R. M., Connor, N., Mills, J. D., Kirchhof, P., Gupta, D. Tags: Open access, Cardiovascular medicine, General practice / Family practice, Pharmacology and therapeutics Research Source Type: research

Atrial fibrillation and chronic kidney disease: focus on rivaroxaban.
Authors: Barrios V, Górriz JL Abstract Renal insufficiency increases the risk of stroke and bleeding in atrial fibrillation patients. Although vitamin K antagonists reduce the risk of stroke in patients with moderate renal dysfunction, this observation is less clear in patients with renal impairment. Moreover, the risk of bleeding with vitamin K antagonists increases as renal function worsens. Maintaining international normalized ratio values within therapeutic targets is more difficult in patients with renal dysfunction, and those agents may cause warfarin-related nephropathy and vascular calcification. Rivaroxa...
Source: Journal of Comparative Effectiveness Research - December 2, 2015 Category: Journals (General) Tags: J Comp Eff Res Source Type: research

Apixaban versus edoxaban for stroke prevention in nonvalvular atrial fibrillation.
Authors: Xiong Q, Lau YC, Lip GY Abstract Oral anticoagulation therapy is the mainstay of stroke prevention in nonvalvular atrial fibrillation patients. Vitamin K antagonists (such as warfarin) have been effective conventional oral anticoagulants for several decades. However, due to their limitations in clinical use, several nonvitamin K antagonist oral anticoagulants (NOACs, including dabigatran, rivaroxaban, apixaban and edoxaban) have been developed. Nonetheless, no head to head trials have been performed to directly compare these NOACs in patient cohorts. In this review article, two direct factor Xa inhibitors,...
Source: Journal of Comparative Effectiveness Research - December 2, 2015 Category: Journals (General) Tags: J Comp Eff Res Source Type: research

Prediction of individual combined benefit and harm for patients with atrial fibrillation considering warfarin therapy: a study protocol
This study has been approved by the KPCO Institutional Review Board and the Hamilton Integrated Research Ethics Board. Results from this study will be published in a peer-reviewed journal electronically and in print. The prediction models may aid in patient-physician shared decision-making when they are considering warfarin therapy.
Source: BMJ Open - November 5, 2015 Category: Journals (General) Authors: Li, G., Holbrook, A., Delate, T., Witt, D. M., Levine, M. A., Thabane, L. Tags: Open access, Cardiovascular medicine, Epidemiology, Pharmacology and therapeutics, Public health Protocol Source Type: research

Correspondence Intracerebral haemorrhage, atrial fibrillation, and anticoagulation – Authors' reply
We thank Duncan Wilson and colleagues for their comments about our Review.1 These authors discuss an important issue and suggest that non-vitamin K antagonist oral anticoagulants might provide a strong option to reduce ischaemic stroke in patients who have atrial fibrillation and have suffered an intracranial haemorrhage. A fundamental advantage of non-vitamin K antagonist oral anticoagulants over warfarin is the substantially lower risk of intracranial haemorrhage,2 and this feature might be particularly important for patients at high risk of intracranial haemorrhage, including those with previous history of this disorder.
Source: LANCET - October 30, 2015 Category: Journals (General) Authors: Freek W A Verheugt, Christopher B Granger Tags: Correspondence Source Type: research