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Total 84 results found since Jan 2013.

Comparison of hemodynamic effects of sevoflurane and ketamine as basal anesthesia by a new and direct monitoring during induction in children with ventricular septal defect: A prospective, randomized research
Background: Sevoflurane and ketamine are commonly used to obtain sedation and facilitate intravenous anesthetic induction in children undergoing cardiac surgery who are uncooperative. We used a new and direct systemic hemodynamic monitoring technique pressure recording analytical method and compared the hemodynamic effects of sevoflurane and ketamine to facilitate intravenous anesthetic induction. Methods: Forty-four children with ventricular septal defect (2.2 ± 1.2 years) were enrolled and randomized to receive sevoflurane (Group S) or intramuscular ketamine (Group K) for sedation, followed by intravenous mid...
Source: Medicine - December 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Total Intravenous Versus Volatile Induction and Maintenance of Anesthesia in Elective Carotid Endarterectomy: Effects on Cerebral Oxygenation and Cognitive Functions
Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD.
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 2, 2018 Category: Anesthesiology Authors: Vsevolod V. Kuzkov, Maxim Y. Obraztsov, Oleg Y. Ivashchenko, Nadezhda Y. Ivashchenko, Valery M. Gorenkov, Mikhail Y. Kirov Tags: Original Article Source Type: research

Effects of sevoflurane preconditioning on microglia/macrophage dynamics and phagocytosis profile against cerebral ischemia in rats.
CONCLUSIONS: Our current study has identified the impact of sevoflurane preconditioning on microglia/macrophage dynamics, including its migration, phagocytosis, and proliferation at early stage after brain ischemia and reperfusion. Sevoflurane might enhance microglia/macrophage activation and promote brain repair. These results could help to approach more relevant microglia/macrophage cell-based strategy for human stroke therapy. PMID: 29427321 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - February 9, 2018 Category: Neuroscience Authors: Dang DD, Saiyin H, Yu Q, Liang WM Tags: CNS Neurosci Ther Source Type: research

Inhalational anesthetics accelerate desensitization of acid-sensing ion channels.
Abstract Acid-sensing ion channels (ASICs) are neuronal Na+ channels that are activated by extracellular acidification. Inhibiting ASICs is neuroprotective in mouse models of ischemic stroke. As inhalational anesthetics interact with many ion channels and as some of them have neuroprotective effects, we hypothesized that inhalational anesthetics modulate ASICs. We expressed different homo- and heteromeric ASICs heterologously in Xenopus oocytes. We co-applied with acidic pH the halogenated inhalational anesthetics sevoflurane, desflurane, and isoflurane and the noble gases xenon and argon at concentrations that ar...
Source: Neuropharmacology - April 5, 2018 Category: Drugs & Pharmacology Authors: Lehmke L, Coburn M, Möller M, Blaumeiser-Debarry R, Lenzig P, Wiemuth D, Gründer S Tags: Neuropharmacology Source Type: research

Total Intravenous Versus Volatile Induction and Maintenance of Anesthesia in Elective Carotid Endarterectomy: Effects on Cerebral Oxygenation and Cognitive Functions
Carotid endarterectomy (CEA) is effective for the prevention of stroke, yet can be associated with a postoperative cognitive dysfunction (POCD) that may be affected by the type of anesthesia. The aim of the study was to compare the effects of total intravenous anesthesia (TIVA) with propofol to volatile induction and maintenance of anesthesia (VIMA) with sevoflurane on cerebral tissue oxygen saturation (SctO2) and POCD.
Source: Journal of Cardiothoracic and Vascular Anesthesia - February 2, 2018 Category: Anesthesiology Authors: Vsevolod V. Kuzkov, Maxim Y. Obraztsov, Oleg Y. Ivashchenko, Nadezhda Y. Ivashchenko, Valery M. Gorenkov, Mikhail Y. Kirov Tags: Original Article Source Type: research

Regulation of Tau Protein on the Antidepressant Effects of Ketamine in the Chronic Unpredictable Mild Stress Model
This study was carried out in accordance with the recommendations of the “Institutional Animal Care and Use Committee of China Medical University.” The protocol was approved by the “Institutional Animal Care and Use Committee of China Medical University.”Author ContributionsXWu and GW conceived and designed the experiments. YLi, RD, XR, WR, HYa, and YT performed the experiments. HYu, XZ, JY and XWa helped to analyze and interpret the data. GW drafted the manuscript. XWu, EX, YLu, and GZ provided critical revisions. All the authors reviewed and approved the final manuscript.FundingThe present stu...
Source: Frontiers in Psychiatry - April 29, 2019 Category: Psychiatry Source Type: research

Comparison of the Effects of Target-Controlled Infusion of Propofol and Sevoflurane as Maintenance of Anesthesia on Hemodynamic Profile in Kidney Transplantation.
Conclusion: Intraoperative hemodynamic profile was similar between the TCI propofol and sevoflurane group during kidney transplant surgery. The TCI propofol group had higher CI and SVI but showed significantly lower SVRI as compared to the sevoflurane group. The incidence of postanesthesia agitation, postoperative outcome, and complication were not significantly different between the two groups. PMID: 31885551 [PubMed]
Source: Anesthesiology Research and Practice - January 1, 2020 Category: Anesthesiology Tags: Anesthesiol Res Pract Source Type: research

Fast-track anesthesia in lateral mini-thoracotomy for transapical transcatheter valve implantation
CONCLUSIONS: Fast-track anesthesia using paravertebral-blockade for transcatheter transapical valve replacement in high-risk patients is a possible anesthetic approach. An effective PVB, in addition to a double-lumen laryngeal mask, provide an alternative strategy to conventional general anesthesia. These promising results could encourage further consideration of this approach in similar cardiac surgery patients.PMID:34527324 | PMC:PMC8411149 | DOI:10.21037/jtd-21-751
Source: Journal of Thoracic Disease - September 16, 2021 Category: Respiratory Medicine Authors: Ali Haddad Cynthia Szalai Lena van Brakel Yacine Elhmidi Sven Arends Marco Rabis Anca Pop Arjang Ruhparwar Thorsten Brenner Sharaf-Eldin Shehada Source Type: research